Ademetionine 200mg tablets
Prescription only
Requires a prescription from a doctor or prescriber
Tablet
200mg
Oral
Physiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms.
Active ingredients:
Ademetionine
No active safety alerts
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Safety monitoring data
Yellow Card reports
MHRA
The MHRA Yellow Card scheme collects reports of suspected side effects from healthcare professionals and patients. View the Drug Analysis Profile (iDAP) for real-world adverse reaction data.
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Data from the MHRA Yellow Card scheme. A reported reaction does not necessarily mean the medicine caused it. Contains public sector information licensed under the Open Government Licence v3.0.
EudraVigilance
EMA
The European Medicines Agency (EMA) collects suspected adverse reaction reports from across the EU/EEA through the EudraVigilance system. Search for safety data on this medicine.
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Suspected adverse reactions reported for Ademetionine
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EudraVigilance data is published by the European Medicines Agency (EMA). A suspected adverse reaction is not necessarily caused by the medicine.
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Clinical guidelines and formulary information
British National Formulary
Ademetionine
BNF
Drug monograph — bnf.nice.org.ukSource: British National Formulary, NICE. Joint Formulary Committee. Contains public sector information licensed under the Open Government Licence v3.0.
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NHS UK identifiers
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SNOMED CT and dm+d codes from NHS TRUD (Technology Reference data Update Distribution), licensed under the Open Government Licence v3.0. BNF codes from NHS Business Services Authority (NHSBSA). ATC codes from the WHO Collaborating Centre for Drug Statistics Methodology (whocc.no).
Active and completed clinical studies from ClinicalTrials.gov
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Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine (NLM), National Institutes of Health (NIH). Data accessed via ClinicalTrials.gov API v2. Trial information is provided for research purposes and does not constitute medical advice.
Pharmacology and chemical data from DrugBank
Key facts
Drug status
Approved
Major interactions
None known
Half-life
Not available
Mechanism
S-Adenosylmethionine (SAMe) is a natural substance present in the cells of the body.
Food interactions
None known
Human targets
8 targets
Data: DrugBank · CC BY-NC 4.0
Pharmacokinetics at a glance
Absorption
S-Adenosylmethionine is absorbed from the small intestine following oral intake.…
Metabolism
50%
Significant first-pass metabolism in the liver. Approximately 50% of S-Adenosylmethionine (SAMe) is metabolized in the liver.…
Pharmacokinetic data: DrugBank · CC BY-NC 4.0
Status:
Approved
Investigational
Nutraceutical
Small molecule
About this compound
Physiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed)
Properties:
solid
Avg. mass: 398.44 Da
DrugBank indication
S-Adenosylmethionine (SAMe) is used as a drug in Europe for the treatment of depression, liver disorders, fibromyalgia, and osteoarthritis. It has also been introduced into the United States market as a dietary supplement for the support of bone and joint health, as well as mood and emotional well being.
Also known as(56)
Ademetionine
AdoMet
L-S-Adenosylmethionine
S-Adenosylmethionine
SAM
SAM-e
SAMe
2.1.1.6
Dosage forms(13)
Tablet, delayed release (Oral) — 300 MG
Tablet, delayed release (Oral) — 500 MG
Tablet (Oral)
Solution (Intravenous)
Injection, powder, for solution (Intramuscular; Intravenous) — 100 MG/5ML
Injection, powder, for solution (Intramuscular; Intravenous) — 200 MG/5ML
Injection, powder, for solution (Intramuscular; Intravenous) — 400 MG/5ML
Tablet, delayed release (Oral) — 200 MG
Molecular properties(19)
Drug interactions(29)
Known interactions with other medications. Always consult a healthcare professional.
The metabolism of Enflurane can be decreased when combined with Ademetionine.
Trimethadione
Moderate
The metabolism of Trimethadione can be decreased when combined with Ademetionine.
Chlorzoxazone
Moderate
The metabolism of Chlorzoxazone can be decreased when combined with Ademetionine.
Isoflurane
Moderate
The metabolism of Isoflurane can be decreased when combined with Ademetionine.
The metabolism of Ethanol can be decreased when combined with Ademetionine.
Methoxyflurane
Moderate
The metabolism of Methoxyflurane can be decreased when combined with Ademetionine.
The metabolism of Halothane can be decreased when combined with Ademetionine.
Sevoflurane
Moderate
The metabolism of Sevoflurane can be decreased when combined with Ademetionine.
Nilvadipine
Moderate
The metabolism of Nilvadipine can be decreased when combined with Ademetionine.
The metabolism of Aniline can be decreased when combined with Ademetionine.
Benzyl alcohol
Moderate
The metabolism of Benzyl alcohol can be decreased when combined with Ademetionine.
The metabolism of Felbamate can be decreased when combined with Ademetionine.
Cenobamate
Moderate
The metabolism of Cenobamate can be decreased when combined with Ademetionine.
Carvedilol
Moderate
The metabolism of Carvedilol can be decreased when combined with Ademetionine.
The metabolism of Phenytoin can be decreased when combined with Ademetionine.
Fingolimod
Moderate
The metabolism of Fingolimod can be decreased when combined with Ademetionine.
Ethosuximide
Moderate
The metabolism of Ethosuximide can be decreased when combined with Ademetionine.
Selumetinib
Moderate
The metabolism of Selumetinib can be decreased when combined with Ademetionine.
The metabolism of Primidone can be decreased when combined with Ademetionine.
Benzocaine
Moderate
The metabolism of Benzocaine can be decreased when combined with Ademetionine.
Rosiglitazone
Moderate
The metabolism of Rosiglitazone can be decreased when combined with Ademetionine.
The metabolism of Tamoxifen can be decreased when combined with Ademetionine.
Trabectedin
Moderate
The metabolism of Trabectedin can be decreased when combined with Ademetionine.
Theophylline
Moderate
The metabolism of Theophylline can be decreased when combined with Ademetionine.
Aminophylline
Moderate
The metabolism of Aminophylline can be decreased when combined with Ademetionine.
Phenobarbital
Moderate
The metabolism of Phenobarbital can be decreased when combined with Ademetionine.
Acetaminophen
Moderate
Ademetionine may increase the hepatotoxic activities of Acetaminophen.
Propacetamol
Moderate
Ademetionine may increase the hepatotoxic activities of Propacetamol.
Pirfenidone
Moderate
The metabolism of Pirfenidone can be decreased when combined with Ademetionine.
Showing 29 of 29 interactions
Toxicity & overdose
Irritating to mucus membranes and upper respiratory tract. Can cause CNS depression.
How it works
Mechanism of action
S-Adenosylmethionine (SAMe) is a natural substance present in the cells of the body. It is a direct metabolite of the essential amino acid L-methionine. SAMe plays a crucial biochemical role in the body by donating a one-carbon methyl group in a process called transmethylation. SAMe, formed from the reaction of L-methionine and adenosine triphosphate catalyzed by the enzyme S-adenosylmethionine synthetase, is the methyl-group donor in the biosynthesis of both DNA and RNA nucleic acids, phospholipids, proteins, epinephrine, melatonin, creatine and other molecules.
Pharmacodynamics
S-adenosylmethionine is an intermediate metabolite of methionine. Its involvement in methylation assists in cellular growth and repair, maintains the phospho-bilipid layer in cell membranes. It also helps in the maintenance of the action of several hormones and neurotransmitters that affect mood. Highest concentration are found in the brain and the liver.
Pharmacokinetics
How the body processes this drug — absorption, distribution, metabolism, and elimination
Absorption
S-Adenosylmethionine is absorbed from the small intestine following oral intake. As absorption is affected by food, it is best to take on an empty stomach. Bioavailability is low following oral intake.
Metabolism
Significant first-pass metabolism in the liver. Approximately 50% of S-Adenosylmethionine (SAMe) is metabolized in the liver. SAMe is metabolized to S-adenosylhomocysteine, which is then metabolized to homocysteine.
Homocysteine can either be metabolized to cystathionine and then cysteine or to methionine. The cofactor in the metabolism of homocysteine to cysteine is vitamin B6. Cofactors for the metabolism of homocysteine to methionine are folic acid, vitamin B12 and betaine.
Homocysteine can either be metabolized to cystathionine and then cysteine or to methionine. The cofactor in the metabolism of homocysteine to cysteine is vitamin B6. Cofactors for the metabolism of homocysteine to methionine are folic acid, vitamin B12 and betaine.
Drug targets(8)
Proteins and enzymes this drug interacts with in the body
Catechol O-methyltransferase
COMT
cofactor
Specific functioncatechol O-methyltransferase activity
Cellular location
Cytoplasm
General function & pharmacology
Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
CMTR1
Specific functionmRNA (nucleoside-2'-O-)-methyltransferase activity
Cellular location
Nucleus
General function & pharmacology
S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts.
Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway
Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway
Arsenite methyltransferase
AS3MT
Specific functionarsenite methyltransferase activity
Cellular location
Cytoplasm, cytosol
General function & pharmacology
Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals .
PMID:16407288 PMID:25997655
It methylates arsenite to form methylarsonate, Me-AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2 .
PMID:16407288 PMID:25997655
Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH PMID:16407288 PMID:25997655
PMID:16407288 PMID:25997655
It methylates arsenite to form methylarsonate, Me-AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2 .
PMID:16407288 PMID:25997655
Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH PMID:16407288 PMID:25997655
Glycine N-methyltransferase
GNMT
cofactor
Specific functionfolic acid binding
Cellular location
Cytoplasm
General function & pharmacology
Catalyzes the methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy), a reaction regulated by the binding of 5-methyltetrahydrofolate. Plays an important role in the regulation of methyl group metabolism by regulating the ratio between S-adenosyl-L-methionine and S-adenosyl-L-homocysteine
S-adenosylmethionine decarboxylase proenzyme
AMD1
cofactor
Specific functionadenosylmethionine decarboxylase activity
General function & pharmacology
Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels
Metabolizing enzymes(2)
Enzymes involved in drug metabolism — important for understanding drug interactions
Enzyme activity key
substrate
inhibitor
inducer
SRMSpermidine synthase
substrate
CYP2E1Cytochrome P450 2E1
inhibitor
Biological pathways(978)
metabolic
Involved compounds
Oxogluric acid,2-Amino-3-Ketobutyric Acid,2-Oxobutanoic Acid,3-Hydroxypyruvic Acid,Adenosine phosphate,ATP,Aminolevulinic acid,Creatine,D-Serine,N,N-dimethylglycine,Pyrophosphoric acid,Flavin adenine dinucleotide,Formaldehyde,Glycine,Glyoxylic acid,Alanine,Arginine,Cysteine,Glutamic acid,Methionine,Serine,Magnesium cation,Glycocyamine,NADH,Orotidylic acid,Dexfosfoserine,Pyridoxal phosphate,Pyruvic acid,Pyruvaldehyde,Ademetionine,Tetrahydrofolic acid,Zinc
metabolic
Involved compounds
Oxogluric acid,1,2-Dihydroxybenzene,2-(3,4-Dihydroxyphenyl)Acetic Acid,Homogentisic acid,4-Hydroxyphenylpyruvic acid,Acetoacetic acid,Calcium,Dopamine,Epinephrine,Flavin adenine dinucleotide,Iron,Aspartic acid,Glutamic acid,Tyrosine,Levodopa,Magnesium cation,Maleic acid,Methylamine,NADH,Norepinephrine,Pyridoxal phosphate,Pyrroloquinoline Quinone,Ademetionine,Sapropterin,Ascorbic acid,Zinc
metabolic
metabolic
Involved compounds
Oxogluric acid,3,4-Dihydro-2h-Pyrrolium-5-Carboxylate,4-Carboxy-4-Aminobutanal,Adenosine phosphate,ATP,Creatine,Pyrophosphoric acid,Flavin adenine dinucleotide,Glycine,Arginine,Aspartic acid,Citrulline,Glutamic acid,Ornithine,Proline,Maleic acid,Mesoheme,Glycocyamine,N(5)-[(hydroxyamino)(imino)methyl]-L-ornithine,NADH,Nitric Oxide,Pyridoxal phosphate,Flavin mononucleotide,Ademetionine,Succinic acid,Sapropterin,Urea
metabolic
Involved compounds
2-Oxobutanoic Acid,4-methylthio-2-oxobutanoic acid,Adenosine,Adenosine phosphate,ATP,Choline,N,N-dimethylglycine,Pyrophosphoric acid,Flavin adenine dinucleotide,Glycine,Cysteine,L-Homoserine,Methionine,Serine,Magnesium cation,NADH,Potassium cation,Putrescine,Pyridoxal phosphate,Ademetionine,Spermidine,Tetrahydrofolic acid,Zinc
metabolic
metabolic
Involved compounds
Oxogluric acid,Indoleacetic acid,Tryptamine,3-hydroxyanthranilic acid,Anthranilic acid,ATP,Pyrophosphoric acid,Flavin adenine dinucleotide,Formic acid,Iron,Kynurenine,Alanine,Glutamic acid,Tryptophan,Melatonin,Mesoheme,N-acetylserotonin,NADH,Oxitriptan,Pyridoxal phosphate,Quinolinic Acid,Ademetionine,Sapropterin
metabolic
Involved compounds
metabolic
disease
Involved compounds
Oxogluric acid,1,2-Dihydroxybenzene,2-(3,4-Dihydroxyphenyl)Acetic Acid,Homogentisic acid,4-Hydroxyphenylpyruvic acid,Acetoacetic acid,Calcium,Dopamine,Epinephrine,Flavin adenine dinucleotide,Iron,Aspartic acid,Glutamic acid,Tyrosine,Levodopa,Magnesium cation,Maleic acid,Methylamine,NADH,Norepinephrine,Pyridoxal phosphate,Pyrroloquinoline Quinone,Ademetionine,Sapropterin,Ascorbic acid,Zinc
Involved compounds
2-Oxobutanoic Acid,4-methylthio-2-oxobutanoic acid,Adenosine,Adenosine phosphate,ATP,Choline,N,N-dimethylglycine,Pyrophosphoric acid,Flavin adenine dinucleotide,Glycine,Cysteine,L-Homoserine,Methionine,Serine,Magnesium cation,NADH,Potassium cation,Putrescine,Pyridoxal phosphate,Ademetionine,Spermidine,Tetrahydrofolic acid,Zinc
Involved compounds
Oxogluric acid,2-Amino-3-Ketobutyric Acid,2-Oxobutanoic Acid,3-Hydroxypyruvic Acid,Adenosine phosphate,ATP,Aminolevulinic acid,Creatine,D-Serine,N,N-dimethylglycine,Pyrophosphoric acid,Flavin adenine dinucleotide,Formaldehyde,Glycine,Glyoxylic acid,Alanine,Arginine,Cysteine,Glutamic acid,Methionine,Serine,Magnesium cation,Glycocyamine,NADH,Orotidylic acid,Dexfosfoserine,Pyridoxal phosphate,Pyruvic acid,Pyruvaldehyde,Ademetionine,Tetrahydrofolic acid,Zinc
Involved compounds
Oxogluric acid,3,4-Dihydro-2h-Pyrrolium-5-Carboxylate,4-Carboxy-4-Aminobutanal,Adenosine phosphate,ATP,Creatine,Pyrophosphoric acid,Flavin adenine dinucleotide,Glycine,Arginine,Aspartic acid,Citrulline,Glutamic acid,Ornithine,Proline,Maleic acid,Mesoheme,Glycocyamine,N(5)-[(hydroxyamino)(imino)methyl]-L-ornithine,NADH,Nitric Oxide,Pyridoxal phosphate,Flavin mononucleotide,Ademetionine,Succinic acid,Sapropterin,Urea
disease
Involved compounds
Oxogluric acid,1,2-Dihydroxybenzene,2-(3,4-Dihydroxyphenyl)Acetic Acid,Homogentisic acid,4-Hydroxyphenylpyruvic acid,Acetoacetic acid,Calcium,Dopamine,Epinephrine,Flavin adenine dinucleotide,Iron,Aspartic acid,Glutamic acid,Tyrosine,Levodopa,Magnesium cation,Maleic acid,Methylamine,NADH,Norepinephrine,Pyridoxal phosphate,Pyrroloquinoline Quinone,Ademetionine,Sapropterin,Ascorbic acid,Zinc
disease
disease
Involved compounds
Oxogluric acid,3,4-Dihydro-2h-Pyrrolium-5-Carboxylate,4-Carboxy-4-Aminobutanal,Adenosine phosphate,ATP,Creatine,Pyrophosphoric acid,Flavin adenine dinucleotide,Glycine,Arginine,Aspartic acid,Citrulline,Glutamic acid,Ornithine,Proline,Maleic acid,Mesoheme,Glycocyamine,N(5)-[(hydroxyamino)(imino)methyl]-L-ornithine,NADH,Nitric Oxide,Pyridoxal phosphate,Flavin mononucleotide,Ademetionine,Succinic acid,Sapropterin,Urea
disease
Involved compounds
Oxogluric acid,3,4-Dihydro-2h-Pyrrolium-5-Carboxylate,4-Carboxy-4-Aminobutanal,Adenosine phosphate,ATP,Creatine,Pyrophosphoric acid,Flavin adenine dinucleotide,Glycine,Arginine,Aspartic acid,Citrulline,Glutamic acid,Ornithine,Proline,Maleic acid,Mesoheme,Glycocyamine,N(5)-[(hydroxyamino)(imino)methyl]-L-ornithine,NADH,Nitric Oxide,Pyridoxal phosphate,Flavin mononucleotide,Ademetionine,Succinic acid,Sapropterin,Urea
Involved compounds
2-Oxobutanoic Acid,4-methylthio-2-oxobutanoic acid,Adenosine,Adenosine phosphate,ATP,Choline,N,N-dimethylglycine,Pyrophosphoric acid,Flavin adenine dinucleotide,Glycine,Cysteine,L-Homoserine,Methionine,Serine,Magnesium cation,NADH,Potassium cation,Putrescine,Pyridoxal phosphate,Ademetionine,Spermidine,Tetrahydrofolic acid,Zinc
disease
Involved compounds
Oxogluric acid,1,2-Dihydroxybenzene,2-(3,4-Dihydroxyphenyl)Acetic Acid,Homogentisic acid,4-Hydroxyphenylpyruvic acid,Acetoacetic acid,Calcium,Dopamine,Epinephrine,Flavin adenine dinucleotide,Iron,Aspartic acid,Glutamic acid,Tyrosine,Levodopa,Magnesium cation,Maleic acid,Methylamine,NADH,Norepinephrine,Pyridoxal phosphate,Pyrroloquinoline Quinone,Ademetionine,Sapropterin,Ascorbic acid,Zinc
Involved compounds
2-Oxobutanoic Acid,4-methylthio-2-oxobutanoic acid,Adenosine,Adenosine phosphate,ATP,Choline,N,N-dimethylglycine,Pyrophosphoric acid,Flavin adenine dinucleotide,Glycine,Cysteine,L-Homoserine,Methionine,Serine,Magnesium cation,NADH,Potassium cation,Putrescine,Pyridoxal phosphate,Ademetionine,Spermidine,Tetrahydrofolic acid,Zinc
Involved compounds
2-Oxobutanoic Acid,4-methylthio-2-oxobutanoic acid,Adenosine,Adenosine phosphate,ATP,Choline,N,N-dimethylglycine,Pyrophosphoric acid,Flavin adenine dinucleotide,Glycine,Cysteine,L-Homoserine,Methionine,Serine,Magnesium cation,NADH,Potassium cation,Putrescine,Pyridoxal phosphate,Ademetionine,Spermidine,Tetrahydrofolic acid,Zinc
disease
Involved compounds
Oxogluric acid,2-Amino-3-Ketobutyric Acid,2-Oxobutanoic Acid,3-Hydroxypyruvic Acid,Adenosine phosphate,ATP,Aminolevulinic acid,Creatine,D-Serine,N,N-dimethylglycine,Pyrophosphoric acid,Flavin adenine dinucleotide,Formaldehyde,Glycine,Glyoxylic acid,Alanine,Arginine,Cysteine,Glutamic acid,Methionine,Serine,Magnesium cation,Glycocyamine,NADH,Orotidylic acid,Dexfosfoserine,Pyridoxal phosphate,Pyruvic acid,Pyruvaldehyde,Ademetionine,Tetrahydrofolic acid,Zinc
Involved compounds
Oxogluric acid,2-Amino-3-Ketobutyric Acid,2-Oxobutanoic Acid,3-Hydroxypyruvic Acid,Adenosine phosphate,ATP,Aminolevulinic acid,Creatine,D-Serine,N,N-dimethylglycine,Pyrophosphoric acid,Flavin adenine dinucleotide,Formaldehyde,Glycine,Glyoxylic acid,Alanine,Arginine,Cysteine,Glutamic acid,Methionine,Serine,Magnesium cation,Glycocyamine,NADH,Orotidylic acid,Dexfosfoserine,Pyridoxal phosphate,Pyruvic acid,Pyruvaldehyde,Ademetionine,Tetrahydrofolic acid,Zinc
disease
Involved compounds
Oxogluric acid,2-Amino-3-Ketobutyric Acid,2-Oxobutanoic Acid,3-Hydroxypyruvic Acid,Adenosine phosphate,ATP,Aminolevulinic acid,Creatine,D-Serine,N,N-dimethylglycine,Pyrophosphoric acid,Flavin adenine dinucleotide,Formaldehyde,Glycine,Glyoxylic acid,Alanine,Arginine,Cysteine,Glutamic acid,Methionine,Serine,Magnesium cation,Glycocyamine,NADH,Orotidylic acid,Dexfosfoserine,Pyridoxal phosphate,Pyruvic acid,Pyruvaldehyde,Ademetionine,Tetrahydrofolic acid,Zinc
Involved compounds
2-Oxobutanoic Acid,4-methylthio-2-oxobutanoic acid,Adenosine,Adenosine phosphate,ATP,Choline,N,N-dimethylglycine,Pyrophosphoric acid,Flavin adenine dinucleotide,Glycine,Cysteine,L-Homoserine,Methionine,Serine,Magnesium cation,NADH,Potassium cation,Putrescine,Pyridoxal phosphate,Ademetionine,Spermidine,Tetrahydrofolic acid,Zinc
disease
Involved compounds
2-Oxobutanoic Acid,4-methylthio-2-oxobutanoic acid,Adenosine,Adenosine phosphate,ATP,Choline,N,N-dimethylglycine,Pyrophosphoric acid,Flavin adenine dinucleotide,Glycine,Cysteine,L-Homoserine,Methionine,Serine,Magnesium cation,NADH,Potassium cation,Putrescine,Pyridoxal phosphate,Ademetionine,Spermidine,Tetrahydrofolic acid,Zinc
disease
Involved compounds
Oxogluric acid,3,4-Dihydro-2h-Pyrrolium-5-Carboxylate,4-Carboxy-4-Aminobutanal,Adenosine phosphate,ATP,Creatine,Pyrophosphoric acid,Flavin adenine dinucleotide,Glycine,Arginine,Aspartic acid,Citrulline,Glutamic acid,Ornithine,Proline,Maleic acid,Mesoheme,Glycocyamine,N(5)-[(hydroxyamino)(imino)methyl]-L-ornithine,NADH,Nitric Oxide,Pyridoxal phosphate,Flavin mononucleotide,Ademetionine,Succinic acid,Sapropterin,Urea
disease
Involved compounds
Oxogluric acid,3,4-Dihydro-2h-Pyrrolium-5-Carboxylate,4-Carboxy-4-Aminobutanal,Adenosine phosphate,ATP,Creatine,Pyrophosphoric acid,Flavin adenine dinucleotide,Glycine,Arginine,Aspartic acid,Citrulline,Glutamic acid,Ornithine,Proline,Maleic acid,Mesoheme,Glycocyamine,N(5)-[(hydroxyamino)(imino)methyl]-L-ornithine,NADH,Nitric Oxide,Pyridoxal phosphate,Flavin mononucleotide,Ademetionine,Succinic acid,Sapropterin,Urea
Involved compounds
Oxogluric acid,3,4-Dihydro-2h-Pyrrolium-5-Carboxylate,4-Carboxy-4-Aminobutanal,Adenosine phosphate,ATP,Creatine,Pyrophosphoric acid,Flavin adenine dinucleotide,Glycine,Arginine,Aspartic acid,Citrulline,Glutamic acid,Ornithine,Proline,Maleic acid,Mesoheme,Glycocyamine,N(5)-[(hydroxyamino)(imino)methyl]-L-ornithine,NADH,Nitric Oxide,Pyridoxal phosphate,Flavin mononucleotide,Ademetionine,Succinic acid,Sapropterin,Urea
Involved compounds
Oxogluric acid,3,4-Dihydro-2h-Pyrrolium-5-Carboxylate,4-Carboxy-4-Aminobutanal,Adenosine phosphate,ATP,Creatine,Pyrophosphoric acid,Flavin adenine dinucleotide,Glycine,Arginine,Aspartic acid,Citrulline,Glutamic acid,Ornithine,Proline,Maleic acid,Mesoheme,Glycocyamine,N(5)-[(hydroxyamino)(imino)methyl]-L-ornithine,NADH,Nitric Oxide,Pyridoxal phosphate,Flavin mononucleotide,Ademetionine,Succinic acid,Sapropterin,Urea
Involved compounds
Uric acid,2'-Deoxyguanosine-5'-Monophosphate,Adenine,Adenosine,Adenosine phosphate,ATP,AICA ribonucleotide,5-O-phosphono-alpha-D-ribofuranosyl diphosphate,Azathioprine,Calcium,Cyclic adenosine monophosphate,Pyrophosphoric acid,Flavin adenine dinucleotide,Glycine,Guanine,Guanosine,Guanosine-5'-Monophosphate,Hypoxanthine,Inosine,Aspartic acid,Glutamic acid,L-Glutamine,Magnesium cation,Maleic acid,Mercaptopurine,Mesoheme,NADH,Potassium cation,Ribose-1-Phosphate,Ademetionine,Tetrahydrofolic acid,Xanthine,Zinc
Involved compounds
Uric acid,2'-Deoxyguanosine-5'-Monophosphate,Adenine,Adenosine,Adenosine phosphate,ATP,AICA ribonucleotide,5-O-phosphono-alpha-D-ribofuranosyl diphosphate,Calcium,Cyclic adenosine monophosphate,Pyrophosphoric acid,Flavin adenine dinucleotide,Glycine,Guanine,Guanosine,Guanosine-5'-Monophosphate,Hypoxanthine,Inosine,Aspartic acid,Glutamic acid,L-Glutamine,Magnesium cation,Maleic acid,Mercaptopurine,Mesoheme,NADH,Potassium cation,Ribose-1-Phosphate,Ademetionine,Tetrahydrofolic acid,Xanthine,Zinc
Involved compounds
Oxogluric acid,1,2-Dihydroxybenzene,2-(3,4-Dihydroxyphenyl)Acetic Acid,Homogentisic acid,4-Hydroxyphenylpyruvic acid,Acetic acid,Acetoacetic acid,Adenosine phosphate,ATP,Calcium,Pyrophosphoric acid,Disulfiram,Dopamine,Epinephrine,Ethanol,Flavin adenine dinucleotide,Iron,Aspartic acid,Glutamic acid,Tyrosine,Levodopa,Magnesium cation,Maleic acid,Mesoheme,Methylamine,NADH,Norepinephrine,Pyridoxal phosphate,Pyrroloquinoline Quinone,Ademetionine,Sapropterin,Ascorbic acid,Zinc
Involved compounds
Uric acid,2'-Deoxyguanosine-5'-Monophosphate,Adenine,Adenosine,Adenosine phosphate,ATP,AICA ribonucleotide,5-O-phosphono-alpha-D-ribofuranosyl diphosphate,Calcium,Cyclic adenosine monophosphate,Pyrophosphoric acid,Flavin adenine dinucleotide,Glycine,Guanine,Guanosine,Guanosine-5'-Monophosphate,Hypoxanthine,Inosine,Aspartic acid,Glutamic acid,L-Glutamine,Magnesium cation,Maleic acid,Mercaptopurine,Mesoheme,NADH,Potassium cation,Ribose-1-Phosphate,Ademetionine,Tetrahydrofolic acid,Tioguanine,Xanthine,Zinc
metabolic
metabolic
Involved compounds
Oxogluric acid,2-Amino-3-Ketobutyric Acid,2-Oxobutanoic Acid,3-Hydroxypyruvic Acid,Adenosine phosphate,ATP,Aminolevulinic acid,Creatine,D-Serine,N,N-dimethylglycine,Pyrophosphoric acid,Flavin adenine dinucleotide,Formaldehyde,Glycine,Glyoxylic acid,Alanine,Arginine,Cysteine,Glutamic acid,Methionine,Serine,Magnesium cation,Glycocyamine,NADH,Orotidylic acid,Dexfosfoserine,Pyridoxal phosphate,Pyruvic acid,Pyruvaldehyde,Ademetionine,Tetrahydrofolic acid,Zinc
disease
Involved compounds
Oxogluric acid,2-Amino-3-Ketobutyric Acid,2-Oxobutanoic Acid,3-Hydroxypyruvic Acid,Adenosine phosphate,ATP,Aminolevulinic acid,Creatine,D-Serine,N,N-dimethylglycine,Pyrophosphoric acid,Flavin adenine dinucleotide,Formaldehyde,Glycine,Glyoxylic acid,Alanine,Arginine,Cysteine,Glutamic acid,Methionine,Serine,Magnesium cation,Glycocyamine,NADH,Orotidylic acid,Dexfosfoserine,Pyridoxal phosphate,Pyruvic acid,Pyruvaldehyde,Ademetionine,Tetrahydrofolic acid,Zinc
Involved compounds
Oxogluric acid,1,2-Dihydroxybenzene,2-(3,4-Dihydroxyphenyl)Acetic Acid,Homogentisic acid,4-Hydroxyphenylpyruvic acid,Acetoacetic acid,Calcium,Dopamine,Epinephrine,Flavin adenine dinucleotide,Iron,Aspartic acid,Glutamic acid,Tyrosine,Levodopa,Magnesium cation,Maleic acid,Methylamine,NADH,Norepinephrine,Pyridoxal phosphate,Pyrroloquinoline Quinone,Ademetionine,Sapropterin,Ascorbic acid,Zinc
Involved compounds
Oxogluric acid,1,2-Dihydroxybenzene,2-(3,4-Dihydroxyphenyl)Acetic Acid,Homogentisic acid,4-Hydroxyphenylpyruvic acid,Acetoacetic acid,Calcium,Dopamine,Epinephrine,Flavin adenine dinucleotide,Iron,Aspartic acid,Glutamic acid,Tyrosine,Levodopa,Magnesium cation,Maleic acid,Methylamine,NADH,Norepinephrine,Pyridoxal phosphate,Pyrroloquinoline Quinone,Ademetionine,Sapropterin,Ascorbic acid,Zinc
Involved compounds
Oxogluric acid,3,4-Dihydro-2h-Pyrrolium-5-Carboxylate,4-Carboxy-4-Aminobutanal,Adenosine phosphate,ATP,Creatine,Pyrophosphoric acid,Flavin adenine dinucleotide,Glycine,Arginine,Aspartic acid,Citrulline,Glutamic acid,Ornithine,Proline,Maleic acid,Mesoheme,Glycocyamine,N(5)-[(hydroxyamino)(imino)methyl]-L-ornithine,NADH,Nitric Oxide,Pyridoxal phosphate,Flavin mononucleotide,Ademetionine,Succinic acid,Sapropterin,Urea
Involved compounds
Oxogluric acid,3,4-Dihydro-2h-Pyrrolium-5-Carboxylate,4-Carboxy-4-Aminobutanal,Adenosine phosphate,ATP,Creatine,Pyrophosphoric acid,Flavin adenine dinucleotide,Glycine,Arginine,Aspartic acid,Citrulline,Glutamic acid,Ornithine,Proline,Maleic acid,Mesoheme,Glycocyamine,N(5)-[(hydroxyamino)(imino)methyl]-L-ornithine,NADH,Nitric Oxide,Pyridoxal phosphate,Flavin mononucleotide,Ademetionine,Succinic acid,Sapropterin,Urea
Involved compounds
Oxogluric acid,3,4-Dihydro-2h-Pyrrolium-5-Carboxylate,4-Carboxy-4-Aminobutanal,Adenosine phosphate,ATP,Creatine,Pyrophosphoric acid,Flavin adenine dinucleotide,Glycine,Arginine,Aspartic acid,Citrulline,Glutamic acid,Ornithine,Proline,Maleic acid,Mesoheme,Glycocyamine,N(5)-[(hydroxyamino)(imino)methyl]-L-ornithine,NADH,Nitric Oxide,Pyridoxal phosphate,Flavin mononucleotide,Ademetionine,Succinic acid,Sapropterin,Urea
Involved compounds
Oxogluric acid,3,4-Dihydro-2h-Pyrrolium-5-Carboxylate,4-Carboxy-4-Aminobutanal,Adenosine phosphate,ATP,Creatine,Pyrophosphoric acid,Flavin adenine dinucleotide,Glycine,Arginine,Aspartic acid,Citrulline,Glutamic acid,Ornithine,Proline,Maleic acid,Mesoheme,Glycocyamine,N(5)-[(hydroxyamino)(imino)methyl]-L-ornithine,NADH,Nitric Oxide,Pyridoxal phosphate,Flavin mononucleotide,Ademetionine,Succinic acid,Sapropterin,Urea
Involved compounds
Oxogluric acid,1,2-Dihydroxybenzene,2-(3,4-Dihydroxyphenyl)Acetic Acid,Homogentisic acid,4-Hydroxyphenylpyruvic acid,Acetoacetic acid,Calcium,Dopamine,Epinephrine,Flavin adenine dinucleotide,Iron,Aspartic acid,Glutamic acid,Tyrosine,Levodopa,Magnesium cation,Maleic acid,Methylamine,NADH,Norepinephrine,Pyridoxal phosphate,Pyrroloquinoline Quinone,Ademetionine,Sapropterin,Ascorbic acid,Zinc
Homocystinuria-Megaloblastic Anemia Due to Defect in Cobalamin Metabolism, cblG Complementation Type
disease
Involved compounds
2-Oxobutanoic Acid,4-methylthio-2-oxobutanoic acid,Adenosine,Adenosine phosphate,ATP,Choline,N,N-dimethylglycine,Pyrophosphoric acid,Flavin adenine dinucleotide,Glycine,Cysteine,L-Homoserine,Methionine,Serine,Magnesium cation,NADH,Potassium cation,Putrescine,Pyridoxal phosphate,Ademetionine,Spermidine,Tetrahydrofolic acid,Zinc
metabolic
Involved compounds
Involved compounds
Oxogluric acid,2-Amino-3-Ketobutyric Acid,2-Oxobutanoic Acid,3-Hydroxypyruvic Acid,Adenosine phosphate,ATP,Aminolevulinic acid,Creatine,D-Serine,N,N-dimethylglycine,Pyrophosphoric acid,Flavin adenine dinucleotide,Formaldehyde,Glycine,Glyoxylic acid,Alanine,Arginine,Cysteine,Glutamic acid,Methionine,Serine,Magnesium cation,Glycocyamine,NADH,Orotidylic acid,Dexfosfoserine,Pyridoxal phosphate,Pyruvic acid,Pyruvaldehyde,Ademetionine,Tetrahydrofolic acid,Zinc
metabolic
metabolic
Scientific references(5)
Finkelstein J.D., Martin J.J.
Homocysteine.
The International Journal of Biochemistry & Cell Biology
200032(4):385-389. doi: 10.1016/s1357-2725(99)00138-7
Fodinger M., Horl W.H., Sunder-Plassmann G.
Recent insights into the molecular genetics of the homocysteine metabolism.
Kidney International
200159(s78):238-242. doi: 10.1046/j.1523-1755.59.s78.58.x
Roje S.
S-Adenosyl-l-methionine: Beyond the universal methyl group donor.
Phytochemistry
200667(15):1686-1698. doi: 10.1016/j.phytochem.2006.04.019
Loenen W.A.
S-Adenosylmethionine: jack of all trades and master of everything?.
Biochemical Society Transactions
200634(2):330. doi: 10.1042/bst20060330
Chiang P.K., Gordon R.K., Tal J., Zeng G.C., Doctor B.P., Pardhasaradhi K., McCann P.P.
S‐Adenosylmetliionine and methylation.
The FASEB Journal
199610(4):471-480. doi: 10.1096/fasebj.10.4.8647346
ATC classification(1 code)
ATC A16AA02
Affected organisms(1)
Humans and other mammals
International brands(4)
Salt forms(5)
Ademetionine butanedisulfonate(DBSALT000873)
Ademetionine disulfate ditosylate(DBSALT000875)
Ademetionine disulfate monotosylate(DBSALT000876)
Ademetionine disulfate tosylate(DBSALT000874)
Ademetionine tosylate(DBSALT000872)
Experimental properties(1)
Chemical identifiers
CAS, UNII, InChI Key and database cross-references
Show
Chemical identifiers
CAS, UNII, InChI Key and database cross-references
Linked compound data from DrugBank Open Data (CC BY-NC 4.0)
Ademetionine
Additional database identifiers
ChemSpider
31982
BindingDB
28422
PDB
SAM
HUGO Gene Nomenclature Committee (HGNC)
HGNC:2228
GenAtlas
COMT
GeneCards
COMT
GenBank Gene Database
M65212
GenBank Protein Database
180920
Guide to Pharmacology
2472
UniProt Accession
COMT_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:21077
GeneCards
CMTR1
UniProt Accession
CMTR1_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:17452
GeneCards
AS3MT
UniProt Accession
AS3MT_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:4415
GenAtlas
GNMT
GeneCards
GNMT
GenBank Gene Database
AF101477
GenBank Protein Database
8671584
UniProt Accession
GNMT_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:457
GenAtlas
AMD1
GeneCards
AMD1
GenBank Gene Database
M21154
GenBank Protein Database
178518
UniProt Accession
DCAM_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:6904
GenAtlas
MAT2A
GeneCards
MAT2A
GenBank Gene Database
X68836
GenBank Protein Database
36327
UniProt Accession
METK2_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:1550
GenAtlas
CBS
GeneCards
CBS
GenBank Gene Database
L19501
GenBank Protein Database
388716
Guide to Pharmacology
1443
UniProt Accession
CBS_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:6903
GenAtlas
MAT1A
GeneCards
MAT1A
GenBank Gene Database
D49357
GenBank Protein Database
220066
UniProt Accession
METK1_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:11296
GenAtlas
SRM
GeneCards
SRM
GenBank Gene Database
M34338
GenBank Protein Database
531202
UniProt Accession
SPEE_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:2631
GeneCards
CYP2E1
GenBank Gene Database
J02625
GenBank Protein Database
181360
Guide to Pharmacology
1330
UniProt Accession
CP2E1_HUMAN
International reference pricing
3 formulations
Reference pricing from DrugBank. Prices are indicative and may not reflect current UK costs.
From $0.59/tablet
To $0.86/tablet
Sam-e 200 mg tablet
$0.59/tablet
CVS Pharmacy sam-e 400 mg tablet
$0.79/tablet
Sam-e 400 mg tablet
$0.86/tablet
Source: DrugBank. Used under CC BY-NC 4.0 academic licence for non-commercial purposes.
DrugBank citations
If you use DrugBank data in your research, please cite the following publications:
Knox C., Wilson M., Klinger C.M., et al
DrugBank 6.
0: the DrugBank Knowledgebase for 2024
Nucleic Acids Res. 2024 Jan 552(D1):D1265-D1275
Wishart D.S., Feunang Y.D., Guo A.C., et al
DrugBank 5.
0: a major update to the DrugBank database for 2018
Nucleic Acids Res. 2017 Nov 846(D1):D1074-D1082
Show earlier publications
Law V., Knox C., Djoumbou Y., et al
DrugBank 4.
0: shedding new light on drug metabolism
Nucleic Acids Res. 2014 Jan 142(1):D1091-7
Knox C., Law V., Jewison T., et al
DrugBank 3.
0: a comprehensive resource for 'omics' research on drugs
Nucleic Acids Res. 2011 Jan39(Database issue):D1035-41
Wishart D.S., Knox C., Guo A.C., et al
DrugBank: a knowledgebase for drugs, drug actions and drug targets.
Nucleic Acids Research
2008 Jan36(Database issue):D901-6
Wishart D.S., Knox C., Guo A.C., et al
DrugBank: a comprehensive resource for in silico drug discovery and exploration.
Nucleic Acids Research
2006 Jan 134(Database issue):D668-72
Source: go.drugbank.comCC BY-NC 4.0
Updated 26 days ago(8 Mar 2026)