Collagenase clostridium histolyticum 900microgram powder and solvent for solution for injection vials
Collagenase clostridium histolyticum is an enzyme produced by the bacterium Clostridium histolyticum.
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Data from the MHRA Yellow Card scheme. A reported reaction does not necessarily mean the medicine caused it. Contains public sector information licensed under the Open Government Licence v3.0.
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Suspected adverse reactions reported for Collagenase clostridium histolyticum
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Xiapex 0.9mg powder and solvent for solution for injection vials
Guidelines from the National Institute for Health and Care Excellence
NICE clinical guidance(1)
Source: National Institute for Health and Care Excellence (NICE). Contains public sector information licensed under the Open Government Licence v3.0.
Check stock at pharmacies and supply information
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Supply & safety information
Official UK regulator monitoring and safety alerts
Pharmacy links redirect to the retailer's own search and do not represent real-time stock levels. Shortage and safety information sourced from MHRA drug safety updates (gov.uk, Crown Copyright under OGL v3.0).
Codes for healthcare professionals and prescribing systems
These codes are used by healthcare IT systems and prescribers to identify this medicine.
NHS UK identifiers
Browse tools
SNOMED CT and dm+d codes from NHS TRUD (Technology Reference data Update Distribution), licensed under the Open Government Licence v3.0. BNF code shown is the factual mapping value distributed by NHS Business Services Authority (NHSBSA) in the dm+d supplementary file under OGL v3.0; it is not affiliated with, nor licensed from, the publishers of the British National Formulary. ATC codes from the WHO Collaborating Centre for Drug Statistics Methodology (whocc.no).
Active and completed clinical studies from ClinicalTrials.gov
Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine (NLM), National Institutes of Health (NIH). Data accessed via ClinicalTrials.gov API v2. Trial information is provided for research purposes and does not constitute medical advice.
Academic studies and reviews for this medicine's active substance
Showing the 50 most relevant studies.
Reviews & meta-analyses: 31 · Randomised trials: 6 · 1981–2026
Showing the 50 most relevant studies, sorted by most relevant.
Rémy Liechti, Dominique Merky, Damian Sutter, et al.
Archives of Orthopaedic and Trauma Surgery, 2023
- Microbial Collagenase
- Dupuytren Contracture
- Fasciotomy
Francesco Smeraglia, Angelo Del Buono, Nicola Maffulli
British Medical Bulletin, 2016
- Fasciotomy
- Microbial Collagenase
- Cost-Benefit Analysis
Jevan Cevik, Rohan Rajaram, Michael Pollock, et al.
Journal of plastic surgery and hand surgery, 2025
- Microbial Collagenase
- Dupuytren Contracture
- Fasciotomy
Miriam Brazzelli, Moira Cruickshank, Emma Tassie, et al.
Health Technology Assessment, 2015
- Microbial Collagenase
- Cost-Benefit Analysis
- Dupuytren Contracture
I. Seth, Vicki McClure, Bryan Lim, et al.
Life, 2025
Yicheng Guo, Yingying Yang, Qiancheng Mao, et al.
Sexual medicine reviews, 2024
- Penile Induration
- Microbial Collagenase
- Penis
Jose A. Foppiani, MD, Otakar Raska, MUDr, PhD, Cécilia Galinaud, et al.
Plastic and Reconstructive Surgery, Global Open, 2024
Michael Nocek, BA, Dorothy Wakefield, MS, PStat, Mark A. Vitale, MD, MPH
Journal of Hand Surgery Global Online, 2026
Mefford AT, Raheem O, Yafi FA, et al.
2021
Tokai B. Cooper, Keshav Poonit, Chenglun Yao, et al.
Journal of orthopaedic surgery, 2020
- Fasciotomy
- Microbial Collagenase
- Clostridium
Sources: aggregated from Europe PMC (EMBL-EBI), OpenAlex, Crossref, PubMed and other open scholarly databases. Retracted articles are excluded. Study information is provided for research purposes and does not constitute medical advice.
Pharmacology and chemical data from DrugBank
Key facts
Drug status
Approved
Major interactions
None known
Half-life
Not available
Mechanism
Peyronie's disease is a fibrous lesion of the tunica albuginea in the penile tissues.
Food interactions
None known
Human targets
3 targets
Data: DrugBank · CC BY-NC 4.0
Pharmacokinetics at a glance
Absorption
5 ng/mL
[L14912]…
Protein binding
[L14912]
Volume of distribution
[L14912]…
Metabolism
[A215277]
Clearance
[L14912]
Pharmacokinetic data: DrugBank · CC BY-NC 4.0
On July 6, 2020 a combination of injectable bacterial collagenases was approved by the FDA for the treatment of cellulite in adult women.[L14872] Also known as Qwo, this injection is the first approved injectable treatment for cellulite and was developed by Endo International.[L14892]
[L14882]
Collagenase ointment is used for the tissue debridement of chronic dermal ulcers and severely burned tissues.
[L14952]
The combination collagenase product, also known as Qwo, is used for the treatment of moderate to severe cellulite in the buttocks of adult women.
[L14872]
Known interactions with other medications. Always consult a healthcare professional.
Showing 50 of 100 interactions
[L14912]
If required, the collagenase enzymes can be inactivated with a povidone-iodine wash.
[L14912]
These enzymes are proteinases acting to hydrolyze collagen's triple-helical conformation, resulting in the lysis of collagen deposits and relief from the necrotic tissue and plaques associated with several conditions.[L14882][L14912] On a molecular level, collagenases cleave polypeptide chains that make up the collagen triple helix structure at various loci, leading to solubilization from the collagen fibril.[A215197]
How the body processes this drug — absorption, distribution, metabolism, and elimination
[L14912]
In a pharmacokinetic study, the serum concentrations of clostridium type I collagenase (AUX-I) and clostridium type II collagenase (AUX-II) were measured. Both were detected under the lower limit of quantitation of 5 ng/mL and 25 ng/mL, respectively, in volunteers administered one dose of the collagenase histolyticum combination product, Qwo, at a dose of up to 3.36 mg in a maximum of 4 body areas.
[L14872]
[L14912]
[L14912]
Systemic pharmacokinetic studies evaluation volume of distribution have not been performed, however, collagenase histolyticum is likely to have local degradative effects in the region of the application without effects on the vasculature and elastic tissue.
[A215277]
[A215277]
[L14912]
Proteins and enzymes this drug interacts with in the body
ATC D03BA02
ATC M09AB02
ATC D03BA52
Chemical identifiers
CAS, UNII, InChI Key and database cross-references
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Chemical identifiers
CAS, UNII, InChI Key and database cross-references
Linked compound data from DrugBank Open Data (CC BY-NC 4.0)
Collagenase clostridium histolyticum
Additional database identifiers
Drugs Product Database (DPD)
21378
Drugs Product Database (DPD)
2150
HUGO Gene Nomenclature Committee (HGNC)
HGNC:2197
GenAtlas
COL1A1
GeneCards
COL1A1
GenBank Gene Database
Z74615
GenBank Protein Database
1418928
UniProt Accession
CO1A1_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:2200
GenAtlas
COL2A1
GeneCards
COL2A1
GenBank Gene Database
X16468
GenBank Protein Database
29516
UniProt Accession
CO2A1_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:2201
GenAtlas
COL3A1
GeneCards
COL3A1
GenBank Gene Database
X14420
GenBank Protein Database
30058
UniProt Accession
CO3A1_HUMAN
DrugBank citations
If you use DrugBank data in your research, please cite the following publications:
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Structured knowledge from the free knowledge base
Linked open data from Wikidata (Q5145911), a free and open knowledge base operated by the Wikimedia Foundation. Data is available under the Creative Commons CC0 1.0 Public Domain Dedication.