Benzocaine 2% / Chloroxylenol 0.106% oromucosal gel sugar free
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Data from the MHRA Yellow Card scheme. A reported reaction does not necessarily mean the medicine caused it. Contains public sector information licensed under the Open Government Licence v3.0.
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Therapeutically similar medicines
Similarity is based on WHO Anatomical Therapeutic Chemical (ATC) classification and on a factual NHS dm+d therapeutic-grouping code prefix. Source data: NHS dm+d via TRUD (OGL v3.0), WHO ATC/DDD Index.
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Codes for healthcare professionals and prescribing systems
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SNOMED CT and dm+d codes from NHS TRUD (Technology Reference data Update Distribution), licensed under the Open Government Licence v3.0. BNF code shown is the factual mapping value distributed by NHS Business Services Authority (NHSBSA) in the dm+d supplementary file under OGL v3.0; it is not affiliated with, nor licensed from, the publishers of the British National Formulary.
Active and completed clinical studies from ClinicalTrials.gov
Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine (NLM), National Institutes of Health (NIH). Data accessed via ClinicalTrials.gov API v2. Trial information is provided for research purposes and does not constitute medical advice.
Academic studies and reviews for this medicine's active substance
Showing the 50 most relevant studies.
Reviews & meta-analyses: 4 · Randomised trials: 9 · 2015–2025
Showing the 50 most relevant studies, sorted by most relevant.
V. Naik, Deepak Sharma, Ashish K. Jain, et al.
Cureus, 2024
Aim The aim of this study was to evaluate the effectiveness of 5% eutectic mixture of local anesthetics (EMLA) cream and 20% benzocaine gel in reduction of pain during rubber dam clamp placement in the treatment of non-carious cervical lesions (NCCLs). Methodology In this split-mouth single-blind randomized clinical trial, 50 adult participants were selected from the outpatient department. The test group was treated using 5% EMLA cream for three minutes, and visual analog scale (VAS) scores were recorded. The comparison group was treated using 20% benzocaine gel and procedure was repeated as that in the test group. After recording the VAS scores, NCCLs in both the groups were restored using composite restoration. Results In the included 50 participants, 70% were males, with an age group of 31-67 years. The mean VAS score at 3 minutes in EMLA group was significantly lower than that in benzocaine group. Conclusion Application of 5% EMLA cream for 3 minutes showed greater pain reduction during rubber dam clamp placement as compared to 20% benzocaine gel in adult patients with NCCLs.
Abstract licence: CC BY
Manisha Nair, D. Gurunathan
Journal of Anaesthesiology, Clinical Pharmacology, 2019
L. Eslamian, A. Borzabadi-Farahani, H. Gholami
Australasian Orthodontic Journal, 2016
Stephan Warnke, Jongcheol Seo, J. Boschmans, et al.
Journal of the American Chemical Society, 2015
Nurain Rehman, S. R. Qazi
Anesthesia progress, 2019
Rita El Feghali, Karen Tatarian, C. Zogheib, et al.
Photonics, 2022
L. Eslamian, H. Gholami, S. Mortazavi, et al.
Orthodontics & craniofacial research, 2016
Henry Lukabwe, Rogers Kajabwangu, Dale Mugisha, et al.
The Pan African Medical Journal, 2020
Huda Ibrahim, Amina M. Abdelrahman
2020
Guilherme Camponogara de Freiras, R. T. Pozzobon, D. Blaya, et al.
Anesthesia progress, 2015
Sources: aggregated from Europe PMC (EMBL-EBI), OpenAlex, Crossref, PubMed and other open scholarly databases. Retracted articles are excluded. Study information is provided for research purposes and does not constitute medical advice.
Scientific data (pharmacology, interactions, ADME) is not yet available for this medicine. Clinical sections are sourced from the NHS dm+d database.