Felodipine 5mg modified-release tablets

Cabren 5mg modified-release tablets

Viatris UK Healthcare Ltd

Discontinued

Felogen XL 5mg tablets

Discontinued

Felotens XL 5mg tablets

Thornton & Ross Ltd

Discontinued

Folpik XL 5mg tablets

Discontinued

Keloc SR 5mg tablets

Discontinued

Parmid XL 5mg tablets

Sandoz Ltd

Discontinued

Plendil 5mg modified-release tablets

AstraZeneca UK Ltd

Discontinued

Source: NHS dm+dOGL 3.0

Updated about 1 month ago(1 Mar 2026)

Price & daily doseShow details

£3.87indicative price

This is the NHS Drug Tariff indicative price used for reimbursement purposes. It may not reflect the price paid by patients or pharmacies.

View full Drug Tariff

Source: NHS Drug Tariff via NHSBSA. Derived from dm+d VMPP (Virtual Medicinal Product Pack) pricing data. Contains public sector information licensed under the Open Government Licence v3.0.

WHO defined daily dose (DDD)

5 mg

Not a recommended dose. The DDD is the assumed average maintenance dose per day for a drug used for its main indication in adults. It is a statistical measure used for research and comparison purposes only.

Source: WHO Collaborating Centre for Drug Statistics Methodology, distributed via NHS dm+d BNF mapping files. Contains public sector information licensed under the Open Government Licence v3.0.

Therapeutically similar medicines

10 similarShow details

Amlodipine 2.5mg tablets

Tablet

2.5mg

Lacidipine 6mg tablets

Tablet

6mg

Amlodipine 5mg/5ml oral suspension sugar free

Oral suspension

5mg/5ml

Nimodipine 60mg/5ml oral suspension

Oral suspension

60mg/5ml

Felodipine 2.5mg/5ml oral suspension

Oral suspension

2.5mg/5ml

Drug monograph — bnf.nice.org.uk

Similarity based on WHO Anatomical Therapeutic Chemical (ATC) classification and NHS BNF section grouping. Source data: NHS dm+d via TRUD (OGL v3.0), WHO ATC/DDD Index.

NHS prescribing volume and spending trends

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Clinical guidelines and formulary information

British National Formulary

Felodipine

BNF

Source: British National Formulary, NICE. Joint Formulary Committee. Contains public sector information licensed under the Open Government Licence v3.0.

NICE clinical guidance(2)

Stable angina: management (CG126)

Stable angina (QS21)

Source: National Institute for Health and Care Excellence (NICE). Contains public sector information licensed under the Open Government Licence v3.0.

Check stock at pharmacies and supply information

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Pharmacy stock checkers

Search for this medicine at major UK pharmacy chains. These links open the retailer's own website — results depend on their current online catalogue.

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Supply & product information

Official product databases and supply status monitoring

Shortages info

NHS Specialist Pharmacy Service (SPS)

emc product search

Discontinuations & alternatives for Felodipine

Pharmacy links redirect to the retailer's own search and do not represent real-time stock levels. emc (electronic medicines compendium) is operated by Datapharm Ltd. Shortage information sourced from NHS Specialist Pharmacy Service (SPS), sps.nhs.uk.

Codes for healthcare professionals and prescribing systems

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These codes are used by healthcare IT systems and prescribers to identify this medicine.

NHS UK identifiers

SNOMED CT

39020611000001109

dm+d ID

39020611000001109

VTM (Virtual Therapeutic Moiety)

775923000

VMP (Virtual Medicinal Product)

39020611000001109

BNF code

02060200

International identifiers

ATC code — Anatomical Therapeutic Chemical (WHO)

C08CA02

Browse tools

dm+d Browser

NHSBSA medicines dictionary lookup

SNOMED CT and dm+d codes from NHS TRUD (Technology Reference data Update Distribution), licensed under the Open Government Licence v3.0. BNF codes from NHS Business Services Authority (NHSBSA). ATC codes from the WHO Collaborating Centre for Drug Statistics Methodology (whocc.no).

Active and completed clinical studies from ClinicalTrials.gov

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Searching UK clinical trials...

Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine (NLM), National Institutes of Health (NIH). Data accessed via ClinicalTrials.gov API v2. Trial information is provided for research purposes and does not constitute medical advice.

Pharmacology and chemical data from DrugBank

go.drugbank.com

Key facts

Drug status

Approved

Major interactions

28 found

Half-life

17.5-31.5 hours

Mechanism

Felodipine decreases arterial smooth muscle contractility and subsequent vasocon…

Food interactions

2 warnings

Human targets

13 targets

Data: DrugBank · CC BY-NC 4.0

Pharmacokinetics at a glance

Absorption

15%

Is completely absorbed from the gastrointestinal tract; however, extensive first-pass metabolism through the portal circulation results in a low systemic availability of 15%.…

Half-life

17.5-31.5 hours

17.5-31.5 hours in hypertensive patients; 19.1-35.9 hours in elderly hypertensive patients; 8.5-19.7 in healthy volunteers.

Protein binding

99%

99%, primarily to the albumin fraction.

Volume of distribution

10 L/kg

* 10 L/kg

Metabolism

Hepatic metabolism primarily via cytochrome P450 3A4. Six metabolites with no appreciable vasodilatory effects have been identified.

Elimination

Although higher concentrations of the metabolites are present in the plasma due to decreased urinary excretion, these are inactive.…

Clearance

0.8 L

* 0.8 L/min [Young healthy subjects]

Pharmacokinetic data: DrugBank · CC BY-NC 4.0

Status:

Approved

Small molecule

About this compound

Felodipine is a long-acting 1,4-dihydropyridine calcium channel blocker (CCB)b. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, felodipine prevents calcium-dependent myocyte contraction and vasoconstriction. Felodipine is the most potent CCB in use and is unique in that it exhibits fluorescent activity. In addition to binding to L-type calcium channels, felodipine binds to a number of calcium-binding proteins, exhibits competitive antagonism of the mineralcorticoid receptor, inhibits the activity of calmodulin-dependent cyclic nucleotide phosphodiesterase, and blocks calcium influx through voltage-gated T-type calcium channels. Felodipine is used to treat mild to moderate essential hypertension.

Properties:

solid

Avg. mass: 384.25 Da

View FDA drug label

DrugBank indication

For the treatment of mild to moderate essential hypertension.

Also known as(116)

(±)-ethyl methyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate

3-ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate

4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid ethyl methyl ester

Felodipina

Felodipine

Felodipino

Felodipinum

CACH2

Dosage forms(32)

Tablet (Oral)

Tablet, coated (Oral)

Tablet (Oral) — 5.0000 mg

Tablet, delayed release (Oral) — 10 mg

Tablet, delayed release (Oral) — 5 mg

Tablet (Oral) — 5 MG

Tablet, extended release (Oral)

Tablet, film coated (Oral) — 10 mg

Molecular properties(19)

Drug interactions(1611)

Known interactions with other medications. Always consult a healthcare professional.

Duloxetine

Major

DB00476

The risk or severity of orthostatic hypotension and syncope can be increased when Felodipine is combined with Duloxetine.

Levodopa

Major

DB01235

The risk or severity of hypotension and orthostatic hypotension can be increased when Felodipine is combined with Levodopa.

Risperidone

Moderate

DB00734

Felodipine may increase the hypotensive activities of Risperidone.

Ursodeoxycholic acid

Moderate

DB01586

Ursodeoxycholic acid may decrease the excretion rate of Felodipine which could result in a higher serum level.

Cholic Acid

Moderate

DB02659

Cholic Acid may decrease the excretion rate of Felodipine which could result in a higher serum level.

Valinomycin

Moderate

DB14057

Valinomycin may decrease the excretion rate of Felodipine which could result in a higher serum level.

Olmesartan

Moderate

DB00275

Olmesartan may decrease the excretion rate of Felodipine which could result in a higher serum level.

Fusidic acid

Moderate

DB02703

Fusidic acid may decrease the excretion rate of Felodipine which could result in a higher serum level.

Simeprevir

Moderate

DB06290

Simeprevir may decrease the excretion rate of Felodipine which could result in a higher serum level.

Lenvatinib

Moderate

DB09078

Lenvatinib may decrease the excretion rate of Felodipine which could result in a higher serum level.

Pralsetinib

Moderate

DB15822

Pralsetinib may decrease the excretion rate of Felodipine which could result in a higher serum level.

Ceritinib

Moderate

DB09063

Felodipine may increase the bradycardic activities of Ceritinib.

Ivabradine

Moderate

DB09083

Felodipine may increase the bradycardic activities of Ivabradine.

Ruxolitinib

Moderate

DB08877

Ruxolitinib may increase the bradycardic activities of Felodipine.

Alfuzosin

Moderate

DB00346

Alfuzosin may increase the hypotensive activities of Felodipine.

Amifostine

Moderate

DB01143

Felodipine may increase the hypotensive activities of Amifostine.

Diazoxide

Moderate

DB01119

Diazoxide may increase the hypotensive activities of Felodipine.

Methylphenidate

Moderate

DB00422

Methylphenidate may decrease the antihypertensive activities of Felodipine.

Dexmethylphenidate

Moderate

DB06701

Dexmethylphenidate may decrease the antihypertensive activities of Felodipine.

Obinutuzumab

Moderate

DB08935

Felodipine may increase the hypotensive activities of Obinutuzumab.

Pentoxifylline

Moderate

DB00806

Pentoxifylline may increase the hypotensive activities of Felodipine.

Rituximab

Moderate

DB00073

Felodipine may increase the hypotensive activities of Rituximab.

Desmopressin

Moderate

DB00035

Desmopressin may decrease the antihypertensive activities of Felodipine.

Zolmitriptan

Moderate

DB00315

Zolmitriptan may decrease the antihypertensive activities of Felodipine.

Doxapram

Moderate

DB00561

Doxapram may decrease the antihypertensive activities of Felodipine.

Phenmetrazine

Moderate

DB00830

Phenmetrazine may decrease the antihypertensive activities of Felodipine.

Naratriptan

Moderate

DB00952

Naratriptan may decrease the antihypertensive activities of Felodipine.

Rizatriptan

Moderate

DB00953

Rizatriptan may decrease the antihypertensive activities of Felodipine.

Dopamine

Moderate

DB00988

Dopamine may decrease the antihypertensive activities of Felodipine.

Frovatriptan

Moderate

DB00998

Frovatriptan may decrease the antihypertensive activities of Felodipine.

Epicaptopril

Moderate

DB02032

Epicaptopril may decrease the antihypertensive activities of Felodipine.

1-benzylimidazole

Moderate

DB04581

1-benzylimidazole may decrease the antihypertensive activities of Felodipine.

Amineptine

Moderate

DB04836

Amineptine may decrease the antihypertensive activities of Felodipine.

Naluzotan

Moderate

DB05562

Naluzotan may decrease the antihypertensive activities of Felodipine.

Nitrous oxide

Moderate

DB06690

Nitrous oxide may decrease the antihypertensive activities of Felodipine.

Cinitapride

Moderate

DB08810

Cinitapride may decrease the antihypertensive activities of Felodipine.

Tyramine

Moderate

DB08841

Tyramine may decrease the antihypertensive activities of Felodipine.

Ifenprodil

Moderate

DB08954

Ifenprodil may decrease the antihypertensive activities of Felodipine.

Dimetacrine

Moderate

DB08996

Dimetacrine may decrease the antihypertensive activities of Felodipine.

Moxisylyte

Moderate

DB09205

Moxisylyte may decrease the antihypertensive activities of Felodipine.

Oxaprotiline

Moderate

DB09307

Oxaprotiline may decrease the antihypertensive activities of Felodipine.

Atipamezole

Moderate

DB11481

Atipamezole may decrease the antihypertensive activities of Felodipine.

Tetrahydrocannabivarin

Moderate

DB11755

Tetrahydrocannabivarin may decrease the antihypertensive activities of Felodipine.

Piclozotan

Moderate

DB12361

Piclozotan may decrease the antihypertensive activities of Felodipine.

Idazoxan

Moderate

DB12551

Idazoxan may decrease the antihypertensive activities of Felodipine.

Tramazoline

Moderate

DB13064

Tramazoline may decrease the antihypertensive activities of Felodipine.

Amitriptylinoxide

Moderate

DB13114

Amitriptylinoxide may decrease the antihypertensive activities of Felodipine.

Dibenzepin

Moderate

DB13225

Dibenzepin may decrease the antihypertensive activities of Felodipine.

Quinupramine

Moderate

DB13246

Quinupramine may decrease the antihypertensive activities of Felodipine.

Trichloroethylene

Moderate

DB13323

Trichloroethylene may decrease the antihypertensive activities of Felodipine.