Dexmedetomidine 1mg/10ml solution for infusion ampoules
Requires a prescription from a doctor or prescriber
An agonist of receptors, adrenergic alpha-2 that is used in veterinary medicine for its analgesic and sedative properties.
Official documents, adverse reaction reporting, and safety monitoring
Report a side effect
Submit a Yellow Card report to the MHRA
Official medicine documents
Safety monitoring data
Yellow Card reports
The MHRA Yellow Card scheme collects reports of suspected side effects from healthcare professionals and patients. View the Drug Analysis Profile (iDAP) for real-world adverse reaction data.
View Drug Analysis Profile
Suspected adverse reactions reported for Dexmedetomidine
Browse all iDAP reports
Interactive Drug Analysis Profiles for all medicines
Report a side effect
Submit a Yellow Card report to the MHRA
Data from the MHRA Yellow Card scheme. A reported reaction does not necessarily mean the medicine caused it. Contains public sector information licensed under the Open Government Licence v3.0.
EudraVigilance
The European Medicines Agency (EMA) collects suspected adverse reaction reports from across the EU/EEA through the EudraVigilance system. Search for safety data on this medicine.
View EudraVigilance report
Suspected adverse reactions reported for Dexmedetomidine
About EudraVigilance
Learn about EU pharmacovigilance and safety monitoring
EudraVigilance data is published by the European Medicines Agency (EMA). A suspected adverse reaction is not necessarily caused by the medicine.
1 branded products available
MHRA licensed products
View all licensed products for Dexmedetomidine on the MHRA register
Dexmedetomidine 1mg/10ml concentrate for solution for infusion ampoules
Therapeutically similar medicines
Similarity is based on WHO Anatomical Therapeutic Chemical (ATC) classification and on a factual NHS dm+d therapeutic-grouping code prefix. Source data: NHS dm+d via TRUD (OGL v3.0), WHO ATC/DDD Index.
Check stock at pharmacies and supply information
Pharmacy stock checkers
Search for this medicine at major UK pharmacy chains. These links open the retailer's own website — results depend on their current online catalogue.
Supply & safety information
Official UK regulator monitoring and safety alerts
Pharmacy links redirect to the retailer's own search and do not represent real-time stock levels. Shortage and safety information sourced from MHRA drug safety updates (gov.uk, Crown Copyright under OGL v3.0).
Codes for healthcare professionals and prescribing systems
These codes are used by healthcare IT systems and prescribers to identify this medicine.
NHS UK identifiers
Browse tools
SNOMED CT and dm+d codes from NHS TRUD (Technology Reference data Update Distribution), licensed under the Open Government Licence v3.0. BNF code shown is the factual mapping value distributed by NHS Business Services Authority (NHSBSA) in the dm+d supplementary file under OGL v3.0; it is not affiliated with, nor licensed from, the publishers of the British National Formulary. ATC codes from the WHO Collaborating Centre for Drug Statistics Methodology (whocc.no).
Active and completed clinical studies from ClinicalTrials.gov
Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine (NLM), National Institutes of Health (NIH). Data accessed via ClinicalTrials.gov API v2. Trial information is provided for research purposes and does not constitute medical advice.
Academic studies and reviews for this medicine's active substance
Showing the 50 most relevant studies.
Reviews & meta-analyses: 37 · Randomised trials: 13 · 2008–2026
Showing the 50 most relevant studies, sorted by most relevant.
X. Duan, M. Coburn, R. Rossaint, et al.
BJA: British Journal of Anaesthesia, 2018
L. Vorobeichik, L. Vorobeichik, R. Brull, et al.
BJA: British Journal of Anaesthesia, 2017
Kun Wang, Mengge Wu, Jian Xu, et al.
British Journal of Anaesthesia, 2019
- Immunity
- Inflammation
- Intraoperative Complications
Clemens R. M. Barends, Anthony Absalom, Baucke van Minnen, et al.
PLoS ONE, 2017
- Hemodynamics
- Hypnotics and Sedatives
- Midazolam
S. Grape, K. Kirkham, J. Frauenknecht, et al.
Anaesthesia, 2019
Faraj W. Abdallah, Richard Brull
British Journal of Anaesthesia, 2013
- Nerve Block
- Adjuvants, Anesthesia
- Anesthetics, Local
Jen Tan, Kwok M. Ho
Intensive Care Medicine, 2010
- Hypnotics and Sedatives
- Intensive Care Units
- Length of Stay
K. Lewis, F. Alshamsi, K. Carayannopoulos, et al.
Intensive Care Medicine, 2022
Xian Su, Zhaoting Meng, Xinhai Wu, et al.
The Lancet, 2016
- China
- Confusion
- Critical Care
Yoanna Skrobik, Matthew S. Duprey, Nicholas S. Hill, et al.
American Journal of Respiratory and Critical Care Medicine, 2018
- Benzodiazepines
- Critical Care
- Delirium
Sources: aggregated from Europe PMC (EMBL-EBI), OpenAlex, Crossref, PubMed and other open scholarly databases. Retracted articles are excluded. Study information is provided for research purposes and does not constitute medical advice.
Pharmacology and chemical data from DrugBank
Key facts
Drug status
Approved
Major interactions
10 found
Half-life
2 hours
Mechanism
Dexmedetomidine is a specific and selective alpha-2 adrenoceptor agonist.
Food interactions
None known
Human targets
1 target
Data: DrugBank · CC BY-NC 4.0
Pharmacokinetics at a glance
Half-life
2 hours
Protein binding
94%
Volume of distribution
118 L
Metabolism
Elimination
95%
Clearance
39 L/h
Pharmacokinetic data: DrugBank · CC BY-NC 4.0
[L41374]
It is also available as a buccally- or sublingually-administered dissolvable film for the acute treatment of agitation associated with schizophrenia or bipolar I or II disorder.
[L41379]
Known interactions with other medications. Always consult a healthcare professional.
Showing 50 of 1797 interactions
How the body processes this drug — absorption, distribution, metabolism, and elimination
Proteins and enzymes this drug interacts with in the body
Enzymes involved in drug metabolism — important for understanding drug interactions
ATC N05CM18
Chemical identifiers
CAS, UNII, InChI Key and database cross-references
Show
Chemical identifiers
CAS, UNII, InChI Key and database cross-references
Linked compound data from DrugBank Open Data (CC BY-NC 4.0)
Dexmedetomidine
Additional database identifiers
Drugs Product Database (DPD)
20527
Drugs Product Database (DPD)
20565
ChemSpider
4470605
BindingDB
50085683
PDB
CZX
ZINC
ZINC000004632106
HUGO Gene Nomenclature Committee (HGNC)
HGNC:281
GenAtlas
ADRA2A
GeneCards
ADRA2A
GenBank Gene Database
M23533
GenBank Protein Database
178196
Guide to Pharmacology
25
UniProt Accession
ADA2A_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:2631
GeneCards
CYP2E1
GenBank Gene Database
J02625
GenBank Protein Database
181360
Guide to Pharmacology
1330
UniProt Accession
CP2E1_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:2596
GenAtlas
CYP1A2
GeneCards
CYP1A2
GenBank Gene Database
Z00036
Guide to Pharmacology
1319
UniProt Accession
CP1A2_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:2595
GeneCards
CYP1A1
GenBank Gene Database
K03191
GenBank Protein Database
181276
Guide to Pharmacology
1318
UniProt Accession
CP1A1_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:2625
GenAtlas
CYP2D6
GeneCards
CYP2D6
GenBank Gene Database
M20403
GenBank Protein Database
181350
Guide to Pharmacology
1329
UniProt Accession
CP2D6_HUMAN
DrugBank citations
If you use DrugBank data in your research, please cite the following publications:
Show earlier publications
Structured knowledge from the free knowledge base
ATC classifications (Wikidata)
Linked open data from Wikidata (Q412133), a free and open knowledge base operated by the Wikimedia Foundation. Data is available under the Creative Commons CC0 1.0 Public Domain Dedication. WHO INN from the World Health Organization.