Do I need a prescription for Biotin 25mg/5ml oral solution?

Biotin 25mg/5ml oral solution is classified as a Valid as a prescribable product in the UK. However, always consult a pharmacist or doctor before use. (Source: NHS dm+d)

What are the brand names for Biotin 25mg/5ml oral solution?

Biotin 25mg/5ml oral solution is the generic name. It is available under brand names including: Biotin 25mg/5ml oral solution. (Source: NHS dm+d — Actual Medicinal Products)

Biotin 25mg/5ml oral solution

Prescription only

Requires a prescription from a doctor or prescriber

Oral solution

25mg/5ml

Oral

A water-soluble, enzyme co-factor present in minute amounts in every living cell.

Active ingredients:

Biotin

BNF classificationBrowse formulary

Where this medicine sits in the British National Formulary — the UK's standard prescribing reference

BNF 09.06.02.08

ATC classificationBrowse ATC index

International classification by the WHO, grouping medicines by the organ system they act on

ATC A11HA05

Chemical classBrowse classes

Classification based on the molecule's chemical structure and properties

Check interactions for Biotin

No active safety alerts

Official documents, adverse reaction reporting, and safety monitoring

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Official medicine documents

Yellow Card

Report side effects (MHRA)

Drug safety updates

MHRA alerts for Biotin

Source: MHRA Products DatabaseOGL 3.0

Updated 3 months ago(16 Jan 2026)

Safety monitoring data

Yellow Card reports

MHRA

The MHRA Yellow Card scheme collects reports of suspected side effects from healthcare professionals and patients. View the Drug Analysis Profile (iDAP) for real-world adverse reaction data.

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Suspected adverse reactions reported for Biotin

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Submit a Yellow Card report to the MHRA

Data from the MHRA Yellow Card scheme. A reported reaction does not necessarily mean the medicine caused it. Contains public sector information licensed under the Open Government Licence v3.0.

EudraVigilance

EMA

The European Medicines Agency (EMA) collects suspected adverse reaction reports from across the EU/EEA through the EudraVigilance system. Search for safety data on this medicine.

View EudraVigilance report

Suspected adverse reactions reported for Biotin

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Learn about EU pharmacovigilance and safety monitoring

EudraVigilance data is published by the European Medicines Agency (EMA). A suspected adverse reaction is not necessarily caused by the medicine.

1 branded products available

1 productsShow details

1 products

Possibly available on the UK marketRestricted supplyDiscontinuedAvailability per NHS dm+d

MHRA licensed products

View all licensed products for Biotin on the MHRA register

Biotin 25mg/5ml oral solution

Special Order

None

Special

Source: NHS dm+dOGL 3.0

Updated about 1 month ago(1 Mar 2026)

Therapeutically similar medicines

10 similarShow details

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50mg

Same therapeutic group

Pyridoxal phosphate 25mg capsules

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25mg

Same therapeutic group

Pyridoxal phosphate 25mg tablets

Tablet

25mg

Same therapeutic group

Nicotinamide 750mg capsules

Capsule

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Same therapeutic group

Nicotinamide 50mg capsules

Capsule

50mg

Same therapeutic group

Similarity based on WHO Anatomical Therapeutic Chemical (ATC) classification and NHS BNF section grouping. Source data: NHS dm+d via TRUD (OGL v3.0), WHO ATC/DDD Index.

NHS prescribing volume and spending trends

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Clinical guidelines and formulary information

British National Formulary

Biotin

BNF

Drug monograph — bnf.nice.org.uk

Source: British National Formulary, NICE. Joint Formulary Committee. Contains public sector information licensed under the Open Government Licence v3.0.

NICE clinical guidance(2)

Thyroid disease: assessment and management (NG145)

NG145

NICE guideline

Updated Oct 2023

RIDASCREEN tests for monitoring infliximab in inflammatory bowel disease (MIB109)

MIB109

Guidance

Updated Jun 2017

Source: National Institute for Health and Care Excellence (NICE). Contains public sector information licensed under the Open Government Licence v3.0.

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Search for this medicine at major UK pharmacy chains. These links open the retailer's own website — results depend on their current online catalogue.

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Discontinuations & alternatives for Biotin

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Codes for healthcare professionals and prescribing systems

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These codes are used by healthcare IT systems and prescribers to identify this medicine.

NHS UK identifiers

SNOMED CT

8305911000001104

dm+d ID

8305911000001104

VTM (Virtual Therapeutic Moiety)

774863007

VMP (Virtual Medicinal Product)

8305911000001104

BNF code

09060208

International identifiers

ATC code — Anatomical Therapeutic Chemical (WHO)

A11HA05

Browse tools

dm+d Browser

NHSBSA medicines dictionary lookup

SNOMED CT and dm+d codes from NHS TRUD (Technology Reference data Update Distribution), licensed under the Open Government Licence v3.0. BNF codes from NHS Business Services Authority (NHSBSA). ATC codes from the WHO Collaborating Centre for Drug Statistics Methodology (whocc.no).

Active and completed clinical studies from ClinicalTrials.gov

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Searching UK clinical trials...

Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine (NLM), National Institutes of Health (NIH). Data accessed via ClinicalTrials.gov API v2. Trial information is provided for research purposes and does not constitute medical advice.

Pharmacology and chemical data from DrugBank

go.drugbank.com

Key facts

Drug status

Approved

Major interactions

None known

Half-life

Not available

Mechanism

Biotin is necessary for the proper functioning of enzymes that transport carboxy…

Food interactions

1 warning

Human targets

8 targets

Data: DrugBank · CC BY-NC 4.0

Pharmacokinetics at a glance

Absorption

50%

Systemic - approximately 50%

Pharmacokinetic data: DrugBank · CC BY-NC 4.0

Status:

Approved

Investigational

Nutraceutical

Small molecule

About this compound

A water-soluble, enzyme co-factor present in minute amounts in every living cell. It occurs mainly bound to proteins or polypeptides and is abundant in liver, kidney, pancreas, yeast, and milk.

Properties:

solid

Avg. mass: 244.31 Da

DrugBank indication

For nutritional supplementation, also for treating dietary shortage or imbalance.

Also known as(62)

(+)-cis-Hexahydro-2-oxo-1H-thieno[3,4]imidazole-4-valeric acid

(3aS,4S,6aR)-Hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-valeric acid

5-(2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid

Biotin

Biotina

Biotine

Biotinum

cis-(+)-Tetrahydro-2-oxothieno[3,4]imidazoline-4-valeric acid

Dosage forms(86)

Tablet (Oral) — 300 mcg

Tablet, chewable (Oral) — 2500 ug/1

Soap (Topical)

Solution (Intravenous) — 1.914 mg

Solution (Oral)

Tablet, delayed release (Oral)

Tablet (Oral)

Granule, effervescent — 20 MG

Molecular properties(19)

Food & lifestyle interactions

Advice

Avoid dietary avidin (a glycoprotein in uncooked egg-whites). Avidin binds with biotin in the gastrointestinal tract preventing biotin absorption. Avidin is denatured by cooking; therefore, cooked egg whites do not reduce biotin absorption.

Toxicity & overdose

Prolonged skin contact may cause irritation.

How it works

Mechanism of action

Biotin is necessary for the proper functioning of enzymes that transport carboxyl units and fix carbon dioxide, and is required for various metabolic functions, including gluconeogenesis, lipogenesis, fatty acid biosynthesis, propionate metabolism, and catabolism of branched-chain amino acids.

Pharmacodynamics

Biotin is a water-soluble B-complex vitamin which is composed of an ureido ring fused with a tetrahydrothiophene ring, which attaches a valeric acid substituent at one of its carbon atoms. Biotin is used in cell growth, the production of fatty acids, metabolism of fats, and amino acids. It plays a role in the Kreb cycle, which is the process in which energy is released from food. Biotin not only assists in various metabolic chemical conversions, but also helps with the transfer of carbon dioxide. Biotin is also helpful in maintaining a steady blood sugar level. Biotin is often recommended for strengthening hair and nails. Consequenty, it is found in many cosmetic and health products for the hair and skin. Biotin deficiency is a rare nutritional disorder caused by a deficiency of biotin. Initial symptoms of biotin deficiency include: Dry skin, Seborrheic dermatitis, Fungal infections, rashes including erythematous periorofacial macular rash, fine and brittle hair, and hair loss or total alopecia. If left untreated, neurological symptoms can develop, including mild depression, which may progress to profound lassitude and, eventually, to somnolence; changes in mental status, generalized muscular pains (myalgias), hyperesthesias and paresthesias. The treatment for biotin deficiency is to simply start taking some biotin supplements. A lack of biotin in infants will lead to a condition called seborrheic dermatitis or "cradle cap". Biotin deficiencies are extremely rare in adults but if it does occur, it will lead to anemia, depression, hair loss, high blood sugar levels, muscle pain, nausea, loss of appetite and inflamed mucous membranes.

Pharmacokinetics

How the body processes this drug — absorption, distribution, metabolism, and elimination

Absorption

Systemic - approximately 50%

Drug targets(8)

Proteins and enzymes this drug interacts with in the body

Propionyl-CoA carboxylase beta chain, mitochondrial

BE0000544

PCCB

cofactor

Specific functionATP binding

Cellular location

Mitochondrion matrix

General function & pharmacology

This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and valine and other metabolites .
PMID:15890657 PMID:6765947
Propionyl-CoA carboxylase catalyzes the carboxylation of propionyl-CoA/propanoyl-CoA to D-methylmalonyl-CoA/(S)-methylmalonyl-CoA .
PMID:15890657 PMID:6765947
Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain, while the beta subunit then transfers the carboxyl group from carboxylated biotin to propionyl-CoA (By similarity). Propionyl-CoA carboxylase also significantly acts on butyryl-CoA/butanoyl-CoA, which is converted to ethylmalonyl-CoA/(2S)-ethylmalonyl-CoA at a much lower rate .
PMID:6765947
Other alternative minor substrates include (2E)-butenoyl-CoA/crotonoyl-CoA (By similarity)

Biotin--protein ligase

BE0000159

HLCS

substrate

Specific functionATP binding

Cellular location

Cytoplasm

General function & pharmacology

Biotin--protein ligase catalyzing the biotinylation of the 4 biotin-dependent carboxylases acetyl-CoA-carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, and methylcrotonyl-CoA carboxylase

Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial

BE0000072

MCCC2

cofactor

Specific functionATP binding

Cellular location

Mitochondrion matrix

General function & pharmacology

Carboxyltransferase subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism

Acetyl-CoA carboxylase 2

BE0000702

ACACB

cofactor

Specific functionacetyl-CoA carboxylase activity

Cellular location

Mitochondrion

General function & pharmacology

Mitochondrial enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA and plays a central role in fatty acid metabolism .
PMID:16854592 PMID:19236960 PMID:19900410 PMID:20457939 PMID:20952656 PMID:26976583

Catalyzes a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA .
PMID:19236960 PMID:20457939 PMID:20952656 PMID:26976583

Through the production of malonyl-CoA that allosterically inhibits carnitine palmitoyltransferase 1 at the mitochondria, negatively regulates fatty acid oxidation (By similarity). Together with its cytosolic isozyme ACACA, which is involved in de novo fatty acid biosynthesis, promotes lipid storage (By similarity)

Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

BE0000445

MCCC1

cofactor

Specific functionATP binding

Cellular location

Mitochondrion matrix

General function & pharmacology

Biotin-attachment subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism

Metabolizing enzymes(1)

Enzymes involved in drug metabolism — important for understanding drug interactions

Enzyme activity key

substrate

inhibitor

inducer

CYP1B1Cytochrome P450 1B1

inducer

Transporters(2)

Proteins that transport this drug across cell membranes

Sodium-dependent multivitamin transporter

BE0000094

SLC5A6

substrate

Specific functionbiotin transmembrane transporter activity

Cellular location

Cell membrane

General function & pharmacology

Sodium-dependent multivitamin transporter that mediates the electrogenic transport of pantothenate, biotin, lipoate and iodide .
PMID:10329687 PMID:15561972 PMID:19211916 PMID:20980265 PMID:21570947 PMID:22015582 PMID:25809983 PMID:25971966 PMID:27904971 PMID:28052864 PMID:31754459

Functions as a Na(+)-coupled substrate symporter where the stoichiometry of Na(+):substrate is 2:1, creating an electrochemical Na(+) gradient used as driving force for substrate uptake .
PMID:10329687 PMID:20980265
Required for biotin and pantothenate uptake in the intestine across the brush border membrane .
PMID:19211916
Plays a role in the maintenance of intestinal mucosa integrity, by providing the gut mucosa with biotin (By similarity). Contributes to the luminal uptake of biotin and pantothenate into the brain across the blood-brain barrier PMID:25809983

Sodium-coupled monocarboxylate transporter 1

BE0004708

SLC5A8

substrate

Specific functioniodide channel activity

Cellular location

Apical cell membrane

General function & pharmacology

Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1 .
PMID:14966140 PMID:15090606 PMID:16729224 PMID:16805814 PMID:17178845 PMID:17245649 PMID:17526579 PMID:20211600 PMID:30604288

Catalyzes passive carrier mediated diffusion of iodide .
PMID:12107270
Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane .
PMID:12107270
May be responsible for the absorption of D-lactate and monocarboxylate drugs from the intestinal tract .
PMID:17245649
Acts as a tumor suppressor, suppressing colony formation in colon cancer, prostate cancer and glioma cell lines .
PMID:12829793 PMID:15867356 PMID:18037591

May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na(+) gradient and hence contribute to the maintenance of the energy status and function of neurons .
PMID:16805814
Mediates sodium-coupled electrogenic transport of pyroglutamate (5-oxo-L-proline) .
PMID:20211600
Can mediate the transport of chloride, bromide, iodide and nitrate ions when the external concentration of sodium ions is reduced PMID:19864324

Biological pathways(66)

Propanoate Metabolism

metabolic

Involved compounds

Oxogluric acid,2-Oxobutanoic Acid,Hydracrylic acid,Adenosine phosphate,ATP,beta-Alanine,Biotin,Pyrophosphoric acid,Flavin adenine dinucleotide,Glutamic acid,Valine,Malonyl-CoA,Methylmalonic Acid,NADH,Propanoic acid,Pyridoxal phosphate

Valine, Leucine, and Isoleucine Degradation

metabolic

Involved compounds

Oxogluric acid,alpha-Ketoisocaproic acid,Acetoacetic acid,ATP,alpha-Ketoisovalerate,Biotin,Flavin adenine dinucleotide,Glutamic acid,Isoleucine,Leucine,Valine,Methylmalonic Acid,NADH,Pyridoxal,Pyridoxal phosphate,Succinic acid

Alanine Metabolism

metabolic

Involved compounds

Oxogluric acid,Adenosine phosphate,ATP,Biotin,Pyrophosphoric acid,Glycine,Glyoxylic acid,Alanine,Glutamic acid,Pyridoxal phosphate,Pyruvic acid,Zinc

Citric Acid Cycle

metabolic

Involved compounds

Oxogluric acid,ATP,Biotin,Citric acid,Flavin adenine dinucleotide,Magnesium cation,Maleic acid,NADH,Pyruvic acid,Succinic acid

Biotin Metabolism

metabolic

Involved compounds

ATP,Biotin,Pyrophosphoric acid,Lysine

Gluconeogenesis

metabolic

Involved compounds

Oxogluric acid,Dihydroxyacetone phosphate,2-phospho-D-glyceric acid,ATP,Biotin,D-glyceraldehyde 3-phosphate,Magnesium cation,NADH,Phosphoenolpyruvate,Pyruvic acid

2-Methyl-3-hydroxybutryl-CoA Dehydrogenase Deficiency

disease

Involved compounds

3-Hydroxy-3-methylglutaryl-CoA Lyase Deficiency

disease

Involved compounds

3-Methylglutaconic Aciduria Type I

disease

Involved compounds

3-Methylglutaconic Aciduria Type III

disease

Involved compounds

3-Methylglutaconic Aciduria Type IV

disease

Involved compounds

beta-Ketothiolase Deficiency

disease

Involved compounds

Biotinidase Deficiency

disease

Involved compounds

ATP,Biotin,Pyrophosphoric acid,Lysine

Malonic Aciduria

disease

Involved compounds

Maple Syrup Urine Disease

disease

Involved compounds

Methylmalonic Aciduria

disease

Involved compounds

Methylmalonic Aciduria Due to Cobalamin-Related Disorders

disease

Involved compounds

Propionic Acidemia

disease

Involved compounds

3-Methylcrotonyl-CoA Carboxylase Deficiency Type I

disease

Involved compounds

Isovaleric Aciduria

disease

Involved compounds

Lactic Acidemia

disease

Involved compounds

Oxogluric acid,Adenosine phosphate,ATP,Biotin,Pyrophosphoric acid,Glycine,Glyoxylic acid,Alanine,Glutamic acid,Pyridoxal phosphate,Pyruvic acid,Zinc

Pyruvate Carboxylase Deficiency

disease

Involved compounds

Oxogluric acid,Adenosine phosphate,ATP,Biotin,Pyrophosphoric acid,Glycine,Glyoxylic acid,Alanine,Glutamic acid,Pyridoxal phosphate,Pyruvic acid,Zinc

Primary Hyperoxaluria Type I

disease

Involved compounds

Oxogluric acid,Adenosine phosphate,ATP,Biotin,Pyrophosphoric acid,Glycine,Glyoxylic acid,Alanine,Glutamic acid,Pyridoxal phosphate,Pyruvic acid,Zinc

Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease

disease

Involved compounds

Oxogluric acid,Dihydroxyacetone phosphate,2-phospho-D-glyceric acid,ATP,Biotin,D-glyceraldehyde 3-phosphate,Magnesium cation,NADH,Phosphoenolpyruvate,Pyruvic acid

Methylmalonate Semialdehyde Dehydrogenase Deficiency

disease

Involved compounds

Threonine and 2-Oxobutanoate Degradation

metabolic

Involved compounds

2-Oxobutanoic Acid,ATP,Biotin,Flavin adenine dinucleotide,Threonine,NADH,Pyridoxal phosphate

Fatty Acid Biosynthesis

metabolic

Involved compounds

(3R)-3-HYDROXYDODECANOIC ACID,(R)-3-hydroxytetradecanoic acid,Acetic acid,Acetoacetic acid,Biotin,Butyric Acid,Butenoic Acid,Caprylic acid,Capric acid,Lauric acid,Malonic acid,Malonyl-CoA,Myristic acid,Palmitic Acid

Transfer of Acetyl Groups into Mitochondria

metabolic

Involved compounds

ATP,Biotin,Citric acid,NADH,Pyruvic acid

Malonyl-CoA Decarboxylase Deficiency

disease

Involved compounds

3-Hydroxyisobutyric Acid Dehydrogenase Deficiency

disease

Involved compounds

3-Hydroxyisobutyric Aciduria

disease

Involved compounds

Isobutyryl-CoA Dehydrogenase Deficiency

disease

Involved compounds

Isovaleric Acidemia

disease

Involved compounds

Congenital Lactic Acidosis

disease

Involved compounds

Oxogluric acid,ATP,Biotin,Citric acid,Flavin adenine dinucleotide,Magnesium cation,Maleic acid,NADH,Pyruvic acid,Succinic acid

Fumarase Deficiency

disease

Involved compounds

Oxogluric acid,ATP,Biotin,Citric acid,Flavin adenine dinucleotide,Magnesium cation,Maleic acid,NADH,Pyruvic acid,Succinic acid

Mitochondrial Complex II Deficiency

disease

Involved compounds

Oxogluric acid,ATP,Biotin,Citric acid,Flavin adenine dinucleotide,Magnesium cation,Maleic acid,NADH,Pyruvic acid,Succinic acid

2-Ketoglutarate Dehydrogenase Complex Deficiency

disease

Involved compounds

Oxogluric acid,ATP,Biotin,Citric acid,Flavin adenine dinucleotide,Magnesium cation,Maleic acid,NADH,Pyruvic acid,Succinic acid

Pyruvate Dehydrogenase Deficiency (E3)

disease

Involved compounds

Oxogluric acid,ATP,Biotin,Citric acid,Flavin adenine dinucleotide,Magnesium cation,Maleic acid,NADH,Pyruvic acid,Succinic acid

Pyruvate Dehydrogenase Deficiency (E2)

disease

Involved compounds

Oxogluric acid,ATP,Biotin,Citric acid,Flavin adenine dinucleotide,Magnesium cation,Maleic acid,NADH,Pyruvic acid,Succinic acid

Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1)

disease

Involved compounds

Oxogluric acid,Dihydroxyacetone phosphate,2-phospho-D-glyceric acid,ATP,Biotin,D-glyceraldehyde 3-phosphate,Magnesium cation,NADH,Phosphoenolpyruvate,Pyruvic acid

Fructose-1,6-diphosphatase Deficiency

disease

Involved compounds

Oxogluric acid,Dihydroxyacetone phosphate,2-phospho-D-glyceric acid,ATP,Biotin,D-glyceraldehyde 3-phosphate,Magnesium cation,NADH,Phosphoenolpyruvate,Pyruvic acid

Triosephosphate Isomerase

disease

Involved compounds

Oxogluric acid,Dihydroxyacetone phosphate,2-phospho-D-glyceric acid,ATP,Biotin,D-glyceraldehyde 3-phosphate,Magnesium cation,NADH,Phosphoenolpyruvate,Pyruvic acid

Multiple Carboxylase Deficiency, Neonatal or Early Onset Form

disease

Involved compounds

ATP,Biotin,Pyrophosphoric acid,Lysine

Glycogenosis, Type IB

disease

Involved compounds

Oxogluric acid,Dihydroxyacetone phosphate,2-phospho-D-glyceric acid,ATP,Biotin,D-glyceraldehyde 3-phosphate,Magnesium cation,NADH,Phosphoenolpyruvate,Pyruvic acid

Glycogenosis, Type IC

disease

Involved compounds

Oxogluric acid,Dihydroxyacetone phosphate,2-phospho-D-glyceric acid,ATP,Biotin,D-glyceraldehyde 3-phosphate,Magnesium cation,NADH,Phosphoenolpyruvate,Pyruvic acid

Glycogenosis, Type IA. Von Gierke Disease

disease

Involved compounds

Oxogluric acid,Dihydroxyacetone phosphate,2-phospho-D-glyceric acid,ATP,Biotin,D-glyceraldehyde 3-phosphate,Magnesium cation,NADH,Phosphoenolpyruvate,Pyruvic acid

Warburg Effect

metabolic

Involved compounds

Oxogluric acid,Dihydroxyacetone phosphate,2-phospho-D-glyceric acid,ATP,Biotin,Citric acid,Flavin adenine dinucleotide,D-glyceraldehyde 3-phosphate,Glutamic acid,L-Glutamine,Magnesium cation,Maleic acid,NADH,Phosphoenolpyruvate,Potassium cation,Pyruvic acid,Ribulose-5-Phosphate,Succinic acid

The Oncogenic Action of 2-Hydroxyglutarate

disease

Involved compounds

Oxogluric acid,ATP,Biotin,Citric acid,Flavin adenine dinucleotide,Glutamic acid,L-Glutamine,Magnesium cation,Maleic acid,NADH,Pyruvic acid,Succinic acid

The Oncogenic Action of Succinate

disease

Involved compounds

Oxogluric acid,ATP,Biotin,Citric acid,Flavin adenine dinucleotide,Iron,Proline,Magnesium cation,Maleic acid,NADH,Pyruvic acid,Succinic acid,Ascorbic acid

The Oncogenic Action of Fumarate

disease

Involved compounds

Oxogluric acid,ATP,Biotin,Citric acid,Flavin adenine dinucleotide,Iron,Proline,Magnesium cation,Maleic acid,NADH,Pyruvic acid,Succinic acid,Ascorbic acid

Glutaminolysis and Cancer

disease

Involved compounds

Oxogluric acid,ATP,Biotin,Citric acid,Flavin adenine dinucleotide,Alanine,Aspartic acid,Glutamic acid,L-Glutamine,Leucine,Magnesium cation,Maleic acid,NADH,Pyridoxal phosphate,Pyruvic acid,Succinic acid

The Oncogenic Action of L-2-Hydroxyglutarate in Hydroxygluaricaciduria

disease

Involved compounds

Oxogluric acid,ATP,Biotin,Citric acid,Flavin adenine dinucleotide,Glutamic acid,L-Glutamine,Magnesium cation,Maleic acid,NADH,Pyruvic acid,Succinic acid

The Oncogenic Action of D-2-Hydroxyglutarate in Hydroxygluaricaciduria

disease

Involved compounds

Oxogluric acid,ATP,Biotin,Citric acid,Flavin adenine dinucleotide,Glutamic acid,L-Glutamine,Magnesium cation,Maleic acid,NADH,Pyruvic acid,Succinic acid

Scientific references(1)

Holmberg A., Blomstergren A., Nord O., Lukacs M., Lundeberg J., Uhlen M.

The biotin‐streptavidin interaction can be reversibly broken using water at elevated temperatures.

ELECTROPHORESIS

200526(3):501-510. doi: 10.1002/elps.200410070

PMID: 15690449 DOI: 10.1002/elps.200410070

ATC classification(1 code)

ATC A11HA05

Affected organisms(1)

Humans and other mammals

International brands(5)

Experimental properties(3)

External resources(2)

PDRhealth Drugs.com

Protein Data Bank entries(132)

Commercial products(662)

Chemical identifiers

CAS, UNII, InChI Key and database cross-references

Show

Linked compound data from DrugBank Open Data (CC BY-NC 4.0)

Biotin

DB00121

CAS number

58-85-5

UNII (FDA)

6SO6U10H04

InChI Key (molecular fingerprint)

YBJHBAHKTGYVGT-ZKWXMUAHSA-N

Additional database identifiers

Drugs Product Database (DPD)

4962

ChEBI

15956

PubChem Compound

171548

PubChem Substance

46508694

KEGG Compound

C00120

KEGG Drug

D00029

ChemSpider

149962

BindingDB

PharmGKB

PA448625

PDB

BTN

Wikipedia

Biotin

ChEMBL

CHEMBL857

ZINC

ZINC000035024346

RxCUI

1588

HUGO Gene Nomenclature Committee (HGNC)

HGNC:8654

GenAtlas

PCCB

GeneCards

PCCB

GenBank Gene Database

X73424

GenBank Protein Database

312812

UniProtKB

P05166

UniProt Accession

PCCB_HUMAN

HUGO Gene Nomenclature Committee (HGNC)

HGNC:4976

GenAtlas

HLCS

GeneCards

HLCS

GenBank Gene Database

D23672

GenBank Protein Database

577625

UniProtKB

P50747

UniProt Accession

BPL1_HUMAN

HUGO Gene Nomenclature Committee (HGNC)

HGNC:6937

GenAtlas

MCCC2

GeneCards

MCCC2

GenBank Gene Database

AB050049

GenBank Protein Database

10934059

UniProtKB

Q9HCC0

UniProt Accession

MCCB_HUMAN

HUGO Gene Nomenclature Committee (HGNC)

HGNC:85

GenAtlas

ACACB

GeneCards

ACACB

GenBank Gene Database

U89344

GenBank Protein Database

2138330

Guide to Pharmacology

1264

UniProtKB

O00763

UniProt Accession

ACACB_HUMAN

HUGO Gene Nomenclature Committee (HGNC)

HGNC:6936

GenAtlas

MCCC1

GeneCards

MCCC1

GenBank Gene Database

AF310972

GenBank Protein Database

12382296

UniProtKB

Q96RQ3

UniProt Accession

MCCA_HUMAN

HUGO Gene Nomenclature Committee (HGNC)

HGNC:8636

GenAtlas

GeneCards

GenBank Gene Database

U04641

GenBank Protein Database

458236

UniProtKB

P11498

UniProt Accession

PYC_HUMAN

HUGO Gene Nomenclature Committee (HGNC)

HGNC:8653

GenAtlas

PCCA

GeneCards

PCCA

GenBank Gene Database

X14608

GenBank Protein Database

296366

UniProtKB

P05165

UniProt Accession

PCCA_HUMAN

HUGO Gene Nomenclature Committee (HGNC)

HGNC:84

GenAtlas

ACACA

GeneCards

ACACA

GenBank Gene Database

U19822

GenBank Protein Database

849083

Guide to Pharmacology

1263

UniProtKB

Q13085

UniProt Accession

ACACA_HUMAN

HUGO Gene Nomenclature Committee (HGNC)

HGNC:2597

GenAtlas

CYP1B1

GeneCards

CYP1B1

GenBank Gene Database

U03688

GenBank Protein Database

501031

Guide to Pharmacology

1320

UniProtKB

Q16678

UniProt Accession

CP1B1_HUMAN

HUGO Gene Nomenclature Committee (HGNC)

HGNC:11041

GenAtlas

SLC5A6

GeneCards

SLC5A6

GenBank Gene Database

AF116241

GenBank Protein Database

5006439

UniProtKB

Q9Y289

UniProt Accession

SC5A6_HUMAN

HUGO Gene Nomenclature Committee (HGNC)

HGNC:19119

GeneCards

SLC5A8

Guide to Pharmacology

922

UniProtKB

Q8N695

UniProt Accession

SC5A8_HUMAN

International reference pricing

8 formulations

Reference pricing from DrugBank. Prices are indicative and may not reflect current UK costs.

From $0.03/tablet

To $14.69/g

Biotin 300 mcg tablet

$0.03/tablet

Biotin 800 mcg tablet

$0.06/tablet

Stress 600 tablet

$0.08/tablet

Stress b tablet

$0.10/tablet

Appearex 2.5 mg tablet

$0.26/tablet

Source: DrugBank. Used under CC BY-NC 4.0 academic licence for non-commercial purposes.

DrugBank citations

If you use DrugBank data in your research, please cite the following publications:

Knox C., Wilson M., Klinger C.M., et al

DrugBank 6.

0: the DrugBank Knowledgebase for 2024

Nucleic Acids Res. 2024 Jan 552(D1):D1265-D1275

PMID: 37953279

Wishart D.S., Feunang Y.D., Guo A.C., et al

DrugBank 5.

0: a major update to the DrugBank database for 2018

Nucleic Acids Res. 2017 Nov 846(D1):D1074-D1082

PMID: 29126136

Show earlier publications

Law V., Knox C., Djoumbou Y., et al

DrugBank 4.

0: shedding new light on drug metabolism

Nucleic Acids Res. 2014 Jan 142(1):D1091-7

PMID: 24203711

Knox C., Law V., Jewison T., et al

DrugBank 3.

0: a comprehensive resource for 'omics' research on drugs

Nucleic Acids Res. 2011 Jan39(Database issue):D1035-41

PMID: 21059682

Wishart D.S., Knox C., Guo A.C., et al

DrugBank: a knowledgebase for drugs, drug actions and drug targets.

Nucleic Acids Research

2008 Jan36(Database issue):D901-6

PMID: 18048412

Wishart D.S., Knox C., Guo A.C., et al

DrugBank: a comprehensive resource for in silico drug discovery and exploration.

Nucleic Acids Research

2006 Jan 134(Database issue):D668-72

PMID: 16381955

Source: go.drugbank.comCC BY-NC 4.0

Updated 27 days ago(8 Mar 2026)

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