L-Serine powder
A non-essential amino acid occurring in natural form as the L-isomer.
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Safety monitoring data
Yellow Card reports
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Data from the MHRA Yellow Card scheme. A reported reaction does not necessarily mean the medicine caused it. Contains public sector information licensed under the Open Government Licence v3.0.
EudraVigilance
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EudraVigilance data is published by the European Medicines Agency (EMA). A suspected adverse reaction is not necessarily caused by the medicine.
1 branded products available
Therapeutically similar medicines
Similarity is based on WHO Anatomical Therapeutic Chemical (ATC) classification and on a factual NHS dm+d therapeutic-grouping code prefix. Source data: NHS dm+d via TRUD (OGL v3.0), WHO ATC/DDD Index.
NHS prescribing volume and spending trends
Check stock at pharmacies and supply information
Pharmacy stock checkers
Search for this medicine at major UK pharmacy chains. These links open the retailer's own website — results depend on their current online catalogue.
Supply & safety information
Official UK regulator monitoring and safety alerts
Pharmacy links redirect to the retailer's own search and do not represent real-time stock levels. Shortage and safety information sourced from MHRA drug safety updates (gov.uk, Crown Copyright under OGL v3.0).
Codes for healthcare professionals and prescribing systems
These codes are used by healthcare IT systems and prescribers to identify this medicine.
NHS UK identifiers
SNOMED CT and dm+d codes from NHS TRUD (Technology Reference data Update Distribution), licensed under the Open Government Licence v3.0. BNF code shown is the factual mapping value distributed by NHS Business Services Authority (NHSBSA) in the dm+d supplementary file under OGL v3.0; it is not affiliated with, nor licensed from, the publishers of the British National Formulary.
Active and completed clinical studies from ClinicalTrials.gov
Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine (NLM), National Institutes of Health (NIH). Data accessed via ClinicalTrials.gov API v2. Trial information is provided for research purposes and does not constitute medical advice.
Academic studies and reviews for this medicine's active substance
Showing the 50 most relevant studies.
Reviews & meta-analyses: 17 · Randomised trials: 1 · 1946–2026
Showing the 50 most relevant studies, sorted by most relevant.
V. Fridman, S. Suriyanarayanan, P. Novak, et al.
Neurology, 2019
L. Tabatabaie, Leo W. J. Klomp, Ruud Berger, et al.
Molecular Genetics and Metabolism, 2009
- Amino Acid Metabolism, Inborn Errors
- Transaminases
- Brain
Juliette Le Douce, Marianne Maugard, Julien Veran, et al.
Cell Metabolism, 2020
- Glycolysis
- Alzheimer Disease
- Astrocytes
Marianne Maugard, Pierre-Antoine Vigneron, Juan P. Bolaños, et al.
Progress in Neurobiology, 2020
- Synaptic Transmission
- Adenosine Triphosphate
- Astrocytes
Emmy P. Rogakou, Duane R. Pilch, Ann H. Orr, et al.
Journal of Biological Chemistry, 1998
- Gamma Rays
- Amino Acid Sequence
- Cells, Cultured
Jiping Zha, Hisashi Harada, Elizabeth Yang, et al.
Cell, 1996
- Tyrosine 3-Monooxygenase
- Amino Acid Sequence
- Carrier Proteins
Herman Wolosker, Seth Blackshaw, Solomon H. Snyder
Proceedings of the National Academy of Sciences, 1999
- Serine Racemase
- Amino Acid Sequence
- Astrocytes
Herman Wolosker, Kevin N. Sheth, Masaaki Takahashi, et al.
Proceedings of the National Academy of Sciences, 1999
- Amino Acid Isomerases
- Aminooxyacetic Acid
- Cerebral Cortex
Neil D. Rawlings, Alan J. Barrett
Methods in Enzymology, 1994
Walfred Leinfelder, Eva Zehelein, Marie‐Andrée Mandrand‐Berthelot, et al.
Nature, 1988
- Genes, Bacterial
- Protein Biosynthesis
- Base Sequence
Sources: aggregated from Europe PMC (EMBL-EBI), OpenAlex, Crossref, PubMed and other open scholarly databases. Retracted articles are excluded. Study information is provided for research purposes and does not constitute medical advice.
Pharmacology and chemical data from DrugBank
Key facts
Drug status
Approved
Major interactions
None known
Half-life
Not available
Mechanism
L-Serine plays a role in cell growth and development (cellular proliferation).
Food interactions
None known
Human targets
7 targets
Data: DrugBank · CC BY-NC 4.0
Pharmacokinetics at a glance
Proteins and enzymes this drug interacts with in the body
PMID:20506325 PMID:23974653 PMID:23981774
Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity)
PMID:20106978 PMID:23391306 PMID:29277459
D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine (By similarity)
PMID:19416851 PMID:19648650 PMID:20504773 PMID:20920666
The SPT complex is composed of SPTLC1, SPTLC2 or SPTLC3 and SPTSSA or SPTSSB. Within this complex, the heterodimer consisting of SPTLC1 and SPTLC2/SPTLC3 forms the catalytic core .
PMID:19416851
The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference .
PMID:19416851
The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA .
PMID:19416851 PMID:19648650
The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference .
PMID:19416851 PMID:19648650
Crucial for adipogenesis (By similarity)
PMID:19416851 PMID:33558762 PMID:36170811
The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference .
PMID:19416851 PMID:33558762
The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA .
PMID:19416851 PMID:19648650
The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference .
PMID:19416851 PMID:19648650 PMID:33558761 PMID:33558762
Required for adipocyte cell viability and metabolic homeostasis (By similarity)
Proteins that transport this drug across cell membranes
PMID:11827462 PMID:18337592 PMID:28754537
Mediates both uptake and efflux of 3,5,3'-triiodothyronine (T3) and 3,5,3',5'-tetraiodothyronine (T4) with high affinity, suggesting a role in the homeostasis of thyroid hormone levels .
PMID:18337592
Responsible for low affinity bidirectional transport of the aromatic amino acids, such as phenylalanine, tyrosine, tryptophan and L-3,4-dihydroxyphenylalanine (L-dopa) .
PMID:11827462 PMID:28754537
Plays an important role in homeostasis of aromatic amino acids (By similarity)
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Chemical identifiers
CAS, UNII, InChI Key and database cross-references
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Chemical identifiers
CAS, UNII, InChI Key and database cross-references
Linked compound data from DrugBank Open Data (CC BY-NC 4.0)
Serine
Matched from: L-Serine
Additional database identifiers
Drugs Product Database (DPD)
9927
ChemSpider
5736
BindingDB
50357212
PDB
SER
Guide to Pharmacology
726
ZINC
ZINC000000895034
HUGO Gene Nomenclature Committee (HGNC)
HGNC:1550
GenAtlas
CBS
GeneCards
CBS
GenBank Gene Database
L19501
GenBank Protein Database
388716
Guide to Pharmacology
1443
UniProt Accession
CBS_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:10691
GenAtlas
SDS
GeneCards
SDS
GenBank Gene Database
J05037
GenBank Protein Database
338030
UniProt Accession
SDHL_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:14398
GenAtlas
SRR
GeneCards
SRR
GenBank Gene Database
AF169974
GenBank Protein Database
11034785
UniProt Accession
SRR_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:11278
GenAtlas
SPTLC2
GeneCards
SPTLC2
GenBank Gene Database
Y08686
GenBank Protein Database
2564249
UniProt Accession
SPTC2_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:11277
GenAtlas
SPTLC1
GeneCards
SPTLC1
GenBank Gene Database
Y08685
GenBank Protein Database
2564247
UniProt Accession
SPTC1_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:10537
GenAtlas
SARS
GeneCards
SARS1
GenBank Gene Database
X91257
GenBank Protein Database
1050527
UniProt Accession
SYSC_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:341
GenAtlas
AGXT
GeneCards
AGXT
GenBank Gene Database
X56092
GenBank Protein Database
36582
UniProt Accession
AGT1_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:17027
GeneCards
SLC16A10
GenBank Gene Database
AB057445
GenBank Protein Database
18640047
UniProt Accession
MOT10_HUMAN
DrugBank citations
If you use DrugBank data in your research, please cite the following publications:
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Structured knowledge from the free knowledge base
Linked open data from Wikidata (Q106345473), a free and open knowledge base operated by the Wikimedia Foundation. Data is available under the Creative Commons CC0 1.0 Public Domain Dedication.