L-Methionine 250mg tablets
A sulfur containing essential amino acid that is important in many body functions.
Official documents, adverse reaction reporting, and safety monitoring
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Official medicine documents
Safety monitoring data
Yellow Card reports
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Data from the MHRA Yellow Card scheme. A reported reaction does not necessarily mean the medicine caused it. Contains public sector information licensed under the Open Government Licence v3.0.
EudraVigilance
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4 branded products available
Therapeutically similar medicines
Similarity based on WHO Anatomical Therapeutic Chemical (ATC) classification and NHS BNF section grouping. Source data: NHS dm+d via TRUD (OGL v3.0), WHO ATC/DDD Index.
NHS prescribing volume and spending trends
Clinical guidelines and formulary information
British National Formulary
L-Methionine
Source: British National Formulary, NICE. Joint Formulary Committee. Contains public sector information licensed under the Open Government Licence v3.0.
NICE clinical guidance(1)
Source: National Institute for Health and Care Excellence (NICE). Contains public sector information licensed under the Open Government Licence v3.0.
Check stock at pharmacies and supply information
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Search for this medicine at major UK pharmacy chains. These links open the retailer's own website — results depend on their current online catalogue.
Supply & product information
Official product databases and supply status monitoring
Pharmacy links redirect to the retailer's own search and do not represent real-time stock levels. emc (electronic medicines compendium) is operated by Datapharm Ltd. Shortage information sourced from NHS Specialist Pharmacy Service (SPS), sps.nhs.uk.
Codes for healthcare professionals and prescribing systems
These codes are used by healthcare IT systems and prescribers to identify this medicine.
NHS UK identifiers
Browse tools
SNOMED CT and dm+d codes from NHS TRUD (Technology Reference data Update Distribution), licensed under the Open Government Licence v3.0. BNF codes from NHS Business Services Authority (NHSBSA). ATC codes from the WHO Collaborating Centre for Drug Statistics Methodology (whocc.no).
Active and completed clinical studies from ClinicalTrials.gov
Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine (NLM), National Institutes of Health (NIH). Data accessed via ClinicalTrials.gov API v2. Trial information is provided for research purposes and does not constitute medical advice.
Pharmacology and chemical data from DrugBank
Key facts
Drug status
Approved
Major interactions
None known
Half-life
Not available
Mechanism
The mechanism of the possible anti-hepatotoxic activity of L-methionine is not entirely clear.
Food interactions
1 warning
Human targets
5 targets
Data: DrugBank · CC BY-NC 4.0
Pharmacokinetics at a glance
Absorption
Metabolism
Pharmacokinetic data: DrugBank · CC BY-NC 4.0
Known interactions with other medications. Always consult a healthcare professional.
Showing 1 of 1 interactions
Healthy adults taking 13.9 grams of L-methionine daily for five days were found to have changes in serum pH and potassium and increased urinary calcium excretion. Schizophrenic patients given 10 to 20 grams of L-methionine daily for two weeks developed functional psychoses. Single doses of 8 grams precipitated encephalopathy in patients with cirrhosis.
How the body processes this drug — absorption, distribution, metabolism, and elimination
Proteins and enzymes this drug interacts with in the body
PMID:17892308
Cobalamin (vitamin B12) forms a complex with MTR to serve as an intermediary in methyl transfer reactions that cycles between MTR-bound methylcob(III)alamin and MTR bound-cob(I)alamin forms, and occasional oxidative escape of the cob(I)alamin intermediate during the catalytic cycle leads to the inactive cob(II)alamin species (Probable). The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine .
PMID:27771510
Also necessary for the utilization of methyl groups from the folate cycle, thereby affecting transgenerational epigenetic inheritance (By similarity). Also acts as a molecular chaperone for methionine synthase by stabilizing apoMTR and incorporating methylcob(III)alamin into apoMTR to form the holoenzyme .
PMID:16769880
Also serves as an aquacob(III)alamin reductase by reducing aquacob(III)alamin to cob(II)alamin; this reduction leads to stimulation of the conversion of apoMTR and aquacob(III)alamin to MTR holoenzyme PMID:16769880
PMID:16769880 PMID:17288554 PMID:27771510
MeCbl is an active form of cobalamin (vitamin B12) used as a cofactor for methionine biosynthesis. Cob(I)alamin form is regenerated to MeCbl by a transfer of a methyl group from 5-methyltetrahydrofolate .
PMID:16769880 PMID:17288554 PMID:27771510
The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine PMID:16769880 PMID:27771510
Enzymes involved in drug metabolism — important for understanding drug interactions
Proteins that transport this drug across cell membranes
PMID:11827462 PMID:18337592 PMID:28754537
Mediates both uptake and efflux of 3,5,3'-triiodothyronine (T3) and 3,5,3',5'-tetraiodothyronine (T4) with high affinity, suggesting a role in the homeostasis of thyroid hormone levels .
PMID:18337592
Responsible for low affinity bidirectional transport of the aromatic amino acids, such as phenylalanine, tyrosine, tryptophan and L-3,4-dihydroxyphenylalanine (L-dopa) .
PMID:11827462 PMID:28754537
Plays an important role in homeostasis of aromatic amino acids (By similarity)
Involved compounds
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ATC V03AB26
Chemical identifiers
CAS, UNII, InChI Key and database cross-references
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Chemical identifiers
CAS, UNII, InChI Key and database cross-references
Linked compound data from DrugBank Open Data (CC BY-NC 4.0)
Methionine
Matched from: L-Methionine
Additional database identifiers
Drugs Product Database (DPD)
3180
Drugs Product Database (DPD)
7217
ChemSpider
5907
BindingDB
50142500
PDB
MET
ZINC
ZINC000001532529
HUGO Gene Nomenclature Committee (HGNC)
HGNC:7473
GenAtlas
MTRR
GeneCards
MTRR
GenBank Gene Database
AF121213
GenBank Protein Database
6572540
UniProt Accession
MTRR_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:7468
GenAtlas
MTR
GeneCards
MTR
GenBank Gene Database
U71285
GenBank Protein Database
1923221
UniProt Accession
METH_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:16672
GenAtlas
METAP2
GeneCards
METAP2
GenBank Gene Database
U29607
GenBank Protein Database
903982
Guide to Pharmacology
1573
UniProt Accession
MAP2_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:1047
GenAtlas
BHMT
GeneCards
BHMT
GenBank Gene Database
U50929
GenBank Protein Database
1522683
UniProt Accession
BHMT1_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:1048
GenAtlas
BHMT2
GeneCards
BHMT2
GenBank Gene Database
AF257473
GenBank Protein Database
11907831
UniProt Accession
BHMT2_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:6904
GenAtlas
MAT2A
GeneCards
MAT2A
GenBank Gene Database
X68836
GenBank Protein Database
36327
UniProt Accession
METK2_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:17061
GenAtlas
MSRB2
GeneCards
MSRB2
GenBank Gene Database
AF151889
GenBank Protein Database
4929731
UniProt Accession
MSRB2_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:6903
GenAtlas
MAT1A
GeneCards
MAT1A
GenBank Gene Database
D49357
GenBank Protein Database
220066
UniProt Accession
METK1_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:14133
GenAtlas
SEPX1
GeneCards
MSRB1
GenBank Gene Database
AF166124
GenBank Protein Database
6649219
UniProt Accession
MSRB1_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:7377
GenAtlas
MSRA
GeneCards
MSRA
GenBank Gene Database
AJ242973
GenBank Protein Database
6136945
UniProt Accession
MSRA_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:6898
GenAtlas
MARS
GeneCards
MARS1
GenBank Gene Database
X94754
GenBank Protein Database
1702932
UniProt Accession
SYMC_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:25133
GenAtlas
MARS2
GeneCards
MARS2
GenBank Gene Database
AB107013
GenBank Protein Database
37196758
UniProt Accession
SYMM_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:6905
GenAtlas
MAT2B
GeneCards
MAT2B
GenBank Gene Database
AF182814
GenBank Protein Database
6815285
UniProt Accession
MAT2B_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:1048
GenAtlas
BHMT2
GeneCards
BHMT2
GenBank Gene Database
AF257473
GenBank Protein Database
11907831
UniProt Accession
BHMT2_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:4341
GenAtlas
GLUL
GeneCards
GLUL
GenBank Gene Database
Y00387
GenBank Protein Database
31833
UniProt Accession
GLNA_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:7436
GenAtlas
MTHFR
GeneCards
MTHFR
GenBank Gene Database
U09806
GenBank Protein Database
6139053
UniProt Accession
MTHR_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:17027
GeneCards
SLC16A10
GenBank Gene Database
AB057445
GenBank Protein Database
18640047
UniProt Accession
MOT10_HUMAN
International reference pricing
Reference pricing from DrugBank. Prices are indicative and may not reflect current UK costs.
Source: DrugBank. Used under CC BY-NC 4.0 academic licence for non-commercial purposes.
Patent information
1 active patent
Source: DrugBank · CC BY-NC 4.0. Patent data sourced from national patent offices. Expiry dates may not reflect extensions, regulatory exclusivity periods, or legal challenges.
DrugBank citations
If you use DrugBank data in your research, please cite the following publications: