Deoxycholic acid 20mg/2ml solution for injection vials
Deoxycholic acid is a a bile acid which emulsifies and solubilizes dietary fats in the intestine, and when injected subcutaneously, it disrupts cell membranes in adipocytes and destroys fat cells in that tissue.
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Safety monitoring data
Yellow Card reports
The MHRA Yellow Card scheme collects reports of suspected side effects from healthcare professionals and patients. View the Drug Analysis Profile (iDAP) for real-world adverse reaction data.
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Suspected adverse reactions reported for Deoxycholic acid
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Report a side effect
Submit a Yellow Card report to the MHRA
Data from the MHRA Yellow Card scheme. A reported reaction does not necessarily mean the medicine caused it. Contains public sector information licensed under the Open Government Licence v3.0.
EudraVigilance
The European Medicines Agency (EMA) collects suspected adverse reaction reports from across the EU/EEA through the EudraVigilance system. Search for safety data on this medicine.
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Suspected adverse reactions reported for Deoxycholic acid
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EudraVigilance data is published by the European Medicines Agency (EMA). A suspected adverse reaction is not necessarily caused by the medicine.
1 branded products available
Therapeutically similar medicines
Similarity based on WHO Anatomical Therapeutic Chemical (ATC) classification and NHS BNF section grouping. Source data: NHS dm+d via TRUD (OGL v3.0), WHO ATC/DDD Index.
NHS prescribing volume and spending trends
Clinical guidelines and formulary information
British National Formulary
Deoxycholic acid
Source: British National Formulary, NICE. Joint Formulary Committee. Contains public sector information licensed under the Open Government Licence v3.0.
Check stock at pharmacies and supply information
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Supply & product information
Official product databases and supply status monitoring
Pharmacy links redirect to the retailer's own search and do not represent real-time stock levels. emc (electronic medicines compendium) is operated by Datapharm Ltd. Shortage information sourced from NHS Specialist Pharmacy Service (SPS), sps.nhs.uk.
Codes for healthcare professionals and prescribing systems
These codes are used by healthcare IT systems and prescribers to identify this medicine.
NHS UK identifiers
SNOMED CT and dm+d codes from NHS TRUD (Technology Reference data Update Distribution), licensed under the Open Government Licence v3.0. BNF codes from NHS Business Services Authority (NHSBSA).
Active and completed clinical studies from ClinicalTrials.gov
Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine (NLM), National Institutes of Health (NIH). Data accessed via ClinicalTrials.gov API v2. Trial information is provided for research purposes and does not constitute medical advice.
Pharmacology and chemical data from DrugBank
Key facts
Drug status
Approved
Major interactions
None known
Half-life
Not available
Mechanism
As a bile acid, deoxycholic acid emulsifies fat in the gut.
Food interactions
None known
Human targets
6 targets
Data: DrugBank · CC BY-NC 4.0
Pharmacokinetics at a glance
Absorption
100mg
Protein binding
98%
Metabolism
Elimination
Pharmacokinetic data: DrugBank · CC BY-NC 4.0
Known interactions with other medications. Always consult a healthcare professional.
Showing 50 of 240 interactions
How the body processes this drug — absorption, distribution, metabolism, and elimination
Proteins and enzymes this drug interacts with in the body
PMID:9084911
Participates in the formation of novel hepoxilin regioisomers .
PMID:21046276
Negatively regulates CDK5 activity via p25/p35 translocation to prevent neurodegeneration
Also regulates lipid and glucose homeostasis and is involved innate immune response .
PMID:10334992 PMID:10334993 PMID:21383957 PMID:22820415
The FXR-RXR heterodimer binds predominantly to farnesoid X receptor response elements (FXREs) containing two inverted repeats of the consensus sequence 5'-AGGTCA-3' in which the monomers are spaced by 1 nucleotide (IR-1) but also to tandem repeat DR1 sites with lower affinity, and can be activated by either FXR or RXR-specific ligands. It is proposed that monomeric nuclear receptors such as NR5A2/LRH-1 bound to coregulatory nuclear responsive element (NRE) halfsites located in close proximity to FXREs modulate transcriptional activity (By similarity). In the liver activates transcription of the corepressor NR0B2 thereby indirectly inhibiting CYP7A1 and CYP8B1 (involved in BA synthesis) implicating at least in part histone demethylase KDM1A resulting in epigenomic repression, and SLC10A1/NTCP (involved in hepatic uptake of conjugated BAs).
Activates transcription of the repressor MAFG (involved in regulation of BA synthesis) (By similarity). Activates transcription of SLC27A5/BACS and BAAT (involved in BA conjugation), ABCB11/BSEP (involved in bile salt export) by directly recruiting histone methyltransferase CARM1, and ABCC2/MRP2 (involved in secretion of conjugated BAs) and ABCB4 (involved in secretion of phosphatidylcholine in the small intestine) .
PMID:12754200 PMID:15471871 PMID:17895379
Activates transcription of SLC27A5/BACS and BAAT (involved in BA conjugation), ABCB11/BSEP (involved in bile salt export) by directly recruiting histone methyltransferase CARM1, and ABCC2/MRP2 (involved in secretion of conjugated BAs) and ABCB4 (involved in secretion of phosphatidylcholine in the small intestine) .
PMID:10514450 PMID:15239098 PMID:16269519
In the intestine activates FGF19 expression and secretion leading to hepatic CYP7A1 repression .
PMID:12815072 PMID:19085950
The function also involves the coordinated induction of hepatic KLB/beta-klotho expression (By similarity). Regulates transcription of liver UGT2B4 and SULT2A1 involved in BA detoxification; binding to the UGT2B4 promoter seems to imply a monomeric transactivation independent of RXRA .
PMID:12806625 PMID:16946559
Modulates lipid homeostasis by activating liver NR0B2/SHP-mediated repression of SREBF1 (involved in de novo lipogenesis), expression of PLTP (involved in HDL formation), SCARB1 (involved in HDL hepatic uptake), APOE, APOC1, APOC4, PPARA (involved in beta-oxidation of fatty acids), VLDLR and SDC1 (involved in the hepatic uptake of LDL and IDL remnants), and inhibiting expression of MTTP (involved in VLDL assembly .
PMID:12554753 PMID:12660231 PMID:15337761
Increases expression of APOC2 (promoting lipoprotein lipase activity implicated in triglyceride clearance) .
PMID:11579204
Transrepresses APOA1 involving a monomeric competition with NR2A1 for binding to a DR1 element .
PMID:11927623 PMID:21804189
Also reduces triglyceride clearance by inhibiting expression of ANGPTL3 and APOC3 (both involved in inhibition of lipoprotein lipase) .
PMID:12891557
Involved in glucose homeostasis by modulating hepatic gluconeogenesis through activation of NR0B2/SHP-mediated repression of respective genes.
Modulates glycogen synthesis (inducing phosphorylation of glycogen synthase kinase-3) (By similarity). Modulates glucose-stimulated insulin secretion and is involved in insulin resistance .
PMID:20447400
Involved in intestinal innate immunity. Plays a role in protecting the distal small intestine against bacterial overgrowth and preservation of the epithelial barrier (By similarity).
Down-regulates inflammatory cytokine expression in several types of immune cells including macrophages and mononuclear cells .
PMID:21242261
Mediates trans-repression of TLR4-induced cytokine expression; the function seems to require its sumoylation and prevents N-CoR nuclear receptor corepressor clearance from target genes such as IL1B and NOS2 .
PMID:19864602
Involved in the TLR9-mediated protective mechanism in intestinal inflammation. Plays an anti-inflammatory role in liver inflammation; proposed to inhibit pro-inflammatory (but not antiapoptotic) NF-kappa-B signaling) (By similarity)
PMID:35585232
Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways .
PMID:24939902
Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion PMID:24695737
Proteins that transport this drug across cell membranes
PMID:15791618 PMID:16332456 PMID:18985798 PMID:19228692 PMID:20010382 PMID:20398791 PMID:22262466 PMID:24711118 PMID:29507376 PMID:32203132
Transports taurine-conjugated bile salts more rapidly than glycine-conjugated bile salts .
PMID:16332456
Also transports non-bile acid compounds, such as pravastatin and fexofenadine in an ATP-dependent manner and may be involved in their biliary excretion PMID:15901796 PMID:18245269
PMID:19129463 PMID:7557095
Responsible for intestinal absorption of bile acids (By similarity). Transports dehydroepiandrosterone 3-sulfate (DHEAS), a major circulating steroid secreted by the adrenal cortex, as well as estrone 3-sulfate and 17beta-estradiol 17-O-(beta-D-glucuronate) .
PMID:11159893 PMID:12568656 PMID:19129463 PMID:23918469 PMID:25560245 PMID:9539145
Mediates apical uptake of all-trans-retinol (atROL) across human retinal pigment epithelium, which is essential to maintaining the integrity of the visual cycle and thus vision .
PMID:25560245
Involved in the uptake of clinically used drugs .
PMID:17301733 PMID:20686826 PMID:27777271
Capable of thyroid hormone transport (both T3 or 3,3',5'-triiodo-L-thyronine, and T4 or L-tyroxine) .
PMID:19129463 PMID:20358049
Also transports prostaglandin E2 .
PMID:19129463
Plays roles in blood-brain and -cerebrospinal fluid barrier transport of organic anions and signal mediators, and in hormone uptake by neural cells (By similarity). May also play a role in the reuptake of neuropeptides such as substance P/TAC1 and vasoactive intestinal peptide/VIP released from retinal neurons .
PMID:25132355
May play an important role in plasma and tissue distribution of the structurally diverse chemotherapeutic drugs methotrexate and paclitaxel .
PMID:23243220
Shows a pH-sensitive substrate specificity which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment .
PMID:19129463
Hydrogencarbonate/HCO3(-) acts as the probable counteranion that exchanges for organic anions .
PMID:19129463
May contribute to regulate the transport of organic compounds in testis across the blood-testis-barrier (Probable)
PMID:7592981 PMID:9458785 PMID:9856990
Transports various bile acids, unconjugated or conjugated, such as cholate and taurocholate .
PMID:7592981 PMID:9458785 PMID:9856990
Also responsible for bile acid transport in the renal proximal tubules, a salvage mechanism that helps conserve bile acids (Probable). Works collaboratively with the Na(+)-taurocholate cotransporting polypeptide (NTCP), the organic solute transporter (OST), and the bile salt export pump (BSEP), to ensure efficacious biological recycling of bile acids during enterohepatic circulation PMID:33222321
PMID:14660639 PMID:24867799 PMID:34060352 PMID:8132774
It is strictly dependent on the extracellular presence of sodium .
PMID:14660639 PMID:24867799 PMID:34060352 PMID:8132774
It exhibits broad substrate specificity and transports various bile acids, such as taurocholate, cholate, as well as non-bile acid organic compounds, such as estrone sulfate .
PMID:14660639 PMID:34060352
Works collaboratively with the ileal transporter (NTCP2), the organic solute transporter (OST), and the bile salt export pump (BSEP), to ensure efficacious biological recycling of bile acids during enterohepatic circulation PMID:33222321
ATC D11AX24
Chemical identifiers
CAS, UNII, InChI Key and database cross-references
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Chemical identifiers
CAS, UNII, InChI Key and database cross-references
Linked compound data from DrugBank Open Data (CC BY-NC 4.0)
Deoxycholic acid
Additional database identifiers
Drugs Product Database (DPD)
6906
ChemSpider
193196
BindingDB
50375599
PDB
DXC
ZINC
ZINC000003914810
HUGO Gene Nomenclature Committee (HGNC)
HGNC:4638
GenAtlas
GSTP1
GeneCards
GSTP1
GenBank Gene Database
M24485
GenBank Protein Database
31946
UniProt Accession
GSTP1_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:7967
GenAtlas
NR1H4
GeneCards
NR1H4
GenBank Gene Database
U68233
GenBank Protein Database
1546084
Guide to Pharmacology
603
UniProt Accession
NR1H4_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:19680
GeneCards
GPBAR1
Guide to Pharmacology
37
UniProt Accession
GPBAR_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:8729
GeneCards
PCNA
UniProt Accession
PCNA_HUMAN
GenBank Gene Database
L13127
GenBank Protein Database
309871
UniProt Accession
SDIS_PSEPU
GenBank Gene Database
AF505790
UniProt Accession
Q8GGK7_GEOSN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:25789
GeneCards
EFL1
GenBank Gene Database
AK023181
GenBank Protein Database
10434992
UniProt Accession
EFL1_HUMAN
GenBank Gene Database
U20191
GenBank Protein Database
882252
UniProt Accession
CBH_CLOPE
GenBank Gene Database
M64541
GenBank Protein Database
145222
UniProt Accession
ALDA_ECOLI
GenBank Gene Database
M57680
GenBank Protein Database
15022167
UniProt Accession
COX2_CERSP
GenBank Gene Database
M94248
GenBank Protein Database
290406
UniProt Accession
ACRB_ECOLI
GenBank Gene Database
X62645
GenBank Protein Database
21955871
UniProt Accession
COX1_CERSP
HUGO Gene Nomenclature Committee (HGNC)
HGNC:4626
GenAtlas
GSTA1
GeneCards
GSTA1
GenBank Gene Database
M15872
GenBank Protein Database
306809
UniProt Accession
GSTA1_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:4627
GenAtlas
GSTA2
GeneCards
GSTA2
GenBank Gene Database
M16594
GenBank Protein Database
306811
UniProt Accession
GSTA2_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:4632
GenAtlas
GSTM1
GeneCards
GSTM1
GenBank Gene Database
X08020
GenBank Protein Database
31924
UniProt Accession
GSTM1_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:4634
GenAtlas
GSTM2
GeneCards
GSTM2
GenBank Gene Database
M63509
GenBank Protein Database
183301
UniProt Accession
GSTM2_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:4635
GenAtlas
GSTM3
GeneCards
GSTM3
GenBank Gene Database
J05459
GenBank Protein Database
306820
UniProt Accession
GSTM3_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:4636
GenAtlas
GSTM4
GeneCards
GSTM4
GenBank Gene Database
M96234
GenBank Protein Database
306819
UniProt Accession
GSTM4_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:4637
GenAtlas
GSTM5
GeneCards
GSTM5
GenBank Gene Database
L02321
GenBank Protein Database
468260
UniProt Accession
GSTM5_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:4638
GenAtlas
GSTP1
GeneCards
GSTP1
GenBank Gene Database
M24485
GenBank Protein Database
31946
UniProt Accession
GSTP1_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:4641
GenAtlas
GSTT1
GeneCards
GSTT1
GenBank Gene Database
X79389
GenBank Protein Database
510905
UniProt Accession
GSTT1_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:4642
GeneCards
GSTT2
UniProt Accession
GST2_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:33437
GeneCards
GSTT2B
UniProt Accession
GSTT2_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:17890
GeneCards
HPGDS
GenBank Gene Database
D82073
GenBank Protein Database
3046817
Guide to Pharmacology
1381
UniProt Accession
HPGDS_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:42
GenAtlas
ABCB11
GeneCards
ABCB11
GenBank Gene Database
AF091582
GenBank Protein Database
3873243
Guide to Pharmacology
778
UniProt Accession
ABCBB_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:10956
GeneCards
SLCO1A2
GenBank Gene Database
U21943
GenBank Protein Database
885978
Guide to Pharmacology
1219
UniProt Accession
SO1A2_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:10906
GeneCards
SLC10A2
GenBank Gene Database
U10417
GenBank Protein Database
595399
Guide to Pharmacology
960
UniProt Accession
NTCP2_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:10905
GeneCards
SLC10A1
GenBank Gene Database
L21893
GenBank Protein Database
410214
Guide to Pharmacology
959
UniProt Accession
NTCP_HUMAN
Patent information
14 active patents, 2 expired
Source: DrugBank · CC BY-NC 4.0. Patent data sourced from national patent offices. Expiry dates may not reflect extensions, regulatory exclusivity periods, or legal challenges.
DrugBank citations
If you use DrugBank data in your research, please cite the following publications: