Cangrelor 50mg powder for solution for injection vials
Requires a prescription from a doctor or prescriber
Cangrelor is an intravenous, direct-acting, reversible P2Y12 inhibitor for patients undergoing percutaneous coronary intervention (PCI) who have not been yet treated by oral P2Y12 inhibitors.
Official documents, adverse reaction reporting, and safety monitoring
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Official medicine documents
Safety monitoring data
Yellow Card reports
The MHRA Yellow Card scheme collects reports of suspected side effects from healthcare professionals and patients. View the Drug Analysis Profile (iDAP) for real-world adverse reaction data.
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Suspected adverse reactions reported for Cangrelor
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Submit a Yellow Card report to the MHRA
Data from the MHRA Yellow Card scheme. A reported reaction does not necessarily mean the medicine caused it. Contains public sector information licensed under the Open Government Licence v3.0.
EudraVigilance
The European Medicines Agency (EMA) collects suspected adverse reaction reports from across the EU/EEA through the EudraVigilance system. Search for safety data on this medicine.
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Suspected adverse reactions reported for Cangrelor
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EudraVigilance data is published by the European Medicines Agency (EMA). A suspected adverse reaction is not necessarily caused by the medicine.
2 branded products available
MHRA licensed products
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Kengrexal 50mg powder for concentrate for solution for injection / infusion vials
Kengrexal 50mg powder for concentrate for solution for injection / infusion vials
Therapeutically similar medicines
Similarity is based on WHO Anatomical Therapeutic Chemical (ATC) classification and on a factual NHS dm+d therapeutic-grouping code prefix. Source data: NHS dm+d via TRUD (OGL v3.0), WHO ATC/DDD Index.
Guidelines from the National Institute for Health and Care Excellence
NICE clinical guidance(2)
Coronary revascularisation: Cangrelor (ESNM63)
Cangrelor for reducing atherothrombotic events in people undergoing percutaneous coronary intervention or awaiting surgery requiring interruption of anti‑platelet therapy (terminated appraisal) (TA351)
Source: National Institute for Health and Care Excellence (NICE). Contains public sector information licensed under the Open Government Licence v3.0.
Check stock at pharmacies and supply information
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Supply & safety information
Official UK regulator monitoring and safety alerts
Pharmacy links redirect to the retailer's own search and do not represent real-time stock levels. Shortage and safety information sourced from MHRA drug safety updates (gov.uk, Crown Copyright under OGL v3.0).
Codes for healthcare professionals and prescribing systems
These codes are used by healthcare IT systems and prescribers to identify this medicine.
NHS UK identifiers
Browse tools
SNOMED CT and dm+d codes from NHS TRUD (Technology Reference data Update Distribution), licensed under the Open Government Licence v3.0. BNF code shown is the factual mapping value distributed by NHS Business Services Authority (NHSBSA) in the dm+d supplementary file under OGL v3.0; it is not affiliated with, nor licensed from, the publishers of the British National Formulary. ATC codes from the WHO Collaborating Centre for Drug Statistics Methodology (whocc.no).
Active and completed clinical studies from ClinicalTrials.gov
Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine (NLM), National Institutes of Health (NIH). Data accessed via ClinicalTrials.gov API v2. Trial information is provided for research purposes and does not constitute medical advice.
Academic studies and reviews for this medicine's active substance
Showing the 50 most relevant studies.
Reviews & meta-analyses: 29 · Randomised trials: 8 · 2007–2026
Showing the 50 most relevant studies, sorted by most relevant.
H. Desai, M. Al-Salihi, R. Morsi, et al.
Frontiers in Neurology, 2023
Nangorgo Jean Oumar Coulibaly, Mohammed H. Elgouhari, Muhammad Haseeb Arshad, et al.
Interventional Neuroradiology, 2024
J. D’Andria Ursoleo, L. Baldetti, M. Pieri, et al.
Medicina, 2024
- Shock, Cardiogenic
- Adenosine Monophosphate
- Platelet Aggregation Inhibitors
O. Gonçalves, Ana B. Santos, Anthony Hong, et al.
Neuroradiology, 2025
- Cerebrovascular Disorders
- Adenosine Monophosphate
- Endovascular Procedures
Hendrianus H, Jeong YH, Lee SY, et al.
2025
Anthony Del Vecchio, Lam-Phong Pham, John S. McNeil, et al.
Journal of cardiothoracic and vascular anesthesia, 2024
- Thrombocytopenia
- Heparin
- Adenosine Monophosphate
M. Mostafa, M. Eid, A. Awad, et al.
American Journal of Cardiovascular Drugs, 2023
Subhro Chakraborty, Debalina Sarkar, S. Samajdar, et al.
The Egyptian Heart Journal, 2024
Fernandes JVA, de Oliveira Ramos JV, de Almeida Holanda MM
2025
Ellebedy M, Mohamed RG, Lamie MI, et al.
2026
Sources: aggregated from Europe PMC (EMBL-EBI), OpenAlex, Crossref, PubMed and other open scholarly databases. Retracted articles are excluded. Study information is provided for research purposes and does not constitute medical advice.
Pharmacology and chemical data from DrugBank
Key facts
Drug status
Approved
Major interactions
153 found
Half-life
3-6 minutes
Mechanism
Cangrelor is a selective, reversible, P2Y12 platelet receptor antagonist which inhibits ADP platelet aggregation.
Food interactions
1 warning
Human targets
1 target
Data: DrugBank · CC BY-NC 4.0
Pharmacokinetics at a glance
Half-life
3-6 minutes
Protein binding
97-98%
Volume of distribution
3.9 L
Metabolism
Elimination
3H
Clearance
43.2 L/h
Pharmacokinetic data: DrugBank · CC BY-NC 4.0
Known interactions with other medications. Always consult a healthcare professional.
Showing 50 of 646 interactions
How the body processes this drug — absorption, distribution, metabolism, and elimination
Proteins and enzymes this drug interacts with in the body
ATC B01AC25
Chemical identifiers
CAS, UNII, InChI Key and database cross-references
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Chemical identifiers
CAS, UNII, InChI Key and database cross-references
Linked compound data from DrugBank Open Data (CC BY-NC 4.0)
Cangrelor
Additional database identifiers
Drugs Product Database (DPD)
23813
ChemSpider
8029718
BindingDB
50118225
ZINC
ZINC000085537017
HUGO Gene Nomenclature Committee (HGNC)
HGNC:18124
GenAtlas
P2RY12
GeneCards
P2RY12
GenBank Gene Database
AF313449
GenBank Protein Database
12083902
Guide to Pharmacology
328
UniProt Accession
P2Y12_HUMAN
DrugBank citations
If you use DrugBank data in your research, please cite the following publications:
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Structured knowledge from the free knowledge base
ATC classifications (Wikidata)
Linked open data from Wikidata (Q3655338), a free and open knowledge base operated by the Wikimedia Foundation. Data is available under the Creative Commons CC0 1.0 Public Domain Dedication. WHO INN from the World Health Organization.