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Therapeutically similar medicines
Similarity is based on WHO Anatomical Therapeutic Chemical (ATC) classification and on a factual NHS dm+d therapeutic-grouping code prefix. Source data: NHS dm+d via TRUD (OGL v3.0), WHO ATC/DDD Index.
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Icosapent ethyl with statin therapy for reducing the risk of cardiovascular events in people with raised triglycerides (TA805)
Stable angina: management (CG126)
Acne vulgaris: management (NG198)
Cardiovascular disease: risk assessment and reduction, including lipid modification (NG238)
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Inducing labour (NG207)
Source: National Institute for Health and Care Excellence (NICE). Contains public sector information licensed under the Open Government Licence v3.0.
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Active and completed clinical studies from ClinicalTrials.gov
Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine (NLM), National Institutes of Health (NIH). Data accessed via ClinicalTrials.gov API v2. Trial information is provided for research purposes and does not constitute medical advice.
Academic studies and reviews for this medicine's active substance
Showing the 50 most relevant studies.
Reviews & meta-analyses: 11 · Randomised trials: 22 · 1990–2026
Showing the 50 most relevant studies, sorted by most relevant.
Güner Emül T, Kaplan Serin E
2026
- Pregnancy Complications
- Oils, Volatile
- Plant Oils
BackgroundStriae gravidarum is a skin change that occurs during pregnancy, which does not pose a physiological threat to health but can cause psychological distress for individuals. Women may use moisturizers or aromatherapeutic oils in attempts to prevent the formation of striae.AimThe purpose of this study is to review the literature on randomized controlled trials evaluating the effectiveness of aromatherapy oils in preventing striae gravidarum.MethodsThe protocol for this systematic review and the writing of the article were based on the PRISMA-P (Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols) criteria. The systematic review was conducted using the Google Scholar, PubMed, Web of Science, Scopus, and Cochrane Library databases between December 2024 and January 2025. Studies were selected by defining inclusion and exclusion criteria according to the PICOS method.ResultsThis systematic review included four randomized controlled trials with a total of participants. Two of the studies were published in 2024, one in 2022, and the other in 2020. This systematic review included four randomized controlled trials with a total of 671 pregnant participants. The essential oils used in the studies included coconut oil, rose oil, sesame oil, sweet almond oil, and olive oil. The studies found that coconut oil was effective in preventing striae gravidarum, while rose, sesame, and sweet almond oils were not effective.ConclusionThere is some evidence for the effect of aromatherapy in preventing striae gravidarum. However, larger sample sizes, higher-quality studies, and randomized controlled trials with blinding methods are needed to evaluate the effectiveness of aromatherapy oils and determine their beneficial effects on pregnant women.
Abstract licence: CC BY
Sarmadi S, Sanaie N, Ghanbari Nasab H, et al.
2026
- Plant Oils
- Pressure Ulcer
- Incidence
IntroductionThe high incidence of pressure ulcers, particularly among patients with impaired mobility, necessitates implementing preventive measures. In addition to risk factor management, complementary medicine modalities are effective. Consequently, a scoping review was designed and conducted to assess the effectiveness of herbal oils in the prevention and management of pressure ulcers.MethodA five-step process outlined by Arksey and O'Malley (2005) guided this scoping review. This scoping review adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Extension for Scoping Reviews (PRISMA-ScR) guidelines. Five electronic databases were searched from their respective inception dates through February 6, 2025, to identify relevant studies. Additionally, an update was performed for searches using the same search strings on 1 January 2026. Web of Science, Scopus, PubMed, Embase, and CINAHL were among the searched databases. Two authors independently performed study selection, risk-of-bias assessments, and data extraction.ResultsThe review comprised 21 studies that examined a cohort of 3028 patients. Olive oil was used as an intervention in 17 studies. Other studies employed sweet almond, coconut, fish, and henna oil as interventions. Olive oil proved more effective than other treatments. Olive oil demonstrated efficacy comparable to hyperoxigenated fatty acids (HOFA) in preventing both the onset and worsening of pressure ulcers. The findings require further investigation to reach a conclusive result. Additional research is needed to validate the findings regarding other herbal oils.ConclusionsOur study showed that the use of herbal oils, particularly olive oil, can be beneficial. However, most studies focused on olive oil; study quality varied, evidence for other oils was limited or inconsistent, and further research is needed to confirm efficacy and assess potential side effects.
Abstract licence: CC BY-NC-ND
Dash B, Sarangi A, Nayak A, et al.
2026
BackgroundIn recent years, there has been increasing interest in novel plant-based oil sources as sustainable alternatives to conventional edible oils. This shift is driven by consumer demand for natural, nutrient-dense, and health-promoting products. Among these, cold-pressed oils have gained prominence as specialty oils. Cold-press extraction is a mechanical, environmental friendly and energy-efficient technique that eliminates the use of heat and solvents, thereby preserving the natural physicochemical and nutritional properties of oils. This method is applied to seeds, kernels, fruits, and peels to obtain oils rich in bioactive compounds.Aim of the reviewThis systematic review aims to summarize and critically evaluate the extraction techniques, stability-enhancing strategies, physicochemical characteristics, nutritional composition, and pharmacological activities of various cold-pressed oils. It also highlights current research gaps to guide future investigations.MethodsRelevant literature was collected from scientific databases, including PubMed, Scopus, Web of Science, Google Scholar, and NCBI, as well as peer-reviewed journals. Additional gray literature, including web articles were also examined to ensure a comprehensive review of available information.ResultsCold-pressed oils retain significantly higher levels of polyunsaturated fatty acids, antioxidants, vitamins, and other bioactive compounds compared to refined oils due to minimal processing. These constituents contribute to enhanced biological activities, including antioxidant, anti-inflammatory, and anticancer properties. Consequently, cold-pressed oils exhibit improved nutritional quality and potential health benefits. However, their quality and shelf life are strongly influenced by factors, including the source of raw materials, plant genotype, harvest timing, moisture content, storage conditions, pre-processing steps, and extraction parameters. Oils rich in mono-and polyunsaturated fatty acids are particularly susceptible to oxidation, which can compromise stability and health benefits. To address this, various strategies, including the use of natural antioxidants, encapsulation, optimized storage conditions, and advanced extraction technologies, have been proposed to enhance oxidative stability.ConclusionCold-pressed oils offer valuable therapeutic and nutritional benefits due to their rich profile of bioactive compounds. Despite their potential, research gaps remain, in developing integrated approaches to maintain and enhance their stability, nutritional value, and pharmacological properties. Addressing these gaps is crucial for fully understanding and maximizing the health benefits of plant-based, cold-pressed oils.
Abstract licence: CC BY
Ribeiro-Silva B, Turri JAO, Simões RDS, et al.
2026
Breast cancer remains the most prevalent malignancy among women worldwide, and experimental tumor models are essential for evaluating new therapeutic approaches before clinical application. The Walker-256 carcinoma model exhibits biological behavior comparable to human carcinoma and allows short-term assessment of tumor progression. This study aimed to conduct a systematic review and meta-analysis of the effects of dietary supplementation on Walker-256 tumor growth. We followed the PRISMA guidelines and searched the PubMed, Embase, and Cochrane databases without time restrictions. The meta-analysis included clustering based on the type of supplementation received, comparing treatment groups with control groups. Twenty-one studies were included, analyzing 18 different supplements, and 12 studies were considered for quantitative synthesis. The overall effect indicated a significant reduction in tumor growth with supplementation (SMD = 2.83, 95% CI = 1.99-3.66, p 2 = 93.3%). Oils had the greatest impact, particularly fish oil (SMD = 6.99, 95% CI = 3.15-10.83, p p < 0.01).
Abstract licence: CC BY
Tahere Khezeli, A. Daneshfar, R. Sahraei
Talanta, 2016
Riedler K, Hecker A, Bauer B, et al.
2023
Background and objectivesEssential oils are a complementary treatment and can play an important role in scar care. The aim of this study was to evaluate and compare the efficacy of a new essential oil (regeneration oil) with a control group on scar quality in healed split-thickness skin graft donor sites.Materials and methodsA single-center blinded randomized controlled study was performed on 30 patients with healed split-thickness skin graft donor site. The patients were randomly allocated into blended regeneration oil (n = 14) and pure almond oil (n = 16) groups. Application of the assigned oil occurred twice a day for 6 months. Scarring (Patient and Observer Scar Assessment Scale), itching (ITCH Assessment Scale) and scar discoloration (colorimetry) of the donor sites were assessed after 1, 3 and 6 months.ResultsWe found no statistically significant differences between the groups in any applied parameter. We observed comparable outcomes (scar quality, itchiness, colorit) in healed split-thickness skin graft donor sites for both oils.ConclusionsRegeneration oil and control oil presented comparable results regarding scar quality, itchiness and colorit in healed split-thickness skin graft donor sites after 6 months of application. Both oils are suitable for skin/scar care in split-thickness skin graft donor sites.
Abstract licence: CC BY
Tran V, Urwin CS, Tieland M, et al.
2026
- Obesity
- Postmenopause
- Dietary Supplements
BackgroundSarcopenia, characterised by declines in muscle mass and function, is expected to impact many postmenopausal women due to ageing and sedentary lifestyles. Hormonal changes during menopause exacerbate loss of lean mass, visceral fat gain, and risk of cardiometabolic disease. Resistance and high-intensity interval training (HIIT) are effective countermeasures, with adequate protein and fibre intake essential to support favourable adaptations. However, many women fall short of these protein and fibre dietary recommendations, particularly at breakfast. Defatted almond protein powder (APP), a by-product of almond oil production, is rich in protein and fibre and may enhance exercise-induced adaptations, though its effects remain untested.MethodsThis protocol outlines a 12-week study comprising a 10-week supervised resistance and HIIT intervention, with baseline and post-intervention assessments conducted over one-week periods immediately before and after the intervention. The randomised, double-blind, placebo-controlled trial will investigate the effects of defatted APP supplementation in postmenopausal women. We aim to recruit 48 participants who will be randomly allocated to receive either APP or an energy-matched placebo (maltodextrin). Primary outcomes include changes in total and regional lean mass which will be assessed using dual-energy X-ray absorptiometry (DXA). Secondary outcomes include strength, assessed via 3-repetition maximum (3-RM) chest press and leg press, and maximal handgrip strength; cardiovascular fitness (VO₂peak); total body fat (absolute and %), blood lipids; blood glucose; insulin response; appetite; supplement acceptability; and dietary intake. Data will be analysed using linear regression and mixed-effects models under intention-to-treat and per-protocol frameworks.DiscussionThis study will be the first to examine the effects of daily supplementation with APP on musculoskeletal and metabolic outcomes in postmenopausal women undergoing structured and supervised exercise training. Findings of this study may assist in developing applications for high protein/fibre by-product from the nut/seed oil industry and determine if supplementation with this almond derived product is an effective nutritional strategy to support training adaptations to strength and HIIT training in ageing women.Trial registrationANZCTR: ACTRN12625000133437 (Date Registered: 06 February 2025). Registration URL: ANZCTR Trial Registration .EthicsDUHREC: (2024/HE000126). Version: 2.0 date (16/02/2026).
Abstract licence: CC BY
Maryam Moradi, Azin Niazi, Fereshteh Mohammadi Payandar, et al.
Taiwanese Journal of Obstetrics & Gynecology, 2025
Sang Wook Lee, You Kyoung Shin, Jeong-Min Lee, et al.
Frontiers in Psychiatry, 2023
Arabi M, Jokar A, Nikkhah M, et al.
2025
- Tinnitus
- Cinnarizine
- Plant Oils
Sources: aggregated from Europe PMC (EMBL-EBI), OpenAlex, Crossref, PubMed and other open scholarly databases. Retracted articles are excluded. Study information is provided for research purposes and does not constitute medical advice.
Scientific data (pharmacology, interactions, ADME) is not yet available for this medicine. Clinical sections are sourced from the NHS dm+d database.