Antazoline 2% ointment
Antazoline is a 1st generation antihistamine with anticholinergic activity.
Official documents, adverse reaction reporting, and safety monitoring
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Official medicine documents
Safety monitoring data
Yellow Card reports
The MHRA Yellow Card scheme collects reports of suspected side effects from healthcare professionals and patients. View the Drug Analysis Profile (iDAP) for real-world adverse reaction data.
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Suspected adverse reactions reported for Antazoline
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Interactive Drug Analysis Profiles for all medicines
Report a side effect
Submit a Yellow Card report to the MHRA
Data from the MHRA Yellow Card scheme. A reported reaction does not necessarily mean the medicine caused it. Contains public sector information licensed under the Open Government Licence v3.0.
EudraVigilance
The European Medicines Agency (EMA) collects suspected adverse reaction reports from across the EU/EEA through the EudraVigilance system. Search for safety data on this medicine.
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Suspected adverse reactions reported for Antazoline
About EudraVigilance
Learn about EU pharmacovigilance and safety monitoring
EudraVigilance data is published by the European Medicines Agency (EMA). A suspected adverse reaction is not necessarily caused by the medicine.
1 branded products available
Therapeutically similar medicines
Similarity is based on WHO Anatomical Therapeutic Chemical (ATC) classification and on a factual NHS dm+d therapeutic-grouping code prefix. Source data: NHS dm+d via TRUD (OGL v3.0), WHO ATC/DDD Index.
NHS prescribing volume and spending trends
Check stock at pharmacies and supply information
Pharmacy stock checkers
Search for this medicine at major UK pharmacy chains. These links open the retailer's own website — results depend on their current online catalogue.
Supply & safety information
Official UK regulator monitoring and safety alerts
Pharmacy links redirect to the retailer's own search and do not represent real-time stock levels. Shortage and safety information sourced from MHRA drug safety updates (gov.uk, Crown Copyright under OGL v3.0).
Codes for healthcare professionals and prescribing systems
These codes are used by healthcare IT systems and prescribers to identify this medicine.
NHS UK identifiers
Browse tools
SNOMED CT and dm+d codes from NHS TRUD (Technology Reference data Update Distribution), licensed under the Open Government Licence v3.0. BNF code shown is the factual mapping value distributed by NHS Business Services Authority (NHSBSA) in the dm+d supplementary file under OGL v3.0; it is not affiliated with, nor licensed from, the publishers of the British National Formulary. ATC codes from the WHO Collaborating Centre for Drug Statistics Methodology (whocc.no).
Active and completed clinical studies from ClinicalTrials.gov
Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine (NLM), National Institutes of Health (NIH). Data accessed via ClinicalTrials.gov API v2. Trial information is provided for research purposes and does not constitute medical advice.
Academic studies and reviews for this medicine's active substance
Showing the 50 most relevant studies.
Reviews & meta-analyses: 4 · 2004–2026
Showing the 50 most relevant studies, sorted by most relevant.
Danyal Bakht, Muhammad Arham, Faiza Yousaf, et al.
JACC, 2026
Raghad Aldulaymi, Ahmad Z. Al Meslamani
Journal of Pharmacy & Pharmacognosy Research, 2022
Krzysztof Palimonka, P. Paśko, M. Szuta, et al.
Acta Poloniae Pharmaceutica - Drug Research, 2020
M. Wybraniec, W. Wróbel, K. Wilkosz, et al.
European Heart Journal, 2019
Ola G. Hussein, Dina A. Ahmed, Mamdouh R. Rezk, et al.
Journal of Pharmaceutical and Biomedical Analysis, 2023
- Antazoline
- Aqueous Humor
- Chromatography, High Pressure Liquid
Ola G. Hussein, M. A. Abdelkawy, Mamdouh R. Rezk, et al.
Results in Chemistry, 2023
Ola G. Hussein, Yasmin Rostom, M. A. Abdelkawy, et al.
Journal of Chromatographic Science, 2023
- Antazoline
- Aqueous Humor
- Densitometry
Ola G. Hussein, Dina A. Ahmed, Mohamed Abdelkawy, et al.
Luminescence, 2024
- Antazoline
- Imidazoles
- Spectrometry, Fluorescence
Yasmin Rostom, Ola G. Hussein, M. A. Abdelkawy, et al.
Journal of Fluorescence, 2024
- Antazoline
- Imidazoles
- Ophthalmic Solutions
Yasmin Rostom, Ola G. Hussein, Amr M. Mahmoud, et al.
Journal of The Electrochemical Society, 2024
Sources: aggregated from Europe PMC (EMBL-EBI), OpenAlex, Crossref, PubMed and other open scholarly databases. Retracted articles are excluded. Study information is provided for research purposes and does not constitute medical advice.
Pharmacology and chemical data from DrugBank
Key facts
Drug status
Approved
Major interactions
None known
Half-life
Not available
Mechanism
Antazoline binds to the histamine H1 receptor.
Food interactions
None known
Human targets
1 target
Data: DrugBank · CC BY-NC 4.0
Pharmacokinetics at a glance
Known interactions with other medications. Always consult a healthcare professional.
Showing 50 of 424 interactions
Proteins and enzymes this drug interacts with in the body
PMID:33828102 PMID:8280179
Through the H1 receptor, histamine mediates the contraction of smooth muscles and increases capillary permeability due to contraction of terminal venules. Also mediates neurotransmission in the central nervous system and thereby regulates circadian rhythms, emotional and locomotor activities as well as cognitive functions (By similarity)
Involved compounds
ATC R06AX05
ATC R01AC04
Chemical identifiers
CAS, UNII, InChI Key and database cross-references
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Chemical identifiers
CAS, UNII, InChI Key and database cross-references
Linked compound data from DrugBank Open Data (CC BY-NC 4.0)
Antazoline
Additional database identifiers
Drugs Product Database (DPD)
6614
Drugs Product Database (DPD)
4165
ChemSpider
2115
BindingDB
76862
ZINC
ZINC000000057204
HUGO Gene Nomenclature Committee (HGNC)
HGNC:5182
GenAtlas
HRH1
GeneCards
HRH1
GenBank Gene Database
Z34897
GenBank Protein Database
510296
Guide to Pharmacology
262
UniProt Accession
HRH1_HUMAN
DrugBank citations
If you use DrugBank data in your research, please cite the following publications:
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Structured knowledge from the free knowledge base
Linked open data from Wikidata (Q771975), a free and open knowledge base operated by the Wikimedia Foundation. Data is available under the Creative Commons CC0 1.0 Public Domain Dedication. WHO INN from the World Health Organization.