Isosorbide dinitrate 5mg/5ml oral solution
Requires a prescription from a doctor or prescriber
A vasodilator used in the treatment of angina pectoris.
Official documents, adverse reaction reporting, and safety monitoring
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Official medicine documents
Safety monitoring data
Yellow Card reports
The MHRA Yellow Card scheme collects reports of suspected side effects from healthcare professionals and patients. View the Drug Analysis Profile (iDAP) for real-world adverse reaction data.
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Submit a Yellow Card report to the MHRA
Data from the MHRA Yellow Card scheme. A reported reaction does not necessarily mean the medicine caused it. Contains public sector information licensed under the Open Government Licence v3.0.
EudraVigilance
The European Medicines Agency (EMA) collects suspected adverse reaction reports from across the EU/EEA through the EudraVigilance system. Search for safety data on this medicine.
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Learn about EU pharmacovigilance and safety monitoring
EudraVigilance data is published by the European Medicines Agency (EMA). A suspected adverse reaction is not necessarily caused by the medicine.
1 branded products available
Part of the Cedocard brand family (generic: Isosorbide dinitrate)
MHRA licensed products
View all licensed products for Isosorbide dinitrate on the MHRA register
WHO defined daily dose (DDD)
60 mg
Not a recommended dose. The DDD is the assumed average maintenance dose per day for a drug used for its main indication in adults. It is a statistical measure used for research and comparison purposes only.
Source: WHO Collaborating Centre for Drug Statistics Methodology, distributed via the NHS dm+d supplementary BNF/ATC mapping files (NHSBSA). Contains public sector information licensed under the Open Government Licence v3.0.
Therapeutically similar medicines
Similarity is based on WHO Anatomical Therapeutic Chemical (ATC) classification and on a factual NHS dm+d therapeutic-grouping code prefix. Source data: NHS dm+d via TRUD (OGL v3.0), WHO ATC/DDD Index.
NHS prescribing volume and spending trends
Guidelines from the National Institute for Health and Care Excellence
NICE clinical guidance(1)
Source: National Institute for Health and Care Excellence (NICE). Contains public sector information licensed under the Open Government Licence v3.0.
Check stock at pharmacies and supply information
Pharmacy stock checkers
Search for this medicine at major UK pharmacy chains. These links open the retailer's own website — results depend on their current online catalogue.
Supply & safety information
Official UK regulator monitoring and safety alerts
Pharmacy links redirect to the retailer's own search and do not represent real-time stock levels. Shortage and safety information sourced from MHRA drug safety updates (gov.uk, Crown Copyright under OGL v3.0).
Codes for healthcare professionals and prescribing systems
These codes are used by healthcare IT systems and prescribers to identify this medicine.
NHS UK identifiers
Browse tools
SNOMED CT and dm+d codes from NHS TRUD (Technology Reference data Update Distribution), licensed under the Open Government Licence v3.0. BNF code shown is the factual mapping value distributed by NHS Business Services Authority (NHSBSA) in the dm+d supplementary file under OGL v3.0; it is not affiliated with, nor licensed from, the publishers of the British National Formulary. ATC codes from the WHO Collaborating Centre for Drug Statistics Methodology (whocc.no).
Active and completed clinical studies from ClinicalTrials.gov
Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine (NLM), National Institutes of Health (NIH). Data accessed via ClinicalTrials.gov API v2. Trial information is provided for research purposes and does not constitute medical advice.
Academic studies and reviews for this medicine's active substance
Showing the 50 most relevant studies.
Reviews & meta-analyses: 4 · Randomised trials: 19 · 1969–2025
Showing the 50 most relevant studies, sorted by most relevant.
Gad Cotter, Einat Metzkor, Edo Kaluski, et al.
The Lancet, 1998
- Acute Disease
- Diuretics
- Furosemide
Yongliang Jia, Fangyi Huang, Shikai Zhang, et al.
International journal of cardiology, 2012
- Salvia miltiorrhiza
- Angina Pectoris
- Drugs, Chinese Herbal
Yao Y, Feng Y, Lin W
2015
- Salvia miltiorrhiza
- Angina Pectoris
- Isosorbide Dinitrate
Bouchahda N, Ben Abdessalem MA, Ben Hlima N, et al.
2023
- Isosorbide Dinitrate
- Percutaneous Coronary Intervention
- Spasm
Zhu Y, Zhang W, Qin K, et al.
2025
- Radial Artery
- Isosorbide Dinitrate
- Nicorandil
Yongliang Jia, Cong Chen, Choi-San Ng, et al.
Evidence-based Complementary and Alternative Medicine : eCAM, 2012
Jay N. Cohn, Gary R. Johnson, Susan Ziesche, et al.
New England Journal of Medicine, 1991
- Chronic Disease
- Death, Sudden
- Enalapril
Anne L. Taylor, Susan Ziesche, Clyde W. Yancy, et al.
New England Journal of Medicine, 2004
- Drug Combinations
- Heart Failure
- Hydralazine
Uri Elkayam, Jay Amin, Anil Mehra, et al.
Circulation, 1990
- Blood Pressure
- Chronic Disease
- Diuretics
Udho Thadani, Ho‐Leung Fung, Andrew C. Darke, et al.
The American Journal of Cardiology, 1982
- Angina Pectoris
- Delayed-Action Preparations
- Physical Exertion
Sources: aggregated from Europe PMC (EMBL-EBI), OpenAlex, Crossref, PubMed and other open scholarly databases. Retracted articles are excluded. Study information is provided for research purposes and does not constitute medical advice.
Pharmacology and chemical data from DrugBank
Key facts
Drug status
Approved
Major interactions
12 found
Half-life
1 hour
Mechanism
Isosorbide dinitrate is converted to the active nitric oxide to activate guanylate cyclase.
Food interactions
1 warning
Human targets
1 target
Data: DrugBank · CC BY-NC 4.0
Pharmacokinetics at a glance
Absorption
10%
Half-life
1 hour
Protein binding
Volume of distribution
2 to 4 L/kg
Metabolism
Pharmacokinetic data: DrugBank · CC BY-NC 4.0
Known interactions with other medications. Always consult a healthcare professional.
Showing 50 of 398 interactions
How the body processes this drug — absorption, distribution, metabolism, and elimination
Proteins and enzymes this drug interacts with in the body
PMID:39543315
Plays an essential role in the regulation of endothelial cell senescence and vascular aging .
PMID:36016499
Upon activation by ANP or BNP, stimulates the production of cyclic guanosine monophosphate (cGMP) that promotes vascular tone and volume homeostasis by activation of protein kinase cGMP-dependent 1/PRKG1 and subsequently PRKAA1, thereby controlling blood pressure and maintaining cardiovascular homeostasis PMID:36016499
Enzymes involved in drug metabolism — important for understanding drug interactions
ATC C01DA08
ATC C01DA58
ATC C05AE02
Chemical identifiers
CAS, UNII, InChI Key and database cross-references
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Chemical identifiers
CAS, UNII, InChI Key and database cross-references
Linked compound data from DrugBank Open Data (CC BY-NC 4.0)
Isosorbide dinitrate
Additional database identifiers
Drugs Product Database (DPD)
9627
ChemSpider
6619
ZINC
ZINC000018089317
HUGO Gene Nomenclature Committee (HGNC)
HGNC:7943
GenAtlas
NPR1
GeneCards
NPR1
GenBank Gene Database
X15357
GenBank Protein Database
28230
Guide to Pharmacology
1747
UniProt Accession
ANPRA_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:2631
GeneCards
CYP2E1
GenBank Gene Database
J02625
GenBank Protein Database
181360
Guide to Pharmacology
1330
UniProt Accession
CP2E1_HUMAN
DrugBank citations
If you use DrugBank data in your research, please cite the following publications:
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Structured knowledge from the free knowledge base
Linked open data from Wikidata (Q179748), a free and open knowledge base operated by the Wikimedia Foundation. Data is available under the Creative Commons CC0 1.0 Public Domain Dedication. WHO INN from the World Health Organization.