Melperone hydrochloride 50mg tablets
Requires a prescription from a doctor or prescriber
Melperone is an atypical antipsychotic of the butyrophenone chemical class, making it structurally related to the typical antipsychotic haloperidol.
Official documents, adverse reaction reporting, and safety monitoring
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Safety monitoring data
Yellow Card reports
The MHRA Yellow Card scheme collects reports of suspected side effects from healthcare professionals and patients. View the Drug Analysis Profile (iDAP) for real-world adverse reaction data.
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Suspected adverse reactions reported for Melperone
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Report a side effect
Submit a Yellow Card report to the MHRA
Data from the MHRA Yellow Card scheme. A reported reaction does not necessarily mean the medicine caused it. Contains public sector information licensed under the Open Government Licence v3.0.
EudraVigilance
The European Medicines Agency (EMA) collects suspected adverse reaction reports from across the EU/EEA through the EudraVigilance system. Search for safety data on this medicine.
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Suspected adverse reactions reported for Melperone
About EudraVigilance
Learn about EU pharmacovigilance and safety monitoring
EudraVigilance data is published by the European Medicines Agency (EMA). A suspected adverse reaction is not necessarily caused by the medicine.
2 branded products available
Therapeutically similar medicines
Similarity is based on WHO Anatomical Therapeutic Chemical (ATC) classification and on a factual NHS dm+d therapeutic-grouping code prefix. Source data: NHS dm+d via TRUD (OGL v3.0), WHO ATC/DDD Index.
Check stock at pharmacies and supply information
Pharmacy stock checkers
Search for this medicine at major UK pharmacy chains. These links open the retailer's own website — results depend on their current online catalogue.
Supply & safety information
Official UK regulator monitoring and safety alerts
Pharmacy links redirect to the retailer's own search and do not represent real-time stock levels. Shortage and safety information sourced from MHRA drug safety updates (gov.uk, Crown Copyright under OGL v3.0).
Codes for healthcare professionals and prescribing systems
These codes are used by healthcare IT systems and prescribers to identify this medicine.
NHS UK identifiers
Browse tools
SNOMED CT and dm+d codes from NHS TRUD (Technology Reference data Update Distribution), licensed under the Open Government Licence v3.0. BNF code shown is the factual mapping value distributed by NHS Business Services Authority (NHSBSA) in the dm+d supplementary file under OGL v3.0; it is not affiliated with, nor licensed from, the publishers of the British National Formulary. ATC codes from the WHO Collaborating Centre for Drug Statistics Methodology (whocc.no).
Active and completed clinical studies from ClinicalTrials.gov
Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine (NLM), National Institutes of Health (NIH). Data accessed via ClinicalTrials.gov API v2. Trial information is provided for research purposes and does not constitute medical advice.
Academic studies and reviews for this medicine's active substance
Showing the 50 most relevant studies.
Reviews & meta-analyses: 1 · 1977–2025
Showing the 50 most relevant studies, sorted by most relevant.
J. Ichikawa, Zhu Li, Jin Dai, et al.
Brain research, 2002
H. Nygaard, E. Fuglum, K. Elgen
Current medical research and opinion, 1992
Tereza Tichá, Barbora Agatha Halouzkova, Jan Miroslav Hartinger, et al.
Monatshefte für Chemie - Chemical Monthly, 2025
L. Bjerkenstedt, P. Eneroth, C. H�rnryd, et al.
Archiv f�r Psychiatrie und Nervenkrankheiten Vereinigt mit Zeitschrift f�r die Gesamte Neurologie und Psychiatrie, 1977
T. Sumiyoshi, K. Jayathilake, H. Meltzer
Schizophrenia research, 2003
L. Barbato, A. Monge, F. Stocchi, et al.
Functional neurology, 1996
Marek Dziadosz, Katarina Bolte, Wolfgang Rosenberger, et al.
Drug Metabolism and Personalized Therapy, 2021
- Butyrophenones
- Tandem Mass Spectrometry
- Chromatography, Liquid
Reactions Weekly, 2019
Reactions Weekly, 2019
Lars Bjerkenstedt, Christer H�rnryd, Veronika Grimm, et al.
Archiv f�r Psychiatrie und Nervenkrankheiten, 1978
Sources: aggregated from Europe PMC (EMBL-EBI), OpenAlex, Crossref, PubMed and other open scholarly databases. Retracted articles are excluded. Study information is provided for research purposes and does not constitute medical advice.
Pharmacology and chemical data from DrugBank
Key facts
Drug status
Investigational
Major interactions
1 found
Half-life
3-4 hours
Mechanism
Melperone demonstrates antagonist activity at D2 dopaminergic and 5HT2A serotonergic receptors [L1319].
Food interactions
None known
Human targets
1 target
Data: DrugBank · CC BY-NC 4.0
Pharmacokinetics at a glance
Absorption
1.5–3.0 hours
[L1345]
Half-life
3-4 hours
[A31862]
After intramuscular injection, the half-life has been found to be approximately 6 hours .
[A31862]…
Protein binding
50-70%
[L1345]
Metabolism
[L1323]
Elimination
[L1323]
Pharmacokinetic data: DrugBank · CC BY-NC 4.0
[L1317][L1319][L1322]
Known interactions with other medications. Always consult a healthcare professional.
Showing 50 of 1716 interactions
How the body processes this drug — absorption, distribution, metabolism, and elimination
[L1345]
[A31862]
After intramuscular injection, the half-life has been found to be approximately 6 hours .
[A31862]
[L1345]
[L1323]
[L1323]
Proteins and enzymes this drug interacts with in the body
PMID:21645528
Positively regulates postnatal regression of retinal hyaloid vessels via suppression of VEGFR2/KDR activity, downstream of OPN5 (By similarity)
Enzymes involved in drug metabolism — important for understanding drug interactions
ATC N05AD03
Chemical identifiers
CAS, UNII, InChI Key and database cross-references
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Chemical identifiers
CAS, UNII, InChI Key and database cross-references
Linked compound data from DrugBank Open Data (CC BY-NC 4.0)
Melperone
Additional database identifiers
ChemSpider
14646
BindingDB
81771
ZINC
ZINC000000001672
HUGO Gene Nomenclature Committee (HGNC)
HGNC:3023
GenAtlas
DRD2
GeneCards
DRD2
GenBank Gene Database
M30625
GenBank Protein Database
181432
Guide to Pharmacology
215
UniProt Accession
DRD2_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:2625
GenAtlas
CYP2D6
GeneCards
CYP2D6
GenBank Gene Database
M20403
GenBank Protein Database
181350
Guide to Pharmacology
1329
UniProt Accession
CP2D6_HUMAN
DrugBank citations
If you use DrugBank data in your research, please cite the following publications:
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Structured knowledge from the free knowledge base
ATC classifications (Wikidata)
Linked open data from Wikidata (Q415972), a free and open knowledge base operated by the Wikimedia Foundation. Data is available under the Creative Commons CC0 1.0 Public Domain Dedication.