Deferasirox 180mg tablets
Requires a prescription from a doctor or prescriber
Deferasirox is an iron chelator and the first oral medication FDA approved for chronic iron overload in patients receiving long term blood transfusions.
Official documents, adverse reaction reporting, and safety monitoring
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Official medicine documents
Safety monitoring data
Yellow Card reports
The MHRA Yellow Card scheme collects reports of suspected side effects from healthcare professionals and patients. View the Drug Analysis Profile (iDAP) for real-world adverse reaction data.
View Drug Analysis Profile
Suspected adverse reactions reported for Deferasirox
Browse all iDAP reports
Interactive Drug Analysis Profiles for all medicines
Report a side effect
Submit a Yellow Card report to the MHRA
Data from the MHRA Yellow Card scheme. A reported reaction does not necessarily mean the medicine caused it. Contains public sector information licensed under the Open Government Licence v3.0.
EudraVigilance
The European Medicines Agency (EMA) collects suspected adverse reaction reports from across the EU/EEA through the EudraVigilance system. Search for safety data on this medicine.
View EudraVigilance report
Suspected adverse reactions reported for Deferasirox
About EudraVigilance
Learn about EU pharmacovigilance and safety monitoring
EudraVigilance data is published by the European Medicines Agency (EMA). A suspected adverse reaction is not necessarily caused by the medicine.
15 branded products available
MHRA licensed products
View all licensed products for Deferasirox on the MHRA register
Exjade 180mg tablets
Deferasirox 180mg tablets
Deferasirox 180mg tablets
Deferasirox 180mg tablets
Deferasirox 180mg tablets
Deferasirox 180mg tablets
Deferasirox 180mg tablets
Deferasirox 180mg tablets
Deferasirox 180mg tablets
Deferasirox 180mg tablets
Deferasirox 180mg tablets
Deferasirox 180mg tablets
This is the NHS Drug Tariff indicative price used for reimbursement purposes. It may not reflect the price paid by patients or pharmacies.
View full Drug TariffSource: NHS Drug Tariff via NHSBSA. Derived from dm+d VMPP (Virtual Medicinal Product Pack) pricing data. Contains public sector information licensed under the Open Government Licence v3.0.
Therapeutically similar medicines
Similarity is based on WHO Anatomical Therapeutic Chemical (ATC) classification and on a factual NHS dm+d therapeutic-grouping code prefix. Source data: NHS dm+d via TRUD (OGL v3.0), WHO ATC/DDD Index.
NHS prescribing volume and spending trends
Check stock at pharmacies and supply information
Pharmacy stock checkers
Search for this medicine at major UK pharmacy chains. These links open the retailer's own website — results depend on their current online catalogue.
Supply & safety information
Official UK regulator monitoring and safety alerts
Pharmacy links redirect to the retailer's own search and do not represent real-time stock levels. Shortage and safety information sourced from MHRA drug safety updates (gov.uk, Crown Copyright under OGL v3.0).
Codes for healthcare professionals and prescribing systems
These codes are used by healthcare IT systems and prescribers to identify this medicine.
NHS UK identifiers
Browse tools
SNOMED CT and dm+d codes from NHS TRUD (Technology Reference data Update Distribution), licensed under the Open Government Licence v3.0. BNF code shown is the factual mapping value distributed by NHS Business Services Authority (NHSBSA) in the dm+d supplementary file under OGL v3.0; it is not affiliated with, nor licensed from, the publishers of the British National Formulary. ATC codes from the WHO Collaborating Centre for Drug Statistics Methodology (whocc.no).
Active and completed clinical studies from ClinicalTrials.gov
Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine (NLM), National Institutes of Health (NIH). Data accessed via ClinicalTrials.gov API v2. Trial information is provided for research purposes and does not constitute medical advice.
Academic studies and reviews for this medicine's active substance
Showing the 50 most relevant studies.
Reviews & meta-analyses: 16 · Randomised trials: 10 · 2005–2026
Showing the 50 most relevant studies, sorted by most relevant.
Brad Spellberg, Ashraf S. Ibrahim, Peter Chin‐Hong, et al.
Journal of Antimicrobial Chemotherapy, 2011
Antonio Piga, Renzo Galanello, Gian Luca Forni, et al.
PubMed, 2006
- Deferasirox
- Benzoates
- Deferoxamine
Ahmed Salem, Payal Desai, Ahmed Elgebaly
Cureus, 2023
George J. Kontoghiorghes, Christina Kontoghiorghe
Drug Design Development and Therapy, 2016
- Deferiprone
- Deferasirox
- Benzoates
D. B. Arrey Agbor, Abhimanyu Karumanchi, Santoshini Adivi, et al.
Cureus, 2024
C McLeod, Nigel Fleeman, Jamie J Kirkham, et al.
Health Technology Assessment, 2009
- Contraindications
- Deferiprone
- Deferasirox
Dudley J. Pennell, John B. Porter, Antonio Piga, et al.
Blood, 2014
- Deferasirox
- Benzoates
- Deferoxamine
Aurelio Maggio, Antonis Kattamis, Mariagrazia Felisi, et al.
The Lancet Haematology, 2020
- Deferiprone
- Deferasirox
- Agranulocytosis
Huihong Dou, Yuan-Han Qin, G. Chen, et al.
Acta Haematologica, 2018
Yi Wu, Lei Ran, Yue Yang, et al.
Life Sciences, 2022
- Gastrointestinal Microbiome
- Ferroptosis
- Colitis
Sources: aggregated from Europe PMC (EMBL-EBI), OpenAlex, Crossref, PubMed and other open scholarly databases. Retracted articles are excluded. Study information is provided for research purposes and does not constitute medical advice.
Pharmacology and chemical data from DrugBank
Key facts
Drug status
Approved
Major interactions
None known
Half-life
8 to 16 hours
Mechanism
Two molecules of deferasirox are capable of binding to 1 atom of iron.
Food interactions
3 warnings
Human targets
1 target
Data: DrugBank · CC BY-NC 4.0
Pharmacokinetics at a glance
Absorption
70%
Half-life
8 to 16 hours
Protein binding
99%
Volume of distribution
2.69 L
Metabolism
8%
Elimination
84%
Renal…
Pharmacokinetic data: DrugBank · CC BY-NC 4.0
Known interactions with other medications. Always consult a healthcare professional.
Showing 50 of 829 interactions
How the body processes this drug — absorption, distribution, metabolism, and elimination
Renal excretion of deferasirox and metabolites is minimal (8% of the administered dose).
Enzymes involved in drug metabolism — important for understanding drug interactions
ATC V03AC03
Chemical identifiers
CAS, UNII, InChI Key and database cross-references
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Chemical identifiers
CAS, UNII, InChI Key and database cross-references
Linked compound data from DrugBank Open Data (CC BY-NC 4.0)
Deferasirox
Additional database identifiers
Drugs Product Database (DPD)
20022
ChemSpider
10770206
BindingDB
50088376
PDB
JBL
ZINC
ZINC000001481815
HUGO Gene Nomenclature Committee (HGNC)
HGNC:2637
GenAtlas
CYP3A4
GeneCards
CYP3A4
GenBank Gene Database
M18907
Guide to Pharmacology
1337
UniProt Accession
CP3A4_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:12530
GeneCards
UGT1A1
GenBank Gene Database
M57899
GenBank Protein Database
184473
Guide to Pharmacology
2990
UniProt Accession
UD11_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:12535
GeneCards
UGT1A3
GenBank Gene Database
M84127
GenBank Protein Database
340135
UniProt Accession
UD13_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:12541
GeneCards
UGT1A9
GenBank Gene Database
S55985
GenBank Protein Database
7690346
UniProt Accession
UD19_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:2622
GenAtlas
CYP2C8
GeneCards
CYP2C8
GenBank Gene Database
M17397
Guide to Pharmacology
1325
UniProt Accession
CP2C8_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:2596
GenAtlas
CYP1A2
GeneCards
CYP1A2
GenBank Gene Database
Z00036
Guide to Pharmacology
1319
UniProt Accession
CP1A2_HUMAN
DrugBank citations
If you use DrugBank data in your research, please cite the following publications:
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Structured knowledge from the free knowledge base
ATC classifications (Wikidata)
Linked open data from Wikidata (Q5251502), a free and open knowledge base operated by the Wikimedia Foundation. Data is available under the Creative Commons CC0 1.0 Public Domain Dedication. WHO INN from the World Health Organization.