Official documents, adverse reaction reporting, and safety monitoring
Report a side effect
Submit a Yellow Card report to the MHRA
Safety monitoring data
Yellow Card reports
The MHRA Yellow Card scheme collects reports of suspected side effects from healthcare professionals and patients. View the Drug Analysis Profile (iDAP) for real-world adverse reaction data.
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Report a side effect
Submit a Yellow Card report to the MHRA
Data from the MHRA Yellow Card scheme. A reported reaction does not necessarily mean the medicine caused it. Contains public sector information licensed under the Open Government Licence v3.0.
EudraVigilance
The European Medicines Agency (EMA) collects suspected adverse reaction reports from across the EU/EEA through the EudraVigilance system. Search for safety data on this medicine.
View EudraVigilance report
Suspected adverse reactions reported for Hydroxyprogesterone
About EudraVigilance
Learn about EU pharmacovigilance and safety monitoring
EudraVigilance data is published by the European Medicines Agency (EMA). A suspected adverse reaction is not necessarily caused by the medicine.
1 branded products available
WHO defined daily dose (DDD)
10 mg
Not a recommended dose. The DDD is the assumed average maintenance dose per day for a drug used for its main indication in adults. It is a statistical measure used for research and comparison purposes only.
Source: WHO Collaborating Centre for Drug Statistics Methodology, distributed via the NHS dm+d supplementary BNF/ATC mapping files (NHSBSA). Contains public sector information licensed under the Open Government Licence v3.0.
Therapeutically similar medicines
Similarity is based on WHO Anatomical Therapeutic Chemical (ATC) classification and on a factual NHS dm+d therapeutic-grouping code prefix. Source data: NHS dm+d via TRUD (OGL v3.0), WHO ATC/DDD Index.
NHS prescribing volume and spending trends
Check stock at pharmacies and supply information
Pharmacy stock checkers
Search for this medicine at major UK pharmacy chains. These links open the retailer's own website — results depend on their current online catalogue.
Supply & safety information
Official UK regulator monitoring and safety alerts
Pharmacy links redirect to the retailer's own search and do not represent real-time stock levels. Shortage and safety information sourced from MHRA drug safety updates (gov.uk, Crown Copyright under OGL v3.0).
Codes for healthcare professionals and prescribing systems
These codes are used by healthcare IT systems and prescribers to identify this medicine.
NHS UK identifiers
Browse tools
SNOMED CT and dm+d codes from NHS TRUD (Technology Reference data Update Distribution), licensed under the Open Government Licence v3.0. BNF code shown is the factual mapping value distributed by NHS Business Services Authority (NHSBSA) in the dm+d supplementary file under OGL v3.0; it is not affiliated with, nor licensed from, the publishers of the British National Formulary. ATC codes from the WHO Collaborating Centre for Drug Statistics Methodology (whocc.no).
Active and completed clinical studies from ClinicalTrials.gov
Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine (NLM), National Institutes of Health (NIH). Data accessed via ClinicalTrials.gov API v2. Trial information is provided for research purposes and does not constitute medical advice.
Academic studies and reviews for this medicine's active substance
Showing the 50 most relevant studies.
Reviews & meta-analyses: 10 · Randomised trials: 13 · 1969–2026
Showing the 50 most relevant studies, sorted by most relevant.
Roberta Mackenzie, Mark Walker, Anthony Armson, et al.
American Journal of Obstetrics and Gynecology, 2006
- Obstetric Labor, Premature
- Pregnancy Trimester, Second
- Progestins
G. Saccone, A. Khalifeh, A. Elimian, et al.
Ultrasound in Obstetrics & Gynecology, 2017
S. Caritis, D. Rouse, A. Peaceman, et al.
Obstetrics & Gynecology, 2009
- 17 alpha-Hydroxyprogesterone Caproate
- Hydroxyprogesterones
- Injections, Intramuscular
C. Andrew Combs, Thomas J. Garite, Kimberly Maurel, et al.
American Journal of Obstetrics and Gynecology, 2011
- Pregnancy, Multiple
- 17 alpha-Hydroxyprogesterone Caproate
- Hydroxyprogesterones
Gabriele Saccone, Anju Suhag, Vincenzo Berghella
American Journal of Obstetrics and Gynecology, 2015
- 17 alpha-Hydroxyprogesterone Caproate
- Hydroxyprogesterones
- Pregnancy Trimester, Third
Abdulaali R. Almutairi (8336850), Hadir I. Aljohani (11774564), Nouf S. Al-fadel (11774567)
2021
C. A. Combs, T. Garite, K. Maurel, et al.
American journal of obstetrics and gynecology, 2010
- Pregnancy, Multiple
- Triplets
- Pregnancy, High-Risk
Marie‐Victoire Sénat, Raphaël Porcher, Norbert Winer, et al.
American Journal of Obstetrics and Gynecology, 2013
- Pregnancy, Twin
- 17 alpha-Hydroxyprogesterone Caproate
- Cervix Uteri
van Limburg Stirum EVJ, de Boer MA, Ravelli ACJ, et al.
2026
P. Rozenberg, A. Chauveaud, P. Deruelle, et al.
American journal of obstetrics and gynecology, 2012
- Tocolysis
- 17 alpha-Hydroxyprogesterone Caproate
- Hydroxyprogesterones
Sources: aggregated from Europe PMC (EMBL-EBI), OpenAlex, Crossref, PubMed and other open scholarly databases. Retracted articles are excluded. Study information is provided for research purposes and does not constitute medical advice.
Pharmacology and chemical data from DrugBank
Key facts
Drug status
Investigational
Major interactions
None known
Half-life
Not available
Mechanism
Not available
Food interactions
None known
Human targets
None mapped
Data: DrugBank · CC BY-NC 4.0
Pharmacokinetics at a glance
Known interactions with other medications. Always consult a healthcare professional.
Showing 50 of 208 interactions
Enzymes involved in drug metabolism — important for understanding drug interactions
ATC G03FA02
ATC G03DA03
Chemical identifiers
CAS, UNII, InChI Key and database cross-references
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Chemical identifiers
CAS, UNII, InChI Key and database cross-references
Linked compound data from DrugBank Open Data (CC BY-NC 4.0)
Hydroxyprogesterone
Additional database identifiers
ChemSpider
6002
BindingDB
50423511
PDB
3QZ
ZINC
ZINC000005434436
HUGO Gene Nomenclature Committee (HGNC)
HGNC:2637
GenAtlas
CYP3A4
GeneCards
CYP3A4
GenBank Gene Database
M18907
Guide to Pharmacology
1337
UniProt Accession
CP3A4_HUMAN
DrugBank citations
If you use DrugBank data in your research, please cite the following publications:
Show earlier publications
Structured knowledge from the free knowledge base
ATC classifications (Wikidata)
Linked open data from Wikidata (Q175901), a free and open knowledge base operated by the Wikimedia Foundation. Data is available under the Creative Commons CC0 1.0 Public Domain Dedication. WHO INN from the World Health Organization.