Hydroxocobalamin 10mg/2ml solution for injection ampoules
Requires a prescription from a doctor or prescriber
Hydroxocobalamin, also known as vitamin B12a and hydroxycobalamin, is an injectable form of vitamin B 12 that has been used therapeutically to treat vitamin B 12 deficiency.
Official documents, adverse reaction reporting, and safety monitoring
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Official medicine documents
Safety monitoring data
Yellow Card reports
The MHRA Yellow Card scheme collects reports of suspected side effects from healthcare professionals and patients. View the Drug Analysis Profile (iDAP) for real-world adverse reaction data.
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Report a side effect
Submit a Yellow Card report to the MHRA
Data from the MHRA Yellow Card scheme. A reported reaction does not necessarily mean the medicine caused it. Contains public sector information licensed under the Open Government Licence v3.0.
EudraVigilance
The European Medicines Agency (EMA) collects suspected adverse reaction reports from across the EU/EEA through the EudraVigilance system. Search for safety data on this medicine.
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Suspected adverse reactions reported for Hydroxocobalamin
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EudraVigilance data is published by the European Medicines Agency (EMA). A suspected adverse reaction is not necessarily caused by the medicine.
1 branded products available
Therapeutically similar medicines
Similarity based on WHO Anatomical Therapeutic Chemical (ATC) classification and NHS BNF section grouping. Source data: NHS dm+d via TRUD (OGL v3.0), WHO ATC/DDD Index.
NHS prescribing volume and spending trends
Clinical guidelines and formulary information
British National Formulary
Hydroxocobalamin
Source: British National Formulary, NICE. Joint Formulary Committee. Contains public sector information licensed under the Open Government Licence v3.0.
NICE clinical guidance(1)
Source: National Institute for Health and Care Excellence (NICE). Contains public sector information licensed under the Open Government Licence v3.0.
Check stock at pharmacies and supply information
Pharmacy stock checkers
Search for this medicine at major UK pharmacy chains. These links open the retailer's own website — results depend on their current online catalogue.
Supply & product information
Official product databases and supply status monitoring
Pharmacy links redirect to the retailer's own search and do not represent real-time stock levels. emc (electronic medicines compendium) is operated by Datapharm Ltd. Shortage information sourced from NHS Specialist Pharmacy Service (SPS), sps.nhs.uk.
Codes for healthcare professionals and prescribing systems
These codes are used by healthcare IT systems and prescribers to identify this medicine.
NHS UK identifiers
Browse tools
SNOMED CT and dm+d codes from NHS TRUD (Technology Reference data Update Distribution), licensed under the Open Government Licence v3.0. BNF codes from NHS Business Services Authority (NHSBSA). ATC codes from the WHO Collaborating Centre for Drug Statistics Methodology (whocc.no).
Active and completed clinical studies from ClinicalTrials.gov
Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine (NLM), National Institutes of Health (NIH). Data accessed via ClinicalTrials.gov API v2. Trial information is provided for research purposes and does not constitute medical advice.
Pharmacology and chemical data from DrugBank
Key facts
Drug status
Approved
Major interactions
None known
Half-life
6 days
Mechanism
Vitamin B12 exists in four major forms referred to collectively as cobalamins; d…
Food interactions
None known
Human targets
7 targets
Data: DrugBank · CC BY-NC 4.0
Pharmacokinetics at a glance
Absorption
Half-life
6 days
Protein binding
90%
Metabolism
8 hours
Elimination
Pharmacokinetic data: DrugBank · CC BY-NC 4.0
Known interactions with other medications. Always consult a healthcare professional.
Showing 50 of 730 interactions
How the body processes this drug — absorption, distribution, metabolism, and elimination
Part of a dose is excreted in the urine, most of it in the first 8 hours.
Proteins and enzymes this drug interacts with in the body
PMID:16769880 PMID:17288554 PMID:27771510
MeCbl is an active form of cobalamin (vitamin B12) used as a cofactor for methionine biosynthesis. Cob(I)alamin form is regenerated to MeCbl by a transfer of a methyl group from 5-methyltetrahydrofolate .
PMID:16769880 PMID:17288554 PMID:27771510
The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine PMID:16769880 PMID:27771510
PMID:20876572 PMID:21138732 PMID:28497574 PMID:28943303
Involved in intracellular vitamin B12 metabolism, mediates the transport of cobalamin (Cbl) into mitochondria for the final steps of adenosylcobalamin (AdoCbl) synthesis .
PMID:20876572 PMID:28497574
Functions as a G-protein chaperone that assists AdoCbl cofactor delivery from MMAB to the methylmalonyl-CoA mutase (MMUT) .
PMID:20876572 PMID:28497574
Plays a dual role as both a protectase and a reactivase for MMUT .
PMID:21138732 PMID:28943303
Protects MMUT from progressive inactivation by oxidation by decreasing the rate of the formation of the oxidized inactive cofactor hydroxocobalamin (OH2Cbl) .
PMID:21138732 PMID:28943303
Additionally acts a reactivase by promoting the replacement of OH2Cbl by the active cofactor AdoCbl, restoring the activity of MMUT in the presence and hydrolysis of GTP PMID:21138732 PMID:28943303
PMID:14576052 PMID:29402915 PMID:30523278
Required for normal CUBN glycosylation and trafficking to the cell surface .
PMID:14576052 PMID:29402915
The complex formed by AMN and CUBN is required for efficient absorption of vitamin B12 .
PMID:12590260 PMID:14576052 PMID:26040326
Required for normal CUBN-mediated protein transport in the kidney (Probable)
Proteins that carry this drug through the body
ATC B03BA53
ATC V03AB33
ATC B03BA03
Chemical identifiers
CAS, UNII, InChI Key and database cross-references
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Chemical identifiers
CAS, UNII, InChI Key and database cross-references
Linked compound data from DrugBank Open Data (CC BY-NC 4.0)
Hydroxocobalamin
Additional database identifiers
Drugs Product Database (DPD)
4971
ChemSpider
21403074
HUGO Gene Nomenclature Committee (HGNC)
HGNC:7468
GenAtlas
MTR
GeneCards
MTR
GenBank Gene Database
U71285
GenBank Protein Database
1923221
UniProt Accession
METH_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:7526
GenAtlas
MUT
GeneCards
MMUT
GenBank Gene Database
M65131
GenBank Protein Database
187452
UniProt Accession
MUTA_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:18871
GenAtlas
MMAA
GeneCards
MMAA
GenBank Gene Database
AF524846
GenBank Protein Database
26006421
UniProt Accession
MMAA_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:11652
GenAtlas
TCN1
GeneCards
TCN1
GenBank Gene Database
J05068
GenBank Protein Database
307479
UniProt Accession
TCO1_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:14604
GenAtlas
AMN
GeneCards
AMN
GenBank Gene Database
AF328788
GenBank Protein Database
13507259
UniProt Accession
AMNLS_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:2548
GenAtlas
CUBN
GeneCards
CUBN
GenBank Gene Database
AF034611
GenBank Protein Database
3929529
UniProt Accession
CUBN_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:24525
GenAtlas
MMACHC
GeneCards
MMACHC
GenBank Gene Database
AL080062
GenBank Protein Database
52545527
UniProt Accession
MMAC_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:11653
GenAtlas
TCN2
GeneCards
TCN2
GenBank Gene Database
M60396
GenBank Protein Database
339196
UniProt Accession
TCO2_HUMAN
International reference pricing
Reference pricing from DrugBank. Prices are indicative and may not reflect current UK costs.
Source: DrugBank. Used under CC BY-NC 4.0 academic licence for non-commercial purposes.
Patent information
All patents expired, 1 expired
Source: DrugBank · CC BY-NC 4.0. Patent data sourced from national patent offices. Expiry dates may not reflect extensions, regulatory exclusivity periods, or legal challenges.
DrugBank citations
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