Mafenide 8.5% cream
Requires a prescription from a doctor or prescriber
Mafenide is a sulfonamide-type antimicrobial agent used to treat severe burns.
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Data from the MHRA Yellow Card scheme. A reported reaction does not necessarily mean the medicine caused it. Contains public sector information licensed under the Open Government Licence v3.0.
EudraVigilance
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1 branded products available
Therapeutically similar medicines
Similarity is based on WHO Anatomical Therapeutic Chemical (ATC) classification and on a factual NHS dm+d therapeutic-grouping code prefix. Source data: NHS dm+d via TRUD (OGL v3.0), WHO ATC/DDD Index.
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Supply & safety information
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Pharmacy links redirect to the retailer's own search and do not represent real-time stock levels. Shortage and safety information sourced from MHRA drug safety updates (gov.uk, Crown Copyright under OGL v3.0).
Codes for healthcare professionals and prescribing systems
These codes are used by healthcare IT systems and prescribers to identify this medicine.
NHS UK identifiers
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SNOMED CT and dm+d codes from NHS TRUD (Technology Reference data Update Distribution), licensed under the Open Government Licence v3.0. BNF code shown is the factual mapping value distributed by NHS Business Services Authority (NHSBSA) in the dm+d supplementary file under OGL v3.0; it is not affiliated with, nor licensed from, the publishers of the British National Formulary. ATC codes from the WHO Collaborating Centre for Drug Statistics Methodology (whocc.no).
Active and completed clinical studies from ClinicalTrials.gov
Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine (NLM), National Institutes of Health (NIH). Data accessed via ClinicalTrials.gov API v2. Trial information is provided for research purposes and does not constitute medical advice.
Academic studies and reviews for this medicine's active substance
Showing the 50 most relevant studies.
Reviews & meta-analyses: 9 · Randomised trials: 1 · 1971–2026
Showing the 50 most relevant studies, sorted by most relevant.
Reza Alipour, Alireza Khorshidi, Abdollah Fallah Shojaeı, et al.
Polymer Testing, 2019
MohammadJalili Manesh, Mohsen Zahmatkesh, Ronak Babashahabi
Iranian Journal of Nursing and Midwifery Research, 2015
Aviv U, Kornhaber R, Harats M, et al.
2017
BackgroundBurns from white phosphorus are rare and remain a challenge for clinicians. White phosphorus burns are often associated with smaller surface areas and high morbidity rates. Classed as a chemical burn, white phosphorus is used for military purposes and within industry, for the manufacture of fireworks and agricultural products.Case presentationIn this report, we discuss the case of a 40 years old female who sustained 2% Total Body Surface Area partial to full thickness burns from white phosphorus. The burns were treated conservatively with mafenide acetate on the medial calf and dorsum of foot and Flaminal Forte was used for the palmar region. The patient was discharged 22 days after admission and followed up in the outpatient clinic. Despite the use of pressure garments, hypertrophic scarring began to develop on the dorsum of her right foot.ConclusionsDuring peacetime, white phosphorus possess a significant danger to civilians. Awareness of the unique nature of white phosphorus among military burn clinicians should be emphasized.
Abstract licence: CC BY
Irma D Fleming, Carla Tang, Giavonni Lewis
Journal of Burn Care & Research, 2021
Hirsch J, DeHoff D, Hollowed K, et al.
2022
Shannon McKenna, B.A. Latenser, Larry M. Jones, et al.
Burns, 1995
- Burns
- Drug Eruptions
- Mafenide
Martin Krátký, Klára Konečná, Adéla Šimková, et al.
Future Medicinal Chemistry, 2023
- Anti-Infective Agents
- Mycobacterium tuberculosis
- Anti-Bacterial Agents
Utsab Manna, Rajdip Roy, Abhishek Dutta, et al.
Organic & Biomolecular Chemistry, 2023
- Flurbiprofen
- Hydrogels
- Mafenide
M. Baver Acaban, Alper Sarı, Hatice Oruç Demirbağ, et al.
Burns, 2023
- Burns
- Mafenide
- Graft Survival
Sadeq R. ATIYAH, Sarmad Al-Edresi
International Journal of Applied Pharmaceutics, 2024
Sources: aggregated from Europe PMC (EMBL-EBI), OpenAlex, Crossref, PubMed and other open scholarly databases. Retracted articles are excluded. Study information is provided for research purposes and does not constitute medical advice.
Pharmacology and chemical data from DrugBank
Key facts
Drug status
Approved
Major interactions
None known
Half-life
Not available
Mechanism
The precise mechanism of mafenide is unknown.
Food interactions
None known
Human targets
5 targets
Data: DrugBank · CC BY-NC 4.0
Pharmacokinetics at a glance
Absorption
Metabolism
Elimination
Pharmacokinetic data: DrugBank · CC BY-NC 4.0
Known interactions with other medications. Always consult a healthcare professional.
Showing 23 of 23 interactions
How the body processes this drug — absorption, distribution, metabolism, and elimination
Proteins and enzymes this drug interacts with in the body
PMID:15563508 PMID:16686544 PMID:16807956 PMID:17127057 PMID:17314045 PMID:17652713 PMID:17705204 PMID:18618712 PMID:19186056 PMID:19206230 PMID:7625839
May stimulate the sodium/bicarbonate transporter activity of SLC4A4 that acts in pH homeostasis .
PMID:15563508
It is essential for acid overload removal from the retina and retina epithelium, and acid release in the choriocapillaris in the choroid PMID:15563508
PMID:11327835 PMID:11802772 PMID:11831900 PMID:12056894 PMID:12171926 PMID:1336460 PMID:14736236 PMID:15300855 PMID:15453828 PMID:15667203 PMID:15865431 PMID:16106378 PMID:16214338 PMID:16290146 PMID:16686544 PMID:16759856 PMID:16807956 PMID:17127057 PMID:17251017 PMID:17314045 PMID:17330962 PMID:17346964 PMID:17540563 PMID:17588751 PMID:17705204 PMID:18024029 PMID:18162396 PMID:18266323 PMID:18374572 PMID:18481843 PMID:18618712 PMID:18640037 PMID:18942852 PMID:1909891 PMID:1910042 PMID:19170619 PMID:19186056 PMID:19206230 PMID:19520834 PMID:19778001 PMID:7761440 PMID:7901850 PMID:8218160 PMID:8262987 PMID:8399159 PMID:8451242 PMID:8485129 PMID:8639494 PMID:9265618 PMID:9398308
Can also hydrate cyanamide to urea .
PMID:10550681 PMID:11015219
Stimulates the chloride-bicarbonate exchange activity of SLC26A6 .
PMID:15990874
Essential for bone resorption and osteoclast differentiation .
PMID:15300855
Involved in the regulation of fluid secretion into the anterior chamber of the eye. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption
ATC G01AE10
ATC D06BA03
Chemical identifiers
CAS, UNII, InChI Key and database cross-references
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Chemical identifiers
CAS, UNII, InChI Key and database cross-references
Linked compound data from DrugBank Open Data (CC BY-NC 4.0)
Mafenide
Additional database identifiers
Drugs Product Database (DPD)
11904
ChemSpider
3858
BindingDB
10860
PDB
6LH
ZINC
ZINC000000001644
HUGO Gene Nomenclature Committee (HGNC)
HGNC:1375
GenAtlas
CA4
GeneCards
CA4
GenBank Gene Database
M83670
GenBank Protein Database
179791
Guide to Pharmacology
2599
UniProt Accession
CAH4_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:1372
GeneCards
CA14
GenBank Gene Database
AB025904
GenBank Protein Database
6009640
Guide to Pharmacology
2598
UniProt Accession
CAH14_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:1371
GenAtlas
CA12
GeneCards
CA12
GenBank Gene Database
AF051882
GenBank Protein Database
2984693
Guide to Pharmacology
2747
UniProt Accession
CAH12_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:1373
GenAtlas
CA2
GeneCards
CA2
GenBank Gene Database
M77181
GenBank Protein Database
179780
Guide to Pharmacology
3092
UniProt Accession
CAH2_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:1380
GeneCards
CA6
UniProt Accession
CAH6_HUMAN
DrugBank citations
If you use DrugBank data in your research, please cite the following publications:
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Structured knowledge from the free knowledge base
ATC classifications (Wikidata)
Linked open data from Wikidata (Q3843044), a free and open knowledge base operated by the Wikimedia Foundation. Data is available under the Creative Commons CC0 1.0 Public Domain Dedication.