Aluminium chloride 35% / Isopropyl alcohol 32.5% solution

Contact allergy (CA) is a frequent condition in children; however, newer estimates of the prevalence of CA in children are lacking. Herein, we aim to provide an estimate of the prevalence of CA in children from 2010 to 2024. Two authors independently searched PubMed, Embase and Web of Science for studies reporting the prevalence of positive patch tests (PPTs) to allergens in populations including ≥ 100 children (< 18 years). Proportion meta-analyses were conducted to calculate the pooled prevalence estimates of CA in children. Seventeen studies comprising 11 593 children undergoing patch testing with 4176 (36%) PPTs were eligible for inclusion. The allergen with the highest prevalence was nickel (11.9% [95% confidence interval [CI], 8.6%-15.71%]), followed by cobalt (6.6% [95% CI, 4.2%-9.5%]), cocamidopropyl betaine (5.5% [95% CI, 3.1-8.7]), bacitracin (5.2% [95% CI, 1.2%-10.0%]), fragrance mix I (4.8% [95% CI, 2.9%-7.1%]) and methylisothiazolinone (4.3% [95% CI, 2.2%-7.2%]). Children with atopic dermatitis had higher rates of PPTs for cocamidopropyl betaine, propylene glycol, lanolin alcohol and carba mix. Across geographical areas, higher prevalences of several allergens were found in the United States compared to Europe, for example, for methylisothiazolinone. This meta-analysis confirmed that CA is frequent in children across geographical areas; however, differences in the frequency of top allergens depend on regulatory interventions, indicating their value.

Abstract licence: CC BY

Hygroscopicity poses a significant challenge in the formulation of pharmaceutical and nutraceutical products, as moisture absorption often leads to chemical degradation, physical instability, and compromised therapeutic efficacy. This narrative literature review, evaluated the comparative effectiveness of various polymeric systems and coating technologies as moisture barriers across diverse dosage forms, including tablets, powders, granules, and particulates. We analyzed a spectrum of barrier materials, including cellulose derivatives, polyvinylpyrrolidone, polyvinyl alcohol (PVA), methacrylates, and shellac, contrasting conventional solvent based techniques (fluid bed, spray drying, freeze drying coating) with advanced methodologies (hot melt coating, electrostatic dry coating, and Atomic Layer Deposition/ALD). Conventional coating systems utilizing HPMC and PVA were found to maintain moisture uptake below 1.5% during long-term storage (40°C/75% RH). However, more advanced strategies demonstrated superior protective capabilities, for instance, hotmelt coating employing lipid-based excipients (Precirol ATO 5) reduced moisture absorption by up to 85% at 75% RH. Furthermore, electrostatic dry coating showed a significant reduction in weight gain, decreasing from 6.5% to 3.3% compared to uncoated cores over a 48-hour period. Notably, ALD provided the most robust protection, preserving the amorphous stability of sensitive particles for up to two years under extreme conditions. This review highlights that film coatings not only mitigate moisture induced degradation but also enhance shelf life and improve the mechanical properties of dosage forms. These results underscore the versatility of coating technologies, enabling formulators to tailor strategies for highly moisture sensitive compounds.

Abstract licence: CC BY-NC

While cockroaches are commonly exhibited in zoos and museums, studied in research laboratories, and even kept as pets, scientifically based guidelines for their euthanasia are lacking. This study assessed euthanasia techniques in four species of cockroaches (Dubia (Blaptica dubia), red runner (Shelfordella lateralis), Madagascar hissing (Gromphadorhina portentosa), and giant cave (Blaberus giganteus)). In an initial pilot study, two hundred fifty adult Dubia cockroaches were exposed in groups of ten to a cotton ball soaked with 2 mL of isoflurane in a 1 L air-tight chamber. Thirty minutes beyond loss of any individual movement, groups were exposed to one of the following secondary treatments: freezing at −18 °C or −80 °C from 0.25 to 24 hours; immersion in 10% neutral buffered formalin, 70% isopropyl alcohol, or reverse osmosis water for 0.25 or 0.5 hours; or intracoelomic injection of potassium chloride (456 mEq/kg) or pentobarbital-based euthanasia solution (3.9 g/kg). A control group remained in the air-tight isoflurane chamber for 24 hours. Following all treatments, cockroaches were monitored for an additional 24 hours for spontaneous movement. Irreversible loss of movement was considered synonymous with irreversible loss of consciousness (death). Across all species, isoflurane anesthesia followed by either 70% isopropyl alcohol immersion for 0.25 or 0.5 hours or isoflurane exposure for 24 hours resulted in euthanasia in 100% of cockroaches. This study is the first evaluation of American Veterinary Medical Association-recommended euthanasia protocols in cockroaches.

Abstract licence: CC BY

Denture fractures are a common problem in dental practice, and their repair is considered a first option to restore their functional properties. However, the inter-material resistance may become compromised. Typically, the bond between these materials weakens. Therefore, various surface treatment methods may be considered to enhance their mechanical properties. Poly(methyl methacrylate) (PMMA) heat-polymerized resin (HPR) was used as the repaired material, cold-polymerized material (CPR) for the repairs, and different variants of alumina abrasive blasting (AB), methyl methacrylate (M), ethyl acetate (EA), methylene chloride (CH), and isopropyl alcohol (IA) treatments were applied. Finally, combined surface treatments were chosen and analyzed. Surface morphologies after treatments were observed by scanning electron microscopy and the flexural, shear, and impact strengths were tested. AB and chemical treatment with CH, M, and EA was used to improve all mechanical properties, and further improvement of the properties could be achieved by combining both types of treatments. Varied changes in surface morphologies were observed. Treatment with IA yielded less favorable results due to the low impact strength. The best results were achieved for the combination of AB and CH, but during the application of CH it was necessary to strictly control the exposure time.

Abstract licence: CC BY

This study is centered on the oxidative transformation of alcohols into their respective aldehyde compounds, employing an S-scheme heterostructure featuring CuO/Cu2O on graphene-like carbon (GLC) derived from a basil seed hydrogel. Experimental characterization and theoretical calculations highlight that the implementation of S-scheme heterostructures achieves not only enhanced charge-separation efficiency, facilitated by the interfacial built-in electric field, Cu co-sharing at the CuO/Cu2O interface, and electron carrier activity of the GLC support, but also maintains a strong driving force for photocatalytic organic conversion. The resulting nanocomposites play a crucial role in transferring and reducing the recombination of photoexcited charge carriers, preserving the oxidizability of CuO holes and the reducibility of Cu2O electrons. Through meticulous adjustment of precursor amounts, the CuO-Cu2O/GLC heterojunction exhibited the highest photocurrent at 6.83 mA cm-2, demonstrating optimal performance in the photocatalytic selective oxidation of benzyl alcohol with an average conversion rate of 95.0%. Furthermore, the stability of CuO-Cu2O/GLC was thoroughly investigated, revealing sustained high conversion even after five repeated experiments, underscoring its potential for practical applications. The study also proposes a plausible mechanism for the transformation of benzyl alcohol into benzaldehyde through capture experiments of active species. Importantly, this research introduces a straightforward in situ hydrothermal growth protocol for efficiently constructing metal oxide heterostructures wrapped in an rGO support. It provides valuable insights into designing new synthetic strategies for preparing efficient photocatalysts and hints at the development of novel, efficient, and practical photocatalytic systems.

Abstract licence: CC BY-NC

Ester compounds, widely found in pharmaceutical and natural products, play a crucial role in organic synthesis, prompting the development of numerous methods for their synthesis. An important chemical approach in synthesizing esters from carboxylic acids involves the activation of the carboxyl function, requiring the conversion of the hydroxyl group into a suitable leaving group. This paper presents the findings of our investigations into an efficient method for producing esters from carboxylic acids and alcohols, using the Lewis acid titanium tetrachloride. Titanium tetrachloride has proven highly effective as a coupling reagent for the one-pot formation of esters from carboxylic acids and alcohols operating under mild and neutral conditions. Notably, the reaction eliminates the need for bases, yielding carboxylic esters in high purity and yields. The method is efficient, even with long-chain carboxylic acids, and operates well with primary alcohols in dichloromethane. Steric hindrance, potentially present in carboxylic acids, has a moderate effect on the reaction. Alcohol substrates that easily form stable carbocations require, instead, the use of non-polar solvents like hexane for the reaction.

Abstract licence: CC BY