What should I avoid while taking L-Methionine 250mg tablets?

Take with food. (Source: DrugBank, licensed under CC BY-NC 4.0)

Do I need a prescription for L-Methionine 250mg tablets?

L-Methionine 250mg tablets is classified as a Valid as a prescribable product in the UK. However, always consult a pharmacist or doctor before use. (Source: NHS dm+d)

What are the brand names for L-Methionine 250mg tablets?

L-Methionine 250mg tablets is the generic name. It is available under brand names including: Methionine 250mg tablets, Methionine 250mg tablets, Methionine 250mg tablets, Methionine 250mg tablets. (Source: NHS dm+d — Actual Medicinal Products)

L-Methionine 250mg tablets

Tablet

250mg

Oral

A sulfur containing essential amino acid that is important in many body functions.

Active ingredients:

L-Methionine

ATC classificationBrowse ATC index

International classification by the WHO, grouping medicines by the organ system they act on

ATC V03AB26

Chemical classBrowse classes

Classification based on the molecule's chemical structure and properties

Check interactions for L-Methionine

No active safety alerts

Official documents, adverse reaction reporting, and safety monitoring

Report a side effect

Submit a Yellow Card report to the MHRA

Official medicine documents

Yellow Card

Report side effects (MHRA)

Drug safety updates

MHRA alerts for L-Methionine

Source: MHRA Products DatabaseOGL 3.0

Updated 16 Jan 2026

Safety monitoring data

Yellow Card reports

MHRA

The MHRA Yellow Card scheme collects reports of suspected side effects from healthcare professionals and patients. View the Drug Analysis Profile (iDAP) for real-world adverse reaction data.

View Drug Analysis Profile

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Report a side effect

Submit a Yellow Card report to the MHRA

Data from the MHRA Yellow Card scheme. A reported reaction does not necessarily mean the medicine caused it. Contains public sector information licensed under the Open Government Licence v3.0.

EudraVigilance

EMA

The European Medicines Agency (EMA) collects suspected adverse reaction reports from across the EU/EEA through the EudraVigilance system. Search for safety data on this medicine.

Search EudraVigilance database

Browse substances A–Z in the European adverse reaction database

About EudraVigilance

Learn about EU pharmacovigilance and safety monitoring

EudraVigilance data is published by the European Medicines Agency (EMA). A suspected adverse reaction is not necessarily caused by the medicine.

4 branded products available

4 products

Possibly available on the UK marketDiscontinuedAvailability per NHS dm+d

MHRA licensed products

View all licensed products for L-Methionine on the MHRA register

Methionine 250mg tablets

A A H Pharmaceuticals Ltd

Discontinued

Methionine 250mg tablets

The Boots Company Plc

Discontinued

Methionine 250mg tablets

UCB Pharma Ltd

Discontinued

Methionine 250mg tablets

Alliance Healthcare (Distribution) Ltd

Discontinued

Source: NHS dm+dOGL 3.0

Updated 1 Mar 2026

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Similarity is based on WHO Anatomical Therapeutic Chemical (ATC) classification and on a factual NHS dm+d therapeutic-grouping code prefix. Source data: NHS dm+d via TRUD (OGL v3.0), WHO ATC/DDD Index.

NHS prescribing volume and spending trends

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Guidelines from the National Institute for Health and Care Excellence

NICE clinical guidance(1)

Active B12 assay for diagnosing vitamin B12 deficiency (MIB40)

MIB40

Guidance

Updated Sept 2015

Source: National Institute for Health and Care Excellence (NICE). Contains public sector information licensed under the Open Government Licence v3.0.

Check stock at pharmacies and supply information

Pharmacy stock checkers

Search for this medicine at major UK pharmacy chains. These links open the retailer's own website — results depend on their current online catalogue.

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Supply & safety information

Official UK regulator monitoring and safety alerts

MHRA drug safety updates

UK regulator alerts and supply notices

Pharmacy links redirect to the retailer's own search and do not represent real-time stock levels. Shortage and safety information sourced from MHRA drug safety updates (gov.uk, Crown Copyright under OGL v3.0).

Codes for healthcare professionals and prescribing systems

These codes are used by healthcare IT systems and prescribers to identify this medicine.

NHS UK identifiers

SNOMED CT

41986411000001102

dm+d ID

41986411000001102

VTM (Virtual Therapeutic Moiety)

42596011000001101

VMP (Virtual Medicinal Product)

41986411000001102

International identifiers

ATC code — Anatomical Therapeutic Chemical (WHO)

V03AB26

Browse tools

dm+d Browser

NHSBSA medicines dictionary lookup

SNOMED CT and dm+d codes from NHS TRUD (Technology Reference data Update Distribution), licensed under the Open Government Licence v3.0. ATC codes from the WHO Collaborating Centre for Drug Statistics Methodology (whocc.no).

Active and completed clinical studies from ClinicalTrials.gov

Searching UK clinical trials...

Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine (NLM), National Institutes of Health (NIH). Data accessed via ClinicalTrials.gov API v2. Trial information is provided for research purposes and does not constitute medical advice.

Academic studies and reviews for this medicine's active substance

Showing the 50 most relevant studies.

Reviews & meta-analyses: 16 · 1953–2024

Sort

Efficacy and acceptability of S-adenosyl-L-methionine (SAMe) for depressed patients: A systematic review and meta- analysis.

Limveeraprajak N, Nakhawatchana S, Visukamol A, et al.

2024

Systematic review

Cited by 6

S-Adenosylmethionine
Antidepressive Agents
Depression

Assessing the nutritional equivalency of DL-methionine and L-methionine in broiler chickens: a meta-analytical study.

Asasi R, Ahmadi H, Torshizi MAK, et al.

2023

Meta-analysis

Open access

Cited by 4

Chickens
Animal Feed
Methionine

The purpose of this study was to perform a meta-analysis comparing the biological efficiency of DL-methionine and L-methionine (DL-Met and L-Met) in broiler nutrition. This analysis was based on a dataset comprising experiment results published in peer-reviewed papers since 2007. All experiments investigated the response of broilers (aged 0-21 d) to different dietary concentrations of DL- and L-Met, achieved by supplementing crystalline Met. A graphical analysis was conducted on the database using ellipses coverage and nonparametric density techniques. Two methods of linear and nonlinear exponential meta-regression analysis were used to determine relative bioavailability based on average daily gain (ADG) and feed conversion ratio (FCR) responses to dietary Met sources. The analyses of ADG and FCR obtained from both linear and exponential models showed a relative difference between the tested methionine sources. The results showed that both ADG and FCR were improved in L-Met compared to DL-Met supplemented diets. Linear regression analysis revealed that DL-Met was 94.97% (for ADG) and 95.63% (for FCR) as efficacious as L-Met (P < 0.01). In contrast, the analysis of the fitted nonlinear exponential model showed that the biological efficiencies of DL-Met were 91.33% and 76.57% of the values for L-Met for ADG (P = 0.01) and FCR (P = 0.09), respectively. Based on the meta-analytical results, an equivalence of relative biological efficiency of DL-Met in comparison with L-Met for young broilers could not be confirmed.

Abstract licence: CC BY-NC-ND

S-Adenosyl-L-methionine: beyond the universal methyl group donor.

S. Roje

Phytochemistry, 2006

Review

Cited by 440

Data for meta-analysis need standardization-a response to "Assessing the nutritional equivalency of DL-methionine and L-methionine in broiler chickens: a meta-analytical study" by Asasi et al.

Lemme A, Afsar A

2024

Meta-analysis

Chickens
Methionine
Animal Feed

Methionine Metabolism Shapes T Helper Cell Responses through Regulation of Epigenetic Reprogramming.

D. Roy, Jocelyn Chen, V. Mamane, et al.

Cell metabolism, 2020

Cited by 297

Neuropharmacology of S-adenosyl-L-methionine.

Ross J. Baldessarini

The American journal of medicine, 1987

Review

Cited by 134

Antioxidant effects of alpha tocopherol, ascorbic acid and L-methionine on lead induced oxidative stress to the liver, kidney and brain in rats.

R. C. Patra, D. Swarup, S. Dwivedi

Toxicology, 2001

Cited by 497

Nonenzymatic methylation of DNA by the intracellular methyl group donor S‐adenosyl‐L‐methionine is a potentially mutagenic reaction.

B. Rydberg, T. Lindahl

The EMBO Journal, 1982

Cited by 398

S-Adenosylmethionine; a new intermediate formed enzymatically from L-methionine and adenosinetriphosphate.

G. Cantoni

Journal of Biological Chemistry, 1953

Cited by 386

On the role of S-adenosyl-L-methionine in the biosynthesis of spermidine by rat prostate.

A. Pegg, H. Williams-Ashman

The Journal of biological chemistry, 1969

Cited by 356

Sources: aggregated from Europe PMC (EMBL-EBI), OpenAlex, Crossref, PubMed and other open scholarly databases. Retracted articles are excluded. Study information is provided for research purposes and does not constitute medical advice.

Pharmacology and chemical data from DrugBank

go.drugbank.com

Key facts

Drug status

Approved

Major interactions

None known

Half-life

Not available

Mechanism

The mechanism of the possible anti-hepatotoxic activity of L-methionine is not entirely clear.

Food interactions

1 warning

Human targets

5 targets

Data: DrugBank · CC BY-NC 4.0

Pharmacokinetics at a glance

Absorption

Absorbed from the lumen of the small intestine into the enterocytes by an active transport process.

Metabolism

Hepatic

Pharmacokinetic data: DrugBank · CC BY-NC 4.0

Status:

Approved

Investigational

Nutraceutical

Small molecule

About this compound

A sulfur containing essential amino acid that is important in many body functions. It is a chelating agent for heavy metals.

Properties:

solid

Avg. mass: 149.21 Da

DrugBank indication

Used for protein synthesis including the formation of SAMe, L-homocysteine, L-cysteine, taurine, and sulfate.

Also known as(92)

(2S)-2-amino-4-(methylsulfanyl)butanoic acid

(S)-2-amino-4-(methylthio)butanoic acid

(S)-2-amino-4-(methylthio)butyric acid

(S)-methionine

L-(−)-methionine

L-a-Amino-g-methylthiobutyric acid

L-Methionin

L-Methionine

Molecular properties(19)

Drug interactions(1)

Known interactions with other medicines. Always consult a healthcare professional.

Levodopa

Moderate

DB01235

The therapeutic efficacy of Levodopa can be decreased when used in combination with Methionine.

Check this interaction

Showing 1 of 1 interactions

Food & lifestyle interactions

Take With Food

Take with food.

Toxicity & overdose

Doses of L-methionine of up to 250 mg daily are generally well tolerated. Higher doses may cause nausea, vomiting and headache. Healthy adults taking 8 grams of L-methionine daily for four days were found to have reduced serum folate levels and leucocytosis.

Healthy adults taking 13.9 grams of L-methionine daily for five days were found to have changes in serum pH and potassium and increased urinary calcium excretion. Schizophrenic patients given 10 to 20 grams of L-methionine daily for two weeks developed functional psychoses. Single doses of 8 grams precipitated encephalopathy in patients with cirrhosis.

How it works

Mechanism of action

The mechanism of the possible anti-hepatotoxic activity of L-methionine is not entirely clear. It is thought that metabolism of high doses of acetaminophen in the liver lead to decreased levels of hepatic glutathione and increased oxidative stress. L-methionine is a precursor to L-cysteine. L-cysteine itself may have antioxidant activity. L-cysteine is also a precursor to the antioxidant glutathione. Antioxidant activity of L-methionine and metabolites of L-methionine appear to account for its possible anti-hepatotoxic activity. Recent research suggests that methionine itself has free-radical scavenging activity by virtue of its sulfur, as well as its chelating ability.

Pharmacodynamics

L-Methionine is a principle supplier of sulfur which prevents disorders of the hair, skin and nails; helps lower cholesterol levels by increasing the liver's production of lecithin; reduces liver fat and protects the kidneys; a natural chelating agent for heavy metals; regulates the formation of ammonia and creates ammonia-free urine which reduces bladder irritation; influences hair follicles and promotes hair growth. L-methionine may protect against the toxic effects of hepatotoxins, such as acetaminophen. Methionine may have antioxidant activity.

Pharmacokinetics

How the body processes this drug — absorption, distribution, metabolism, and elimination

Absorption

Absorbed from the lumen of the small intestine into the enterocytes by an active transport process.

Metabolism

Hepatic

Drug targets(5)

Proteins and enzymes this drug interacts with in the body

Methionine synthase reductase

BE0000763

MTRR

product of

Specific function[methionine synthase] reductase (NADPH) activity

Cellular location

Cytoplasm

General function & pharmacology

Key enzyme in methionine and folate homeostasis responsible for the reactivation of methionine synthase (MTR/MS) activity by catalyzing the reductive methylation of MTR-bound cob(II)alamin .
PMID:17892308
Cobalamin (vitamin B12) forms a complex with MTR to serve as an intermediary in methyl transfer reactions that cycles between MTR-bound methylcob(III)alamin and MTR bound-cob(I)alamin forms, and occasional oxidative escape of the cob(I)alamin intermediate during the catalytic cycle leads to the inactive cob(II)alamin species (Probable). The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine .
PMID:27771510
Also necessary for the utilization of methyl groups from the folate cycle, thereby affecting transgenerational epigenetic inheritance (By similarity). Also acts as a molecular chaperone for methionine synthase by stabilizing apoMTR and incorporating methylcob(III)alamin into apoMTR to form the holoenzyme .
PMID:16769880
Also serves as an aquacob(III)alamin reductase by reducing aquacob(III)alamin to cob(II)alamin; this reduction leads to stimulation of the conversion of apoMTR and aquacob(III)alamin to MTR holoenzyme PMID:16769880

Methionine synthase

BE0000734

MTR

product of

Specific functioncobalamin binding

Cellular location

Cytoplasm

General function & pharmacology

Catalyzes the transfer of a methyl group from methylcob(III)alamin (MeCbl) to homocysteine, yielding enzyme-bound cob(I)alamin and methionine in the cytosol .
PMID:16769880 PMID:17288554 PMID:27771510

MeCbl is an active form of cobalamin (vitamin B12) used as a cofactor for methionine biosynthesis. Cob(I)alamin form is regenerated to MeCbl by a transfer of a methyl group from 5-methyltetrahydrofolate .
PMID:16769880 PMID:17288554 PMID:27771510

The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine PMID:16769880 PMID:27771510

Methionine aminopeptidase 2

BE0001534

METAP2

product of

Specific functionaminopeptidase activity

Cellular location

Cytoplasm

General function & pharmacology

Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo

Betaine--homocysteine S-methyltransferase 1

BE0000845

BHMT

product of

Specific functionbetaine-homocysteine S-methyltransferase activity

Cellular location

Cytoplasm, cytosol

General function & pharmacology

Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline

S-methylmethionine--homocysteine S-methyltransferase BHMT2

BE0002249

BHMT2

product of

Specific functionS-methylmethionine-homocysteine S-methyltransferase activity

General function & pharmacology

Involved in the regulation of homocysteine metabolism. Converts homocysteine to methionine using S-methylmethionine (SMM) as a methyl donor

Metabolizing enzymes(11)

Enzymes involved in drug metabolism — important for understanding drug interactions

Enzyme activity key

substrate

inhibitor

inducer

MAT2AS-adenosylmethionine synthase isoform type-2

substrate

MSRB2Methionine-R-sulfoxide reductase B2, mitochondrial

substrate

MAT1AS-adenosylmethionine synthase isoform type-1

substrate

MSRB1Methionine-R-sulfoxide reductase B1

substrate

MSRAMitochondrial peptide methionine sulfoxide reductase

substrate

MARS1Methionine--tRNA ligase, cytoplasmic

substrate

MARS2Methionine--tRNA ligase, mitochondrial

substrate

MAT2BMethionine adenosyltransferase 2 subunit beta

substrate

BHMT2S-methylmethionine--homocysteine S-methyltransferase BHMT2

product of

GLULGlutamine synthetase

inhibitor

MTHFRMethylenetetrahydrofolate reductase (NADPH)

inhibitor

Transporters(1)

Proteins that transport this drug across cell membranes

Monocarboxylate transporter 10

BE0003654

SLC16A10

inhibitor

Specific functionamino acid transmembrane transporter activity

Cellular location

Cell membrane

General function & pharmacology

Sodium- and proton-independent thyroid hormones and aromatic acids transporter .
PMID:11827462 PMID:18337592 PMID:28754537

Mediates both uptake and efflux of 3,5,3'-triiodothyronine (T3) and 3,5,3',5'-tetraiodothyronine (T4) with high affinity, suggesting a role in the homeostasis of thyroid hormone levels .
PMID:18337592
Responsible for low affinity bidirectional transport of the aromatic amino acids, such as phenylalanine, tyrosine, tryptophan and L-3,4-dihydroxyphenylalanine (L-dopa) .
PMID:11827462 PMID:28754537
Plays an important role in homeostasis of aromatic amino acids (By similarity)

Biological pathways(49)

Betaine Metabolism

metabolic

Involved compounds

Betaine aldehyde,Adenosine,ATP,Choline,N,N-dimethylglycine,Pyrophosphoric acid,Flavin adenine dinucleotide,Methionine,Magnesium cation,NADH,Potassium cation,Ademetionine,Tetrahydrofolic acid,Zinc

Azithromycin Action Pathway

Involved compounds

Adenosine phosphate,ATP,Azithromycin,Cytidine-5'-Triphosphate,D-Serine,Pyrophosphoric acid,Guanosine-5'-Monophosphate,Alanine,Asparagine,Histidine,Isoleucine,Leucine,Methionine,Proline,Threonine,Valine,Uridine monophosphate

Clarithromycin Action Pathway

Involved compounds

Adenosine phosphate,ATP,Clarithromycin,Cytidine-5'-Triphosphate,D-Serine,Pyrophosphoric acid,Guanosine-5'-Monophosphate,Alanine,Asparagine,Histidine,Isoleucine,Leucine,Methionine,Proline,Threonine,Valine,Uridine monophosphate

Clindamycin Action Pathway

Involved compounds

Adenosine phosphate,ATP,Clindamycin,Cytidine-5'-Triphosphate,D-Serine,Pyrophosphoric acid,Guanosine-5'-Monophosphate,Alanine,Asparagine,Histidine,Isoleucine,Leucine,Methionine,Proline,Threonine,Valine,Uridine monophosphate

Erythromycin Action Pathway

Involved compounds

Adenosine phosphate,ATP,Cytidine-5'-Triphosphate,D-Serine,Pyrophosphoric acid,Erythromycin,Guanosine-5'-Monophosphate,Alanine,Asparagine,Histidine,Isoleucine,Leucine,Methionine,Proline,Threonine,Valine,Uridine monophosphate

Roxithromycin Action Pathway

Involved compounds

Adenosine phosphate,ATP,Cytidine-5'-Triphosphate,D-Serine,Pyrophosphoric acid,Guanosine-5'-Monophosphate,Alanine,Asparagine,Histidine,Isoleucine,Leucine,Methionine,Proline,Threonine,Valine,Roxithromycin,Uridine monophosphate

Telithromycin Action Pathway

Involved compounds

Amikacin Action Pathway

Involved compounds

Adenosine phosphate,ATP,Amikacin,Cytidine-5'-Triphosphate,D-Serine,Pyrophosphoric acid,Guanosine-5'-Monophosphate,Alanine,Asparagine,Histidine,Isoleucine,Leucine,Methionine,Proline,Threonine,Valine,Uridine monophosphate

Gentamicin Action Pathway

Involved compounds

Adenosine phosphate,ATP,Cytidine-5'-Triphosphate,D-Serine,Pyrophosphoric acid,Gentamicin,Guanosine-5'-Monophosphate,Alanine,Asparagine,Histidine,Isoleucine,Leucine,Methionine,Proline,Threonine,Valine,Uridine monophosphate

Kanamycin Action Pathway

Involved compounds

Adenosine phosphate,ATP,Cytidine-5'-Triphosphate,D-Serine,Pyrophosphoric acid,Guanosine-5'-Monophosphate,Kanamycin,Alanine,Asparagine,Histidine,Isoleucine,Leucine,Methionine,Proline,Threonine,Valine,Uridine monophosphate

Neomycin Action Pathway

Involved compounds

Adenosine phosphate,ATP,Cytidine-5'-Triphosphate,D-Serine,Pyrophosphoric acid,Framycetin,Guanosine-5'-Monophosphate,Alanine,Asparagine,Histidine,Isoleucine,Leucine,Methionine,Proline,Threonine,Valine,Uridine monophosphate

Netilmicin Action Pathway

Involved compounds

Spectinomycin Action Pathway

Involved compounds

Streptomycin Action Pathway

Involved compounds

Clomocycline Action Pathway

Involved compounds

Adenosine phosphate,ATP,Clomocycline,Cytidine-5'-Triphosphate,D-Serine,Pyrophosphoric acid,Guanosine-5'-Monophosphate,Alanine,Asparagine,Histidine,Isoleucine,Leucine,Methionine,Proline,Threonine,Valine,Uridine monophosphate

Demeclocycline Action Pathway

Involved compounds

Adenosine phosphate,ATP,Cytidine-5'-Triphosphate,D-Serine,Demeclocycline,Pyrophosphoric acid,Guanosine-5'-Monophosphate,Alanine,Asparagine,Histidine,Isoleucine,Leucine,Methionine,Proline,Threonine,Valine,Uridine monophosphate

Doxycycline Action Pathway

Involved compounds

Adenosine phosphate,ATP,Cytidine-5'-Triphosphate,D-Serine,Pyrophosphoric acid,Doxycycline,Guanosine-5'-Monophosphate,Alanine,Asparagine,Histidine,Isoleucine,Leucine,Methionine,Proline,Threonine,Valine,Uridine monophosphate

Minocycline Action Pathway

Involved compounds

Oxytetracycline Action Pathway

Involved compounds

Tetracycline Action Pathway

Involved compounds

Lymecycline Action Pathway

Involved compounds

Spermidine and Spermine Biosynthesis

metabolic

Involved compounds

ATP,Pyrophosphoric acid,Methionine,Ornithine,Magnesium cation,Potassium cation,Putrescine,Pyridoxal phosphate,Pyruvaldehyde,Ademetionine,Spermidine,Spermine

Tobramycin Action Pathway

Involved compounds

Tigecycline Action Pathway

Involved compounds

Arbekacin Action Pathway

Involved compounds

Adenosine phosphate,ATP,Arbekacin,Cytidine-5'-Triphosphate,D-Serine,Pyrophosphoric acid,Guanosine-5'-Monophosphate,Alanine,Asparagine,Histidine,Isoleucine,Leucine,Methionine,Proline,Threonine,Valine,Uridine monophosphate

Paromomycin Action Pathway

Involved compounds

Rolitetracycline Action Pathway

Involved compounds

Methacycline Action Pathway

Involved compounds

Lincomycin Action Pathway

Involved compounds

Chloramphenicol Action Pathway

Involved compounds

Adenosine phosphate,ATP,Chloramphenicol,Cytidine-5'-Triphosphate,D-Serine,Pyrophosphoric acid,Guanosine-5'-Monophosphate,Alanine,Asparagine,Histidine,Isoleucine,Leucine,Methionine,Proline,Threonine,Valine,Uridine monophosphate

Troleandomycin Action Pathway

Involved compounds

Josamycin Action Pathway

Involved compounds

Adenosine phosphate,ATP,Cytidine-5'-Triphosphate,D-Serine,Pyrophosphoric acid,Guanosine-5'-Monophosphate,Josamycin,Alanine,Asparagine,Histidine,Isoleucine,Leucine,Methionine,Proline,Threonine,Valine,Uridine monophosphate

Sarcosine Oncometabolite Pathway

disease

Involved compounds

Betaine aldehyde,ATP,Choline,N,N-dimethylglycine,Pyrophosphoric acid,Flavin adenine dinucleotide,Glycine,Methionine,Serine,Magnesium cation,NADH,Potassium cation,Pyridoxal phosphate,Ademetionine,Tetrahydrofolic acid,Zinc

ATC classification(1 code)

ATC V03AB26

Affected organisms(1)

Humans and other mammals

Salt forms(1)

Methionine hydrochloride(DBSALT002219)

Experimental properties(5)

External resources(1)

PDRhealth

Chemical identifiers

CAS, UNII, InChI Key and database cross-references

Show

Linked compound data from DrugBank Open Data (CC BY-NC 4.0)

Methionine

Matched from: L-Methionine

DB00134

CAS number

63-68-3

UNII (FDA)

AE28F7PNPL

InChI Key (molecular fingerprint)

FFEARJCKVFRZRR-BYPYZUCNSA-N

Synonym match

95% confidence

Additional database identifiers

Drugs Product Database (DPD)

3180

Drugs Product Database (DPD)

7217

ChEBI

57844

PubChem Compound

6137

PubChem Substance

46505750

KEGG Compound

C00073

KEGG Drug

D00019

ChemSpider

5907

BindingDB

50142500

PharmGKB

PA450423

PDB

MET

Wikipedia

Methionine

ChEMBL

CHEMBL42336

ZINC

ZINC000001532529

RxCUI

6837

HUGO Gene Nomenclature Committee (HGNC)

HGNC:7473

GenAtlas

MTRR

GeneCards

MTRR

GenBank Gene Database

AF121213

GenBank Protein Database

6572540

UniProtKB

Q9UBK8

UniProt Accession

MTRR_HUMAN

HUGO Gene Nomenclature Committee (HGNC)

HGNC:7468

GenAtlas

MTR

GeneCards

MTR

GenBank Gene Database

U71285

GenBank Protein Database

1923221

UniProtKB

Q99707

UniProt Accession

METH_HUMAN

HUGO Gene Nomenclature Committee (HGNC)

HGNC:16672

GenAtlas

METAP2

GeneCards

METAP2

GenBank Gene Database

U29607

GenBank Protein Database

903982

Guide to Pharmacology

1573

UniProtKB

P50579

UniProt Accession

MAP2_HUMAN

HUGO Gene Nomenclature Committee (HGNC)

HGNC:1047

GenAtlas

BHMT

GeneCards

BHMT

GenBank Gene Database

U50929

GenBank Protein Database

1522683

UniProtKB

Q93088

UniProt Accession

BHMT1_HUMAN

HUGO Gene Nomenclature Committee (HGNC)

HGNC:1048

GenAtlas

BHMT2

GeneCards

BHMT2

GenBank Gene Database

AF257473

GenBank Protein Database

11907831

UniProtKB

Q9H2M3

UniProt Accession

BHMT2_HUMAN

HUGO Gene Nomenclature Committee (HGNC)

HGNC:6904

GenAtlas

MAT2A

GeneCards

MAT2A

GenBank Gene Database

X68836

GenBank Protein Database

36327

UniProtKB

P31153

UniProt Accession

METK2_HUMAN

HUGO Gene Nomenclature Committee (HGNC)

HGNC:17061

GenAtlas

MSRB2

GeneCards

MSRB2

GenBank Gene Database

AF151889

GenBank Protein Database

4929731

UniProtKB

Q9Y3D2

UniProt Accession

MSRB2_HUMAN

HUGO Gene Nomenclature Committee (HGNC)

HGNC:6903

GenAtlas

MAT1A

GeneCards

MAT1A

GenBank Gene Database

D49357

GenBank Protein Database

220066

UniProtKB

Q00266

UniProt Accession

METK1_HUMAN

HUGO Gene Nomenclature Committee (HGNC)

HGNC:14133

GenAtlas

SEPX1

GeneCards

MSRB1

GenBank Gene Database

AF166124

GenBank Protein Database

6649219

UniProtKB

Q9NZV6

UniProt Accession

MSRB1_HUMAN

HUGO Gene Nomenclature Committee (HGNC)

HGNC:7377

GenAtlas

MSRA

GeneCards

MSRA

GenBank Gene Database

AJ242973

GenBank Protein Database

6136945

UniProtKB

Q9UJ68

UniProt Accession

MSRA_HUMAN

HUGO Gene Nomenclature Committee (HGNC)

HGNC:6898

GenAtlas

MARS

GeneCards

MARS1

GenBank Gene Database

X94754

GenBank Protein Database

1702932

UniProtKB

P56192

UniProt Accession

SYMC_HUMAN

HUGO Gene Nomenclature Committee (HGNC)

HGNC:25133

GenAtlas

MARS2

GeneCards

MARS2

GenBank Gene Database

AB107013

GenBank Protein Database

37196758

UniProtKB

Q96GW9

UniProt Accession

SYMM_HUMAN

HUGO Gene Nomenclature Committee (HGNC)

HGNC:6905

GenAtlas

MAT2B

GeneCards

MAT2B

GenBank Gene Database

AF182814

GenBank Protein Database

6815285

UniProtKB

Q9NZL9

UniProt Accession

MAT2B_HUMAN

HUGO Gene Nomenclature Committee (HGNC)

HGNC:1048

GenAtlas

BHMT2

GeneCards

BHMT2

GenBank Gene Database

AF257473

GenBank Protein Database

11907831

UniProtKB

Q9H2M3

UniProt Accession

BHMT2_HUMAN

HUGO Gene Nomenclature Committee (HGNC)

HGNC:4341

GenAtlas

GLUL

GeneCards

GLUL

GenBank Gene Database

Y00387

GenBank Protein Database

31833

UniProtKB

P15104

UniProt Accession

GLNA_HUMAN

HUGO Gene Nomenclature Committee (HGNC)

HGNC:7436

GenAtlas

MTHFR

GeneCards

MTHFR

GenBank Gene Database

U09806

GenBank Protein Database

6139053

UniProtKB

P42898

UniProt Accession

MTHR_HUMAN

HUGO Gene Nomenclature Committee (HGNC)

HGNC:17027

GeneCards

SLC16A10

GenBank Gene Database

AB057445

GenBank Protein Database

18640047

UniProtKB

Q8TF71

UniProt Accession

MOT10_HUMAN

DrugBank citations

If you use DrugBank data in your research, please cite:

DrugBank 6.02024Recommended citation
Knox C., Wilson M., Klinger C.M., et al
DrugBank 6.
0: the DrugBank Knowledgebase for 2024
Nucleic Acids Res. 2024 Jan 552(D1):D1265-D1275
PMID: 37953279
DrugBank 5.02018
Wishart D.S., Feunang Y.D., Guo A.C., et al
DrugBank 5.
0: a major update to the DrugBank database for 2018
Nucleic Acids Res. 2017 Nov 846(D1):D1074-D1082
PMID: 29126136
DrugBank 4.02014
Law V., Knox C., Djoumbou Y., et al
DrugBank 4.
0: shedding new light on drug metabolism
Nucleic Acids Res. 2014 Jan 142(1):D1091-7
PMID: 24203711
DrugBank 3.02011
Knox C., Law V., Jewison T., et al
DrugBank 3.
0: a comprehensive resource for 'omics' research on drugs
Nucleic Acids Res. 2011 Jan39(Database issue):D1035-41
PMID: 21059682
DrugBank 2.02008
Wishart D.S., Knox C., Guo A.C., et al
DrugBank: a knowledgebase for drugs, drug actions and drug targets.
Nucleic Acids Research
2008 Jan36(Database issue):D901-6
PMID: 18048412
DrugBank 1.02006
Wishart D.S., Knox C., Guo A.C., et al
DrugBank: a comprehensive resource for in silico drug discovery and exploration.
Nucleic Acids Research
2006 Jan 134(Database issue):D668-72
PMID: 16381955

Source: go.drugbank.comCC BY-NC 4.0

Updated 4 Mar 2026

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