Gemeprost 1mg pessaries
Gemeprost is a prostaglandin E1 (PGE1) analog and antiprogestogen used for preoperative dilation of the cervix before surgical abortion.
Official documents, adverse reaction reporting, and safety monitoring
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Safety monitoring data
Yellow Card reports
The MHRA Yellow Card scheme collects reports of suspected side effects from healthcare professionals and patients. View the Drug Analysis Profile (iDAP) for real-world adverse reaction data.
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Suspected adverse reactions reported for Gemeprost
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Report a side effect
Submit a Yellow Card report to the MHRA
Data from the MHRA Yellow Card scheme. A reported reaction does not necessarily mean the medicine caused it. Contains public sector information licensed under the Open Government Licence v3.0.
EudraVigilance
The European Medicines Agency (EMA) collects suspected adverse reaction reports from across the EU/EEA through the EudraVigilance system. Search for safety data on this medicine.
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Learn about EU pharmacovigilance and safety monitoring
EudraVigilance data is published by the European Medicines Agency (EMA). A suspected adverse reaction is not necessarily caused by the medicine.
2 branded products available
WHO defined daily dose (DDD)
1 mg
Not a recommended dose. The DDD is the assumed average maintenance dose per day for a drug used for its main indication in adults. It is a statistical measure used for research and comparison purposes only.
Source: WHO Collaborating Centre for Drug Statistics Methodology, distributed via the NHS dm+d supplementary BNF/ATC mapping files (NHSBSA). Contains public sector information licensed under the Open Government Licence v3.0.
Therapeutically similar medicines
Similarity is based on WHO Anatomical Therapeutic Chemical (ATC) classification and on a factual NHS dm+d therapeutic-grouping code prefix. Source data: NHS dm+d via TRUD (OGL v3.0), WHO ATC/DDD Index.
NHS prescribing volume and spending trends
Guidelines from the National Institute for Health and Care Excellence
NICE clinical guidance(1)
Source: National Institute for Health and Care Excellence (NICE). Contains public sector information licensed under the Open Government Licence v3.0.
Check stock at pharmacies and supply information
Pharmacy stock checkers
Search for this medicine at major UK pharmacy chains. These links open the retailer's own website — results depend on their current online catalogue.
Supply & safety information
Official UK regulator monitoring and safety alerts
Pharmacy links redirect to the retailer's own search and do not represent real-time stock levels. Shortage and safety information sourced from MHRA drug safety updates (gov.uk, Crown Copyright under OGL v3.0).
Codes for healthcare professionals and prescribing systems
These codes are used by healthcare IT systems and prescribers to identify this medicine.
NHS UK identifiers
Browse tools
SNOMED CT and dm+d codes from NHS TRUD (Technology Reference data Update Distribution), licensed under the Open Government Licence v3.0. BNF code shown is the factual mapping value distributed by NHS Business Services Authority (NHSBSA) in the dm+d supplementary file under OGL v3.0; it is not affiliated with, nor licensed from, the publishers of the British National Formulary. ATC codes from the WHO Collaborating Centre for Drug Statistics Methodology (whocc.no).
Active and completed clinical studies from ClinicalTrials.gov
Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine (NLM), National Institutes of Health (NIH). Data accessed via ClinicalTrials.gov API v2. Trial information is provided for research purposes and does not constitute medical advice.
Academic studies and reviews for this medicine's active substance
Showing the 50 most relevant studies.
Reviews & meta-analyses: 8 · Randomised trials: 12 · 1984–2026
Showing the 50 most relevant studies, sorted by most relevant.
K. S. Wong, C. Ngai, A. Wong, et al.
Contraception, 1998
- Abortion, Induced
- Abortifacient Agents, Nonsteroidal
- Administration, Intravaginal
J. Bartley, A. Brown, R. Elton, et al.
Human reproduction, 2001
- Abortion, Induced
- Gestational Age
- Abortifacient Agents, Nonsteroidal
Pak Chung Ho, Y.F. Chan, Winnie Nga Ting Lau
Contraception, 1996
- Abortifacient Agents
- Abortion, Induced
- Alprostadil
Daniel Seow Choon Koh, Esther Pei Jing Ang, Jurja Chua Coyuco, et al.
Journal of Family Planning and Reproductive Health Care, 2017
Prasad, RNV, Templeton, A, Dhall, GI, et al.
British Journal of Obstetrics and Gynaecology, 2001
H. El‐Refaey, Allan Templeton, L. Calder, et al.
Lancet, 1994
- Abortifacient Agents, Nonsteroidal
- Abortion, Induced
- Alprostadil
Ka Sing Wong, C. S. W. Ngai, Ka‐man Chan, et al.
Contraception, 1996
- Abortion, Induced
- Administration, Intravaginal
- Alprostadil
2001
- Abortion, Induced
- Mifepristone
- Abortifacient Agents, Nonsteroidal
Erling Ekerhovd
Obstetrics and Gynecology, 2003
- Abortion, Induced
- Cervical Ripening
- Abortifacient Agents, Nonsteroidal
Wolfgang Eppel, Fabio Facchinetti, E Schleußner, et al.
American Journal of Obstetrics and Gynecology, 2005
- Abortifacient Agents, Nonsteroidal
- Abortion, Induced
- Administration, Intravaginal
Sources: aggregated from Europe PMC (EMBL-EBI), OpenAlex, Crossref, PubMed and other open scholarly databases. Retracted articles are excluded. Study information is provided for research purposes and does not constitute medical advice.
Pharmacology and chemical data from DrugBank
Key facts
Drug status
Approved
Major interactions
None known
Half-life
Not available
Mechanism
As a prostaglandin analog, gemeprost binds to prostaglandin E2 and E3 receptors…
Food interactions
None known
Human targets
2 targets
Data: DrugBank · CC BY-NC 4.0
Pharmacokinetics at a glance
Absorption
12-28%
[L878]…
Metabolism
10-15 minutes
Elimination
50%
Pharmacokinetic data: DrugBank · CC BY-NC 4.0
Known interactions with other medications. Always consult a healthcare professional.
Showing 1 of 1 interactions
Oral LD50 is 300 mg/kg in mouse, 980 mg/kg in rat and 3200 mg/kg in rabbit MSDS.
How the body processes this drug — absorption, distribution, metabolism, and elimination
[L878]
Following vaginal administration, peak plasma concentration is reached after 2-3 hours .
[A19726]
[A19726]
Proteins and enzymes this drug interacts with in the body
PMID:7883006 PMID:7981210 PMID:8117308 PMID:8135729 PMID:8307176
The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G(i) proteins, and to an elevation of intracellular calcium .
PMID:7883006 PMID:7981210 PMID:8117308 PMID:8135729
Required for normal development of fever in response to pyrinogens, including IL1B, prostaglandin E2 and bacterial lipopolysaccharide (LPS). Required for normal potentiation of platelet aggregation by prostaglandin E2, and thus plays a role in the regulation of blood coagulation. Required for increased HCO3(-) secretion in the duodenum in response to mucosal acidification, and thereby contributes to the protection of the mucosa against acid-induced ulceration.
Not required for normal kidney function, normal urine volume and osmolality (By similarity)
ATC G02AD03
Chemical identifiers
CAS, UNII, InChI Key and database cross-references
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Chemical identifiers
CAS, UNII, InChI Key and database cross-references
Linked compound data from DrugBank Open Data (CC BY-NC 4.0)
Gemeprost
Additional database identifiers
ChemSpider
4445416
ZINC
ZINC000004216393
HUGO Gene Nomenclature Committee (HGNC)
HGNC:9595
GenAtlas
PTGER3
GeneCards
PTGER3
GenBank Gene Database
S69200
Guide to Pharmacology
342
UniProt Accession
PE2R3_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:9594
GenAtlas
PTGER2
GeneCards
PTGER2
GenBank Gene Database
U19487
GenBank Protein Database
632650
Guide to Pharmacology
341
UniProt Accession
PE2R2_HUMAN
DrugBank citations
If you use DrugBank data in your research, please cite the following publications:
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Structured knowledge from the free knowledge base
ATC classifications (Wikidata)
Linked open data from Wikidata (Q2760221), a free and open knowledge base operated by the Wikimedia Foundation. Data is available under the Creative Commons CC0 1.0 Public Domain Dedication. WHO INN from the World Health Organization.