Doxycycline 100mg capsules
Requires a prescription from a doctor or prescriber
Antibacterial drugs
Official documents, adverse reaction reporting, and safety monitoring
Report a side effect
Submit a Yellow Card report to the MHRA
Official medicine documents
Safety monitoring data
Yellow Card reports
The MHRA Yellow Card scheme collects reports of suspected side effects from healthcare professionals and patients. View the Drug Analysis Profile (iDAP) for real-world adverse reaction data.
View Drug Analysis Profile
Suspected adverse reactions reported for Doxycycline
Browse all iDAP reports
Interactive Drug Analysis Profiles for all medicines
Report a side effect
Submit a Yellow Card report to the MHRA
Data from the MHRA Yellow Card scheme. A reported reaction does not necessarily mean the medicine caused it. Contains public sector information licensed under the Open Government Licence v3.0.
EudraVigilance
The European Medicines Agency (EMA) collects suspected adverse reaction reports from across the EU/EEA through the EudraVigilance system. Search for safety data on this medicine.
View EudraVigilance report
Suspected adverse reactions reported for Doxycycline
About EudraVigilance
Learn about EU pharmacovigilance and safety monitoring
EudraVigilance data is published by the European Medicines Agency (EMA). A suspected adverse reaction is not necessarily caused by the medicine.
25 branded products available
Part of the Vibramycin brand family (generic: Doxycycline)
MHRA licensed products
View all licensed products for Doxycycline on the MHRA register
Doxycycline 100mg capsules
Doxycycline 100mg capsules
Doxycycline 100mg capsules
Doxycycline 100mg capsules
Doxycycline 100mg capsules
Doxycycline 100mg capsules
Doxycycline 100mg capsules
Doxycycline 100mg capsules
Doxycycline 100mg capsules
Doxycycline 100mg capsules
Doxycycline 100mg capsules
Doxycycline 100mg capsules
This is the NHS Drug Tariff indicative price used for reimbursement purposes. It may not reflect the price paid by patients or pharmacies.
View full Drug TariffSource: NHS Drug Tariff via NHSBSA. Derived from dm+d VMPP (Virtual Medicinal Product Pack) pricing data. Contains public sector information licensed under the Open Government Licence v3.0.
WHO defined daily dose (DDD)
100 mg
Not a recommended dose. The DDD is the assumed average maintenance dose per day for a drug used for its main indication in adults. It is a statistical measure used for research and comparison purposes only.
Source: WHO Collaborating Centre for Drug Statistics Methodology, distributed via NHS dm+d BNF mapping files. Contains public sector information licensed under the Open Government Licence v3.0.
Therapeutically similar medicines
Similarity based on WHO Anatomical Therapeutic Chemical (ATC) classification and NHS BNF section grouping. Source data: NHS dm+d via TRUD (OGL v3.0), WHO ATC/DDD Index.
NHS prescribing volume and spending trends
Clinical guidelines and formulary information
British National Formulary
Doxycycline
Source: British National Formulary, NICE. Joint Formulary Committee. Contains public sector information licensed under the Open Government Licence v3.0.
NICE clinical guidance(14)
Lyme disease (NG95)
Cough (acute): antimicrobial prescribing (NG120)
Human and animal bites: antimicrobial prescribing (NG184)
Sinusitis (acute): antimicrobial prescribing (NG79)
Abortion care (NG140)
Acne vulgaris: management (NG198)
Chronic obstructive pulmonary disease (acute exacerbation): antimicrobial prescribing (NG114)
COVID-19 rapid guideline: managing COVID-19 (NG191)
Bronchiectasis (non-cystic fibrosis), acute exacerbation: antimicrobial prescribing (NG117)
Leg ulcer infection: antimicrobial prescribing (NG152)
Cellulitis and erysipelas: antimicrobial prescribing (NG141)
Pneumonia: diagnosis and management (NG250)
Inflammatory lesions of papulopustular rosacea: ivermectin 10 mg/g cream (ESNM68)
Prostatitis (acute): antimicrobial prescribing (NG110)
Source: National Institute for Health and Care Excellence (NICE). Contains public sector information licensed under the Open Government Licence v3.0.
Check stock at pharmacies and supply information
Pharmacy stock checkers
Search for this medicine at major UK pharmacy chains. These links open the retailer's own website — results depend on their current online catalogue.
Supply & product information
Official product databases and supply status monitoring
Pharmacy links redirect to the retailer's own search and do not represent real-time stock levels. emc (electronic medicines compendium) is operated by Datapharm Ltd. Shortage information sourced from NHS Specialist Pharmacy Service (SPS), sps.nhs.uk.
Codes for healthcare professionals and prescribing systems
These codes are used by healthcare IT systems and prescribers to identify this medicine.
NHS UK identifiers
Browse tools
SNOMED CT and dm+d codes from NHS TRUD (Technology Reference data Update Distribution), licensed under the Open Government Licence v3.0. BNF codes from NHS Business Services Authority (NHSBSA). ATC codes from the WHO Collaborating Centre for Drug Statistics Methodology (whocc.no).
Active and completed clinical studies from ClinicalTrials.gov
Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine (NLM), National Institutes of Health (NIH). Data accessed via ClinicalTrials.gov API v2. Trial information is provided for research purposes and does not constitute medical advice.
Pharmacology and chemical data from DrugBank
Key facts
Drug status
Approved
Major interactions
None known
Half-life
Not available
Mechanism
Protein synthesis is essential for survival and functioning of cells, including bacteria.
Food interactions
2 warnings
Human targets
None mapped
Data: DrugBank · CC BY-NC 4.0
Pharmacokinetics at a glance
Absorption
73-95%
[A1424]…
Half-life
Protein binding
[L42880]
Volume of distribution
Metabolism
Elimination
40%
[L42870]…
Clearance
18 years
Pharmacokinetic data: DrugBank · CC BY-NC 4.0
- Early Lyme disease (as evidenced by erythema migraines) due to Borrelia burgdorferi in adults and pediatric patients 8 years of age and older weighing 45 kg and above [L42875]
- Rickettsial infections,[L42870] such as Rocky Mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsialpox, and tick fevers [L42880]
- Sexually transmitted infections [L42870]
- Respiratory tract infections [L42870] caused by Mycoplasma pneumoniae and Haemophilus influenzae [L42880]
- Specific bacterial infections [L42870] after indicative bacteriologic testing. These include infections caused by Escherichia coli, Enterobacter aerogenes, Shigella species, Acinetobacter species, and Klebsiella species [L42880]
- Ophthalmic infections,[L42870] such as inclusion conjunctivitis caused by Chlamydia trachomatis [L42880]
- Anthrax, including inhalational anthrax (post-exposure) [L42870]
- Alternative treatment for selected infections when [penicillin] is contraindicated [L42870]
- Adjunctive therapy in acute intestinal amebiasis and severe acne [L42870][L42880]
- Lymphogranuloma venereum caused by Chlamydia trachomatis [L42880]
- Psittacosis (ornithosis) caused by Chlamydophila psittaci [L42880]
- Trachoma caused by Chlamydia trachomatis, although the infectious agent is not always eliminated, as judged by immunofluorescence [L42880]
- Uncomplicated urethral, endocervical, or rectal infections in adults caused by Chlamydia trachomatis [L42880]
- Nongonococcal urethritis caused by Ureaplasma urealyticum [L42880]
- Relapsing fever due to Borrelia recurrentis [L42880]
- Prophylaxis of malaria due to Plasmodium falciparum in short-term travelers (<4 months) to areas with chloroquine and/or pyrimethamine-sulfadoxine resistant strains [L42870, L42880]
It is also used to treat infections caused by the following gram-negative microorganisms:
- Chancroid caused by Haemophilus ducreyi [L42880]
- Plague due to Yersinia pestis [L42880]
- Tularemia due to Francisella tularensis [L42880]
- Cholera caused by Vibrio cholerae [L42880]
- Campylobacter fetus infections caused by Campylobacter fetus [L42880]
- Brucellosis due to Brucella species (in conjunction with [streptomycin]) [L42880]
- Bartonellosis due to Bartonella bacilliformis [L42880]
- Granuloma inguinale caused by Klebsiella granulomatis [L42880]
Known interactions with other medications. Always consult a healthcare professional.
Showing 50 of 1099 interactions
[L42905]
In case of overdosage, doxycycline should be discontinued and symptomatic and supportive treatment should be initiated. Dialysis does not alter serum half-life and thus would not be of benefit in treating cases of overdosage.
[L42870]
Doxycycline mediates anti-inflammatory actions by preventing calcium-dependent microtubular assembly and lymphocytic proliferation, thereby inhibiting leukocyte movement during inflammation.[A251730] It also inhibits nitric oxide synthase, which is an enzyme that produces nitric oxide, an inflammatory signaling molecule.[A251730]
As it is a highly lipophilic drug, doxycycline crosses multiple membranes of target molecules.[A251730] Doxycycline shows favorable intra-cellular penetration, with bacteriostatic activity against a wide range of bacteria.[A174028] Doxycycline also exhibits antiparasitic properties [A372][A373][A174025] and anti-inflammatory actions.[A174031][A251730] Its anti-inflammatory effects were investigated in various inflammatory skin conditions, such as bullous dermatoses [A251730] and rosacea.[A174031][A251730]
How the body processes this drug — absorption, distribution, metabolism, and elimination
[A1424]
Following an oral dose of 500 mg, the Cmax of 15.3 mg/L was reached in four hours.
[A1424]
Following a 200 mg dose, normal adult volunteers averaged peak serum levels of 2.6 mcg/mL of doxycycline at 2 hours, decreasing to 1.45 mcg/mL at 24 hours.
[L42880]
While a high-fat meal lowers Cmax and the rate of absorption, the effect is not clinically significant.
[L42870]
[L42880]
[L42870]
Excretion of doxycycline by the kidney is about 40%/72 hours in individuals with a creatinine clearance of about 75 mL/min. This percentage may fall as low as 1-5%/72 hours in individuals with a creatinine clearance below 10 mL/min.
[L42870]
[L42880]
Enzymes involved in drug metabolism — important for understanding drug interactions
Proteins that transport this drug across cell membranes
PMID:11669456 PMID:11907186 PMID:14675047 PMID:22108572 PMID:23832370 PMID:28534121 PMID:9950961
Mediates the uptake of OA across the basolateral side of proximal tubule epithelial cells, thereby contributing to the renal elimination of endogenous OA from the systemic circulation into the urine .
PMID:9887087
Functions as a biopterin transporters involved in the uptake and the secretion of coenzymes tetrahydrobiopterin (BH4), dihydrobiopterin (BH2) and sepiapterin to urine, thereby determining baseline levels of blood biopterins .
PMID:28534121
Transports prostaglandin E2 (PGE2) and prostaglandin F2-alpha (PGF2-alpha) and may contribute to their renal excretion .
PMID:11907186
Also mediates the uptake of cyclic nucleotides such as cAMP and cGMP .
PMID:26377792
Involved in the transport of neuroactive tryptophan metabolites kynurenate (KYNA) and xanthurenate (XA) and may contribute to their secretion from the brain .
PMID:22108572 PMID:23832370
May transport glutamate .
PMID:26377792
Also involved in the disposition of uremic toxins and potentially toxic xenobiotics by the renal organic anion secretory pathway, helping reduce their undesired toxicological effects on the body .
PMID:11669456 PMID:14675047
Uremic toxins include the indoxyl sulfate (IS), hippurate/N-benzoylglycine (HA), indole acetate (IA), 3-carboxy-4- methyl-5-propyl-2-furanpropionate (CMPF) and urate .
PMID:14675047 PMID:26377792
Xenobiotics include the mycotoxin ochratoxin (OTA) .
PMID:11669456
May also contribute to the transport of organic compounds in testes across the blood-testis-barrier PMID:35307651
PMID:12960149 PMID:15205344 PMID:15899824 PMID:22306008
Specifically present in limbal stem cells, where it plays a key role in corneal development and repair (By similarity)
Proteins that carry this drug through the body
PMID:19021548
Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity).
Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (By similarity). The shared binding site between zinc and calcium at residue Asp-273 suggests a crosstalk between zinc and calcium transport in the blood (By similarity). The rank order of affinity is zinc > calcium > magnesium (By similarity).
Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E.coli from ferric transferrin, and may thereby limit the utilization of iron and growth of enteric bacteria such as E.coli .
PMID:6234017
Does not prevent iron uptake by the bacterial siderophore aerobactin PMID:6234017
ATC J01AA02
ATC A01AB22
ATC J01AA20
Chemical identifiers
CAS, UNII, InChI Key and database cross-references
Show
Chemical identifiers
CAS, UNII, InChI Key and database cross-references
Linked compound data from DrugBank Open Data (CC BY-NC 4.0)
Doxycycline
Additional database identifiers
Drugs Product Database (DPD)
8642
Drugs Product Database (DPD)
8644
ChemSpider
10469369
BindingDB
50041429
PDB
DXT
ZINC
ZINC000016052277
HUGO Gene Nomenclature Committee (HGNC)
HGNC:2637
GenAtlas
CYP3A4
GeneCards
CYP3A4
GenBank Gene Database
M18907
Guide to Pharmacology
1337
UniProt Accession
CP3A4_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:399
GenAtlas
ALB
GeneCards
ALB
GenBank Gene Database
V00494
GenBank Protein Database
28590
UniProt Accession
ALBU_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:10970
GenAtlas
hROAT1
GeneCards
SLC22A6
GenBank Gene Database
AF057039
GenBank Protein Database
3831566
Guide to Pharmacology
1025
UniProt Accession
S22A6_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:46
GenAtlas
ABCB5
GeneCards
ABCB5
GenBank Gene Database
AY090613
UniProt Accession
ABCB5_HUMAN
International reference pricing
Reference pricing from DrugBank. Prices are indicative and may not reflect current UK costs.
Source: DrugBank. Used under CC BY-NC 4.0 academic licence for non-commercial purposes.
Patent information
5 active patents, 13 expired
Source: DrugBank · CC BY-NC 4.0. Patent data sourced from national patent offices. Expiry dates may not reflect extensions, regulatory exclusivity periods, or legal challenges.
DrugBank citations
If you use DrugBank data in your research, please cite the following publications: