Ibuprofen 200mg / Pseudoephedrine hydrochloride 30mg tablets
Available from a pharmacy with pharmacist advice
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Data from the MHRA Yellow Card scheme. A reported reaction does not necessarily mean the medicine caused it. Contains public sector information licensed under the Open Government Licence v3.0.
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5 branded products available
Part of the Orbifen brand family (generic: Ibuprofen + Pseudoephedrine)
MHRA licensed products
View all licensed products for Ibuprofen + Pseudoephedrine on the MHRA register
Nurofen Cold and Flu tablets
Sudafed Sinus Pressure & Pain tablets
Nurofen Sinus Pressure & Headache Relief 200mg/30mg tablets
Reckitt Benckiser Healthcare (UK) Ltd
This is the NHS Drug Tariff indicative price used for reimbursement purposes. It may not reflect the price paid by patients or pharmacies.
View full Drug TariffSource: NHS Drug Tariff via NHSBSA. Derived from dm+d VMPP (Virtual Medicinal Product Pack) pricing data. Contains public sector information licensed under the Open Government Licence v3.0.
Therapeutically similar medicines
Similarity is based on WHO Anatomical Therapeutic Chemical (ATC) classification and on a factual NHS dm+d therapeutic-grouping code prefix. Source data: NHS dm+d via TRUD (OGL v3.0), WHO ATC/DDD Index.
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SNOMED CT and dm+d codes from NHS TRUD (Technology Reference data Update Distribution), licensed under the Open Government Licence v3.0. BNF code shown is the factual mapping value distributed by NHS Business Services Authority (NHSBSA) in the dm+d supplementary file under OGL v3.0; it is not affiliated with, nor licensed from, the publishers of the British National Formulary. ATC codes from the WHO Collaborating Centre for Drug Statistics Methodology (whocc.no).
Active and completed clinical studies from ClinicalTrials.gov
Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine (NLM), National Institutes of Health (NIH). Data accessed via ClinicalTrials.gov API v2. Trial information is provided for research purposes and does not constitute medical advice.
Academic studies and reviews for this medicine's active substance
Showing the 50 most relevant studies.
Reviews & meta-analyses: 15 · Randomised trials: 3 · 2009–2026
Showing the 50 most relevant studies, sorted by most relevant.
S. Mitra, I. Flórez, Maria E Tamayo, et al.
JAMA, 2018
K. Thybo, Daniel Hägi‐Pedersen, J. Dahl, et al.
JAMA, 2019
S. Chopra, Dharmender Kumar
Heliyon, 2020
A. Ohlsson, R. Walia, Sachin S Shah
The Cochrane database of systematic reviews, 2018
Joanna Żur, Artur Piński, Ariel Marchlewicz, et al.
Environmental Science and Pollution Research International, 2018
Baldacci S, Santoro M, Mezzasalma L, et al.
2024
- Gastroschisis
- Phenylpropanolamine
- Aspirin
ObjectivesThe aetiology of gastroschisis is considered multifactorial. We conducted a systematic review and meta-analysis to assess whether the use of medications during pregnancy, is associated with the risk of gastroschisis in offspring.MethodsPubMed, EMBASE, and Scopus were searched from 1st January 1990 to 31st December 2020 to identify observational studies examining the association between medication use during pregnancy and the risk of gastroschisis. The Newcastle-Ottawa Scale was used for the quality assessment of the individual studies. We pooled adjusted measures using a random-effect model to estimate relative risk [RR] and the 95% confidence interval [CI]. I2 statistic for heterogeneity and publication bias was calculated.ResultsEighteen studies providing data on 751,954 pregnancies were included in the meta-analysis. Pooled RRs showed significant associations between aspirin (RR 1.66, 95% CI 1.16-2.38; I2 = 58.3%), oral contraceptives (RR 1.52, 95% CI 1.21-1.92; I2 = 22.0%), pseudoephedrine and phenylpropanolamine (RR 1.51, 95% CI 1.16-1.97; I2 = 33.2%), ibuprofen (RR 1.42, 95% CI 1.26-1.60; I2 = 0.0%), and gastroschisis. No association was observed between paracetamol and gastroschisis (RR 1.16, 95% CI 0.96-1.41; I2 = 39.4%).ConclusionsThese results suggest that the exposure in the first trimester of pregnancy to over the counter medications (OTC) such as aspirin, ibuprofen, pseudoephedrine and phenylpropanolamine as well as to oral contraceptives, was associated with an increased risk of gastroschisis. However, these associations are significant only in particular subgroups defined by geographic location, adjustment variables and type of control. Therefore, further research is needed to investigate them as potential risk factors for gastroschisis, to assess their safety in pregnancy and to develop treatment strategies to reduce the risk of gastroschisis in offspring. PROSPERO registration number: CRD42021287529.
Abstract licence: CC BY
M. Zoubek, M. Lucena, R. Andrade, et al.
Alimentary Pharmacology & Therapeutics, 2020
G. Varrassi, J. Pergolizzi, P. Dowling, et al.
Advances in Therapy, 2019
J. Jan-Roblero, J. A. Cruz-Maya
Molecules, 2023
Jia-le Wu, Ze-hua Liu, Qing-guang Ma, et al.
The Science of the total environment, 2023
Sources: aggregated from Europe PMC (EMBL-EBI), OpenAlex, Crossref, PubMed and other open scholarly databases. Retracted articles are excluded. Study information is provided for research purposes and does not constitute medical advice.
Scientific data (pharmacology, interactions, ADME) is not yet available for this medicine. Clinical sections are sourced from the NHS dm+d database.