Menaquinone-7 60microgram / Menatetrenone 60microgram capsules
Requires a prescription from a doctor or prescriber
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Data from the MHRA Yellow Card scheme. A reported reaction does not necessarily mean the medicine caused it. Contains public sector information licensed under the Open Government Licence v3.0.
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1 branded products available
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SNOMED CT and dm+d codes from NHS TRUD (Technology Reference data Update Distribution), licensed under the Open Government Licence v3.0.
Active and completed clinical studies from ClinicalTrials.gov
Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine (NLM), National Institutes of Health (NIH). Data accessed via ClinicalTrials.gov API v2. Trial information is provided for research purposes and does not constitute medical advice.
Academic studies and reviews for this medicine's active substance
Showing the 50 most relevant studies.
Reviews & meta-analyses: 11 · Randomised trials: 11 · 1995–2026
Showing the 50 most relevant studies, sorted by most relevant.
Sabine R. Zwakenberg, P. A. D. Jong, J. Bartstra, et al.
The American Journal of Clinical Nutrition, 2019
Nuanjanthip Naiyarakseree, J. Phannajit, W. Naiyarakseree, et al.
Nutrients, 2023
F. Kampmann, Sanne Marie Thysen, Camilla Friis Bryde Nielsen, et al.
BMJ Open, 2023
Liv M Vossen, Peter W. de Leeuw, L. Schurgers, et al.
JAMA cardiology, 2026
Masataka Shiraki, Yumiko Shiraki, Choju Aoki, et al.
Journal of Bone and Mineral Research, 2000
Nakagawa K, Hirota Y, Sawada N, et al.
2010
- Bone and Bones
- Cell Line
- Osteoblasts
J. Lindholt, N. Frandsen, M. Fredgart, et al.
BMJ Open, 2018
M. Knapen, L. Braam, N. Drummen, et al.
Thrombosis and Haemostasis, 2015
N. Karamzad, Esmaeil Faraji, Shaghayegh Adeli, et al.
Nutrition & Diabetes, 2022
Iwamoto J
2014
- Osteoporosis, Postmenopausal
- Vitamin K 2
- Osteocalcin
Vitamin K may play an important role in the prevention of fractures in postmenopausal women with osteoporosis. Menatetrenone is the brand name of a synthetic vitamin K2 that is chemically identical to menaquinone-4. The present review study aimed to clarify the effect of menatetrenone on the skeleton in postmenopausal women with osteoporosis, by reviewing the results of randomized controlled trials (RCTs) in the literature. RCTs that investigated the effect of menatetrenone on bone mineral density (BMD), measured by dual-energy X-ray absorptiometry and fracture incidence in postmenopausal women with osteoporosis, were identified by a PubMed search for literature published in English. Eight studies met the criteria for RCTs. Small RCTs showed that menatetrenone monotherapy decreased serum undercarboxylated osteocalcin (ucOC) concentrations, modestly increased lumbar spine BMD, and reduced the incidence of fractures (mainly vertebral fracture), and that combined alendronate and menatetrenone therapy enhanced the decrease in serum ucOC concentrations and further increased femoral neck BMD. This review of the literature revealed positive evidence for the effects of menatetrenone monotherapy on fracture incidence in postmenopausal women with osteoporosis. Further studies are required to clarify the efficacy of menatetrenone in combination with bisphosphonates against fractures in postmenopausal women with osteoporosis.
Abstract licence: CC BY
Sources: aggregated from Europe PMC (EMBL-EBI), OpenAlex, Crossref, PubMed and other open scholarly databases. Retracted articles are excluded. Study information is provided for research purposes and does not constitute medical advice.
Scientific data (pharmacology, interactions, ADME) is not yet available for this medicine. Clinical sections are sourced from the NHS dm+d database.