Chorionic gonadotrophin 5,000unit powder and solvent for solution for injection pre-filled syringes
Requires a prescription from a doctor or prescriber
Human chorionic gonadotropin (HCG), a polypeptide hormone produced by the human placenta.
Minimal controls; includes benzodiazepines and anabolic steroids
Legal requirements and restrictions
Anabolic steroids and related substances. Possession for personal use is not an offence, but supply is controlled.
Legal requirements
- Prescriptions valid for 28 days
- No controlled drugs register required
- No safe custody requirements
- Import/export restrictions apply
Other medicines in this category
Official documents, adverse reaction reporting, and safety monitoring
Report a side effect
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Official medicine documents
Safety monitoring data
Yellow Card reports
The MHRA Yellow Card scheme collects reports of suspected side effects from healthcare professionals and patients. View the Drug Analysis Profile (iDAP) for real-world adverse reaction data.
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Suspected adverse reactions reported for Chorionic gonadotrophin
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Interactive Drug Analysis Profiles for all medicines
Report a side effect
Submit a Yellow Card report to the MHRA
Data from the MHRA Yellow Card scheme. A reported reaction does not necessarily mean the medicine caused it. Contains public sector information licensed under the Open Government Licence v3.0.
EudraVigilance
The European Medicines Agency (EMA) collects suspected adverse reaction reports from across the EU/EEA through the EudraVigilance system. Search for safety data on this medicine.
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Suspected adverse reactions reported for Chorionic gonadotrophin
About EudraVigilance
Learn about EU pharmacovigilance and safety monitoring
EudraVigilance data is published by the European Medicines Agency (EMA). A suspected adverse reaction is not necessarily caused by the medicine.
1 branded products available
MHRA licensed products
View all licensed products for Chorionic gonadotrophin on the MHRA register
Zivafert PFS 5,000unit powder and solvent for solution for injection pre-filled syringes
WHO defined daily dose (DDD)
250 unit
Not a recommended dose. The DDD is the assumed average maintenance dose per day for a drug used for its main indication in adults. It is a statistical measure used for research and comparison purposes only.
Source: WHO Collaborating Centre for Drug Statistics Methodology, distributed via the NHS dm+d supplementary BNF/ATC mapping files (NHSBSA). Contains public sector information licensed under the Open Government Licence v3.0.
Therapeutically similar medicines
Similarity is based on WHO Anatomical Therapeutic Chemical (ATC) classification and on a factual NHS dm+d therapeutic-grouping code prefix. Source data: NHS dm+d via TRUD (OGL v3.0), WHO ATC/DDD Index.
NHS prescribing volume and spending trends
Guidelines from the National Institute for Health and Care Excellence
NICE clinical guidance(7)
Ectopic pregnancy and miscarriage: diagnosis and initial management (NG126)
Ovarian cancer: recognition and initial management (CG122)
Metastatic malignant disease of unknown primary origin in adults: diagnosis and management (CG104)
Ectopic pregnancy and miscarriage (QS69)
Needle and syringe programmes (PH52)
Abortion care (NG140)
Tests in secondary care to identify people at high risk of ovarian cancer (HTG453)
Source: National Institute for Health and Care Excellence (NICE). Contains public sector information licensed under the Open Government Licence v3.0.
Check stock at pharmacies and supply information
Pharmacy stock checkers
Search for this medicine at major UK pharmacy chains. These links open the retailer's own website — results depend on their current online catalogue.
Supply & safety information
Official UK regulator monitoring and safety alerts
Pharmacy links redirect to the retailer's own search and do not represent real-time stock levels. Shortage and safety information sourced from MHRA drug safety updates (gov.uk, Crown Copyright under OGL v3.0).
Codes for healthcare professionals and prescribing systems
These codes are used by healthcare IT systems and prescribers to identify this medicine.
NHS UK identifiers
Browse tools
SNOMED CT and dm+d codes from NHS TRUD (Technology Reference data Update Distribution), licensed under the Open Government Licence v3.0. BNF code shown is the factual mapping value distributed by NHS Business Services Authority (NHSBSA) in the dm+d supplementary file under OGL v3.0; it is not affiliated with, nor licensed from, the publishers of the British National Formulary. ATC codes from the WHO Collaborating Centre for Drug Statistics Methodology (whocc.no).
Active and completed clinical studies from ClinicalTrials.gov
Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine (NLM), National Institutes of Health (NIH). Data accessed via ClinicalTrials.gov API v2. Trial information is provided for research purposes and does not constitute medical advice.
Academic studies and reviews for this medicine's active substance
Showing the 50 most relevant studies.
Reviews & meta-analyses: 13 · Randomised trials: 1 · 1966–2020
Showing the 50 most relevant studies, sorted by most relevant.
Christos Venetis, Efstratios M. Κolibianakis, Evangelos Papanikolaou, et al.
Human Reproduction Update, 2007
- Pregnancy Rate
- Fertilization
- Fertilization in Vitro
Mohamed Youssef, Ahmed M Abou-Setta, Wai Lam
Cochrane Database of Systematic Reviews, 2016
- Fertilization in Vitro
- Chorionic Gonadotropin
- Luteinizing Hormone
Glenn D. Braunstein, JUDITH L. VAITUKAITIS, PAUL P. CARBONE, et al.
Annals of Internal Medicine, 1973
- Biological Assay
- Chromatography
- Gastrointestinal Neoplasms
C. Ong, A. Liao, K. Spencer, et al.
BJOG: An International Journal of Obstetrics & Gynaecology, 2000
- Pregnancy Complications
- Pregnancy Outcome
- Pregnancy Trimester, First
Ri‐Cheng Chian, William Buckett, Togas Tulandi, et al.
Human Reproduction, 2000
- Cell Count
- Cells, Cultured
- Embryo, Mammalian
Martin M. Matzuk, Irving Boime
The Journal of Cell Biology, 1988
- Amino Acid Sequence
- Asparagine
- Cell Line
C. Chabrolle, L. Tosca, J. Dupont
Reproduction, 2007
Virginie Gridelet, Sophie Perrier d'HAUTERIVE, Barbara Polese, et al.
Frontiers in Immunology, 2020
- Abortion, Spontaneous
- Autoimmune Diseases
- Embryo Transfer
Thomas S, Sebastian T, Karthikeyan M, et al.
2019
- Birth Rate
- Chorionic Gonadotropin
- Luteinizing Hormone
M. Bonduelle, R. Dodd, I. Liebaers, et al.
Human reproduction, 1988
- Gene Expression Regulation
- Genetic Markers
- Blastocyst
Sources: aggregated from Europe PMC (EMBL-EBI), OpenAlex, Crossref, PubMed and other open scholarly databases. Retracted articles are excluded. Study information is provided for research purposes and does not constitute medical advice.
Pharmacology and chemical data from DrugBank
Key facts
Drug status
Approved
Major interactions
None known
Half-life
Not available
Mechanism
Not available
Food interactions
None known
Human targets
1 target
Data: DrugBank · CC BY-NC 4.0
Pharmacokinetics at a glance
HCG is composed of an alpha and a beta sub-unit. The alpha sub-unit is essentially identical to the alpha sub units of the human pituitary gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), as well as to the alpha sub-unit of human thyroid-stimulating hormone (TSH), while the beta sub units of these hormones differ in amino acid sequence. As a drug product, chorionic gonadotropin is a highly purified pyrogen-free preparation obtained from the urine of pregnant females.
Proteins and enzymes this drug interacts with in the body
PMID:11847099
The activity of this receptor is mediated by G proteins which activate adenylate cyclase PMID:11847099
ATC G03GA01
Chemical identifiers
CAS, UNII, InChI Key and database cross-references
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Chemical identifiers
CAS, UNII, InChI Key and database cross-references
Linked compound data from DrugBank Open Data (CC BY-NC 4.0)
Chorionic Gonadotropin (Human)
Matched from: Chorionic gonadotrophin
Additional database identifiers
Drugs Product Database (DPD)
7358
HUGO Gene Nomenclature Committee (HGNC)
HGNC:6585
GenAtlas
LHCGR
GeneCards
LHCGR
GenBank Gene Database
M73746
GenBank Protein Database
903746
Guide to Pharmacology
254
UniProt Accession
LSHR_HUMAN
DrugBank citations
If you use DrugBank data in your research, please cite the following publications:
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Structured knowledge from the free knowledge base
Linked open data from Wikidata (Q407172), a free and open knowledge base operated by the Wikimedia Foundation. Data is available under the Creative Commons CC0 1.0 Public Domain Dedication.