Clove oil 20% dental gel sugar free
Available from pharmacies, supermarkets, and retail outlets
Clove oil is obtained by extraction from the dried flower buds of the clove plant.
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Dentogen Clove Oil 20% dental gel
Therapeutically similar medicines
Similarity is based on WHO Anatomical Therapeutic Chemical (ATC) classification and on a factual NHS dm+d therapeutic-grouping code prefix. Source data: NHS dm+d via TRUD (OGL v3.0), WHO ATC/DDD Index.
NHS prescribing volume and spending trends
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Source: National Institute for Health and Care Excellence (NICE). Contains public sector information licensed under the Open Government Licence v3.0.
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Codes for healthcare professionals and prescribing systems
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NHS UK identifiers
SNOMED CT and dm+d codes from NHS TRUD (Technology Reference data Update Distribution), licensed under the Open Government Licence v3.0. BNF code shown is the factual mapping value distributed by NHS Business Services Authority (NHSBSA) in the dm+d supplementary file under OGL v3.0; it is not affiliated with, nor licensed from, the publishers of the British National Formulary.
Active and completed clinical studies from ClinicalTrials.gov
Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine (NLM), National Institutes of Health (NIH). Data accessed via ClinicalTrials.gov API v2. Trial information is provided for research purposes and does not constitute medical advice.
Academic studies and reviews for this medicine's active substance
Showing all 30 studies.
Reviews & meta-analyses: 6 · 2021–2025
Showing all 30 studies, sorted by most relevant.
José Nabor Haro-González, G. Castillo-Herrera, M. Martínez-Velázquez, et al.
Molecules, 2021
- Anti-Infective Agents
- Anti-Inflammatory Agents
- Antineoplastic Agents, Phytogenic
L. Myrtaceae) is an aromatic plant widely cultivated in tropical and subtropical countries, rich in volatile compounds and antioxidants such as eugenol, β-caryophyllene, and α-humulene. Clove essential oil has received considerable interest due to its wide application in the perfume, cosmetic, health, medical, flavoring, and food industries. Clove essential oil has biological activity relevant to human health, including antimicrobial, antioxidant, and insecticidal activity. The impacts of the extraction method (hydrodistillation, steam distillation, ultrasound-assisted extraction, microwave-assisted extraction, cold pressing, and supercritical fluid extraction) on the concentration of the main volatile compounds in clove essential oil and organic clove extracts are shown. Eugenol is the major compound, accounting for at least 50%. The remaining 10-40% consists of eugenyl acetate, β-caryophyllene, and α-humulene. The main biological activities reported are summarized. Furthermore, the main applications in clove essential oil in the food industry are presented. This review presents new biological applications beneficial for human health, such as anti-inflammatory, analgesic, anesthetic, antinociceptive, and anticancer activity. This review aims to describe the effects of different methods of extracting clove essential oil on its chemical composition and food applications and the biological activities of interest to human health.
Abstract licence: CC BY
V. Pandey, Shivangi Srivastava, Ashish, et al.
Heliyon, 2023
, commonly called clove, is a culinary spice with medical uses. Clove is utilized in cosmetics, medicine, gastronomy, and agriculture due to its abundance of bioactive components such as gallic acid, flavonoids, eugenol acetate, and eugenol. Clove essential oil has been revealed to have antibacterial, antinociceptive, antibacterial activities, antifungal, and anticancerous qualities. Anti-inflammatory chemicals, including eugenol and flavonoids, are found in clove that help decrease inflammation and alleviate pain. The anti-inflammatory and analgesic qualities of clove oil have made it a popular natural cure for toothaches and gum discomfort. Due to its therapeutic potential, it has been used as a bioactive ingredient in coating fresh fruits and vegetables. This review article outlines the potential food processing applications of clove essential oil. The chemical structures of components, bioactive properties, and medicinal potential of clove essential oil, including phytochemical importance in food, have also been thoroughly addressed.
Abstract licence: CC BY-NC-ND
Rafael Liñán-Atero, F. Aghababaei, Samuel Rodríguez García, et al.
Antioxidants, 2024
Plants have proven to be important sources for discovering new compounds that are useful in the treatment of various diseases due to their phytoconstituents. Clove (Syzygium aromaticum L.), an aromatic plant widely cultivated around the world, has been traditionally used for food preservation and medicinal purposes. In particular, clove essential oil (CEO) has attracted attention for containing various bioactive compounds, such as phenolics (eugenol and eugenol acetate), terpenes (β-caryophyllene and α-humulene), and hydrocarbons. These constituents have found applications in cosmetics, food, and medicine industries due to their bioactivity. Pharmacologically, CEO has been tested against a variety of parasites and pathogenic microorganisms, demonstrating antibacterial and antifungal properties. Additionally, many studies have also demonstrated the analgesic, antioxidant, anticancer, antiseptic, and anti-inflammatory effects of this essential oil. However, CEO could degrade for different reasons, impacting its quality and bioactivity. To address this challenge, encapsulation is viewed as a promising strategy that could prolong the shelf life of CEO, improving its physicochemical stability and application in various areas. This review examines the phytochemical composition and biological activities of CEO and its constituents, as well as extraction methods to obtain it. Moreover, encapsulation strategies for CEO and numerous applications in different food fields are also highlighted.
Abstract licence: CC BY
Marina Vinhas Silva, Alice da Conceição Alves de Lima, Marina Gomes Silva, et al.
Food Bioscience, 2024
The present review provides a comprehensive overview of clove essential oil, including an outline of extraction methods, a review of its medical applications, an approach to toxicity and antimicrobial activity of eugenol, an exploration of recent advancements in polymeric materials, and an emphasis on important methodologies for assessing the antimicrobial properties of films in active food packaging incorporating clove oil extracts into polymer formulations. By employing bibliometric research methods, the review also explores the evolution of scientific production on clove oil, highlighting significant contributions to the field. Specifically, in the field of active packaging, the integration of clove oil and eugenol to produce antimicrobial packaging offers substantial benefits for food preservation, yet it also presents several challenges that must be addressed through continued research. By overcoming these challenges and navigating the regulatory landscape, eugenol-based packaging could play a significant role in the future of sustainable food preservation, offering both enhanced safety and extended shelf life for a wide range of food products.
Abstract licence: CC BY-NC-ND
Vinay Kumar Pandey, Rafeeya Shams, Rahul Singh, et al.
Frontiers in Nutrition, 2022
Many studies have demonstrated the use of synthetic preservatives and chemical additives in food is causing poisoning, cancer, and other degenerative disorders. New solutions for food preservation with quality maintenance are currently emerging. As a result, public concern has grown, as they desire to eat healthier products that use natural preservatives and compounds rather than synthetic ones. Clove is a highly prized spice used as a food preservative and for a variety of therapeutic reasons. Clove essential oil and its principal active component, eugenol, indicate antibacterial and antifungal action, aromaticity, and safety as promising and valuable antiseptics in the food sector. Clove essential oil and eugenol are found to have strong inhibition effects on a variety of food-source bacteria, and the mechanisms are linked to lowering migration and adhesion, as well as blocking the creation of biofilm and various virulence factors. This review emphasizes the importance of CEO (clove essential oil) in the food industry and how it can be explored with edible coatings to deliver its functional properties in food preservation.
Abstract licence: CC BY
Swarup Roy, Ruchir Priyadarshi, J. Rhim
Food research international, 2022
- Red Meat
- Pork Meat
- Listeria monocytogenes
Mahmoud K. M. Elbestawy, Gamal M. El-Sherbiny, Saad A. Moghannem
Molecules, 2023
- Oils, Volatile
- Helicobacter pylori
- Syzygium
Eugenol essential oil (EEO) is the major component in aromatic extracts of Syzygium aromaticum (clove) and has several biological properties, such as antibacterial, antioxidant, and anti-inflammatory activities, as well as controlling vomiting, coughing, nausea, flatulence, diarrhea, dyspepsia, stomach distension, and gastrointestinal spasm pain. It also stimulates the nerves. Therefore, the aim of this study was to extract and purify EEO from clove buds and assess its ability to combat resistant Helicobacter pylori. Additionally, EEO’s anti-inflammatory activity and its ability to suppress H. pylori biofilm formation, which is responsible for antibiotic resistance, was also investigated. Syzygium aromaticum buds were purchased from a local market, ground, and the EEO was extracted by using hydro-distillation and then purified and chemically characterized using gas chromatography–mass spectrometry (GC–MS). A disk-diffusion assay showed that Helicobacter pylori is sensitive to EEO, with an inhibition zone ranging from 10 ± 06 to 22 ± 04 mm. The minimum inhibition concentration (MIC) of EEO ranged from 23.0 to 51.0 μg/mL against both Helicobacter pylori clinical isolates and standard strains. In addition, EEO showed antibiofilm activity at 25 µg/mL and 50 µg/mL against various Helicobacter pylori strains, with suppression percentages of 49.32% and 73.21%, respectively. The results obtained from the anti-inflammatory assay revealed that EEO possesses strong anti-inflammatory activity, with human erythrocyte hemolysis inhibition percentages of 53.04, 58.74, 61.07, and 63.64% at concentrations of 4, 8, 16, and 32 μg/L, respectively. GC–MS analysis revealed that EEO is a major component of Syzygium aromaticum when extracted with a hydro-distillation technique, which was confirmed by its purification using a chemical separation process. EEO exhibited antibacterial action against resistant Helicobacter pylori strains, as well as antibiofilm and anti-inflammatory activities, and is a promising natural alternative in clinical therapy.
Abstract licence: CC BY
Nicky Rahmana Putra, D. N. Rizkiyah, M. A. Che Yunus, et al.
Journal of Essential Oil Bearing Plants, 2024
Yun Xiong, Meetaksh Kamboj, S. Ajlouni, et al.
Food Control, 2021
Litong Rui, Ying Li, Xiaodan Wu, et al.
International journal of biological macromolecules, 2024
- Oils, Volatile
- Syzygium
- Chitosan
Sources: aggregated from Europe PMC (EMBL-EBI), OpenAlex, Crossref, PubMed and other open scholarly databases. Retracted articles are excluded. Study information is provided for research purposes and does not constitute medical advice.
Pharmacology and chemical data from DrugBank
Key facts
Drug status
Approved
Major interactions
None known
Half-life
18.3 h
Mechanism
The chief constituent present in clove oil is the phenol "eugenol" which is present in amounts up to 85%.
Food interactions
None known
Human targets
4 targets
Data: DrugBank · CC BY-NC 4.0
Pharmacokinetics at a glance
Absorption
Half-life
18.3 h
Metabolism
20-30%
[L2850]
In…
Elimination
24 hours
Pharmacokinetic data: DrugBank · CC BY-NC 4.0
Clove is native of Indonesia but is now cultured in several parts of the world, including Brazil in the state of Bahia. This plant represents one of the richest source of phenolic compounds such as eugenol, eugenol acetate and gallic acid and has great potential for pharmaceutical, cosmetic, food and agricultural applications [A33133].
Interestingly, clove oil has been studied for its potential benefit in treating neuropathic pain, as well as vaginal candidiasis with promising results [A33137], [A33144].
The FDA categorizes clove oil as generally recognized as safe (GRAS) for use in dental cement or as a food additive F108.
[L2849]
Known interactions with other medications. Always consult a healthcare professional.
Showing 50 of 732 interactions
Clove oil is considered safe in small quantities (< 1,500 ppm) as a food additive [F108]. The lethal oral dose is 3.75 g per kg body weight in humans [F108].
Contact with skin or soft tissue may cause transient irritation, contact dermatitis, inflammation of the lips, and inflammation or ulceration of the mouth. The eugenol present in clove oil may act as an irritant to skin and mucous membranes; it may also cause hypersensitivity and is reported to inhibit prostaglandin synthesis.
Patients may become sensitive to clove oil .
[L2850]
After oral administration of 5-10 ml of clove oil in children below 2 years of age, life-threatening conditions were observed. Adverse effects included coma, acidosis, a generalized seizure, disordered blood clotting, and acute liver damage F108.
Overdose may lead to CNS depression, urinary abnormalities, anion-gap acidosis, deterioration of liver function, coma, seizure and low blood glucose levels. Treatment should be supportive and symptomatic; there have been reports in the literature that N-acetylcysteine has been successfully used as an antidote .
[L2850]
There are no epidemiological studies of potential adverse human health effects related to exposure to clove leave oil or eugenol from any human exposure scenarios.
Nor are there any studies of agricultural use, either in workers or those with bystander exposure or other applications. There are no occupational exposure standards for clove leaf oil or eugenol including OSHA PEL (Permissible Exposure Limit) or AGIHA TLVs (Threshold Limit Value) in air F108.
Clove oil is thought to inhibit prostaglandin synthesis, thereby reducing painful symptoms [A33145].
Eugenol, the main constituent of clove oil is purported to have anticancer action. In one study, eugenol-treated HL-60 cells showed features of apoptosis including DNA fragmentation and formation of DNA ladders in agarose gel electrophoresis. It was observed that eugenol transduced the apoptotic signal via reactive oxygen species (ROS) generation, inducing mitochondrial permeability transition (MPT), decreasing anti-apoptotic protein bcl-2 level, inducing cytochrome c release to the cytosol, and subsequent apoptotic cell death. When taken together, the study showed that ROS plays a critical role in eugenol-induced apoptosis in HL-60, and this is the first report on the mechanism of the anticancer effect of eugenol [A33146].
Clove essential oil, used as an antiseptic in oral infections, inhibits gram-negative and gram-positive bacteria as well as yeast [A24841].
How the body processes this drug — absorption, distribution, metabolism, and elimination
[A33137]
[L2850]
In a pharmacokinetic study in man, 95% of the ingested eugenol dose was recovered in the urine, most of which (greater than 99%) consisted of phenolic conjugates; 50% of the conjugated metabolites were eugenol-glucuronide and sulfate. Other metabolic routes observed were the epoxide-diol pathway, synthesis of a thiophenol and of a substituted propionic acid, allylic oxidation, and migration of the double bond .
[A33147]
[A33147]
Proteins and enzymes this drug interacts with in the body
PMID:31310649
Acts as a major regulator of leukocyte adhesion to the endothelium through interaction with different types of integrins .
PMID:10209034
During inflammatory responses, binds ligands on the surface of activated endothelial cells to initiate the activation of calcium channels and the plasma membrane-associated small GTPase RAC1 leading to leukocyte transendothelial migration .
PMID:22970700
Also serves as a quality-control checkpoint for entry into bone marrow by providing a 'don't-eat-me' stamping in the context of major histocompatibility complex (MHC) class-I presentation PMID:35210567
PMID:11157474 PMID:22652417 PMID:7540647
Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganization .
PMID:12750173 PMID:19151743
In turn, recruitment of activated Th1 lymphocytes occurs at sites of inflammation .
PMID:12663757 PMID:12750173
Activation of the CXCL10/CXCR3 axis also plays an important role in neurons in response to brain injury for activating microglia, the resident macrophage population of the central nervous system, and directing them to the lesion site. This recruitment is an essential element for neuronal reorganization (By similarity)
Chemical identifiers
CAS, UNII, InChI Key and database cross-references
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Chemical identifiers
CAS, UNII, InChI Key and database cross-references
Linked compound data from DrugBank Open Data (CC BY-NC 4.0)
Clove oil
Additional database identifiers
Drugs Product Database (DPD)
3557
HUGO Gene Nomenclature Committee (HGNC)
HGNC:12663
GenAtlas
VCAM1
GeneCards
VCAM1
GenBank Gene Database
M30257
GenBank Protein Database
179886
UniProt Accession
VCAM1_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:10637
GenAtlas
CXCL10
GeneCards
CXCL10
GenBank Gene Database
X02530
GenBank Protein Database
33918
UniProt Accession
CXL10_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:2197
GenAtlas
COL1A1
GeneCards
COL1A1
GenBank Gene Database
Z74615
GenBank Protein Database
1418928
UniProt Accession
CO1A1_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:2435
GenAtlas
CSF2RA
GeneCards
CSF2RA
GenBank Gene Database
X17648
GenBank Protein Database
32089
Guide to Pharmacology
1707
UniProt Accession
CSF2R_HUMAN
DrugBank citations
If you use DrugBank data in your research, please cite the following publications:
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Structured knowledge from the free knowledge base
Molecular structure

Linked open data from Wikidata (Q2195458), a free and open knowledge base operated by the Wikimedia Foundation. Data is available under the Creative Commons CC0 1.0 Public Domain Dedication. Molecular structure images from Wikimedia Commons.