Fibrinogen 350mg/5ml solution for sealant vials

BackgroundGrowing evidence indicates that the pre-operative ratio of fibrinogen to albumin (FAR/AFR) can act as a prognostic predictor for different kinds of cancer. Although a previous meta-analysis briefly involved urological malignancies, it only incorporated one study for bladder cancer (BC) and one for renal cell carcinoma (RCC) with limited data. To date, a comprehensive and systematic quantitative assessment of plasma FAR/AFR as a prognostic indicator in urological cancers remains lacking.ObjectiveThis meta-analysis intended to comprehensively investigate the prognostic significance of plasma FAR/AFR in individuals with urological malignancies.MethodsA thorough search of the PubMed, Embase, and Web of Science databases was carried out up to March 2026, leading to the incorporation of 6 studies for this meta-analysis. The research computed hazard ratios (HRs) together with their 95% confidence intervals (CIs) to evaluate disease-free survival (DFS), overall survival (OS), and cancer-specific survival (CSS).ResultsThe study included a total of 1,603 participants. Patients suffering from RCC and BC who showed an increase in pre-operation FAR or a decrease in pre-operation AFR had poorer overall survival (combined HR = 2.36, 95% CI = 1.92-2.91; p ConclusionsIncreased FAR or decreased AFR act as independent markers of unfavorable survival prognosis in patients with RCC and BC.

Abstract licence: CC BY-NC-ND

Long-duration space missions expose astronauts to microgravity, radiation, confinement, fluid redistribution, and circadian disruption, which together induce physiological adaptations, including cardiovascular hemodynamics. Emerging evidence suggests that spaceflight may modulate hemostasis and potentially increase thrombotic risk in the head/neck; however, the association of circadian disruption and hemostasis in space, and its ground-based analogs, has yet to be systematically evaluated. This systematic review aimed to synthesize evidence from real-spaceflight missions and ground-based analogs to (i) characterize thrombosis-related and hemostatic adaptations, (ii) evaluate circadian remodeling under altered gravitational conditions, and (iii) identify mechanistic and methodological gaps linking biological timing to coagulation regulation in space. A systematic search of PubMed, Scopus, and Web of Science was conducted from January 2016 to January 2026. Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, studies investigating circadian rhythms, clock-gene regulation, autonomic chronobiology, hemostasis, thrombosis, platelet biology, and coagulation pathways, in spaceflight or spaceflight analogs were systematically screened and analyzed. Thirty-eight studies met inclusion criteria, of which 20 (52.6%) primarily examined hemostasis and thrombosis outcomes and 18 (47.4%) focused on circadian regulation. Thrombosis-related investigations demonstrated dynamic modulation of coagulation cascades, platelet activation pathways, fibrinogen levels, endothelial markers, and complement components across dry immersion, head-down bed rest, animal unloading models, radiation exposure, hypergravity, and real astronaut missions. However, most hemostatic studies relied on end point or milestone-based sampling without circadian-phase resolution. In contrast, circadian-focused studies used dense temporal sampling and revealed phase shifts, altered autonomic rhythmicity, and disruption of molecular clock regulators under simulated and real space conditions, yet rarely assessed direct thrombotic end points. Importantly, no included study simultaneously assessed circadian-phase regulation and hemostatic outcomes, highlighting a critical lack of mechanistic evidence linking biological timing to thrombotic regulation in spaceflight environments. The absence of circadian phase-resolved hemostatic assessment represents a fundamental mechanistic gap. Future integrative chronothrombotic study designs are required to determine whether disrupted biological timing directly contributes to thrombotic vulnerability during spaceflight.

Abstract licence: CC BY-NC-ND