Ketamine 100mg/50ml / Morphine sulfate 100mg/50ml solution for infusion pre-filled syringes
Requires a prescription from a doctor or prescriber
Strict controls: safe custody, register required
Legal requirements and restrictions
These are medicines with high potential for misuse but with accepted medical uses. Subject to the strictest controls.
Legal requirements
- Must be stored in a locked controlled drugs cabinet
- Pharmacy must keep a controlled drugs register
- Prescriptions valid for 28 days only
- Prescriptions must include specific details (dose, form, strength, total quantity)
- Cannot be emergency supplied by pharmacists
Other medicines in this category
Morphine, Oxycodone, Fentanyl, Methylphenidate (Ritalin), Amphetamines
Official documents, adverse reaction reporting, and safety monitoring
Report a side effect
Submit a Yellow Card report to the MHRA
Official medicine documents
Yellow Card
Report side effects (MHRA)
Drug safety updates
MHRA alerts for Ketamine + Morphine
Safety monitoring data
Yellow Card reports
The MHRA Yellow Card scheme collects reports of suspected side effects from healthcare professionals and patients. View the Drug Analysis Profile (iDAP) for real-world adverse reaction data.
View Drug Analysis Profile
Browse all Drug Analysis Profiles A–Z
Browse all iDAP reports
Interactive Drug Analysis Profiles for all medicines
Report a side effect
Submit a Yellow Card report to the MHRA
Data from the MHRA Yellow Card scheme. A reported reaction does not necessarily mean the medicine caused it. Contains public sector information licensed under the Open Government Licence v3.0.
EudraVigilance
The European Medicines Agency (EMA) collects suspected adverse reaction reports from across the EU/EEA through the EudraVigilance system. Search for safety data on this medicine.
Search EudraVigilance database
Browse substances A–Z in the European adverse reaction database
About EudraVigilance
Learn about EU pharmacovigilance and safety monitoring
EudraVigilance data is published by the European Medicines Agency (EMA). A suspected adverse reaction is not necessarily caused by the medicine.
1 branded products available
MHRA licensed products
View all licensed products for Ketamine + Morphine on the MHRA register
Ketamine 100mg/50ml / Morphine sulfate 100mg/50ml solution for infusion pre-filled syringes
NHS prescribing volume and spending trends
Guidelines from the National Institute for Health and Care Excellence
NICE clinical guidance(3)
Major trauma: assessment and initial management (NG39)
Spinal injury: assessment and initial management (NG41)
End of life care for infants, children and young people with life-limiting conditions: planning and management (NG61)
Source: National Institute for Health and Care Excellence (NICE). Contains public sector information licensed under the Open Government Licence v3.0.
Check stock at pharmacies and supply information
Pharmacy stock checkers
Search for this medicine at major UK pharmacy chains. These links open the retailer's own website — results depend on their current online catalogue.
Supply & safety information
Official UK regulator monitoring and safety alerts
Pharmacy links redirect to the retailer's own search and do not represent real-time stock levels. Shortage and safety information sourced from MHRA drug safety updates (gov.uk, Crown Copyright under OGL v3.0).
Codes for healthcare professionals and prescribing systems
These codes are used by healthcare IT systems and prescribers to identify this medicine.
NHS UK identifiers
SNOMED CT and dm+d codes from NHS TRUD (Technology Reference data Update Distribution), licensed under the Open Government Licence v3.0.
Active and completed clinical studies from ClinicalTrials.gov
Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine (NLM), National Institutes of Health (NIH). Data accessed via ClinicalTrials.gov API v2. Trial information is provided for research purposes and does not constitute medical advice.
Academic studies and reviews for this medicine's active substance
Showing the 50 most relevant studies.
Reviews & meta-analyses: 21 · Randomised trials: 27 · 2000–2026
Showing the 50 most relevant studies, sorted by most relevant.
Xuemei Wang, Cheng Lin, Lifang Lan, et al.
Journal of clinical anesthesia, 2020
Kevin Laskowski, Alena Stirling, William P. S. McKay, et al.
Canadian Journal of Anesthesia/Journal canadien d anesthésie, 2011
- Analgesics
- Infusions, Intravenous
- Injections, Intravenous
Nadia Elia, Martin R. Tramèr
Pain, 2004
- Age Factors
- Analgesics
- Drug Administration Routes
Kathirvel Subramaniam, Balachundhar Subramaniam, Richard A. Steinbrook
Anesthesia & Analgesia, 2004
- Analgesics, Opioid
- Anesthetics, Dissociative
- Infusions, Intravenous
Rae Frances Bell, Jørgen B. Dahl, R Andrew Moore, et al.
Acta Anaesthesiologica Scandinavica, 2005
- Analgesics, Opioid
- Anesthetics, Dissociative
- Data Interpretation, Statistical
Rae Frances Bell, Christopher Eccleston, Eija Kalso
Cochrane Database of Systematic Reviews, 2017
- Cancer Pain
- Analgesics
- Analgesics, Opioid
Joe E. Wathen, Mark G. Roback, Todd Mackenzie, et al.
Annals of Emergency Medicine, 2000
Aruzhan Zhaksylyk, Y. Abdildin, Suienish Sultangazin, et al.
Frontiers in Medicine, 2024
Sergey Motov, Bradley Rockoff, Victor Cohen, et al.
Annals of Emergency Medicine, 2015
- Analgesics, Opioid
- Anesthetics, Dissociative
- Emergency Service, Hospital
Zhang J, Ma B
2025
- Ketamine
- Morphine
- Analgesics
Sources: aggregated from Europe PMC (EMBL-EBI), OpenAlex, Crossref, PubMed and other open scholarly databases. Retracted articles are excluded. Study information is provided for research purposes and does not constitute medical advice.
Scientific data (pharmacology, interactions, ADME) is not yet available for this medicine. Clinical sections are sourced from the NHS dm+d database.