Lachesis muta 6c homeopathic tablets

Based on the widespread use of homeopathy in dairy farm practice when treating mastitis, a blind randomised controlled trial (RCT) was conducted to assess the effectiveness of homeopathic treatment of clinical mastitis on four dairy farms. The study considered specific guidelines for RCTs as well as the basic principles of individualised homeopathy and involved 180 lactating dairy cows. Evaluation of cure rates was based on clinical investigation of the udder and on laboratory analysis of milk samples. In culture‐positive cases, the antibiotic treatment provided suboptimal bacteriological cures (60–81 per cent) but was more effective than individualised homeopathy (33–43 per cent) whose effects appeared little different to those of placebos (45–47 per cent) (P≤0.05). On the cytological cure level, all three treatment methods were similarly ineffective: antibiotic being 2–21 per cent, individualised homeopathy 0–8 per cent and placebo 3–13 per cent (P≤0.05; P=0.13). Antibiotics, individualised homeopathy and placebo had similar effects on bacteriological and cytological cure in cases of culture‐negative milk samples (P>0.4) and Escherichia coli infections (P=1.0). The study results implied that the effectiveness of individualised homeopathy does not go beyond a placebo effect and successful treatment is highly dependent on the specific mastitis pathogen. Thus, antimicrobial or alternative remedies used should be based on the bacterial culture of the milk sample. Trial registration number NTP‐ID: 00008011‐1‐9, Pre‐results.

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Abstract Background More than 670 million people have been infected by COVID-19. This case series reports 8 of 55 cases in a broader study of COVID-positive clients who sought homeopathic care for symptoms. Existing studies of homeopathy and COVID-19 have sometimes failed to employ the underpinning theoretical framework of homeopathy—the genus epidemicus. Special focus has been placed on standout symptoms not often reported in conventional medical outlets, known among homeopaths as “strange, rare and peculiar” (SRP) symptoms. The Homeopathy Help Network (HHN) team of practitioners noted SRP symptoms across dozens of cases and studied how they shifted collectively as different variants of the virus emerged. Methods COVID-positive individuals self-selected for individualized care for their symptoms using homeopathy. They received tele-health consultations and individualized homeopathy interventions in an out-patient homeopathy clinical setting. Clients were seen by individual professional homeopathy practitioners and students under supervision working at the HHN in the United States. Cases for the series were hand-picked with the aim of being an average representation of the more than 4,000 COVID-positive cases seen by members of the HHN. Cases in the full compendium are grouped according to a predominant case feature: Multiple remedies, Posology, Time ill, Single remedy resolution, Hospitalization and, in this case series, SRP symptoms. Results SRP symptoms included: continually on the verge of unconsciousness; dark green stools; very low pulse alternating with tachycardia; sensation of strong or burning chemical smells; sensation of inhaling water through the nose; recurring electric shock sensations in head or extremities; yellow-green stools. Conclusion Collective SRP symptoms from the pandemic provided the opportunity to study the hallmark features of COVID-19 in depth. The importance of these symptoms highlights the applicability of Hahnemannian principles and good case-taking practices.

Abstract licence: CC BY-NC-ND

Envenomations by snakes represent a neglected health problem in tropical and subtropical countries. In South America, Lachesis muta occasionally causes severe human envenomation, with treatment being conditioned to an unspecific antivenom. In this work, we examined the neutralizing ability of Coutarea hexandra stem bark hydroalcoholic extract ( Ch ‐E), including the commercial phytochemicals coumarin and quinine, on the neuromuscular blockade induced by L. m. muta venom in mouse phrenic nerve‐diaphragm preparation. Biological assays were performed following conventional myographic technique ex vivo. Ch ‐E was phytochemically characterized to detect the presence of coumarin and quinine using analytical methods. Ch ‐E and commercial phytochemicals were tested separately or combined under pre‐ and post‐venom incubation protocols. Ch ‐E attenuated the venom‐induced neuromuscular blockade only under the pre‐venom incubation protocol. Quinine was not detected in Ch ‐E. Commercial coumarin and quinine exhibited a concentration‐dependent counteracting effect on the venom‐induced neuromuscular blockade. The pre‐venom incubation protocol showed to be efficient in attenuating the L. m. muta venom–induced neuromuscular blockade, most likely due to the presence of coumarin derivatives and unknown alkaloids in this extract.

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OBJECTIVE.: To evaluate the in vitro inhibitory activity of Plantago major "llantén" and Piper aduncum "matico" extracts on phospholipase A2 (PLA2) from the venom of the snake Lachesis muta muta. MATERIALS AND METHODS.: We carried out an explanatory study with experimental design. Leaves of P. major and P. aduncum were collected in the province of Huarochirí in Lima, Peru. Then, we prepared alcoholic extracts diluted in distilled water and conducted phytochemical assays, quantification of phenols and flavonoids, thin layer chromatography (TLC) on cellulose and enzymatic activity with PLA2. The ability to inhibit PLA2 with the extracts under study and their fractions was analyzed. The Kruskal Wallis test and Bonferroni multiple comparisons were used during statistical analysis. RESULTS.: Phenols, flavonoids and tannins were qualitatively identified in both P. major and P. aduncum; in addition, P. aduncum presented saponins. The inhibition of PLA2 activity of the venom by the total extract of P. major was 45.3%, and its fractions showed the following inhibition values: 31.1% for LLF-1, 66.3% for LLF-2 and 65.5% for LLF-3. The inhibition values for the total extract of P. aduncum were 86.9%, and its fractions showed the following inhibition rates: 34.3% for MF-1, 67.1% for MF-2 and 54.9% for MF-3. Statistical analysis showed significant differences in the inhibition of PLA2 (p=0.009) by the extracts. CONCLUSION.: The tests demonstrated an association between the anti-inflammatory effect of the extracts and PLA2 inhibition.

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Introduction Homeopathic remedies in ultra-high dilutions (UHDs) have been used for centuries due to their proven therapeutic and biological effects [1-2]. Structural research on UHDs suggests the presence of essential original matters (EOMs) with unique formations [3]. However, a key research gap remains: Can the individualization of EOMs enhance homeopathic treatment? Can their structural characteristics be linked to therapeutic and biological effects? This study confirms the presence of EOMs in UHDs derived from blood samples, exhibiting distinct features. Objectives To analyze the structural properties of EOMs in patient blood samples before homeopathic treatment and compare them with EOMs of prescribed remedies. This study aims to identify correlations that could enable individualized remedy selection. Methodologies Blood samples were collected from four patients diagnosed with specific homeopathic constitutions (Lachesis muta, Calcarea carbonica, Ignatia amara, Staphysagria) before treatment. UHDs of each sample were prepared using standardized dilution and succussion protocols in ultrapure water. EOMs in the final solutions were analyzed via scanning electron microscopy and compared with a reference library of 100 known UHDs, including prescribed remedies. Results SEM analysis revealed distinctive filamentous or elongated structures with variations in curvature, surface texture, and integrity. A remarkable structural similarity was observed and quantified via AI image processing between patient blood UHDs and corresponding homeopathic remedies. These findings provide the first evidence that EOMs are present in UHDs of blood and exhibit unique characteristics, suggesting a potential link between UHD structures and patient-specific biological activity. Conclusion The results indicate that UHDs possess specific structural properties that may contribute to their function. The resemblance between patient-specific UHDs and prescribed homeopathic remedies highlights a potential mechanism for remedy selection. This approach could serve as a diagnostic tool for personalized homeopathic therapy while minimizing human error. Further research is necessary to validate these findings and explore clinical implications.

Abstract licence: CC BY-NC-SA

Abstract Snakebite envenomation is a neglected tropical disease and incidents of the pit viper Lachesis muta cause hemorrhage, muscle damage, blood coagulation disturbances, and even death; the proteases and phospholipase A 2 (PLA 2 ) of snake venoms contribute to such toxic effects. This work evaluated the inhibitory effect of commercial fucoidans from two species of brown seaweeds Fucus vesiculosus (FVF) and Undaria pinnatifida (UPF) against the coagulant and PLA 2 activity of Lachesis muta venom and two purified enzymes, a thrombin-like enzyme and PLA 2 , denoted TLE–1 and LM-PLA 2 –I, respectively. Fucus vesiculosus and U. pinnatifida fucoidans were incubated with L. muta venom and enzymes for 5 min at 37 °C, followed by assays, including the plasma and fibrinogen coagulation, hydrolysis of the substrates of proteases (S–2238 and S–2288), and hydrolysis of the substrate of PLA 2 enzymes, NBD-PC. Fucus vesiculosus and U. pinnatifida fucoidans inhibited the plasma coagulation of L. muta venom, but not the coagulation of TLE–1. However, both fucoidans fully prevented the coagulation of fibrinogen caused by L. muta venom and TLE–1. Fucus vesiculosus and U. pinnatifida fucoidans inhibited 60% and 40% hydrolysis of S–2238 of L. muta venom and TLE–1, respectively. Using the substrate S–2288, the fucoidans did not affect the hydrolysis of L. muta venom and inhibited 40% of hydrolysis caused by TLE–1. Fucus vesiculosus and U. pinnatifida fucoidans inhibited 40% and 20% of the PLA 2 activity of L. muta venom and LM-PLA 2 –I, respectively. These two fucoidans should be investigated as complementary or potential adjuvants for SBE inflicted by L. muta venom in more detail.

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