Glucose 3g/10ml oral solution
Requires a prescription from a doctor or prescriber
Glucose is a simple sugar (monosaccharide) generated during phosynthesis involving water, carbon and sunlight in plants.
Official documents, adverse reaction reporting, and safety monitoring
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Official medicine documents
Safety monitoring data
Yellow Card reports
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Submit a Yellow Card report to the MHRA
Data from the MHRA Yellow Card scheme. A reported reaction does not necessarily mean the medicine caused it. Contains public sector information licensed under the Open Government Licence v3.0.
EudraVigilance
The European Medicines Agency (EMA) collects suspected adverse reaction reports from across the EU/EEA through the EudraVigilance system. Search for safety data on this medicine.
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Suspected adverse reactions reported for Glucose
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EudraVigilance data is published by the European Medicines Agency (EMA). A suspected adverse reaction is not necessarily caused by the medicine.
1 branded products available
Part of the Rapilose brand family (generic: Glucose)
MHRA licensed products
View all licensed products for Glucose on the MHRA register
Therapeutically similar medicines
Similarity based on WHO Anatomical Therapeutic Chemical (ATC) classification and NHS BNF section grouping. Source data: NHS dm+d via TRUD (OGL v3.0), WHO ATC/DDD Index.
NHS prescribing volume and spending trends
Clinical guidelines and formulary information
British National Formulary
Glucose
Source: British National Formulary, NICE. Joint Formulary Committee. Contains public sector information licensed under the Open Government Licence v3.0.
NICE clinical guidance(13)
Diabetes in pregnancy: management from preconception to the postnatal period (NG3)
Diabetes (type 1 and type 2) in children and young people: diagnosis and management (NG18)
Hybrid closed loop systems for managing blood glucose levels in type 1 diabetes (TA943)
Type 1 diabetes in adults: diagnosis and management (NG17)
Intravenous fluid therapy in children and young people in hospital (NG29)
FreeStyle Libre for glucose monitoring (MIB110)
Intravenous fluid therapy in children and young people in hospital (QS131)
Diabetes in pregnancy (QS109)
Type 2 diabetes in adults (QS209)
Type 2 diabetes in adults: management (NG28)
Diabetes in children and young people (QS125)
Type 2 diabetes: prevention in people at high risk (PH38)
MiniMed 640G system with SmartGuard for managing blood glucose levels in people with type 1 diabetes (MIB51)
Source: National Institute for Health and Care Excellence (NICE). Contains public sector information licensed under the Open Government Licence v3.0.
Check stock at pharmacies and supply information
Pharmacy stock checkers
Search for this medicine at major UK pharmacy chains. These links open the retailer's own website — results depend on their current online catalogue.
Supply & product information
Official product databases and supply status monitoring
Pharmacy links redirect to the retailer's own search and do not represent real-time stock levels. emc (electronic medicines compendium) is operated by Datapharm Ltd. Shortage information sourced from NHS Specialist Pharmacy Service (SPS), sps.nhs.uk.
Codes for healthcare professionals and prescribing systems
These codes are used by healthcare IT systems and prescribers to identify this medicine.
NHS UK identifiers
Browse tools
SNOMED CT and dm+d codes from NHS TRUD (Technology Reference data Update Distribution), licensed under the Open Government Licence v3.0. BNF codes from NHS Business Services Authority (NHSBSA). ATC codes from the WHO Collaborating Centre for Drug Statistics Methodology (whocc.no).
Active and completed clinical studies from ClinicalTrials.gov
Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine (NLM), National Institutes of Health (NIH). Data accessed via ClinicalTrials.gov API v2. Trial information is provided for research purposes and does not constitute medical advice.
Pharmacology and chemical data from DrugBank
Key facts
Drug status
Approved
Major interactions
None known
Half-life
14.3 minutes
Mechanism
Glucose supplies most of the energy to all tissues by generating energy molecule…
Food interactions
None known
Human targets
None mapped
Data: DrugBank · CC BY-NC 4.0
Pharmacokinetics at a glance
Absorption
40 minutes
Half-life
14.3 minutes
Volume of distribution
10.6L
Metabolism
Elimination
Clearance
0.37 ml
Pharmacokinetic data: DrugBank · CC BY-NC 4.0
Known interactions with other medications. Always consult a healthcare professional.
Showing 22 of 22 interactions
Glucose can act as precursors to generate other biomolecules such as vitamin C. It plays a role as a signaling molecule to control glucose and energy homeostasis. Glucose can regulate gene transcription, enzyme activity, hormone secretion, and the activity of glucoregulatory neurons. The types, number and kinetics of glucose transporters expressed depends on the tissues and fine-tunes glucose uptake, metabolism, and signal generation in order to preserve cellular and whole body metabolic integrity [A19395].
How the body processes this drug — absorption, distribution, metabolism, and elimination
[A19400]
Oral preparation of glucose reaches the peak concentration within 40 minutes and the intravenous infusions display 100% bioavailability.
Enzymes involved in drug metabolism — important for understanding drug interactions
Proteins that transport this drug across cell membranes
PMID:10227690 PMID:10954735 PMID:18245775 PMID:19449892 PMID:25982116 PMID:27078104 PMID:32860739
Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses .
PMID:18245775 PMID:19449892
Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain .
PMID:10227690
In association with BSG and NXNL1, promotes retinal cone survival by increasing glucose uptake into photoreceptors (By similarity). Required for mesendoderm differentiation (By similarity)
PMID:16186102 PMID:23396969 PMID:28083649 PMID:8027028 PMID:8457197
Likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell .
PMID:8027028
May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney .
PMID:3399500
Also able to mediate the transport of dehydroascorbate PMID:23396969
PMID:26176916 PMID:32860739 PMID:9477959
Can also mediate the uptake of various other monosaccharides across the cell membrane .
PMID:26176916 PMID:9477959
Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate .
PMID:26176916 PMID:9477959
Does not mediate fructose transport .
PMID:26176916 PMID:9477959
Required for mesendoderm differentiation (By similarity)
PMID:28083649
Even if its physiological substrate is subject to discussion, it is able to transport glucose and fructose .
PMID:16186102 PMID:28083649 PMID:29548810
Does not transport galactose, 2-deoxy-d-glucose and xylose PMID:15033637
PMID:27922102
Also able to mediate the transport of dehydroascorbate
PMID:18327257 PMID:18701466 PMID:22647630 PMID:28083649 PMID:36749388
May have a residual high-affinity, low-capacity glucose and fructose transporter activity .
PMID:18327257 PMID:18701466 PMID:18842065
Transports urate at rates 45- to 60-fold faster than glucose .
PMID:18842065
Does not transport galactose .
PMID:28083649
May mediate small uptake of adenine but not of other nucleobases PMID:22647630
PMID:20980548 PMID:34880492 PMID:35077764 PMID:8563765 PMID:37217492
Has a primary role in the transport of dietary monosaccharides from enterocytes to blood. Responsible for the absorption of D-glucose or D-galactose across the apical brush-border membrane of enterocytes, whereas basolateral exit is provided by GLUT2.
Additionally, functions as a D-glucose sensor in enteroendocrine cells, triggering the secretion of the incretins GCG and GIP that control food intake and energy homeostasis (By similarity) .
PMID:8563765
Together with SGLT2, functions in reabsorption of D-glucose from glomerular filtrate, playing a nonredundant role in the S3 segment of the proximal tubules (By similarity). Transports D-glucose into endometrial epithelial cells, controlling glycogen synthesis and nutritional support for the embryo as well as the decidual transformation of endometrium prior to conception .
PMID:28974690
Acts as a water channel enabling passive water transport across the plasma membrane in response to the osmotic gradient created upon sugar and Na(+) uptake. Has high water conductivity, comparable to aquaporins, and therefore is expected to play an important role in transepithelial water permeability, especially in the small intestine
Chemical identifiers
CAS, UNII, InChI Key and database cross-references
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Chemical identifiers
CAS, UNII, InChI Key and database cross-references
Linked compound data from DrugBank Open Data (CC BY-NC 4.0)
Dextrose, unspecified form
Matched from: Glucose
Additional database identifiers
Drugs Product Database (DPD)
42
Drugs Product Database (DPD)
20521
HUGO Gene Nomenclature Committee (HGNC)
HGNC:4922
GenAtlas
HK1
GeneCards
HK1
GenBank Gene Database
M75126
GenBank Protein Database
184021
UniProt Accession
HXK1_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:4195
GenAtlas
GCK
GeneCards
GCK
GenBank Gene Database
M88011
GenBank Protein Database
179427
Guide to Pharmacology
2798
UniProt Accession
HXK4_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:11005
GenAtlas
SLC2A1
GeneCards
SLC2A1
GenBank Gene Database
K03195
GenBank Protein Database
183303
Guide to Pharmacology
875
UniProt Accession
GTR1_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:11006
GenAtlas
SLC2A2
GeneCards
SLC2A2
GenBank Gene Database
J03810
GenBank Protein Database
307125
UniProt Accession
GTR2_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:11007
GeneCards
SLC2A3
UniProt Accession
GTR3_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:11009
GenAtlas
SLC2A4
GeneCards
SLC2A4
GenBank Gene Database
M20747
GenBank Protein Database
307076
UniProt Accession
GLUT4_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:11011
GeneCards
SLC2A6
UniProt Accession
GTR6_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:13445
GeneCards
SLC2A7
UniProt Accession
GTR7_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:13812
GeneCards
SLC2A8
UniProt Accession
SL2A8_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:13446
GeneCards
SLC2A9
UniProt Accession
GTR9_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:13444
GeneCards
SLC2A10
UniProt Accession
GTR10_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:14239
GeneCards
SLC2A11
UniProt Accession
GTR11_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:18067
GeneCards
SLC2A12
UniProt Accession
GTR12_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:11036
GeneCards
SLC5A1
Guide to Pharmacology
915
UniProt Accession
SC5A1_HUMAN
DrugBank citations
If you use DrugBank data in your research, please cite the following publications: