Ascorbic acid 7.5g/50ml solution for infusion vials
Requires a prescription from a doctor or prescriber
A six carbon compound related to glucose.
Official documents, adverse reaction reporting, and safety monitoring
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Official medicine documents
Safety monitoring data
Yellow Card reports
The MHRA Yellow Card scheme collects reports of suspected side effects from healthcare professionals and patients. View the Drug Analysis Profile (iDAP) for real-world adverse reaction data.
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Suspected adverse reactions reported for Ascorbic acid
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Report a side effect
Submit a Yellow Card report to the MHRA
Data from the MHRA Yellow Card scheme. A reported reaction does not necessarily mean the medicine caused it. Contains public sector information licensed under the Open Government Licence v3.0.
EudraVigilance
The European Medicines Agency (EMA) collects suspected adverse reaction reports from across the EU/EEA through the EudraVigilance system. Search for safety data on this medicine.
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Suspected adverse reactions reported for Ascorbic acid
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EudraVigilance data is published by the European Medicines Agency (EMA). A suspected adverse reaction is not necessarily caused by the medicine.
2 branded products available
Part of the Haliborange brand family (generic: Ascorbic acid)
MHRA licensed products
View all licensed products for Ascorbic acid on the MHRA register
Ascorbic acid 7.5g/50ml concentrate for solution for infusion vials
Therapeutically similar medicines
Similarity based on WHO Anatomical Therapeutic Chemical (ATC) classification and NHS BNF section grouping. Source data: NHS dm+d via TRUD (OGL v3.0), WHO ATC/DDD Index.
NHS prescribing volume and spending trends
Clinical guidelines and formulary information
British National Formulary
Ascorbic acid
Source: British National Formulary, NICE. Joint Formulary Committee. Contains public sector information licensed under the Open Government Licence v3.0.
NICE clinical guidance(1)
Source: National Institute for Health and Care Excellence (NICE). Contains public sector information licensed under the Open Government Licence v3.0.
Check stock at pharmacies and supply information
Pharmacy stock checkers
Search for this medicine at major UK pharmacy chains. These links open the retailer's own website — results depend on their current online catalogue.
Supply & product information
Official product databases and supply status monitoring
Pharmacy links redirect to the retailer's own search and do not represent real-time stock levels. emc (electronic medicines compendium) is operated by Datapharm Ltd. Shortage information sourced from NHS Specialist Pharmacy Service (SPS), sps.nhs.uk.
Codes for healthcare professionals and prescribing systems
These codes are used by healthcare IT systems and prescribers to identify this medicine.
NHS UK identifiers
Browse tools
SNOMED CT and dm+d codes from NHS TRUD (Technology Reference data Update Distribution), licensed under the Open Government Licence v3.0. BNF codes from NHS Business Services Authority (NHSBSA). ATC codes from the WHO Collaborating Centre for Drug Statistics Methodology (whocc.no).
Active and completed clinical studies from ClinicalTrials.gov
Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine (NLM), National Institutes of Health (NIH). Data accessed via ClinicalTrials.gov API v2. Trial information is provided for research purposes and does not constitute medical advice.
Pharmacology and chemical data from DrugBank
Key facts
Drug status
Approved
Major interactions
None known
Half-life
16 days
Mechanism
In humans, an exogenous source of ascorbic acid is required for collagen formati…
Food interactions
1 warning
Human targets
24 targets
Data: DrugBank · CC BY-NC 4.0
Pharmacokinetics at a glance
Absorption
70%
Half-life
16 days
Protein binding
25%
Metabolism
Pharmacokinetic data: DrugBank · CC BY-NC 4.0
Known interactions with other medications. Always consult a healthcare professional.
Showing 50 of 64 interactions
How the body processes this drug — absorption, distribution, metabolism, and elimination
Some ascorbic acid is metabolized to inactive compounds including ascorbic acid-2-sulfate and oxalic acid.
Proteins and enzymes this drug interacts with in the body
PMID:10556483 PMID:10556521 PMID:10631088 PMID:36749388
Has retained some ancestral activity toward nucleobases such as urate, an oxidized purine. Low-affinity high-capacity sodium:urate cotransporter, may regulate serum urate levels by serving as a renal urate re-absorber PMID:36749388
PMID:10471399 PMID:10556521
Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate PMID:10471399
PMID:10744784 PMID:12031666 PMID:12923223 PMID:9326939
Does not hydroxylate long and very long straight chain acyl-CoAs or 2-methyl- and 4-methyl-branched acyl-CoAs PMID:10744784 PMID:12923223
Enzymes involved in drug metabolism — important for understanding drug interactions
Proteins that transport this drug across cell membranes
PMID:10556483 PMID:10556521 PMID:10631088 PMID:36749388
Has retained some ancestral activity toward nucleobases such as urate, an oxidized purine. Low-affinity high-capacity sodium:urate cotransporter, may regulate serum urate levels by serving as a renal urate re-absorber PMID:36749388
PMID:10471399 PMID:10556521
Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate PMID:10471399
PMID:10227690 PMID:10954735 PMID:18245775 PMID:19449892 PMID:25982116 PMID:27078104 PMID:32860739
Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses .
PMID:18245775 PMID:19449892
Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain .
PMID:10227690
In association with BSG and NXNL1, promotes retinal cone survival by increasing glucose uptake into photoreceptors (By similarity). Required for mesendoderm differentiation (By similarity)
PMID:26176916 PMID:32860739 PMID:9477959
Can also mediate the uptake of various other monosaccharides across the cell membrane .
PMID:26176916 PMID:9477959
Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate .
PMID:26176916 PMID:9477959
Does not mediate fructose transport .
PMID:26176916 PMID:9477959
Required for mesendoderm differentiation (By similarity)
Proteins that carry this drug through the body
PMID:19021548
Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity).
Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (By similarity). The shared binding site between zinc and calcium at residue Asp-273 suggests a crosstalk between zinc and calcium transport in the blood (By similarity). The rank order of affinity is zinc > calcium > magnesium (By similarity).
Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E.coli from ferric transferrin, and may thereby limit the utilization of iron and growth of enteric bacteria such as E.coli .
PMID:6234017
Does not prevent iron uptake by the bacterial siderophore aerobactin PMID:6234017
Involved compounds
Involved compounds
Involved compounds
Involved compounds
Involved compounds
Involved compounds
Involved compounds
Involved compounds
ATC G01AD03
ATC A11GA01
ATC A11GB01
ATC S01XA15
Chemical identifiers
CAS, UNII, InChI Key and database cross-references
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Chemical identifiers
CAS, UNII, InChI Key and database cross-references
Linked compound data from DrugBank Open Data (CC BY-NC 4.0)
Ascorbic acid
Additional database identifiers
Drugs Product Database (DPD)
646
Drugs Product Database (DPD)
4937
Drugs Product Database (DPD)
5015
Drugs Product Database (DPD)
136
Drugs Product Database (DPD)
4934
Drugs Product Database (DPD)
717
Drugs Product Database (DPD)
645
ChemSpider
10189562
BindingDB
50090256
PDB
ASC
ZINC
ZINC000100006770
HUGO Gene Nomenclature Committee (HGNC)
HGNC:10974
GenAtlas
SLC23A1
GeneCards
SLC23A1
GenBank Gene Database
AF058317
GenBank Protein Database
3789785
Guide to Pharmacology
1041
UniProt Accession
S23A1_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:10973
GeneCards
SLC23A2
UniProt Accession
S23A2_HUMAN
GenBank Gene Database
AE005672
GenBank Protein Database
14971788
UniProt Accession
HYSA_STRPN
GenBank Gene Database
M73789
GenBank Protein Database
153534
UniProt Accession
XYLA_STRRU
HUGO Gene Nomenclature Committee (HGNC)
HGNC:9082
GenAtlas
PLOD2
GeneCards
PLOD2
GenBank Gene Database
U84573
GenBank Protein Database
2138314
UniProt Accession
PLOD2_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:8940
GenAtlas
PHYH
GeneCards
PHYH
GenBank Gene Database
AF023462
GenBank Protein Database
2564671
UniProt Accession
PAHX_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:9083
GenAtlas
PLOD3
GeneCards
PLOD3
GenBank Gene Database
AF046889
GenBank Protein Database
3153235
UniProt Accession
PLOD3_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:964
GenAtlas
BBOX1
GeneCards
BBOX1
GenBank Gene Database
AF082868
GenBank Protein Database
3746805
UniProt Accession
BODG_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:2689
GenAtlas
DBH
GeneCards
DBH
GenBank Gene Database
X13255
GenBank Protein Database
30474
Guide to Pharmacology
2486
UniProt Accession
DOPO_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:8596
GenAtlas
PAM
GeneCards
PAM
GenBank Gene Database
M37721
GenBank Protein Database
189595
UniProt Accession
AMD_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:19316
GenAtlas
LEPRE1
GeneCards
P3H1
GenBank Gene Database
AF097431
GenBank Protein Database
11127636
UniProt Accession
P3H1_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:19317
GenAtlas
LEPREL1
GeneCards
P3H2
GenBank Gene Database
AJ430351
GenBank Protein Database
27526730
UniProt Accession
P3H2_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:19318
GenAtlas
LEPREL2
GeneCards
P3H3
GenBank Gene Database
U47924
GenBank Protein Database
1200503
UniProt Accession
P3H3_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:8546
GenAtlas
P4HA1
GeneCards
P4HA1
GenBank Gene Database
M24486
GenBank Protein Database
190786
UniProt Accession
P4HA1_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:25585
GenAtlas
OGFOD1
GeneCards
OGFOD1
GenBank Gene Database
BC032919
GenBank Protein Database
21410525
UniProt Accession
OGFD1_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:25823
GenAtlas
OGFOD2
GeneCards
OGFOD2
GenBank Gene Database
BX640675
GenBank Protein Database
34364724
UniProt Accession
OGFD2_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:32487
GenAtlas
ALKBH2
GeneCards
ALKBH2
GenBank Gene Database
AY754389
GenBank Protein Database
53988530
UniProt Accession
ALKB2_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:30141
GenAtlas
ALKBH3
GeneCards
ALKBH3
GenBank Gene Database
AB042029
GenBank Protein Database
16326129
UniProt Accession
ALKB3_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:11115
GenAtlas
JARID1D
GeneCards
KDM5D
GenBank Gene Database
U52191
GenBank Protein Database
1661016
UniProt Accession
KDM5D_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:9081
GenAtlas
PLOD1
GeneCards
PLOD1
GenBank Gene Database
L06419
GenBank Protein Database
190074
UniProt Accession
PLOD1_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:18308
GenAtlas
TMLHE
GeneCards
TMLHE
GenBank Gene Database
AF373407
GenBank Protein Database
15553435
UniProt Accession
TMLH_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:28858
GeneCards
P4HTM
GenBank Gene Database
AY198406
GenBank Protein Database
28566186
UniProt Accession
P4HTM_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:1232
GenAtlas
EGLN1
GeneCards
EGLN1
GenBank Gene Database
AF246631
GenBank Protein Database
11345052
Guide to Pharmacology
2833
UniProt Accession
EGLN1_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:14660
GenAtlas
EGLN2
GeneCards
EGLN2
GenBank Gene Database
AJ310544
GenBank Protein Database
14547148
Guide to Pharmacology
2832
UniProt Accession
EGLN2_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:14661
GenAtlas
EGLN3
GeneCards
EGLN3
GenBank Gene Database
AJ310545
GenBank Protein Database
14547150
Guide to Pharmacology
2834
UniProt Accession
EGLN3_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:12437
GenAtlas
TXNRD1
GeneCards
TXNRD1
GenBank Gene Database
X91247
GenBank Protein Database
1237038
UniProt Accession
TRXR1_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:399
GenAtlas
ALB
GeneCards
ALB
GenBank Gene Database
V00494
GenBank Protein Database
28590
UniProt Accession
ALBU_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:10974
GenAtlas
SLC23A1
GeneCards
SLC23A1
GenBank Gene Database
AF058317
GenBank Protein Database
3789785
Guide to Pharmacology
1041
UniProt Accession
S23A1_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:10973
GeneCards
SLC23A2
UniProt Accession
S23A2_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:11005
GenAtlas
SLC2A1
GeneCards
SLC2A1
GenBank Gene Database
K03195
GenBank Protein Database
183303
Guide to Pharmacology
875
UniProt Accession
GTR1_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:11007
GeneCards
SLC2A3
UniProt Accession
GTR3_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:11009
GenAtlas
SLC2A4
GeneCards
SLC2A4
GenBank Gene Database
M20747
GenBank Protein Database
307076
UniProt Accession
GLUT4_HUMAN
International reference pricing
Reference pricing from DrugBank. Prices are indicative and may not reflect current UK costs.
Source: DrugBank. Used under CC BY-NC 4.0 academic licence for non-commercial purposes.
Patent information
11 active patents, 2 expired
Source: DrugBank · CC BY-NC 4.0. Patent data sourced from national patent offices. Expiry dates may not reflect extensions, regulatory exclusivity periods, or legal challenges.
DrugBank citations
If you use DrugBank data in your research, please cite the following publications: