Cinchocaine 1.1% ointment

An electrochemical sensor for cinchocaine (CIN) detection was developed based on surface molecular imprinting technology utilizing screen-printed gold electrodes modified with TiO2 nanoparticles and electropolymerized polypyrrole. A novel sensor was developed using a dual-stage methodology, which entailed initial CIN template immobilization and subsequent electrochemical pyrrole polymerization incorporating titanium dioxide nanoscale particles. The sensor exhibited enhanced electroactive surface area (0.075 cm2) and improved electron transfer kinetics (heterogeneous rate constant 8.2 × 10−3 cm·s−1) compared to unmodified electrodes. Under optimized conditions (pH 5.0, 15-min incubation), the sensor demonstrated two linear response ranges from 0.1–10 and 10–100 μM, with a detection limit of 0.035 μM. The sensor showed excellent selectivity against common interferents, including a 100-fold excess of inorganic ions and a 50-fold excess of structurally similar compounds. Analysis of clinical samples yielded excellent recoveries (97.2–102.3%) with relative standard deviations below 4.3%. The simple fabrication process, rapid response time, and minimal sample preparation requirements make this sensor particularly suitable for point-of-care applications.

Abstract licence: CC BY 4.0