What should I avoid while taking Nortriptyline 25mg capsules?

Avoid alcohol. Take with or without food. Food decreases gastrointestinal irritation. (Source: DrugBank, licensed under CC BY-NC 4.0)

Do I need a prescription for Nortriptyline 25mg capsules?

Nortriptyline 25mg capsules is classified as a Valid as a prescribable product in the UK. However, always consult a pharmacist or doctor before use. (Source: NHS dm+d)

What are the brand names for Nortriptyline 25mg capsules?

Nortriptyline 25mg capsules is the generic name. It is available under brand names including: Nortriptyline 25mg capsules, Nortriptyline 25mg capsules, Nortriptyline 25mg capsules, Nortriptyline 25mg capsules, Nortriptyline 25mg capsules. (Source: NHS dm+d — Actual Medicinal Products)

Nortriptyline 25mg capsules

Prescription only

Requires a prescription from a doctor or prescriber

Capsule

25mg

Oral

Nortriptyline hydrochloride, the active metabolite of [amitriptyline], is a tricyclic antidepressant (TCA).[L11878] It is used in the treatment of major depression and is also used off-label for chronic pain and other conditions.[L11881]

Active ingredients:

Nortriptyline

BNF classificationBrowse formulary

Where this medicine sits in the British National Formulary — the UK's standard prescribing reference

BNF 04.03.01

ATC classificationBrowse ATC index

International classification by the WHO, grouping medicines by the organ system they act on

ATC N06AA10

Chemical classBrowse classes

Classification based on the molecule's chemical structure and properties

Check interactions for Nortriptyline

1 safety notice

Pharmacogenomics

Genetic variations that may affect drug response

7 known genetic variations may influence how your body responds to Nortriptyline 25mg capsules.Gene involved: CYP2D6

These are known genetic variations. They don't mean the medicine won't work for you — speak to your doctor or a pharmacogenomics specialist for personalised advice. Source: DrugBank (CC BY-NC 4.0).

rs3892097

CYP2D6

Cytochrome P450 2D6

Patients with this genotype have reduced metabolism of nortriptyline.

rs35742686

CYP2D6

Cytochrome P450 2D6

The presence of this polymorphism in CYP2D6 is associated with reduced or poor metabolism of nortriptyline.

rs3892097

CYP2D6

Cytochrome P450 2D6

The presence of this polymorphism in CYP2D6 is associated with reduced or poor metabolism of nortriptyline.

Official documents, adverse reaction reporting, and safety monitoring

Report a side effect

Submit a Yellow Card report to the MHRA

Official medicine documents

Yellow Card

Report side effects (MHRA)

Drug safety updates

MHRA alerts for Nortriptyline

Source: MHRA Products DatabaseOGL 3.0

Updated 3 months ago(16 Jan 2026)

Safety monitoring data

Yellow Card reports

MHRA

The MHRA Yellow Card scheme collects reports of suspected side effects from healthcare professionals and patients. View the Drug Analysis Profile (iDAP) for real-world adverse reaction data.

View Drug Analysis Profile

Suspected adverse reactions reported for Nortriptyline

Browse all iDAP reports

Interactive Drug Analysis Profiles for all medicines

Report a side effect

Submit a Yellow Card report to the MHRA

Data from the MHRA Yellow Card scheme. A reported reaction does not necessarily mean the medicine caused it. Contains public sector information licensed under the Open Government Licence v3.0.

EudraVigilance

EMA

The European Medicines Agency (EMA) collects suspected adverse reaction reports from across the EU/EEA through the EudraVigilance system. Search for safety data on this medicine.

View EudraVigilance report

Suspected adverse reactions reported for Nortriptyline

About EudraVigilance

Learn about EU pharmacovigilance and safety monitoring

EudraVigilance data is published by the European Medicines Agency (EMA). A suspected adverse reaction is not necessarily caused by the medicine.

5 branded products available

5 productsShow details

5 products

Possibly available on the UK marketDiscontinuedAvailability per NHS dm+d

MHRA licensed products

View all licensed products for Nortriptyline on the MHRA register

Nortriptyline 25mg capsules

Kent Pharma (UK) Ltd

Nortriptyline 25mg capsules

Alliance Healthcare (Distribution) Ltd

Nortriptyline 25mg capsules

Medihealth (Northern) Ltd

Nortriptyline 25mg capsules

A A H Pharmaceuticals Ltd

Nortriptyline 25mg capsules

DE Pharmaceuticals

Discontinued

Source: NHS dm+dOGL 3.0

Updated about 1 month ago(1 Mar 2026)

Price & daily doseShow details

£17.50indicative price

This is the NHS Drug Tariff indicative price used for reimbursement purposes. It may not reflect the price paid by patients or pharmacies.

View full Drug Tariff

Source: NHS Drug Tariff via NHSBSA. Derived from dm+d VMPP (Virtual Medicinal Product Pack) pricing data. Contains public sector information licensed under the Open Government Licence v3.0.

WHO defined daily dose (DDD)

75 mg

Not a recommended dose. The DDD is the assumed average maintenance dose per day for a drug used for its main indication in adults. It is a statistical measure used for research and comparison purposes only.

Source: WHO Collaborating Centre for Drug Statistics Methodology, distributed via NHS dm+d BNF mapping files. Contains public sector information licensed under the Open Government Licence v3.0.

Therapeutically similar medicines

10 similarShow details

Nortriptyline 10mg capsules

Capsule

10mg

Same therapeutic group

Nortriptyline 10mg/5ml oral solution sugar free

Oral solution

10mg/5ml

Same therapeutic group

Nortriptyline 25mg/5ml oral solution sugar free

Oral solution

25mg/5ml

Same therapeutic group

Clomipramine 250mg/5ml oral suspension

Oral suspension

250mg/5ml

Same therapeutic group

Nortriptyline 50mg/5ml oral solution

Oral solution

50mg/5ml

Same therapeutic group

Similarity based on WHO Anatomical Therapeutic Chemical (ATC) classification and NHS BNF section grouping. Source data: NHS dm+d via TRUD (OGL v3.0), WHO ATC/DDD Index.

NHS prescribing volume and spending trends

Show details

Loading prescribing data...

Clinical guidelines and formulary information

British National Formulary

Nortriptyline

BNF

Drug monograph — bnf.nice.org.uk

Source: British National Formulary, NICE. Joint Formulary Committee. Contains public sector information licensed under the Open Government Licence v3.0.

NICE clinical guidance(1)

Targeted muscle reinnervation for managing limb amputation pain (HTG750)

HTG750

Guidance

Updated Jun 2025

Source: National Institute for Health and Care Excellence (NICE). Contains public sector information licensed under the Open Government Licence v3.0.

Check stock at pharmacies and supply information

Show details

Pharmacy stock checkers

Search for this medicine at major UK pharmacy chains. These links open the retailer's own website — results depend on their current online catalogue.

Boots

Search products

Click & collectNHS

Lloyds

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DeliveryNHS

P2U

Pharmacy2U

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DeliveryNHS

Supply & product information

Official product databases and supply status monitoring

Shortages info

NHS Specialist Pharmacy Service (SPS)

emc product search

Discontinuations & alternatives for Nortriptyline

Pharmacy links redirect to the retailer's own search and do not represent real-time stock levels. emc (electronic medicines compendium) is operated by Datapharm Ltd. Shortage information sourced from NHS Specialist Pharmacy Service (SPS), sps.nhs.uk.

Codes for healthcare professionals and prescribing systems

Show details

These codes are used by healthcare IT systems and prescribers to identify this medicine.

NHS UK identifiers

SNOMED CT

38285911000001106

dm+d ID

38285911000001106

VTM (Virtual Therapeutic Moiety)

776948005

VMP (Virtual Medicinal Product)

38285911000001106

BNF code

04030100

International identifiers

ATC code — Anatomical Therapeutic Chemical (WHO)

N06AA10

Browse tools

dm+d Browser

NHSBSA medicines dictionary lookup

SNOMED CT and dm+d codes from NHS TRUD (Technology Reference data Update Distribution), licensed under the Open Government Licence v3.0. BNF codes from NHS Business Services Authority (NHSBSA). ATC codes from the WHO Collaborating Centre for Drug Statistics Methodology (whocc.no).

Active and completed clinical studies from ClinicalTrials.gov

Show details

Searching UK clinical trials...

Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine (NLM), National Institutes of Health (NIH). Data accessed via ClinicalTrials.gov API v2. Trial information is provided for research purposes and does not constitute medical advice.

Pharmacology and chemical data from DrugBank

go.drugbank.com

Key facts

Drug status

Approved

Major interactions

41 found

Half-life

26 hours

Mechanism

Though prescribing information does not identify a specific mechanism of action…

Food interactions

2 warnings

Human targets

14 targets

Data: DrugBank · CC BY-NC 4.0

Pharmacokinetics at a glance

Absorption

7 to 8.5 hours

Nortriptyline is readily absorbed in the gastrointestinal tract with extensive variation in plasma levels, depending on the patient.…

Half-life

26 hours

The average plasma half-life of nortriptyline in healthy volunteers is about 26 hours, but is said to range from 16 to 38 hours.
[A191098][L11878][L11911]…

Protein binding

93%

The plasma protein binding of nortriptyline is approximately 93%.
[L11911]

Volume of distribution

268 L

The apparent volume of distribution (Vd)β, estimated after intravenous administration is 1633 ± 268 L within the range of 1460 to 2030 (21 ± 4 L/kg).
[L11911]…

Metabolism

Nortriptyline is metabolized via demethylation and hydroxylation in the liver followed by glucuronic acid conjugation.…

Elimination

Nortriptyline and its metabolites are mainly excreted in the urine, where only small amounts (2%) of the total drug is recovered as unchanged parent compound.
[L11911]…

Clearance

54 L/h

The average plasma clearance of nortriptyline in a study of healthy volunteers was 54 L/h.
[A191098]…

Pharmacokinetic data: DrugBank · CC BY-NC 4.0

Status:

Approved

Investigational

Small molecule

About this compound

Properties:

solid

Avg. mass: 263.38 Da

View FDA drug label

DrugBank indication

Nortriptyline is indicated for the relief of the symptoms of major depressive disorder (MDD).
[L11878]
Some off-label uses for this drug include treatment of chronic pain, myofascial pain, neuralgia, and irritable bowel syndrome.
[A191083][L11878]

Also known as(166)

10,11-dihydro-N-methyl-5H-dibenzo[a,d]cycloheptene-Δ5,γ-propylamine

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine

Demethylamitriptyline

Desmethylamitriptyline

Nortriptylina

Nortriptyline

Nortriptylinum

NAT1

Dosage forms(22)

Capsule (Oral) — 10 mg

Capsule (Oral) — 25 mg

Tablet, coated (Oral) — 500 mg

Capsule (Oral) — 10 mg / cap

Capsule (Oral) — 25 mg / cap

Solution (Oral) — 5 MG/ML

Tablet, coated (Oral) — 10 MG

Tablet, coated (Oral) — 25 MG

Molecular properties(18)

Drug interactions(2125)

Known interactions with other medications. Always consult a healthcare professional.

Modafinil

Moderate

DB00745

The metabolism of Nortriptyline can be increased when combined with Modafinil.

Check this interaction

Armodafinil

Moderate

DB06413

The metabolism of Nortriptyline can be increased when combined with Armodafinil.

Check this interaction

Valsartan

Moderate

DB00177

Nortriptyline may decrease the antihypertensive activities of Valsartan.

Check this interaction

Remikiren

Moderate

DB00212

Nortriptyline may decrease the antihypertensive activities of Remikiren.

Check this interaction

Torasemide

Moderate

DB00214

Nortriptyline may decrease the antihypertensive activities of Torasemide.

Check this interaction

Guanadrel

Moderate

DB00226

Nortriptyline may decrease the antihypertensive activities of Guanadrel.

Check this interaction

Olmesartan

Moderate

DB00275

Nortriptyline may decrease the antihypertensive activities of Olmesartan.

Check this interaction

Nitroprusside

Moderate

DB00325

Nortriptyline may decrease the antihypertensive activities of Nitroprusside.

Check this interaction

Minoxidil

Moderate

DB00350

Nortriptyline may decrease the antihypertensive activities of Minoxidil.

Check this interaction

Fosinopril

Moderate

DB00492

Nortriptyline may decrease the antihypertensive activities of Fosinopril.

Check this interaction

Trandolapril

Moderate

DB00519

Nortriptyline may decrease the antihypertensive activities of Trandolapril.

Check this interaction

Benazepril

Moderate

DB00542

Nortriptyline may decrease the antihypertensive activities of Benazepril.

Check this interaction

Cyclothiazide

Moderate

DB00606

Nortriptyline may decrease the antihypertensive activities of Cyclothiazide.

Check this interaction

Candoxatril

Moderate

DB00616

Nortriptyline may decrease the antihypertensive activities of Candoxatril.

Check this interaction

Lisinopril

Moderate

DB00722

Nortriptyline may decrease the antihypertensive activities of Lisinopril.

Check this interaction

Nitroglycerin

Moderate

DB00727

Nortriptyline may decrease the antihypertensive activities of Nitroglycerin.

Check this interaction

Cryptenamine

Moderate

DB00785

Nortriptyline may decrease the antihypertensive activities of Cryptenamine.

Check this interaction

Candesartan cilexetil

Moderate

DB00796

Nortriptyline may decrease the antihypertensive activities of Candesartan cilexetil.

Check this interaction

Fenoldopam

Moderate

DB00800

Nortriptyline may decrease the antihypertensive activities of Fenoldopam.

Check this interaction

Eprosartan

Moderate

DB00876

Nortriptyline may decrease the antihypertensive activities of Eprosartan.

Check this interaction

Quinapril

Moderate

DB00881

Nortriptyline may decrease the antihypertensive activities of Quinapril.

Check this interaction

Telmisartan

Moderate

DB00966

Nortriptyline may decrease the antihypertensive activities of Telmisartan.

Check this interaction

Deserpidine

Moderate

DB01089

Nortriptyline may decrease the antihypertensive activities of Deserpidine.

Check this interaction

Diazoxide

Moderate

DB01119

Nortriptyline may decrease the antihypertensive activities of Diazoxide.

Check this interaction

Epoprostenol

Moderate

DB01240

Nortriptyline may decrease the antihypertensive activities of Epoprostenol.

Check this interaction

Cilazapril

Moderate

DB01340

Nortriptyline may decrease the antihypertensive activities of Cilazapril.

Check this interaction

Saprisartan

Moderate

DB01347

Nortriptyline may decrease the antihypertensive activities of Saprisartan.

Check this interaction

Spirapril

Moderate

DB01348

Nortriptyline may decrease the antihypertensive activities of Spirapril.

Check this interaction

Tienilic acid

Moderate

DB04831

Nortriptyline may decrease the antihypertensive activities of Tienilic acid.

Check this interaction

Diethylnorspermine

Moderate

DB06445

Nortriptyline may decrease the antihypertensive activities of Diethylnorspermine.

Check this interaction

Temocapril

Moderate

DB08836

Nortriptyline may decrease the antihypertensive activities of Temocapril.

Check this interaction

Rauwolfia serpentina root

Moderate

DB09363

Nortriptyline may decrease the antihypertensive activities of Rauwolfia serpentina root.

Check this interaction

Enalaprilat

Moderate

DB09477

Nortriptyline may decrease the antihypertensive activities of Enalaprilat.

Check this interaction

Angiotensin 1-7

Moderate

DB11720

Nortriptyline may decrease the antihypertensive activities of Angiotensin 1-7.

Check this interaction

Imidapril

Moderate

DB11783

Nortriptyline may decrease the antihypertensive activities of Imidapril.

Check this interaction

BQ-123

Moderate

DB12054

Nortriptyline may decrease the antihypertensive activities of BQ-123.

Check this interaction

Zofenopril

Moderate

DB13166

Nortriptyline may decrease the antihypertensive activities of Zofenopril.

Check this interaction

Guanoxan

Moderate

DB13211

Nortriptyline may decrease the antihypertensive activities of Guanoxan.

Check this interaction

Delapril

Moderate

DB13312

Nortriptyline may decrease the antihypertensive activities of Delapril.

Check this interaction

Vincamine

Moderate

DB13374

Nortriptyline may decrease the antihypertensive activities of Vincamine.

Check this interaction

Linsidomine

Moderate

DB13400

Nortriptyline may decrease the antihypertensive activities of Linsidomine.

Check this interaction

Guanoxabenz

Moderate

DB13410

Nortriptyline may decrease the antihypertensive activities of Guanoxabenz.

Check this interaction

Tolonidine

Moderate

DB13429

Nortriptyline may decrease the antihypertensive activities of Tolonidine.

Check this interaction

Endralazine

Moderate

DB13435

Nortriptyline may decrease the antihypertensive activities of Endralazine.

Check this interaction

Cadralazine

Moderate

DB13452

Nortriptyline may decrease the antihypertensive activities of Cadralazine.

Check this interaction

Bietaserpine

Moderate

DB13575

Nortriptyline may decrease the antihypertensive activities of Bietaserpine.

Check this interaction

Guanazodine

Moderate

DB13604

Nortriptyline may decrease the antihypertensive activities of Guanazodine.

Check this interaction

Methoserpidine

Moderate

DB13631

Nortriptyline may decrease the antihypertensive activities of Methoserpidine.

Check this interaction

Guanoclor

Moderate

DB13779

Nortriptyline may decrease the antihypertensive activities of Guanoclor.

Check this interaction

Muzolimine

Moderate

DB13801

Nortriptyline may decrease the antihypertensive activities of Muzolimine.

Check this interaction

Showing 50 of 2125 interactions

Food & lifestyle interactions

Avoid Alcohol

Avoid alcohol.

Advice

Take with or without food. Food decreases gastrointestinal irritation.

Toxicity & overdose

The oral LD50 of nortriptyline in the rat is 405 mg/kg.
[L11920]
Symptoms of overdose with nortriptyline include cardiac arrhythmias, severe hypotension, shock, congestive heart failure, pulmonary edema, convulsions, coma, and CNS depression.
[L11878][L11899]
Changes in the electrocardiogram, particularly in QRS segment, may be indicative of tricyclic antidepressant toxicity.
[A191170]

How it works

Mechanism of action

Though prescribing information does not identify a specific mechanism of action for nortriptyline[L11878], is believed that nortriptyline either inhibits the reuptake of the neurotransmitter serotonin at the neuronal membrane or acts at the level of the beta-adrenergic receptors. It displays a more selective reuptake inhibition for noradrenaline, which may explain increased symptom improvement after nortriptyline therapy.T28 Tricyclic antidepressants do not inhibit monoamine oxidase nor do they affect dopamine reuptake.[L11878] As with other tricyclics, nortriptyline displays affinity for other receptors including mACh receptors, histamine receptors, 5-HT receptors, in addition to other receptors.[A18198,A4909,T28]

Pharmacodynamics

Nortriptyline exerts antidepressant effects likely by inhibiting the reuptake of serotonin and norepinephrine at neuronal cell membranes. It also exerts antimuscarinic effects through its actions on the acetylcholine receptor.[L11878][L11881]

Pharmacokinetics

How the body processes this drug — absorption, distribution, metabolism, and elimination

Absorption

Nortriptyline is readily absorbed in the gastrointestinal tract with extensive variation in plasma levels, depending on the patient. This drug undergoes first-pass metabolism and its plasma concentrations are attained within 7 to 8.5 hours after oral administration.
[L11899]
The bioavailability of nortriptyline varies considerably and ranges from 45 to 85%.
[A191167][L11911]

Half-life

The average plasma half-life of nortriptyline in healthy volunteers is about 26 hours, but is said to range from 16 to 38 hours.
[A191098][L11878][L11911]

One study mentions a mean half-life of about 39 hours.
[A191101]

Protein binding

The plasma protein binding of nortriptyline is approximately 93%.
[L11911]

Volume of distribution

The apparent volume of distribution (Vd)β, estimated after intravenous administration is 1633 ± 268 L within the range of 1460 to 2030 (21 ± 4 L/kg).
[L11911]
Nortriptyline crosses the placenta and is found in the breast milk. It distributes to the heart, lungs, brain, and the liver.
[L11899]

Metabolism

Nortriptyline is metabolized via demethylation and hydroxylation in the liver followed by glucuronic acid conjugation. CYP2D6 plays a large role in nortriptyline metabolism, with contributions from CYP1A2, CYP2C19 and CYP3A4.
[A15182][L11878][A14832]

The main active metabolite is 10-hydroxynortriptyline exists in both cis and a trans form, with the trans form is higher in potency. 10-hydroxynortriptyline is the most frequently found in the plasma. Most of the other metabolites are conjugated, and are less potent.
[L11911]

Route of elimination

Nortriptyline and its metabolites are mainly excreted in the urine, where only small amounts (2%) of the total drug is recovered as unchanged parent compound.
[L11911]
Approximately one-third of a single orally administered dose is excreted in urine within 24 hours.
[L11899]
Small amounts are excreted in feces via biliary elimination.
[L11911]

Clearance

The average plasma clearance of nortriptyline in a study of healthy volunteers was 54 L/h.
[A191098]
The average systemic clearance of nortriptyline is 30.6 ± 6.9 L / h, within the range of 18.6 to 39.6 L/hour.
[L11911]

Drug targets(14)

Proteins and enzymes this drug interacts with in the body

Sodium-dependent noradrenaline transporter

BE0000486

SLC6A2

inhibitor

Specific functionactin binding

Cellular location

Cell membrane

General function & pharmacology

Mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline), the primary signaling neurotransmitter in the autonomic sympathetic nervous system .
PMID:2008212 PMID:8125921 PMID:38750358

Is responsible for norepinephrine re-uptake and clearance from the synaptic cleft, thus playing a crucial role in norepinephrine inactivation and homeostasis (By similarity). Can also mediate sodium- and chloride-dependent transport of dopamine PMID:11093780 PMID:8125921 PMID:39395208 PMID:39048818

Sodium-dependent serotonin transporter

BE0000749

SLC6A4

inhibitor

Specific functionactin filament binding

Cellular location

Cell membrane

General function & pharmacology

Serotonin transporter that cotransports serotonin with one Na(+) ion in exchange for one K(+) ion and possibly one proton in an overall electroneutral transport cycle. Transports serotonin across the plasma membrane from the extracellular compartment to the cytosol thus limiting serotonin intercellular signaling .
PMID:10407194 PMID:12869649 PMID:21730057 PMID:27049939 PMID:27756841 PMID:34851672

Essential for serotonin homeostasis in the central nervous system. In the developing somatosensory cortex, acts in glutamatergic neurons to control serotonin uptake and its trophic functions accounting for proper spatial organization of cortical neurons and elaboration of sensory circuits.

In the mature cortex, acts primarily in brainstem raphe neurons to mediate serotonin uptake from the synaptic cleft back into the pre-synaptic terminal thus terminating serotonin signaling at the synapse (By similarity). Modulates mucosal serotonin levels in the gastrointestinal tract through uptake and clearance of serotonin in enterocytes. Required for enteric neurogenesis and gastrointestinal reflexes (By similarity).

Regulates blood serotonin levels by ensuring rapid high affinity uptake of serotonin from plasma to platelets, where it is further stored in dense granules via vesicular monoamine transporters and then released upon stimulation .
PMID:17506858 PMID:18317590
Mechanistically, the transport cycle starts with an outward-open conformation having Na1(+) and Cl(-) sites occupied. The binding of a second extracellular Na2(+) ion and serotonin substrate leads to structural changes to outward-occluded to inward-occluded to inward-open, where the Na2(+) ion and serotonin are released into the cytosol. Binding of intracellular K(+) ion induces conformational transitions to inward-occluded to outward-open and completes the cycle by releasing K(+) possibly together with a proton bound to Asp-98 into the extracellular compartment.

Na1(+) and Cl(-) ions remain bound throughout the transport cycle .
PMID:10407194 PMID:12869649 PMID:21730057 PMID:27049939 PMID:27756841 PMID:34851672

Additionally, displays serotonin-induced channel-like conductance for monovalent cations, mainly Na(+) ions. The channel activity is uncoupled from the transport cycle and may contribute to the membrane resting potential or excitability (By similarity)

5-hydroxytryptamine receptor 2A

BE0000451

HTR2A

antagonist

Specific function1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding

Cellular location

Cell membrane

General function & pharmacology

G-protein coupled receptor for 5-hydroxytryptamine (serotonin) .
PMID:1330647 PMID:18703043 PMID:19057895 PMID:21645528 PMID:22300836 PMID:35084960 PMID:38552625

Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD) .
PMID:28129538 PMID:35084960
Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors .
PMID:28129538 PMID:35084960
HTR2A is coupled to G(q)/G(11) G alpha proteins and activates phospholipase C-beta, releasing diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers that modulate the activity of phosphatidylinositol 3-kinase and promote the release of Ca(2+) ions from intracellular stores, respectively .
PMID:18703043 PMID:28129538 PMID:35084960

Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways .
PMID:28129538 PMID:35084960
Affects neural activity, perception, cognition and mood .
PMID:18297054
Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction (By similarity)

5-hydroxytryptamine receptor 1A

BE0000291

HTR1A

antagonist

Specific functionG protein-coupled serotonin receptor activity

Cellular location

Cell membrane

General function & pharmacology

G-protein coupled receptor for 5-hydroxytryptamine (serotonin) .
PMID:22957663 PMID:3138543 PMID:33762731 PMID:37935376 PMID:37935377 PMID:8138923 PMID:8393041

Also functions as a receptor for various drugs and psychoactive substances .
PMID:22957663 PMID:3138543 PMID:33762731 PMID:38552625 PMID:8138923 PMID:8393041

Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase .
PMID:22957663 PMID:3138543 PMID:33762731 PMID:8138923 PMID:8393041

HTR1A is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission: signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores .
PMID:33762731 PMID:35610220
Beta-arrestin family members regulate signaling by mediating both receptor desensitization and resensitization processes .
PMID:18476671 PMID:20363322 PMID:20945968

Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism .
PMID:18476671 PMID:20363322 PMID:20945968

Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior .
PMID:18476671 PMID:20363322 PMID:20945968

Plays a role in the response to anxiogenic stimuli PMID:18476671 PMID:20363322 PMID:20945968

Histamine H1 receptor

BE0000442

HRH1

antagonist

Specific functionhistamine receptor activity

Cellular location

Cell membrane

General function & pharmacology

G-protein-coupled receptor for histamine, a biogenic amine that functions as an immune modulator and a neurotransmitter .
PMID:33828102 PMID:8280179
Through the H1 receptor, histamine mediates the contraction of smooth muscles and increases capillary permeability due to contraction of terminal venules. Also mediates neurotransmission in the central nervous system and thereby regulates circadian rhythms, emotional and locomotor activities as well as cognitive functions (By similarity)

Metabolizing enzymes(6)

Enzymes involved in drug metabolism — important for understanding drug interactions

Enzyme activity key

substrate

inhibitor

inducer

CYP2D6Cytochrome P450 2D6

substrate

inhibitor

CYP3A4Cytochrome P450 3A4

substrate

CYP1A2Cytochrome P450 1A2

substrate

CYP2C19Cytochrome P450 2C19

substrate

CYP3A5Cytochrome P450 3A5

substrate

CYP2E1Cytochrome P450 2E1

inhibitor

Transporters(2)

Proteins that transport this drug across cell membranes

Sodium-dependent noradrenaline transporter

BE0000486

SLC6A2

substrate

inhibitor

Specific functionactin binding

Cellular location

Cell membrane

General function & pharmacology

ATP-dependent translocase ABCB1

BE0001032

ABCB1

substrate

Specific functionABC-type xenobiotic transporter activity

Cellular location

Cell membrane

General function & pharmacology

Translocates drugs and phospholipids across the membrane .
PMID:2897240 PMID:35970996 PMID:8898203 PMID:9038218 PMID:35507548

Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins .
PMID:8898203
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells PMID:2897240 PMID:35970996 PMID:9038218

Carriers(2)

Proteins that carry this drug through the body

Albumin

BE0000530

ALB

binder

Specific functionantioxidant activity

Cellular location

Secreted

General function & pharmacology

Binds water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs (Probable). Its main function is the regulation of the colloidal osmotic pressure of blood (Probable). Major zinc transporter in plasma, typically binds about 80% of all plasma zinc .
PMID:19021548
Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity).

Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (By similarity). The shared binding site between zinc and calcium at residue Asp-273 suggests a crosstalk between zinc and calcium transport in the blood (By similarity). The rank order of affinity is zinc > calcium > magnesium (By similarity).

Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E.coli from ferric transferrin, and may thereby limit the utilization of iron and growth of enteric bacteria such as E.coli .
PMID:6234017
Does not prevent iron uptake by the bacterial siderophore aerobactin PMID:6234017

Alpha-1-acid glycoprotein 1

BE0000925

ORM1

binder

Cellular location

Secreted

General function & pharmacology

Functions as a transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body.

Appears to function in modulating the activity of the immune system during the acute-phase reaction

Scientific references(15)

Prochazka A.V., Weaver M.J., Keller R.T., Fryer G.E., Licari P.A., Lofaso D.

A Randomized Trial of Nortriptyline for Smoking Cessation.

Archives of Internal Medicine

1998158(18):2035. doi: 10.1001/archinte.158.18.2035

PMID: 9778204 DOI: 10.1001/archinte.158.18.2035

Nelson J.C., Kennedy J.S., Pollock B.G., Laghrissi-Thode F., Narayan M., Nobler M.S., Robin D.W., Gergel I., McCafferty J., Roose S.

Treatment of major depression with nortriptyline and paroxetine in patients with ischemic heart disease.

American Journal Psychiatry

1999 Jul156(7):1024-8. doi: 10.1176/ajp.156.7.1024

PMID: 10401446 DOI: 10.1176/ajp.156.7.1024

Fabre L.F., Scharf M.B., Itil T.M.

Fluoxetine and nortriptyline are equals in major depression therapy ???.

Inpharma Weekly

1991&NA;(804):15. doi: 10.2165/00128413-199108040-00038

PMID: 2050651 DOI: 10.2165/00128413-199108040-00038

Heymann R.E., Helfenstein M., Feldman D.

A randomized, double-blind, placebo-controlled study of moclobemide and amitriptyline in the treatment of fibromyalgia in females without psychiatric disorder.

Rheumatology

199837(12):1279-1286. doi: 10.1093/rheumatology/37.12.1279

PMID: 11791642 DOI: 10.1093/rheumatology/37.12.1279

Lustman P.J., Griffith L.S., Clouse R.E., Freedland K.E., Eisen S.A., Rubin E.H., Carney R.M., McGill J.B.

Effects of Nortriptyline on Depression and Glycemic Control in Diabetes.

Psychosomatic Medicine

199759(3):241-250. doi: 10.1097/00006842-199705000-00007

PMID: 9178335 DOI: 10.1097/00006842-199705000-00007

Gillman P.K.

Tricyclic antidepressant pharmacology and therapeutic drug interactions updated.

British Journal of Pharmacology

2007151(6):737-748. doi: 10.1038/sj.bjp.0707253

PMID: 17471183 DOI: 10.1038/sj.bjp.0707253

Clouse R.E.

Antidepressants for irritable bowel syndrome.

Gut

2003 Apr52(4):598-9. doi: 10.1136/gut.52.4.598

PMID: 12631677 DOI: 10.1136/gut.52.4.598

Dawling S., Crome P., Braithwaite R.

Pharmacokinetics of single oral doses of nortriptyline in depressed elderly hospital patients and young healthy volunteers.

Clinical Pharmacokinetics

1980 Jul-Aug5(4):394-401. doi: 10.2165/00003088-198005040-00007

PMID: 6994983 DOI: 10.2165/00003088-198005040-00007

Overo K.F.

Pharmacokinetic aspects on once-daily nortriptyline administration.

Neuropsychobiology

19806(1):34-41. doi: 10.1159/000117730

PMID: 7366812 DOI: 10.1159/000117730

Peroutka S.J., Snyder S.H.

ANTIEMETICS: NEUROTRANSMITTER RECEPTOR BINDING PREDICTS THERAPEUTIC ACTIONS.

The Lancet

1982319(8273):658-659. doi: 10.1016/s0140-6736(82)92206-1

PMID: 6121969 DOI: 10.1016/s0140-6736(82)92206-1

Cusack B., Nelson A., Richelson E.

Binding of antidepressants to human brain receptors: focus on newer generation compounds.

Psychopharmacology

1994114(4):559-565. doi: 10.1007/bf02244985

PMID: 7855217 DOI: 10.1007/bf02244985

Gibaldi M.

Comparison of observed and predicted bioavailability of nortriptyline in humans following oral administration.

Journal of Pharmaceutical Sciences

1975 Jun64(6):1036-7. doi: 10.1002/jps.2600640635

PMID: 1133723 DOI: 10.1002/jps.2600640635

Elsamadisi P., Sclafani A., Eche I.M.

Delayed Cardiotoxicity From a Massive Nortriptyline Overdose Requiring Prolonged Treatment. J Pharm Pract. 2019 Apr 14:897190019838700.

doi: 10

1177/0897190019838700

PMID: 30983469 DOI: 10.1177/0897190019838700

Venkatakrishnan K., von Moltke L.L., Greenblatt D.J.

Nortriptyline E‐10‐Hydroxylation in Vitro Is Mediated by Human CYP2D6 (High Affinity) and CYP3A4 (Low Affinity): Implications for Interactions with Enzyme‐Inducing Drugs.

The Journal of Clinical Pharmacology

199939(6):567-577. doi: 10.1177/00912709922008173

PMID: 10354960 DOI: 10.1177/00912709922008173

Olesen O.V., Linnet K.

Metabolism of the Tricyclic Antidepressant Amitriptyline by cDNA-Expressed Human Cytochrome P450 Enzymes.

Pharmacology

199755(5):235-243. doi: 10.1159/000139533

PMID: 9193876 DOI: 10.1159/000139533

ATC classification(1 code)

ATC N06AA10

Affected organisms(1)

Humans and other mammals

International brands(9)

Salt forms(1)

Nortriptyline hydrochloride(DBSALT000641)

Experimental properties(6)

External resources(2)

RxList Drugs.com

Protein Data Bank entries(1)

4m48

Commercial products(257)

Chemical identifiers

CAS, UNII, InChI Key and database cross-references

Show

Linked compound data from DrugBank Open Data (CC BY-NC 4.0)

Nortriptyline

DB00540

CAS number

72-69-5

UNII (FDA)

BL03SY4LXB

InChI Key (molecular fingerprint)

PHVGLTMQBUFIQQ-UHFFFAOYSA-N

Additional database identifiers

Drugs Product Database (DPD)

11121

Drugs Product Database (DPD)

9839

ChEBI

7640

PubChem Compound

4543

PubChem Substance

46507783

KEGG Compound

C07274

KEGG Drug

D08288

ChemSpider

4384

BindingDB

112777

PharmGKB

PA450657

PDB

21B

Therapeutic Targets Database

DAP001152

IUPHAR

2404

Guide to Pharmacology

2404

Wikipedia

Nortriptyline

ChEMBL

CHEMBL445

ZINC

ZINC000001530741

RxCUI

7531

HUGO Gene Nomenclature Committee (HGNC)

HGNC:11048

GenAtlas

SLC6A2

GeneCards

SLC6A2

GenBank Gene Database

M65105

GenBank Protein Database

189258

Guide to Pharmacology

926

UniProtKB

P23975

UniProt Accession

SC6A2_HUMAN

HUGO Gene Nomenclature Committee (HGNC)

HGNC:11050

GenAtlas

SLC6A4

GeneCards

SLC6A4

GenBank Gene Database

X70697

GenBank Protein Database

36433

Guide to Pharmacology

928

UniProtKB

P31645

UniProt Accession

SC6A4_HUMAN

HUGO Gene Nomenclature Committee (HGNC)

HGNC:5293

GenAtlas

HTR2A

GeneCards

HTR2A

GenBank Gene Database

S42168

GenBank Protein Database

36431

IUPHAR

Guide to Pharmacology

UniProtKB

P28223

UniProt Accession

5HT2A_HUMAN

HUGO Gene Nomenclature Committee (HGNC)

HGNC:5286

GenAtlas

HTR1A

GeneCards

HTR1A

GenBank Gene Database

M28269

GenBank Protein Database

189928

IUPHAR

Guide to Pharmacology

UniProtKB

P08908

UniProt Accession

5HT1A_HUMAN

HUGO Gene Nomenclature Committee (HGNC)

HGNC:5182

GenAtlas

HRH1

GeneCards

HRH1

GenBank Gene Database

Z34897

GenBank Protein Database

510296

IUPHAR

262

Guide to Pharmacology

262

UniProtKB

P35367

UniProt Accession

HRH1_HUMAN

HUGO Gene Nomenclature Committee (HGNC)

HGNC:277

GenAtlas

ADRA1A

GeneCards

ADRA1A

GenBank Gene Database

D25235

GenBank Protein Database

433201

IUPHAR

Guide to Pharmacology

UniProtKB

P35348

UniProt Accession

ADA1A_HUMAN

HUGO Gene Nomenclature Committee (HGNC)

HGNC:280

GenAtlas

ADRA1D

GeneCards

ADRA1D

GenBank Gene Database

M76446

GenBank Protein Database

177807

IUPHAR

Guide to Pharmacology

UniProtKB

P25100

UniProt Accession

ADA1D_HUMAN

HUGO Gene Nomenclature Committee (HGNC)

HGNC:5295

GenAtlas

HTR2C

GeneCards

HTR2C

GenBank Gene Database

M81778

GenBank Protein Database

338028

IUPHAR

Guide to Pharmacology

UniProtKB

P28335

UniProt Accession

5HT2C_HUMAN

HUGO Gene Nomenclature Committee (HGNC)

HGNC:278

GenAtlas

ADRA1B

GeneCards

ADRA1B

GenBank Gene Database

M99589

IUPHAR

Guide to Pharmacology

UniProtKB

P35368

UniProt Accession

ADA1B_HUMAN

HUGO Gene Nomenclature Committee (HGNC)

HGNC:281

GenAtlas

ADRA2A

GeneCards

ADRA2A

GenBank Gene Database

M23533

GenBank Protein Database

178196

IUPHAR

Guide to Pharmacology

UniProtKB

P08913

UniProt Accession

ADA2A_HUMAN

HUGO Gene Nomenclature Committee (HGNC)

HGNC:282

GenAtlas

ADRA2B

GeneCards

ADRA2B

GenBank Gene Database

M34041

GenBank Protein Database

178198

IUPHAR

Guide to Pharmacology

UniProtKB

P18089

UniProt Accession

ADA2B_HUMAN

HUGO Gene Nomenclature Committee (HGNC)

HGNC:283

GenAtlas

ADRA2C

GeneCards

ADRA2C

GenBank Gene Database

J03853

GenBank Protein Database

178194

IUPHAR

Guide to Pharmacology

UniProtKB

P18825

UniProt Accession

ADA2C_HUMAN

HUGO Gene Nomenclature Committee (HGNC)

HGNC:285

GenAtlas

ADRB1

GeneCards

ADRB1

GenBank Gene Database

J03019

GenBank Protein Database

178200

IUPHAR

Guide to Pharmacology

UniProtKB

P08588

UniProt Accession

ADRB1_HUMAN

HUGO Gene Nomenclature Committee (HGNC)

HGNC:286

GenAtlas

ADRB2

GeneCards

ADRB2

GenBank Gene Database

Y00106

GenBank Protein Database

29371

IUPHAR

Guide to Pharmacology

UniProtKB

P07550

UniProt Accession

ADRB2_HUMAN

HUGO Gene Nomenclature Committee (HGNC)

HGNC:288

GenAtlas

ADRB3

GeneCards

ADRB3

GenBank Gene Database

M29932

GenBank Protein Database

178896

IUPHAR

Guide to Pharmacology

UniProtKB

P13945

UniProt Accession

ADRB3_HUMAN

HUGO Gene Nomenclature Committee (HGNC)

HGNC:3023

GenAtlas

DRD2

GeneCards

DRD2

GenBank Gene Database

M30625

GenBank Protein Database

181432

IUPHAR

215

Guide to Pharmacology

215

UniProtKB

P14416

UniProt Accession

DRD2_HUMAN

HUGO Gene Nomenclature Committee (HGNC)

HGNC:16090

GeneCards

PGRMC1

UniProtKB

O00264

UniProt Accession

PGRC1_HUMAN

HUGO Gene Nomenclature Committee (HGNC)

HGNC:8157

GenAtlas

OPRS1

GeneCards

SIGMAR1

GenBank Gene Database

U75283

GenBank Protein Database

1783387

Guide to Pharmacology

2552

UniProtKB

Q99720

UniProt Accession

SGMR1_HUMAN

Guide to Pharmacology

UniProtKB

P08909

UniProt Accession

5HT2C_RAT

HUGO Gene Nomenclature Committee (HGNC)

HGNC:1950

GenAtlas

CHRM1

GeneCards

CHRM1

GenBank Gene Database

X52068

GenBank Protein Database

34451

IUPHAR

Guide to Pharmacology

UniProtKB

P11229

UniProt Accession

ACM1_HUMAN

HUGO Gene Nomenclature Committee (HGNC)

HGNC:1951

GenAtlas

CHRM2

GeneCards

CHRM2

GenBank Gene Database

M16404

GenBank Protein Database

177990

IUPHAR

Guide to Pharmacology

UniProtKB

P08172

UniProt Accession

ACM2_HUMAN

HUGO Gene Nomenclature Committee (HGNC)

HGNC:1952

GenAtlas

CHRM3

GeneCards

CHRM3

GenBank Gene Database

X15266

GenBank Protein Database

32324

IUPHAR

Guide to Pharmacology

UniProtKB

P20309

UniProt Accession

ACM3_HUMAN

HUGO Gene Nomenclature Committee (HGNC)

HGNC:1953

GenAtlas

CHRM4

GeneCards

CHRM4

GenBank Gene Database

M16405

GenBank Protein Database

61970253

IUPHAR

Guide to Pharmacology

UniProtKB

P08173

UniProt Accession

ACM4_HUMAN

HUGO Gene Nomenclature Committee (HGNC)

HGNC:1954

GenAtlas

CHRM5

GeneCards

CHRM5

GenBank Gene Database

M80333

GenBank Protein Database

177988

IUPHAR

Guide to Pharmacology

UniProtKB

P08912

UniProt Accession

ACM5_HUMAN

HUGO Gene Nomenclature Committee (HGNC)

HGNC:2625

GenAtlas

CYP2D6

GeneCards

CYP2D6

GenBank Gene Database

M20403

GenBank Protein Database

181350

Guide to Pharmacology

1329

UniProtKB

P10635

UniProt Accession

CP2D6_HUMAN

HUGO Gene Nomenclature Committee (HGNC)

HGNC:2637

GenAtlas

CYP3A4

GeneCards

CYP3A4

GenBank Gene Database

M18907

Guide to Pharmacology

1337

UniProtKB

P08684

UniProt Accession

CP3A4_HUMAN

HUGO Gene Nomenclature Committee (HGNC)

HGNC:2596

GenAtlas

CYP1A2

GeneCards

CYP1A2

GenBank Gene Database

Z00036

Guide to Pharmacology

1319

UniProtKB

P05177

UniProt Accession

CP1A2_HUMAN

HUGO Gene Nomenclature Committee (HGNC)

HGNC:2621

GeneCards

CYP2C19

GenBank Gene Database

M61854

GenBank Protein Database

181344

Guide to Pharmacology

1328

UniProtKB

P33261

UniProt Accession

CP2CJ_HUMAN

HUGO Gene Nomenclature Committee (HGNC)

HGNC:2638

GenAtlas

CYP3A5

GeneCards

CYP3A5

GenBank Gene Database

J04813

GenBank Protein Database

181346

Guide to Pharmacology

1338

UniProtKB

P20815

UniProt Accession

CP3A5_HUMAN

HUGO Gene Nomenclature Committee (HGNC)

HGNC:2631

GeneCards

CYP2E1

GenBank Gene Database

J02625

GenBank Protein Database

181360

Guide to Pharmacology

1330

UniProtKB

P05181

UniProt Accession

CP2E1_HUMAN

HUGO Gene Nomenclature Committee (HGNC)

HGNC:399

GenAtlas

ALB

GeneCards

ALB

GenBank Gene Database

V00494

GenBank Protein Database

28590

UniProtKB

P02768

UniProt Accession

ALBU_HUMAN

HUGO Gene Nomenclature Committee (HGNC)

HGNC:8498

GenAtlas

ORM1

GeneCards

ORM1

GenBank Gene Database

X02544

GenBank Protein Database

757907

UniProtKB

P02763

UniProt Accession

A1AG1_HUMAN

HUGO Gene Nomenclature Committee (HGNC)

HGNC:11048

GenAtlas

SLC6A2

GeneCards

SLC6A2

GenBank Gene Database

M65105

GenBank Protein Database

189258

Guide to Pharmacology

926

UniProtKB

P23975

UniProt Accession

SC6A2_HUMAN

HUGO Gene Nomenclature Committee (HGNC)

HGNC:40

GenAtlas

ABCB1

GeneCards

ABCB1

GenBank Gene Database

M14758

GenBank Protein Database

307180

Guide to Pharmacology

768

UniProtKB

P08183

UniProt Accession

MDR1_HUMAN

International reference pricing

24 formulations

Reference pricing from DrugBank. Prices are indicative and may not reflect current UK costs.

From $0.13/capsule

To $750.05/bottle

Apo-Nortriptyline 10 mg Capsule

$0.13/capsule

Novo-Nortriptyline 10 mg Capsule

$0.13/capsule

Nu-Nortriptyline 10 mg Capsule

$0.13/capsule

Pms-Nortriptyline 10 mg Capsule

$0.13/capsule

Aventyl 10 mg Capsule

$0.24/capsule

Source: DrugBank. Used under CC BY-NC 4.0 academic licence for non-commercial purposes.

DrugBank citations

If you use DrugBank data in your research, please cite the following publications:

Knox C., Wilson M., Klinger C.M., et al

DrugBank 6.

0: the DrugBank Knowledgebase for 2024

Nucleic Acids Res. 2024 Jan 552(D1):D1265-D1275

PMID: 37953279

Wishart D.S., Feunang Y.D., Guo A.C., et al

DrugBank 5.

0: a major update to the DrugBank database for 2018

Nucleic Acids Res. 2017 Nov 846(D1):D1074-D1082

PMID: 29126136

Show earlier publications

Law V., Knox C., Djoumbou Y., et al

DrugBank 4.

0: shedding new light on drug metabolism

Nucleic Acids Res. 2014 Jan 142(1):D1091-7

PMID: 24203711

Knox C., Law V., Jewison T., et al

DrugBank 3.

0: a comprehensive resource for 'omics' research on drugs

Nucleic Acids Res. 2011 Jan39(Database issue):D1035-41

PMID: 21059682

Wishart D.S., Knox C., Guo A.C., et al

DrugBank: a knowledgebase for drugs, drug actions and drug targets.

Nucleic Acids Research

2008 Jan36(Database issue):D901-6

PMID: 18048412

Wishart D.S., Knox C., Guo A.C., et al

DrugBank: a comprehensive resource for in silico drug discovery and exploration.

Nucleic Acids Research

2006 Jan 134(Database issue):D668-72

PMID: 16381955

Source: go.drugbank.comCC BY-NC 4.0

Updated 27 days ago(8 Mar 2026)

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Nortriptyline 25mg capsules

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