Citrulline 500mg/5ml oral solution
Requires a prescription from a doctor or prescriber
Citrulline is an amino acid.
Official documents, adverse reaction reporting, and safety monitoring
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Official medicine documents
Safety monitoring data
Yellow Card reports
The MHRA Yellow Card scheme collects reports of suspected side effects from healthcare professionals and patients. View the Drug Analysis Profile (iDAP) for real-world adverse reaction data.
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Submit a Yellow Card report to the MHRA
Data from the MHRA Yellow Card scheme. A reported reaction does not necessarily mean the medicine caused it. Contains public sector information licensed under the Open Government Licence v3.0.
EudraVigilance
The European Medicines Agency (EMA) collects suspected adverse reaction reports from across the EU/EEA through the EudraVigilance system. Search for safety data on this medicine.
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EudraVigilance data is published by the European Medicines Agency (EMA). A suspected adverse reaction is not necessarily caused by the medicine.
1 branded products available
Therapeutically similar medicines
Similarity based on WHO Anatomical Therapeutic Chemical (ATC) classification and NHS BNF section grouping. Source data: NHS dm+d via TRUD (OGL v3.0), WHO ATC/DDD Index.
NHS prescribing volume and spending trends
Clinical guidelines and formulary information
British National Formulary
Citrulline
Source: British National Formulary, NICE. Joint Formulary Committee. Contains public sector information licensed under the Open Government Licence v3.0.
Check stock at pharmacies and supply information
Pharmacy stock checkers
Search for this medicine at major UK pharmacy chains. These links open the retailer's own website — results depend on their current online catalogue.
Supply & product information
Official product databases and supply status monitoring
Pharmacy links redirect to the retailer's own search and do not represent real-time stock levels. emc (electronic medicines compendium) is operated by Datapharm Ltd. Shortage information sourced from NHS Specialist Pharmacy Service (SPS), sps.nhs.uk.
Codes for healthcare professionals and prescribing systems
These codes are used by healthcare IT systems and prescribers to identify this medicine.
NHS UK identifiers
SNOMED CT and dm+d codes from NHS TRUD (Technology Reference data Update Distribution), licensed under the Open Government Licence v3.0. BNF codes from NHS Business Services Authority (NHSBSA).
Active and completed clinical studies from ClinicalTrials.gov
Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine (NLM), National Institutes of Health (NIH). Data accessed via ClinicalTrials.gov API v2. Trial information is provided for research purposes and does not constitute medical advice.
Pharmacology and chemical data from DrugBank
Key facts
Drug status
Investigational
Major interactions
None known
Half-life
Not available
Mechanism
L-citrulline is converted to L-arginine by argininosuccinate synthase.
Food interactions
None known
Human targets
12 targets
Data: DrugBank · CC BY-NC 4.0
Pharmacokinetics at a glance
Known interactions with other medications. Always consult a healthcare professional.
Showing 50 of 137 interactions
Proteins and enzymes this drug interacts with in the body
PMID:1378832
NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets
PMID:21493890 PMID:37296100
In endothelial cells, induces expression of vascular endothelial growth factor (VEGF) via phosphorylation of the transcription factor SP1 by PKA in a process that is independent of NO and NO synthase (By similarity). Similarly, enhances pancreatic insulin secretion through SP1-mediated transcriptional up-regulation of secretagogin/SCGN, an insulin vesicle docking protein (By similarity).
Upon viral infection, relocates to mitochondria where it promotes mitochondrial fission through activation of DNM1L leading to the inhibition of innate response activation mediated by MAVS PMID:33850055
PMID:2556444 PMID:6372096 PMID:8112735
The urea cycle ensures the detoxification of ammonia by converting it to urea for excretion PMID:2556444
Proteins that transport this drug across cell membranes
PMID:11669456 PMID:11907186 PMID:14675047 PMID:22108572 PMID:23832370 PMID:28534121 PMID:9950961
Mediates the uptake of OA across the basolateral side of proximal tubule epithelial cells, thereby contributing to the renal elimination of endogenous OA from the systemic circulation into the urine .
PMID:9887087
Functions as a biopterin transporters involved in the uptake and the secretion of coenzymes tetrahydrobiopterin (BH4), dihydrobiopterin (BH2) and sepiapterin to urine, thereby determining baseline levels of blood biopterins .
PMID:28534121
Transports prostaglandin E2 (PGE2) and prostaglandin F2-alpha (PGF2-alpha) and may contribute to their renal excretion .
PMID:11907186
Also mediates the uptake of cyclic nucleotides such as cAMP and cGMP .
PMID:26377792
Involved in the transport of neuroactive tryptophan metabolites kynurenate (KYNA) and xanthurenate (XA) and may contribute to their secretion from the brain .
PMID:22108572 PMID:23832370
May transport glutamate .
PMID:26377792
Also involved in the disposition of uremic toxins and potentially toxic xenobiotics by the renal organic anion secretory pathway, helping reduce their undesired toxicological effects on the body .
PMID:11669456 PMID:14675047
Uremic toxins include the indoxyl sulfate (IS), hippurate/N-benzoylglycine (HA), indole acetate (IA), 3-carboxy-4- methyl-5-propyl-2-furanpropionate (CMPF) and urate .
PMID:14675047 PMID:26377792
Xenobiotics include the mycotoxin ochratoxin (OTA) .
PMID:11669456
May also contribute to the transport of organic compounds in testes across the blood-testis-barrier PMID:35307651
Involved compounds
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Chemical identifiers
CAS, UNII, InChI Key and database cross-references
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Chemical identifiers
CAS, UNII, InChI Key and database cross-references
Linked compound data from DrugBank Open Data (CC BY-NC 4.0)
Citrulline
Additional database identifiers
ChemSpider
9367
BindingDB
92903
PDB
CIR
Guide to Pharmacology
722
ZINC
ZINC000001532614
HUGO Gene Nomenclature Committee (HGNC)
HGNC:7876
GenAtlas
NOS3
GeneCards
NOS3
GenBank Gene Database
M93718
GenBank Protein Database
189212
Guide to Pharmacology
1249
UniProt Accession
NOS3_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:758
GenAtlas
ASS1
GeneCards
ASS1
GenBank Gene Database
X01630
GenBank Protein Database
28872
UniProt Accession
ASSY_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:2716
GenAtlas
DDAH2
GeneCards
DDAH2
GenBank Gene Database
AF070667
GenBank Protein Database
4454710
UniProt Accession
DDAH2_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:2715
GenAtlas
DDAH1
GeneCards
DDAH1
GenBank Gene Database
AB001915
GenBank Protein Database
4160666
Guide to Pharmacology
1247
UniProt Accession
DDAH1_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:8512
GenAtlas
OTC
GeneCards
OTC
GenBank Gene Database
K02100
GenBank Protein Database
189407
UniProt Accession
OTC_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:7872
GenAtlas
NOS1
GeneCards
NOS1
GenBank Gene Database
U17327
GenBank Protein Database
642526
Guide to Pharmacology
1251
UniProt Accession
NOS1_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:7873
GenAtlas
NOS2A
GeneCards
NOS2
GenBank Gene Database
L09210
GenBank Protein Database
292242
Guide to Pharmacology
1250
UniProt Accession
NOS2_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:18368
GenAtlas
PADI4
GeneCards
PADI4
GenBank Gene Database
AB017919
GenBank Protein Database
5913971
Guide to Pharmacology
2877
UniProt Accession
PADI4_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:20449
GenAtlas
PADI6
GeneCards
PADI6
GenBank Gene Database
AY422079
GenBank Protein Database
40068449
UniProt Accession
PADI6_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:18367
GenAtlas
PADI1
GeneCards
PADI1
GenBank Gene Database
AB033768
GenBank Protein Database
6116899
Guide to Pharmacology
2894
UniProt Accession
PADI1_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:18337
GenAtlas
PADI3
GeneCards
PADI3
GenBank Gene Database
AB026831
GenBank Protein Database
6172379
UniProt Accession
PADI3_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:18341
GenAtlas
PADI2
GeneCards
PADI2
GenBank Gene Database
AB030176
GenBank Protein Database
5572747
UniProt Accession
PADI2_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:10970
GenAtlas
hROAT1
GeneCards
SLC22A6
GenBank Gene Database
AF057039
GenBank Protein Database
3831566
Guide to Pharmacology
1025
UniProt Accession
S22A6_HUMAN
International reference pricing
Reference pricing from DrugBank. Prices are indicative and may not reflect current UK costs.
Source: DrugBank. Used under CC BY-NC 4.0 academic licence for non-commercial purposes.
DrugBank citations
If you use DrugBank data in your research, please cite the following publications: