Fludarabine phosphate 10mg tablets
Requires a prescription from a doctor or prescriber
Fludarabine is a chemotherapeutic agent used in the treatment of hematological malignancies.
Official documents, adverse reaction reporting, and safety monitoring
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Official medicine documents
Safety monitoring data
Yellow Card reports
The MHRA Yellow Card scheme collects reports of suspected side effects from healthcare professionals and patients. View the Drug Analysis Profile (iDAP) for real-world adverse reaction data.
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Suspected adverse reactions reported for Fludarabine
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Interactive Drug Analysis Profiles for all medicines
Report a side effect
Submit a Yellow Card report to the MHRA
Data from the MHRA Yellow Card scheme. A reported reaction does not necessarily mean the medicine caused it. Contains public sector information licensed under the Open Government Licence v3.0.
EudraVigilance
The European Medicines Agency (EMA) collects suspected adverse reaction reports from across the EU/EEA through the EudraVigilance system. Search for safety data on this medicine.
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Suspected adverse reactions reported for Fludarabine
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EudraVigilance data is published by the European Medicines Agency (EMA). A suspected adverse reaction is not necessarily caused by the medicine.
1 branded products available
MHRA licensed products
View all licensed products for Fludarabine on the MHRA register
Fludara 10mg tablets
Therapeutically similar medicines
Similarity based on WHO Anatomical Therapeutic Chemical (ATC) classification and NHS BNF section grouping. Source data: NHS dm+d via TRUD (OGL v3.0), WHO ATC/DDD Index.
NHS prescribing volume and spending trends
Clinical guidelines and formulary information
British National Formulary
Fludarabine
Source: British National Formulary, NICE. Joint Formulary Committee. Contains public sector information licensed under the Open Government Licence v3.0.
NICE clinical guidance(13)
Fludarabine monotherapy for the first-line treatment of chronic lymphocytic leukaemia (TA119)
Treosulfan with fludarabine for malignant disease before allogeneic stem cell transplant (TA640)
Guidance on the use of fludarabine for B-cell chronic lymphocytic leukaemia (TA29)
Treosulfan with fludarabine before allogeneic stem cell transplant for people aged 1 month to 17 years with non-malignant diseases (terminated appraisal) (TA945)
Rituximab for the treatment of relapsed or refractory chronic lymphocytic leukaemia (TA193)
Bendamustine for the first-line treatment of chronic lymphocytic leukaemia (TA216)
Rituximab for the first-line treatment of chronic lymphocytic leukaemia (TA174)
Obinutuzumab in combination with chlorambucil for untreated chronic lymphocytic leukaemia (TA343)
Idelalisib for treating chronic lymphocytic leukaemia (TA359)
Ibrutinib for previously treated chronic lymphocytic leukaemia and untreated chronic lymphocytic leukaemia with 17p deletion or TP53 mutation (TA429)
Rituximab for the treatment of relapsed or refractory stage 3 or 4 follicular non-Hodgkin's lymphoma (TA137)
Autoimmune haemolytic anaemia: rituximab (ESUOM39)
Zanubrutinib for treating marginal zone lymphoma after anti-CD20-based treatment (TA1001)
Source: National Institute for Health and Care Excellence (NICE). Contains public sector information licensed under the Open Government Licence v3.0.
Check stock at pharmacies and supply information
Pharmacy stock checkers
Search for this medicine at major UK pharmacy chains. These links open the retailer's own website — results depend on their current online catalogue.
Supply & product information
Official product databases and supply status monitoring
Pharmacy links redirect to the retailer's own search and do not represent real-time stock levels. emc (electronic medicines compendium) is operated by Datapharm Ltd. Shortage information sourced from NHS Specialist Pharmacy Service (SPS), sps.nhs.uk.
Codes for healthcare professionals and prescribing systems
These codes are used by healthcare IT systems and prescribers to identify this medicine.
NHS UK identifiers
Browse tools
SNOMED CT and dm+d codes from NHS TRUD (Technology Reference data Update Distribution), licensed under the Open Government Licence v3.0. BNF codes from NHS Business Services Authority (NHSBSA). ATC codes from the WHO Collaborating Centre for Drug Statistics Methodology (whocc.no).
Active and completed clinical studies from ClinicalTrials.gov
Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine (NLM), National Institutes of Health (NIH). Data accessed via ClinicalTrials.gov API v2. Trial information is provided for research purposes and does not constitute medical advice.
Pharmacology and chemical data from DrugBank
Key facts
Drug status
Approved
Major interactions
None known
Half-life
20 hours
Mechanism
Fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then pho…
Food interactions
1 warning
Human targets
5 targets
Data: DrugBank · CC BY-NC 4.0
Pharmacokinetics at a glance
Absorption
55%
Half-life
20 hours
Protein binding
19-29%
Clearance
117-145 mL/min
Pharmacokinetic data: DrugBank · CC BY-NC 4.0
Known interactions with other medications. Always consult a healthcare professional.
Showing 50 of 553 interactions
How the body processes this drug — absorption, distribution, metabolism, and elimination
Proteins and enzymes this drug interacts with in the body
PMID:12808445 PMID:18377927 PMID:19159229 PMID:1996353 PMID:20614893 PMID:20637175
Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents PMID:12808445
These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively. The reason this transfer occurs is because the polymerase alpha has limited processivity and lacks intrinsic 3' exonuclease activity for proofreading error, and therefore is not well suited for replicating long complexes. In the cytosol, responsible for a substantial proportion of the physiological concentration of cytosolic RNA:DNA hybrids, which are necessary to prevent spontaneous activation of type I interferon responses PMID:27019227
PMID:16670267 PMID:23193172 PMID:26166670 PMID:8452534 PMID:9361033
Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4 .
PMID:20959412
Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion .
PMID:11772392
Enhances dendritic cell immunogenicity by affecting dendritic cell costimulatory molecule expression and cytokines and chemokines secretion (By similarity).
Enhances CD4+ T-cell differentiation and proliferation .
PMID:20959412
Acts as a positive modulator of adenosine receptors ADORA1 and ADORA2A, by enhancing their ligand affinity via conformational change .
PMID:23193172
Stimulates plasminogen activation .
PMID:15016824
Plays a role in male fertility .
PMID:21919946 PMID:26166670
Plays a protective role in early postimplantation embryonic development (By similarity). Also responsible for the deamination of cordycepin (3'-deoxyadenosine), a fungal natural product that shows antitumor, antibacterial, antifungal, antivirus, and immune regulation properties PMID:26038697
Proteins that transport this drug across cell membranes
PMID:10722669 PMID:10755314 PMID:12527552 PMID:14759222 PMID:15037197 PMID:17379602 PMID:21795683 PMID:26406980 PMID:27995448 PMID:35790189 PMID:8986748
Functions as a Na(+)-independent transporter .
PMID:8986748
Involved in the transport of nucleosides such as adenosine, guanosine, inosine, uridine, thymidine and cytidine .
PMID:10722669 PMID:10755314 PMID:12527552 PMID:14759222 PMID:15037197 PMID:17379602 PMID:26406980 PMID:8986748
Also transports purine nucleobases (hypoxanthine, adenine, guanine) and pyrimidine nucleobases (thymine, uracil) .
PMID:21795683 PMID:27995448
Mediates basolateral nucleoside uptake into Sertoli cells, thereby regulating the transport of nucleosides in testis across the blood-testis barrier (By similarity). Regulates inosine levels in brown adipocytes tissues (BAT) and extracellular inosine levels, which controls BAT-dependent energy expenditure PMID:35790189
PMID:11032837 PMID:15861042 PMID:16446384 PMID:17140564 PMID:21998139
Involved in the homeostasis of endogenous nucleosides .
PMID:11032837 PMID:15861042
Exhibits the transport characteristics of the nucleoside transport system cib or N3 subtype (N3/cib) (with marked transport of both thymidine and inosine) .
PMID:11032837
Employs a 2:1 sodium/nucleoside ratio .
PMID:11032837
Transports uridine .
PMID:21795683
Also able to transport gemcitabine, 3'-azido-3'-deoxythymidine (AZT), ribavirin and 3-deazauridine PMID:11032837 PMID:17140564
ATC L01BB05
Chemical identifiers
CAS, UNII, InChI Key and database cross-references
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Chemical identifiers
CAS, UNII, InChI Key and database cross-references
Linked compound data from DrugBank Open Data (CC BY-NC 4.0)
Fludarabine
Additional database identifiers
Drugs Product Database (DPD)
11349
ChemSpider
571392
BindingDB
68391
ZINC
ZINC000004216238
HUGO Gene Nomenclature Committee (HGNC)
HGNC:2704
GenAtlas
DCK
GeneCards
DCK
GenBank Gene Database
M60527
UniProt Accession
DCK_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:9173
GenAtlas
POLA1
GeneCards
POLA1
GenBank Gene Database
X06745
GenBank Protein Database
35568
UniProt Accession
DPOLA_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:10451
GenAtlas
RRM1
GeneCards
RRM1
GenBank Gene Database
X59543
GenBank Protein Database
36065
Guide to Pharmacology
2630
UniProt Accession
RIR1_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:186
GenAtlas
ADA
GeneCards
ADA
GenBank Gene Database
X02994
GenBank Protein Database
28380
Guide to Pharmacology
1230
UniProt Accession
ADA_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:11003
GenAtlas
SLC29A1
GeneCards
SLC29A1
GenBank Gene Database
U81375
GenBank Protein Database
1845345
Guide to Pharmacology
1117
UniProt Accession
S29A1_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:16484
GeneCards
SLC28A3
GenBank Gene Database
AF305210
GenBank Protein Database
10732815
Guide to Pharmacology
1116
UniProt Accession
S28A3_HUMAN
International reference pricing
Reference pricing from DrugBank. Prices are indicative and may not reflect current UK costs.
Source: DrugBank. Used under CC BY-NC 4.0 academic licence for non-commercial purposes.
Patent information
All patents expired, 2 expired
Source: DrugBank · CC BY-NC 4.0. Patent data sourced from national patent offices. Expiry dates may not reflect extensions, regulatory exclusivity periods, or legal challenges.
DrugBank citations
If you use DrugBank data in your research, please cite the following publications: