Creatine 1g tablets
An amino acid derivative that occurs in vertebrate tissues and in urine.
Official documents, adverse reaction reporting, and safety monitoring
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Official medicine documents
Safety monitoring data
Yellow Card reports
The MHRA Yellow Card scheme collects reports of suspected side effects from healthcare professionals and patients. View the Drug Analysis Profile (iDAP) for real-world adverse reaction data.
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Data from the MHRA Yellow Card scheme. A reported reaction does not necessarily mean the medicine caused it. Contains public sector information licensed under the Open Government Licence v3.0.
EudraVigilance
The European Medicines Agency (EMA) collects suspected adverse reaction reports from across the EU/EEA through the EudraVigilance system. Search for safety data on this medicine.
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EudraVigilance data is published by the European Medicines Agency (EMA). A suspected adverse reaction is not necessarily caused by the medicine.
1 branded products available
Clinical guidelines and formulary information
British National Formulary
Creatine
Source: British National Formulary, NICE. Joint Formulary Committee. Contains public sector information licensed under the Open Government Licence v3.0.
NICE clinical guidance(14)
Cardiovascular disease: risk assessment and reduction, including lipid modification (NG238)
Migalastat for treating Fabry disease (HST4)
Upadacitinib for treating moderately to severely active ulcerative colitis (TA856)
Familial hypercholesterolaemia: identification and management (CG71)
Telbivudine for the treatment of chronic hepatitis B (TA154)
Trabectedin for the treatment of advanced soft tissue sarcoma (TA185)
Sparsentan for treating primary IgA nephropathy (TA1074)
Parkinson's disease in adults (NG71)
Reslizumab for treating severe eosinophilic asthma (TA479)
Actim Pancreatitis for diagnosing acute pancreatitis (MIB218)
Topotecan, pegylated liposomal doxorubicin hydrochloride, paclitaxel, trabectedin and gemcitabine for treating recurrent ovarian cancer (TA389)
Tests to help assess risk of acute kidney injury for people being considered for critical care admission (ARCHITECT and Alinity i Urine NGAL assays, BioPorto NGAL test and NephroCheck test) (HTG544)
Suspected neurological conditions: recognition and referral (NG127)
Myalgic encephalomyelitis (or encephalopathy)/chronic fatigue syndrome: diagnosis and management (NG206)
Source: National Institute for Health and Care Excellence (NICE). Contains public sector information licensed under the Open Government Licence v3.0.
Check stock at pharmacies and supply information
Pharmacy stock checkers
Search for this medicine at major UK pharmacy chains. These links open the retailer's own website — results depend on their current online catalogue.
Supply & product information
Official product databases and supply status monitoring
Pharmacy links redirect to the retailer's own search and do not represent real-time stock levels. emc (electronic medicines compendium) is operated by Datapharm Ltd. Shortage information sourced from NHS Specialist Pharmacy Service (SPS), sps.nhs.uk.
Codes for healthcare professionals and prescribing systems
These codes are used by healthcare IT systems and prescribers to identify this medicine.
NHS UK identifiers
SNOMED CT and dm+d codes from NHS TRUD (Technology Reference data Update Distribution), licensed under the Open Government Licence v3.0. BNF codes from NHS Business Services Authority (NHSBSA).
Active and completed clinical studies from ClinicalTrials.gov
Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine (NLM), National Institutes of Health (NIH). Data accessed via ClinicalTrials.gov API v2. Trial information is provided for research purposes and does not constitute medical advice.
Pharmacology and chemical data from DrugBank
Key facts
Drug status
Approved
Major interactions
None known
Half-life
3 hours
Mechanism
In the muscles, a fraction of the total creatine binds to phosphate - forming creatine phosphate.
Food interactions
None known
Human targets
5 targets
Data: DrugBank · CC BY-NC 4.0
Pharmacokinetics at a glance
Half-life
3 hours
Pharmacokinetic data: DrugBank · CC BY-NC 4.0
How the body processes this drug — absorption, distribution, metabolism, and elimination
Proteins and enzymes this drug interacts with in the body
PMID:8186255
Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (Probable). Acts as a key regulator of adaptive thermogenesis as part of the futile creatine cycle: localizes to the mitochondria of thermogenic fat cells and acts by mediating phosphorylation of creatine to initiate a futile cycle of creatine phosphorylation and dephosphorylation (By similarity). During the futile creatine cycle, creatine and N-phosphocreatine are in a futile cycle, which dissipates the high energy charge of N-phosphocreatine as heat without performing any mechanical or chemical work (By similarity)
PMID:24415674 PMID:26003046 PMID:26319512
Important in nervous system development PMID:24415674
Proteins that transport this drug across cell membranes
PMID:10454528 PMID:10525100 PMID:10966938 PMID:17509700 PMID:20722056 PMID:33124720
Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium.
Relative uptake activity ratio of carnitine to TEA is 11.3 .
PMID:10454528 PMID:10525100 PMID:10966938
In intestinal epithelia, transports the quorum-sensing pentapeptide CSF (competence and sporulation factor) from B.subtilis which induces cytoprotective heat shock proteins contributing to intestinal homeostasis .
PMID:18005709
May also contribute to regulate the transport of organic compounds in testis across the blood-testis-barrier (Probable)
PMID:17465020 PMID:22644605 PMID:25861866 PMID:7945388 PMID:7953292 PMID:9882430
Plays an important role in supplying creatine to the brain via the blood-brain barrier (By similarity)
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Chemical identifiers
CAS, UNII, InChI Key and database cross-references
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Chemical identifiers
CAS, UNII, InChI Key and database cross-references
Linked compound data from DrugBank Open Data (CC BY-NC 4.0)
Creatine
Additional database identifiers
ChemSpider
566
BindingDB
50357229
PDB
CRN
ZINC
ZINC000003861770
HUGO Gene Nomenclature Committee (HGNC)
HGNC:1994
GenAtlas
CKM
GeneCards
CKM
GenBank Gene Database
M14780
GenBank Protein Database
180576
UniProt Accession
KCRM_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:1995
GenAtlas
CKMT1A
GeneCards
CKMT1B
GenBank Gene Database
J04469
GenBank Protein Database
180590
UniProt Accession
KCRU_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:1991
GenAtlas
CKB
GeneCards
CKB
GenBank Gene Database
M16451
GenBank Protein Database
180572
UniProt Accession
KCRB_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:1996
GenAtlas
CKMT2
GeneCards
CKMT2
GenBank Gene Database
J05401
GenBank Protein Database
338237
UniProt Accession
KCRS_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:4136
GenAtlas
GAMT
GeneCards
GAMT
GenBank Gene Database
Z49878
GenBank Protein Database
1212946
UniProt Accession
GAMT_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:10969
GenAtlas
SLC22A5
GeneCards
SLC22A5
GenBank Gene Database
AF057164
GenBank Protein Database
3273741
UniProt Accession
S22A5_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:11055
GenAtlas
SLC6A8
GeneCards
SLC6A8
GenBank Gene Database
L31409
GenBank Protein Database
493132
UniProt Accession
SC6A8_HUMAN
International reference pricing
Reference pricing from DrugBank. Prices are indicative and may not reflect current UK costs.
Source: DrugBank. Used under CC BY-NC 4.0 academic licence for non-commercial purposes.
DrugBank citations
If you use DrugBank data in your research, please cite the following publications: