Dipivefrine 0.1% eye drops

0.01%

Adrenaline (base) 0.1% eye drops preservative free

0.1%

Apraclonidine 1% eye drops 0.25ml unit dose preservative free

Apraclonidine 5mg/ml eye drops

5mg

Adrenaline (base) 1% eye drops

Drug monograph — bnf.nice.org.uk

Similarity based on WHO Anatomical Therapeutic Chemical (ATC) classification and NHS BNF section grouping. Source data: NHS dm+d via TRUD (OGL v3.0), WHO ATC/DDD Index.

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Clinical guidelines and formulary information

British National Formulary

Dipivefrine

BNF

Source: British National Formulary, NICE. Joint Formulary Committee. Contains public sector information licensed under the Open Government Licence v3.0.

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Official product databases and supply status monitoring

Shortages info

NHS Specialist Pharmacy Service (SPS)

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Discontinuations & alternatives for Dipivefrine

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Codes for healthcare professionals and prescribing systems

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These codes are used by healthcare IT systems and prescribers to identify this medicine.

NHS UK identifiers

SNOMED CT

3368211000001101

dm+d ID

3368211000001101

VTM (Virtual Therapeutic Moiety)

775643008

VMP (Virtual Medicinal Product)

3368211000001101

BNF code

11060000

International identifiers

ATC code — Anatomical Therapeutic Chemical (WHO)

S01EA02

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SNOMED CT and dm+d codes from NHS TRUD (Technology Reference data Update Distribution), licensed under the Open Government Licence v3.0. BNF codes from NHS Business Services Authority (NHSBSA). ATC codes from the WHO Collaborating Centre for Drug Statistics Methodology (whocc.no).

Active and completed clinical studies from ClinicalTrials.gov

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Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine (NLM), National Institutes of Health (NIH). Data accessed via ClinicalTrials.gov API v2. Trial information is provided for research purposes and does not constitute medical advice.

Pharmacology and chemical data from DrugBank

go.drugbank.com

Key facts

Drug status

Approved

Major interactions

None known

Half-life

Not available

Mechanism

Dipivefrin is a prodrug with little or no pharmacologically activity until it is…

Food interactions

None known

Human targets

6 targets

Data: DrugBank · CC BY-NC 4.0

Pharmacokinetics at a glance

Absorption

Well absorbed following occular administration.

Metabolism

Dipivefrin is converted to epinephrine inside the human eye by enzyme hydrolysis.

Pharmacokinetic data: DrugBank · CC BY-NC 4.0

Status:

Approved

Withdrawn

Small molecule

About this compound

Dipivefrin is a prodrug of adrenaline, which is used to treat glaucoma. It is available as ophthalmic solution (eye drops).

Properties:

solid

Avg. mass: 351.44 Da

View FDA drug label

DrugBank indication

Dipivefrin is a prodrug which is used as initial therapy for the control of intraocular pressure in chronic open-angle glaucoma.

Also known as(36)

(±)-4-[1-hydroxy-2-(methylamino)ethyl]-o-phenylene divavalate

1-(3',4'-dipivaloyloxyphenyl)-2-methylamino-1-ethanol

4-[1-hydroxy-2-(methylamino)ethyl]-o-phenylene divavalate

Dipivalyl epinephrine

Dipivefrin

Dipivefrina

Dipivefrine

Dipivéfrine

Dosage forms(10)

Liquid (Ophthalmic) — 0.1 %

Solution (Ophthalmic) — 1 mg/1mL

Solution / drops (Ophthalmic) — 1 mg/1mL

Liquid (Ophthalmic) — .1 %

Solution / drops (Ophthalmic; Topical) — .1 %

Solution / drops (Ophthalmic) — 0.1 %

Liquid (Ophthalmic)

Solution / drops (Ophthalmic)

Molecular properties(19)

Drug interactions(56)

Known interactions with other medications. Always consult a healthcare professional.

Mianserin

Moderate

DB06148

The therapeutic efficacy of Dipivefrin can be decreased when used in combination with Mianserin.

Formoterol

Moderate

DB00983

Dipivefrin may increase the sympathomimetic activities of Formoterol.

Oxymetazoline

Moderate

DB00935

Dipivefrin may increase the hypertensive and vasoconstricting activities of Oxymetazoline.

Vasopressin

Moderate

DB00067

Vasopressin may increase the hypertensive activities of Dipivefrin.

Methacholine

Moderate

DB06709

Dipivefrin may decrease effectiveness of Methacholine as a diagnostic agent.

Methyclothiazide

Unknown severity

DB00232

The risk or severity of hypokalemia can be increased when Dipivefrin is combined with Methyclothiazide.

Bendroflumethiazide

Unknown severity

DB00436

The risk or severity of hypokalemia can be increased when Dipivefrin is combined with Bendroflumethiazide.

Benzthiazide

Unknown severity

DB00562

The risk or severity of hypokalemia can be increased when Dipivefrin is combined with Benzthiazide.

Cyclothiazide

Unknown severity

DB00606

The risk or severity of hypokalemia can be increased when Dipivefrin is combined with Cyclothiazide.

Hydroflumethiazide

Unknown severity

DB00774

The risk or severity of hypokalemia can be increased when Dipivefrin is combined with Hydroflumethiazide.

Chlorothiazide

Unknown severity

DB00880

The risk or severity of hypokalemia can be increased when Dipivefrin is combined with Chlorothiazide.

Hydrochlorothiazide

Unknown severity

DB00999

The risk or severity of hypokalemia can be increased when Dipivefrin is combined with Hydrochlorothiazide.

Trichlormethiazide

Unknown severity

DB01021

The risk or severity of hypokalemia can be increased when Dipivefrin is combined with Trichlormethiazide.

Polythiazide

Unknown severity

DB01324

The risk or severity of hypokalemia can be increased when Dipivefrin is combined with Polythiazide.

Mebutizide

Unknown severity

DB13430

The risk or severity of hypokalemia can be increased when Dipivefrin is combined with Mebutizide.

Cyclopenthiazide

Unknown severity

DB13532

The risk or severity of hypokalemia can be increased when Dipivefrin is combined with Cyclopenthiazide.

Buthiazide

Unknown severity

DB15861

The risk or severity of hypokalemia can be increased when Dipivefrin is combined with Buthiazide.

Caffeine

Unknown severity

DB00201

The risk or severity of hypokalemia can be increased when Caffeine is combined with Dipivefrin.

Theophylline

Unknown severity

DB00277

The risk or severity of hypokalemia can be increased when Theophylline is combined with Dipivefrin.

Dyphylline

Unknown severity

DB00651

The risk or severity of hypokalemia can be increased when Dyphylline is combined with Dipivefrin.

Pentoxifylline

Unknown severity

DB00806

The risk or severity of hypokalemia can be increased when Pentoxifylline is combined with Dipivefrin.

Mercaptopurine

Unknown severity

DB01033

The risk or severity of hypokalemia can be increased when Mercaptopurine is combined with Dipivefrin.

Aminophylline

Unknown severity

DB01223

The risk or severity of hypokalemia can be increased when Aminophylline is combined with Dipivefrin.

Oxtriphylline

Unknown severity

DB01303

The risk or severity of hypokalemia can be increased when Oxtriphylline is combined with Dipivefrin.

Theobromine

Unknown severity

DB01412

The risk or severity of hypokalemia can be increased when Theobromine is combined with Dipivefrin.

Fenethylline

Unknown severity

DB01482

The risk or severity of hypokalemia can be increased when Fenethylline is combined with Dipivefrin.

8-azaguanine

Unknown severity

DB01667

The risk or severity of hypokalemia can be increased when 8-azaguanine is combined with Dipivefrin.

7,9-Dimethylguanine

Unknown severity

DB01978

The risk or severity of hypokalemia can be increased when 7,9-Dimethylguanine is combined with Dipivefrin.

Xanthine

Unknown severity

DB02134

The risk or severity of hypokalemia can be increased when Xanthine is combined with Dipivefrin.

7-Deazaguanine

Unknown severity

DB02245

The risk or severity of hypokalemia can be increased when 7-Deazaguanine is combined with Dipivefrin.

Guanine

Unknown severity

DB02377

The risk or severity of hypokalemia can be increased when Guanine is combined with Dipivefrin.

9-Methylguanine

Unknown severity

DB02489

The risk or severity of hypokalemia can be increased when 9-Methylguanine is combined with Dipivefrin.

Peldesine

Unknown severity

DB02568

The risk or severity of hypokalemia can be increased when Peldesine is combined with Dipivefrin.

Hypoxanthine

Unknown severity

DB04076

The risk or severity of hypokalemia can be increased when Hypoxanthine is combined with Dipivefrin.

9-Deazaguanine

Unknown severity

DB04356

The risk or severity of hypokalemia can be increased when 9-Deazaguanine is combined with Dipivefrin.

Propentofylline

Unknown severity

DB06479

The risk or severity of hypokalemia can be increased when Propentofylline is combined with Dipivefrin.

Valomaciclovir

Unknown severity

DB06575

The risk or severity of hypokalemia can be increased when Valomaciclovir is combined with Dipivefrin.

3-isobutyl-1-methyl-7H-xanthine

Unknown severity

DB07954

The risk or severity of hypokalemia can be increased when 3-isobutyl-1-methyl-7H-xanthine is combined with Dipivefrin.

Uric acid

Unknown severity

DB08844

The risk or severity of hypokalemia can be increased when Uric acid is combined with Dipivefrin.

Doxofylline

Unknown severity

DB09273

The risk or severity of hypokalemia can be increased when Doxofylline is combined with Dipivefrin.

6-O-benzylguanine

Unknown severity

DB11919

The risk or severity of hypokalemia can be increased when 6-O-benzylguanine is combined with Dipivefrin.

Lisofylline

Unknown severity

DB12406

The risk or severity of hypokalemia can be increased when Lisofylline is combined with Dipivefrin.

Lobucavir

Unknown severity

DB12531

The risk or severity of hypokalemia can be increased when Lobucavir is combined with Dipivefrin.

Cafedrine

Unknown severity

DB12926

The risk or severity of hypokalemia can be increased when Cafedrine is combined with Dipivefrin.

Theodrenaline

Unknown severity

DB12927

The risk or severity of hypokalemia can be increased when Theodrenaline is combined with Dipivefrin.

Bamifylline

Unknown severity

DB13203

The risk or severity of hypokalemia can be increased when Bamifylline is combined with Dipivefrin.

Proxyphylline

Unknown severity

DB13449

The risk or severity of hypokalemia can be increased when Proxyphylline is combined with Dipivefrin.

Acefylline

Unknown severity

DB13573

The risk or severity of hypokalemia can be increased when Acefylline is combined with Dipivefrin.

Etamiphylline

Unknown severity

DB13592

The risk or severity of hypokalemia can be increased when Etamiphylline is combined with Dipivefrin.

Pentifylline

Unknown severity

DB13634

The risk or severity of hypokalemia can be increased when Pentifylline is combined with Dipivefrin.