Carfilzomib 30mg powder for solution for infusion vials
Requires a prescription from a doctor or prescriber
Carfilzomib is an injectable antineoplastic agent (IV only).
Official documents, adverse reaction reporting, and safety monitoring
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Official medicine documents
Safety monitoring data
Yellow Card reports
The MHRA Yellow Card scheme collects reports of suspected side effects from healthcare professionals and patients. View the Drug Analysis Profile (iDAP) for real-world adverse reaction data.
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Suspected adverse reactions reported for Carfilzomib
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Report a side effect
Submit a Yellow Card report to the MHRA
Data from the MHRA Yellow Card scheme. A reported reaction does not necessarily mean the medicine caused it. Contains public sector information licensed under the Open Government Licence v3.0.
EudraVigilance
The European Medicines Agency (EMA) collects suspected adverse reaction reports from across the EU/EEA through the EudraVigilance system. Search for safety data on this medicine.
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Suspected adverse reactions reported for Carfilzomib
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EudraVigilance data is published by the European Medicines Agency (EMA). A suspected adverse reaction is not necessarily caused by the medicine.
1 branded products available
MHRA licensed products
View all licensed products for Carfilzomib on the MHRA register
Kyprolis 30mg powder for solution for infusion vials
Therapeutically similar medicines
Similarity based on WHO Anatomical Therapeutic Chemical (ATC) classification and NHS BNF section grouping. Source data: NHS dm+d via TRUD (OGL v3.0), WHO ATC/DDD Index.
Clinical guidelines and formulary information
British National Formulary
Carfilzomib
Source: British National Formulary, NICE. Joint Formulary Committee. Contains public sector information licensed under the Open Government Licence v3.0.
NICE clinical guidance(11)
Carfilzomib for previously treated multiple myeloma (TA657)
Carfilzomib with dexamethasone and lenalidomide for previously treated multiple myeloma (TA695)
Isatuximab with carfilzomib and dexamethasone for treating relapsed or refractory multiple myeloma (terminated appraisal) (TA727)
Carfilzomib with daratumumab and dexamethasone for treating relapsed or refractory multiple myeloma (terminated appraisal) (TA841)
Daratumumab with bortezomib and dexamethasone for previously treated multiple myeloma (TA897)
Selinexor with bortezomib and dexamethasone for previously treated multiple myeloma (TA974)
Daratumumab monotherapy for treating relapsed and refractory multiple myeloma (TA783)
Lenalidomide plus dexamethasone for previously untreated multiple myeloma (TA587)
Belantamab mafodotin with pomalidomide and dexamethasone for previously treated multiple myeloma (TA1133)
Isatuximab with pomalidomide and dexamethasone for treating relapsed and refractory multiple myeloma (TA658)
Daratumumab in combination for treating newly diagnosed systemic amyloid light-chain amyloidosis (TA959)
Source: National Institute for Health and Care Excellence (NICE). Contains public sector information licensed under the Open Government Licence v3.0.
Check stock at pharmacies and supply information
Pharmacy stock checkers
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Supply & product information
Official product databases and supply status monitoring
Pharmacy links redirect to the retailer's own search and do not represent real-time stock levels. emc (electronic medicines compendium) is operated by Datapharm Ltd. Shortage information sourced from NHS Specialist Pharmacy Service (SPS), sps.nhs.uk.
Codes for healthcare professionals and prescribing systems
These codes are used by healthcare IT systems and prescribers to identify this medicine.
NHS UK identifiers
Browse tools
SNOMED CT and dm+d codes from NHS TRUD (Technology Reference data Update Distribution), licensed under the Open Government Licence v3.0. BNF codes from NHS Business Services Authority (NHSBSA). ATC codes from the WHO Collaborating Centre for Drug Statistics Methodology (whocc.no).
Active and completed clinical studies from ClinicalTrials.gov
Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine (NLM), National Institutes of Health (NIH). Data accessed via ClinicalTrials.gov API v2. Trial information is provided for research purposes and does not constitute medical advice.
Pharmacology and chemical data from DrugBank
Key facts
Drug status
Approved
Major interactions
None known
Half-life
1 hour
Mechanism
Carfilzomib is made up of four modified peptides and acts as a proteasome inhibitor.
Food interactions
None known
Human targets
6 targets
Data: DrugBank · CC BY-NC 4.0
Pharmacokinetics at a glance
Absorption
27 mg/m
AUC, single IV dose of 27 mg/m^2 = 379 ng•hr/mL;
Carfilzomib does not accumulation in the systemic.…
Half-life
15 mg/m
Protein binding
97%
Volume of distribution
20 mg/m
Metabolism
Clearance
151 - 263 L/h
Pharmacokinetic data: DrugBank · CC BY-NC 4.0
[L39392][L42350]
Known interactions with other medications. Always consult a healthcare professional.
Showing 50 of 746 interactions
Maximum tolerate dose = 15 mg/m^2
How the body processes this drug — absorption, distribution, metabolism, and elimination
AUC, single IV dose of 27 mg/m^2 = 379 ng•hr/mL;
Carfilzomib does not accumulation in the systemic. At doses between 20 and 36 mg/m2, there was a dose-dependent increase in exposure.
All metabolites are inactive.
Proteins and enzymes this drug interacts with in the body
The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
Within the 20S core complex, PSMB5 displays a chymotrypsin-like activity
Replacement of PSMB5 by PSMB8 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues. Involved in the generation of spliced peptides resulting from the ligation of two separate proteasomal cleavage products that are not contiguous in the parental protein .
PMID:27049119
Acts as a major component of interferon gamma-induced sensitivity. Plays a key role in apoptosis via the degradation of the apoptotic inhibitor MCL1.
May be involved in the inflammatory response pathway. In cancer cells, substitution of isoform 1 (E2) by isoform 2 (E1) results in immunoproteasome deficiency. Required for the differentiation of preadipocytes into adipocytes
The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)
PMID:33727065 PMID:34819510
The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB6 by PSMB9 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues
The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)
Proteins that transport this drug across cell membranes
PMID:2897240 PMID:35970996 PMID:8898203 PMID:9038218 PMID:35507548
Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins .
PMID:8898203
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells PMID:2897240 PMID:35970996 PMID:9038218
ATC L01XG02
Chemical identifiers
CAS, UNII, InChI Key and database cross-references
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Chemical identifiers
CAS, UNII, InChI Key and database cross-references
Linked compound data from DrugBank Open Data (CC BY-NC 4.0)
Carfilzomib
Additional database identifiers
Drugs Product Database (DPD)
22678
ChemSpider
9731489
BindingDB
50277889
ZINC
ZINC000049841054
HUGO Gene Nomenclature Committee (HGNC)
HGNC:9542
GenAtlas
PSMB5
GeneCards
PSMB5
GenBank Gene Database
D29011
GenBank Protein Database
558526
Guide to Pharmacology
2406
UniProt Accession
PSB5_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:9545
GeneCards
PSMB8
Guide to Pharmacology
2408
UniProt Accession
PSB8_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:9537
GenAtlas
PSMB1
GeneCards
PSMB1
GenBank Gene Database
D00761
GenBank Protein Database
220026
Guide to Pharmacology
2404
UniProt Accession
PSB1_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:9546
GeneCards
PSMB9
Guide to Pharmacology
2409
UniProt Accession
PSB9_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:9539
GenAtlas
PSMB2
GeneCards
PSMB2
GenBank Gene Database
D26599
GenBank Protein Database
565649
Guide to Pharmacology
2405
UniProt Accession
PSB2_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:9538
GeneCards
PSMB10
UniProt Accession
PSB10_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:40
GenAtlas
ABCB1
GeneCards
ABCB1
GenBank Gene Database
M14758
GenBank Protein Database
307180
Guide to Pharmacology
768
UniProt Accession
MDR1_HUMAN
Patent information
6 active patents, 6 expired
Source: DrugBank · CC BY-NC 4.0. Patent data sourced from national patent offices. Expiry dates may not reflect extensions, regulatory exclusivity periods, or legal challenges.
DrugBank citations
If you use DrugBank data in your research, please cite the following publications: